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1. 发明授权

US08338474B2 Use of phthalimide and/or sulphonamide derivatives in the treatment of diseases which require reducing the TNF-α levels and an exogenous source of nitric oxide, phthalimide derivatives, sulphonamide derivatives, and a method for obtaining a sulphonamide derivative 失效
标题翻译：邻苯二甲酰亚胺和/或磺酰胺衍生物在治疗需要降低TNF-α水平的疾病和外源性一氧化氮，邻苯二甲酰亚胺衍生物，磺酰胺衍生物和获得磺酰胺衍生物的方法中的用途
公开(公告)号：US08338474B2
公开(公告)日：2012-12-25
申请号：US13404777
申请日：2012-02-24
申请人： Jean Leandro Dos Santos , Chin Chung Man , Lídia Moreira Lima , Fernando Ferreira Costa , Carolina Lanaro
发明人： Jean Leandro Dos Santos , Chin Chung Man , Lídia Moreira Lima , Fernando Ferreira Costa , Carolina Lanaro
IPC分类号： A61K31/4035 , C07D209/48 , C07C311/48 , A61P7/06 , A61P29/00
CPC分类号： A61K31/4196 , A61K9/0019
摘要： Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-α levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.
摘要翻译：具有一氧化氮供体特性的邻苯二甲酰亚胺和/或磺酰胺衍生物的制备和用途，具有增加γ珠蛋白基因表达和抗炎和止痛活性的活性，有效治疗需要降低TNF-α水平的血液学疾病和外源性一氧化氮，如镰状细胞病。功能化的邻苯二甲酰亚胺衍生物是从沙利度胺和羟基脲的原型设计的。

2. 发明授权

US07857191B2 Friction stir welding (FSW) methods and systems and friction stir welded components made thereby 有权
标题翻译：摩擦搅拌焊接（FSW）方法和系统以及由此制成的摩擦搅拌焊接部件
公开(公告)号：US07857191B2
公开(公告)日：2010-12-28
申请号：US12140234
申请日：2008-06-16
申请人： Fernando Ferreira Fernandez , Marcio Cruz
发明人： Fernando Ferreira Fernandez , Marcio Cruz
IPC分类号： B23K20/12 , B23K37/00
CPC分类号： B23K20/1265 , B23K20/1255 , B23K33/004 , B64C1/064 , B64C1/12 , B64C3/182 , B64C3/26 , Y10T428/12347
摘要： Friction stir welding (FSW) processes, systems and the resulting friction stir welded components are disclosed whereby first and second workpieces are welded to one another using a first workpiece having mutually orthogonal structural components and a junction region therebetween which defines a bearing surface of predetermined geometry. A shoulder of a FSW tool may be brought into bearing contact with the bearing surface so that a pin extending from the shoulder of the FSW tool may be advanced into and through the one structural component of the first workpiece at an angle relative thereto so as to thereby form a friction stir weld region between the first and second workpieces. Some preferred embodiments will provide a bearing surface which defines an arcuately concave geometry, in which case the shoulder of the FSW tool defines an arcuately convex geometry conformably mateable with the bearing surface. According to other preferred embodiments, the bearing surface defines an arcuately convex geometry, in which case the shoulder of the FSW tool defines an arcuately concave geometry conformably mateable with the bearing surface. According to yet other preferred embodiments, the bearing surface and the shoulder of the FSW tool are each planar.
摘要翻译：公开了摩擦搅拌焊接（FSW）工艺，系统和所产生的摩擦搅拌焊接部件，由此使用具有相互正交的结构部件的第一工件和它们之间的接合区域将第一和第二工件彼此焊接，从而限定了预定几何形状的轴承表面。可以将FSW工具的肩部与支承面承载接触，使得从FSW工具的肩部延伸的销可以相对于第一工件的一个角度前进并穿过第一工件的一个结构部件，以便从而在第一和第二工件之间形成摩擦搅拌焊接区域。一些优选实施例将提供限定弓形凹形几何形状的支承表面，在这种情况下，FSW工具的肩部限定了与支承表面一致地适配的弧形几何形状。根据其它优选实施例，支承表面限定了弧形凸起的几何形状，在这种情况下，FSW工具的肩部限定了与支承表面一致地适配的弓形凹形几何形状。根据其他优选实施例，FSW工具的支承表面和肩部都是平面的。

