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1. 发明申请

US20130247233A1 G PROTEIN COUPLED RECEPTORS AND USES THEREOF 审中-公开
公开(公告)号：US20130247233A1
公开(公告)日：2013-09-19
申请号：US13796312
申请日：2013-03-12
申请人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
发明人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
IPC分类号： C12Q1/68 , C07K14/705
CPC分类号： G01N33/74 , A61K38/00 , C07K14/705 , C07K14/723 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N2333/726 , G01N2500/04 , G01N2500/10 , Y02A50/463 , Y02A50/469 , Y02A50/475 , Y02A50/48
摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.

2. 发明授权

US09708907B2 Apparatus and method for estimating formation lithology using X-ray flourescence 有权
公开(公告)号：US09708907B2
公开(公告)日：2017-07-18
申请号：US13409289
申请日：2012-03-01
申请人： Fusheng Li
发明人： Fusheng Li
IPC分类号： G01N23/223 , E21B49/06 , E21B49/10 , G01N33/24
CPC分类号： E21B49/06 , E21B49/10 , G01N23/223 , G01N33/241 , G01N2223/076
摘要： An apparatus for estimating properties of an earth formation includes a carrier configured to be disposed in a borehole in the earth formation, and a sample retriever configured to remove a sample of the earth formation, the sample including solid components of the earth formation. The apparatus also includes an analysis assembly including a chamber disposed with the carrier and configured to hold the sample, an X-ray source configured to irradiate the sample with X-ray radiation while the sample is disposed in the chamber, and one or more X-ray detectors configured to detect radiation emitted from the sample in response to irradiation from the X-ray source.

3. 发明申请

US20110214189A1 G PROTEIN COUPLED RECEPTORS AND USES THEREOF 有权
公开(公告)号：US20110214189A1
公开(公告)日：2011-09-01
申请号：US12916227
申请日：2010-10-29
申请人： GEORGE A. GAITANARIS , JOHN E. BERGMANN , ALEXANDER GRAGEROV , JOHN HOHMANN , FUSHENG LI , LINDA MADISEN , KELLIE L. MCILWAIN , MARIA N. PAVLOVA , DEMETRI VASSILATIS , HONGKUI ZENG
发明人： GEORGE A. GAITANARIS , JOHN E. BERGMANN , ALEXANDER GRAGEROV , JOHN HOHMANN , FUSHENG LI , LINDA MADISEN , KELLIE L. MCILWAIN , MARIA N. PAVLOVA , DEMETRI VASSILATIS , HONGKUI ZENG
IPC分类号： A61K49/00 , C12N5/10 , C12Q1/02 , A01K67/027
CPC分类号： A01K67/0278 , A01K2217/00 , A01K2217/052 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K49/0008 , C07K14/723 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5023 , G01N2333/726 , G01N2800/04 , G01N2800/28 , G01N2800/50
摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.

4. 发明申请

US20110185439A1 G PROTEIN COUPLED RECEPTORS AND USES THEREOF 审中-公开
标题翻译： G蛋白偶联受体及其用途
公开(公告)号：US20110185439A1
公开(公告)日：2011-07-28
申请号：US12970094
申请日：2010-12-16
申请人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
发明人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
IPC分类号： G01N33/48 , A01K67/027 , C12N15/87 , C12N5/10 , C07K14/47 , C07H21/04 , A61K31/7088 , A61P25/00 , A61P3/00 , C12Q1/68 , A61P9/00 , A61P17/00 , G01N33/53
CPC分类号： G01N33/74 , A61K38/00 , C07K14/705 , C07K14/723 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N2333/726 , G01N2500/04 , G01N2500/10 , Y02A50/463 , Y02A50/469 , Y02A50/475 , Y02A50/48
摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.
摘要翻译：本发明提供GPCR多肽和多核苷酸，重组材料和转基因小鼠，以及其生产方法。多肽和多核苷酸可用于例如诊断和治疗疾病和病症的方法。本发明还提供使用本发明的GPCR多肽和多核苷酸鉴定化合物（例如激动剂或拮抗剂）以及用GPCR多肽，多核苷酸或鉴定的化合物治疗与GPCR功能障碍相关的病症的方法。本发明还提供用于检测与不适当GPCR活性或水平相关的疾病或病症的诊断测定。

