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    • 9. 发明申请
    • Nanoemulsion containing nonionic polymers, and its uses
    • 含有非离子聚合物的纳米乳液及其用途
    • US20060030655A1
    • 2006-02-09
    • US11248285
    • 2005-10-13
    • Florence L'AlloretOdile Aubrun-SonnevilleJean-Thierry Simonnet
    • Florence L'AlloretOdile Aubrun-SonnevilleJean-Thierry Simonnet
    • C08K5/10B60C1/00
    • A61Q19/007A61K8/062A61K9/1075A61K2800/21A61K2800/262B01F17/0028B01F17/0085B82Y5/00
    • These objects and others may be accomplished with the present invention, the first embodiment of which provides an oil-in-water nanoemulsion, which includes: an oily phase dispersed in an aqueous phase; (i) at least one amphiphilic lipid selected from the group including nonionic amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and (ii) at least one water-soluble nonionic polymer selected from the group including homopolymers and copolymers of ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone; homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl methyl ether; neutral acrylic homopolymers and copolymers; C1-C2 alkyl celluloses and their derivatives; C1-C3 alkyl guar; C1-C3 hydroxyalkyl guar; and combinations thereof; wherein a ratio of the weight of the oily phase to the weight of the amphiphilic lipid (i) ranges from 1.2 to 10; and wherein the oily phase includes oil globules having a number-average size of less than 100 nm. The nanoemulsion obtained is preferably transparent and stable on storage. It may form a composition for topical, preferably cosmetic or dermatological compositions, pharmaceutical compositions and ophthalmological compositions.
    • 这些目的和其它目的可以用本发明来完成,本发明的第一个实施方案提供了一种水包油纳米乳液,其包括:分散在水相中的油相; (i)至少一种选自包括非离子两亲性脂质,阴离子两亲性脂质及其组合的两亲性脂质; 和(ii)至少一种选自包括环氧乙烷的均聚物和共聚物的水溶性非离子聚合物; 聚乙烯醇; 乙烯基吡咯烷酮的均聚物和共聚物; 乙烯基己内酰胺的均聚物和共聚物; 聚乙烯基甲基醚的均聚物和共聚物; 中性丙烯酸均聚物和共聚物; C 1 -C 2烷基纤维素及其衍生物; C 1 -C 3烷基瓜尔胶; C 1 -C 3羟烷基瓜尔胶; 及其组合; 其中所述油相的重量与所述两亲脂质(i)的重量的比率为1.2至10; 并且其中所述油相包括数均分子量小于100nm的油球。 获得的纳米乳液优选在储存时是透明的和稳定的。 它可以形成用于局部,优选化妆品或皮肤病学组合物,药物组合物和眼科学组合物的组合物。