3. 发明授权

US11359897B2 Bullet 有权
公开(公告)号：US11359897B2
公开(公告)日：2022-06-14
申请号：US17056329
申请日：2019-07-12
申请人： Fernando Ferreira Mendes
发明人： Fernando Ferreira Mendes
IPC分类号： F42B14/02 , F42B12/74
摘要： The present invention relates to a bullet. More particularly, the present invention relates to a bullet including concentric and sequentially ordered cylindrical fore, intermediate and aft portions. The aft portion comprises a cross-sectional diameter about equal to the diameter measured across the rifle landings of the riffled barrel operatively to create a gas pressure build up there-behind while the rifling grooves and lands deform and/or cut the aft portion thereby to impart spin to the bullet about the central axial axis thereof. The intermediate portion comprises a cross-sectional diameter smaller than that of the aft portion, which acts as a bearing surface for operatively riding along the rifling lands thereby to inhibit yawing of the bullet while operatively travelling through the rifled barrel. The fore portion comprises a cross-sectional diameter smaller than that of the intermediate portion with an annular stamping surface, for operatively providing a clean cut circular hunting wound, located at or near an interface between the fore and intermediate portions.

4. 发明授权

US09623226B2 Device for efficient delivery of compounds to or through the skin or biological barriers, using light-absorbing thin films 有权
公开(公告)号：US09623226B2
公开(公告)日：2017-04-18
申请号：US14113148
申请日：2012-04-19
申请人： Goncalo Fernando Ferreira De Sa , Carlos Alberto Lourenco De Serpa Soares , Luis Guilherme Da Silva Arnaut Moreira
发明人： Goncalo Fernando Ferreira De Sa , Carlos Alberto Lourenco De Serpa Soares , Luis Guilherme Da Silva Arnaut Moreira
IPC分类号： A61M37/00 , A61K41/00 , G10K15/04 , A61N5/06 , C12N15/87
CPC分类号： A61M37/0092 , A61K41/0047 , A61M37/00 , A61N5/06 , C12N15/87 , G10K15/046
摘要： This invention refers to a device capable of rapidly and efficiently converting the energy in a laser pulse into a high-impulse broadband pressure wave and to its applications in the transient permeabilization of a biological membrane, including the outer layers of the skin, without causing damage or discomfort. A method to deliver drugs and biologically active compounds to or through the skin, or biological barriers, with this device is also disclosed.

5. 发明授权

US09067961B2 Thiocarbon-protecting groups for RNA synthesis 有权
标题翻译：用于RNA合成的硫代保护基团
公开(公告)号：US09067961B2
公开(公告)日：2015-06-30
申请号：US13485592
申请日：2012-05-31
申请人： Douglas J. Dellinger , Agnieszka B. Sierzchala , John Turner , Joel Myerson , Zoltan Kupihar , Fernando Ferreira , Marvin H. Caruthers , Geraldine F. Dellinger
发明人： Douglas J. Dellinger , Agnieszka B. Sierzchala , John Turner , Joel Myerson , Zoltan Kupihar , Fernando Ferreira , Marvin H. Caruthers , Geraldine F. Dellinger
IPC分类号： C07H13/12 , C07H21/02 , C07H19/073 , C07H19/16
CPC分类号： C07H19/073 , C07H13/12 , C07H19/16 , C07H21/02 , Y02P20/55
摘要： Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.
摘要翻译：本发明的方面包括2'受保护的核苷单体，其在2'位置被硫代保护基团保护。感兴趣的硫代碳保护基包括硫代碳酸酯，硫代碳酸酯，二硫代碳酸酯基，以及硫羰氨基保护基。本发明的方面还包括包含本发明的保护基团的核酸以及使用本发明的保护基合成核酸的方法。