5. 发明申请

US20100145398A1 Cancer Treatment Equipment 审中-公开
标题翻译：癌症治疗设备
公开(公告)号：US20100145398A1
公开(公告)日：2010-06-10
申请号：US12514673
申请日：2007-11-05
申请人： Fusheng Li , An Li , Jing Du , Xiaomei Yang
发明人： Fusheng Li , An Li , Jing Du , Xiaomei Yang
IPC分类号： A61N1/00 , A61N1/30
CPC分类号： A61N7/00 , A61B18/18 , A61H7/005 , A61N1/32 , A61N2/002 , A61N5/04
摘要： A cancer treatment equipment includes a case (7), a squeeze-type friction head (1) connected to direct current, a stiction friction head (2) of low-middle frequency current, a friction head (3) with magnetic sheet, a medicated gauze pad fixation clamp (4), a medicated gauze pad (5) and a treatment device of RF, microwave or ultrasonic. The squeeze-type friction head (1) connected to direct current, the stiction friction head (2) of low-middle frequency current and the friction head (3) with magnetic sheet are fixed in the case (7) in parallel. The medicated gauze pad (5) is fixed on the medicated gauze pad fixation clamp (4) on the lower part of the case (7).
摘要翻译：癌症治疗设备包括壳体（7），与直流电连接的挤压式摩擦头（1），低中频电流的静摩擦头（2），具有磁性片的摩擦头（3），药剂纱布固定夹（4），药用纱布垫（5）和RF，微波或超声波处理装置。与直流电连接的挤压式摩擦头（1），低中频电流的静摩擦头（2）和磁片的摩擦头（3）平行地固定在壳体（7）中。药物纱布垫（5）固定在药盒（7）的下部的药物纱布垫固定夹（4）上。

6. 发明申请

US20090178153A1 G PROTEIN COUPLED RECEPTORS AND USES THEREOF 审中-公开
标题翻译： G蛋白偶联受体及其用途
公开(公告)号：US20090178153A1
公开(公告)日：2009-07-09
申请号：US12243731
申请日：2008-10-01
申请人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demitri Vassilatis , Hongkui Zeng
发明人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demitri Vassilatis , Hongkui Zeng
IPC分类号： A01K67/027 , C12Q1/68 , A61K31/7088 , G01N33/53 , C12N15/00 , C12N5/10 , A61K49/00
CPC分类号： G01N33/74 , A61K38/00 , C07K14/705 , C07K14/723 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N2333/726 , G01N2500/04 , G01N2500/10 , Y02A50/463 , Y02A50/469 , Y02A50/475 , Y02A50/48
摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.
摘要翻译：本发明提供GPCR多肽和多核苷酸，重组材料和转基因小鼠，以及其生产方法。多肽和多核苷酸可用于例如诊断和治疗疾病和病症的方法。本发明还提供使用本发明的GPCR多肽和多核苷酸鉴定化合物（例如激动剂或拮抗剂）以及用GPCR多肽，多核苷酸或鉴定的化合物治疗与GPCR功能障碍相关的病症的方法。本发明还提供用于检测与不适当GPCR活性或水平相关的疾病或病症的诊断测定。