6. 发明授权

US08628307B2 Proximity-sensor support, a compressor, a valve plate and a cooler 失效
标题翻译：接近传感器支持，压缩机，阀板和冷却器
公开(公告)号：US08628307B2
公开(公告)日：2014-01-14
申请号：US10556254
申请日：2004-03-19
申请人： Dietmar Erich Bernhard Lilie , Orlando Starke , Alberto Bruno Feldmann , Ingwald Wollrath , Nerian Fernando Ferreira
发明人： Dietmar Erich Bernhard Lilie , Orlando Starke , Alberto Bruno Feldmann , Ingwald Wollrath , Nerian Fernando Ferreira
IPC分类号： G01D21/00 , F04B39/10
CPC分类号： F04B39/1066 , F04B2201/0201
摘要： One describes a support for a proximity sensor to sense the proximity of a piston of a compressor, a compressor proper, a valve plate of a compressor and a cooler provided with these pieces of equipment. One of the objectives of the present invention is achieved by means of a support for a proximity sensor for sensing the proximity of a piston of a compressor comprising a cylinder for the piston, the cylinder being associated to a valve plate, configuring a high-pressure region inside the cylinder and a low-pressure region outside the cylinder, the support comprising a base structure, a first connection end portion and a second connection end portion, the proximity sensor being associated to the high-pressure and the base structure extending as far as the low-pressure region.
摘要翻译：描述了用于感测压缩机的活塞，压缩机本体，压缩机的阀板和设置有这些设备的冷却器的接近度的接近传感器的支撑。本发明的目的之一是通过用于接近传感器的支撑来实现，该接近传感器用于感测压缩机的活塞的接近度，该压缩机包括用于活塞的气缸，气缸与阀板相关联，构成高压气缸内部的低压区域和气缸外部的低压区域，所述支撑件包括基部结构，第一连接端部和第二连接端部，所述接近传感器与所述高压和所述基部结构相关联地延伸至远作为低压区域。

7. 发明授权

US08314255B2 Use of phthalimide and/or sulphonamide derivatives in the treatment of diseases which require reducing the TNF- α levels and an exogenous source of nitric oxide, phthalimide derivatives, sulphonamide derivatives, and a method for obtaining a sulphonamide derivative 失效
标题翻译：邻苯二甲酰亚胺和/或磺酰胺衍生物在治疗需要降低TNF-α水平的疾病和外源性一氧化氮，邻苯二甲酰亚胺衍生物，磺酰胺衍生物和获得磺酰胺衍生物的方法中的应用
公开(公告)号：US08314255B2
公开(公告)日：2012-11-20
申请号：US13404634
申请日：2012-02-24
申请人： Jean Leandro Dos Santos , Chin Chung Man , Lidia Moreira Lima , Fernando Ferreira Costa , Carolina Lanaro
发明人： Jean Leandro Dos Santos , Chin Chung Man , Lidia Moreira Lima , Fernando Ferreira Costa , Carolina Lanaro
IPC分类号： C07D209/44
CPC分类号： A61K31/4196 , A61K9/0019
摘要： Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-α levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.
摘要翻译：具有一氧化氮供体特性的邻苯二甲酰亚胺和/或磺酰胺衍生物的制备和用途，具有增加γ珠蛋白基因表达和抗炎和止痛活性的活性，有效治疗需要降低TNF-α水平的血液学疾病和外源性一氧化氮，如镰状细胞病。功能化的邻苯二甲酰亚胺衍生物是从沙利度胺和羟基脲的原型设计的。

8. 发明申请

US20120245364A1 USE OF PHTHALIMIDE AND/OR SULPHONAMIDE DERIVATIVES IN THE TREATMENT OF DISEASES WHICH REQUIRE REDUCING THE TNF-alpha LEVELS AND AN EXOGENOUS SOURCE OF NITRIC OXIDE, PHTHALIMIDE DERIVATIVES, SULPHONAMIDE DERIVATIVES, AND A METHOD FOR OBTAINING A SULPHONAMIDE DERIVATIVE 失效
公开(公告)号：US20120245364A1
公开(公告)日：2012-09-27
申请号：US13404777
申请日：2012-02-24
申请人： Jean Leandro DOS SANTOS , Chin CHUNG MAN , Lídia MOREIRA LIMA , Fernando FERREIRA COSTA , Carolina LANARO
发明人： Jean Leandro DOS SANTOS , Chin CHUNG MAN , Lídia MOREIRA LIMA , Fernando FERREIRA COSTA , Carolina LANARO
IPC分类号： C07D209/48
CPC分类号： A61K31/4196 , A61K9/0019
摘要： Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-α levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.

9. 发明申请

US20110222671A1 PHONE CALL RECORDING DEVICE TO TELEPHONE APPARATUS WITH USB CONNECTION 审中-公开
标题翻译：电话呼叫记录设备到USB连接的电话设备
公开(公告)号：US20110222671A1
公开(公告)日：2011-09-15
申请号：US12673540
申请日：2008-08-14
申请人： Fernando Ferreira
发明人： Fernando Ferreira
IPC分类号： H04M1/64
CPC分类号： H04M1/656 , H04M1/0289
摘要： Represented by an inventive solution that aggregates value to the telephone apparatus by providing recording, storage, audio and data transmission of phone calls from a single telephone apparatus (A) without the need of being permanently connected to a peripheral device (C), such as a computer, being such device now claimed uses a microprocessor (5) that connected to a telephone interface (7) recognizes the start and the end of the phone call, starting the recording in the flash memory (6), where this memory can store a great volume of recordings, and to recover and hear a recorded call the user should handle on (2a) and (2b) buttons; additionally, according to the user's desire, or whenever the indicator light (8) turns on, the recordings should be transferred from the flash memory (6) to a recording device, through an USB interface (3) connection to a peripheral device (C), such as a computer, for example.
摘要翻译：由通过从单个电话设备（A）提供电话呼叫的记录，存储，音频和数据传输而将价值聚合到电话设备的创造性解决方案代替，而不需要永久连接到外围设备（C），例如现在要求使用的这种设备的计算机使用连接到电话接口（7）的微处理器（5），其识别电话呼叫的开始和结束，开始在闪速存储器（6）中的记录，其中该存储器可以存储大量录音，并恢复和听到用户应在（2a）和（2b）按钮上处理的录音电话; 另外，根据用户的要求，或者每当指示灯（8）接通时，记录应通过与外围设备（C）的USB接口（3）连接从闪存（6）传送到记录设备），例如计算机。

10. 发明申请

US20110103973A1 SYSTEM AND METHOD OF CONTROLLING A LINEAR COMPRESSOR 有权
标题翻译：一种线性压缩机的系统及方法
公开(公告)号：US20110103973A1
公开(公告)日：2011-05-05
申请号：US12918681
申请日：2009-02-20
申请人： Paulo Sergio Dainez , Dietmar Erich Bernhard Lilie , Nerian Fernando Ferreira , Marcelo Knies
发明人： Paulo Sergio Dainez , Dietmar Erich Bernhard Lilie , Nerian Fernando Ferreira , Marcelo Knies
IPC分类号： F04B49/06
CPC分类号： F04B35/045 , F04B49/065 , F04B2201/0206 , H02P25/06
摘要： The present invention relates to a system and method of controlling a linear compressor (10), which is capable of fine-tuning the compressor when necessary, throughout the operating period of the compressor, so that said compressor operates at maximum capacity, wherein the piston (1) achieves a maximum displacement amplitude, closely approaching the cylinder head (2) without colliding with it. The system and the method according to the invention are also intended to control the operation of the linear compressor throughout its operating period, also seeking to maximize its performance and to reduce or optimize its power consumption. According to the present invention, the fine-tuning and control of the operation of the linear compressor are carried out by means of the combination of a technique for controlling a compressor without a sensor, and a technique for controlling the compressor with the aid of a sensor.
摘要翻译：本发明涉及一种控制线性压缩机（10）的系统和方法，该系统和方法能够在压缩机的整个运行周期内根据需要对压缩机进行微调，使得压缩机以最大容量运转，其中活塞（1）实现最大位移振幅，紧密接近气缸盖（2）而不与其碰撞。根据本发明的系统和方法还旨在在其整个运行期间控制线性压缩机的运行，同时寻求使其性能最大化并降低或优化其功率消耗。根据本发明，线性压缩机的操作的微调和控制是通过组合一种用于控制没有传感器的压缩机的技术来实现的，以及一种借助于传感器。

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