7. 发明申请

US20060134109A1 G protein coupled receptors and uses thereof 审中-公开
标题翻译： G蛋白偶联受体及其用途
公开(公告)号：US20060134109A1
公开(公告)日：2006-06-22
申请号：US10527265
申请日：2003-09-09
申请人： George Gaitanaris , John Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie McIlwain , Maria Pavlova , Demitri Vassilatis , Hongkui Zeng
发明人： George Gaitanaris , John Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie McIlwain , Maria Pavlova , Demitri Vassilatis , Hongkui Zeng
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/705
CPC分类号： G01N33/74 , A61K38/00 , C07K14/705 , C07K14/723 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N2333/726 , G01N2500/04 , G01N2500/10 , Y02A50/463 , Y02A50/469 , Y02A50/475 , Y02A50/48
摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.
摘要翻译：本发明提供GPCR多肽和多核苷酸，重组材料和转基因小鼠，以及其生产方法。多肽和多核苷酸可用于例如诊断和治疗疾病和病症的方法。本发明还提供使用本发明的GPCR多肽和多核苷酸鉴定化合物（例如激动剂或拮抗剂）以及用GPCR多肽，多核苷酸或鉴定的化合物治疗与GPCR功能障碍相关的病症的方法。本发明还提供用于检测与不适当GPCR活性或水平相关的疾病或病症的诊断测定。

8. 发明授权

US08476584B2 Methods for sourceless density downhole measurement using pulsed neutron generator 有权
标题翻译：使用脉冲中子发生器的无源密度井下测量方法
公开(公告)号：US08476584B2
公开(公告)日：2013-07-02
申请号：US13222152
申请日：2011-08-31
申请人： Fusheng Li , Xiaogang Han
发明人： Fusheng Li , Xiaogang Han
IPC分类号： G01V5/10
CPC分类号： G01V5/101
摘要： Disclosed is a method for estimating a density of an earth formation penetrated by a borehole. The method includes: emitting a pulse of fast neutrons into the formation during a neutron-pulse time interval; detecting gamma-rays due to inelastic scattering and thermal capture of the emitted neutrons in the formation to provide a gamma-ray energy spectrum due to the inelastic scattering and the thermal capture during a first time interval within the neutron-pulse time interval and to provide a time spectrum of counts or count rates due to thermal capture during a second time interval occurring after the neutron-pulse time interval; determining a macroscopic capture cross section of the formation from a decay in the time spectrum of counts or count rates; determining an elemental weight fraction from the gamma-ray energy spectrum; and estimating the density of the formation using the macroscopic capture cross section and the elemental weight fraction.
摘要翻译：公开了一种用于估计钻孔渗透的地层的密度的方法。该方法包括：在中子脉冲时间间隔期间，将快中子脉冲发射到地层中; 由于在中子脉冲时间间隔期间的第一时间间隔期间由于非弹性散射和热捕获而在地层中发射的中子的非弹性散射和热捕获来检测γ射线以提供伽马射线能谱，并提供在中子脉冲时间间隔后发生的第二时间间隔期间由于热捕获引起的计数或计数率的时间谱; 从计数或计数率的时间谱中的衰减确定地层的宏观捕获截面; 从伽马射线能谱确定元素重量分数; 并使用宏观捕获截面和元素重量分数来估计地层的密度。

9. 发明申请

US20130066605A1 APPARATUS AND METHOD FOR ESTIMATING FORMATION LITHOLOGY USING X-RAY FLOURESCENCE 有权
标题翻译：使用X射线衍射估算地层岩石的装置和方法
公开(公告)号：US20130066605A1
公开(公告)日：2013-03-14
申请号：US13409289
申请日：2012-03-01
申请人： Fusheng Li
发明人： Fusheng Li
IPC分类号： G06F17/10 , G01N23/223
CPC分类号： E21B49/06 , E21B49/10 , G01N23/223 , G01N33/241 , G01N2223/076
摘要： An apparatus for estimating properties of an earth formation includes a carrier configured to be disposed in a borehole in the earth formation, and a sample retriever configured to remove a sample of the earth formation, the sample including solid components of the earth formation. The apparatus also includes an analysis assembly including a chamber disposed with the carrier and configured to hold the sample, an X-ray source configured to irradiate the sample with X-ray radiation while the sample is disposed in the chamber, and one or more X-ray detectors configured to detect radiation emitted from the sample in response to irradiation from the X-ray source.
摘要翻译：用于估计地层的性质的装置包括构造成设置在地层中的钻孔中的载体和被构造成移除地层的样品的样本捕获器，样品包括地层的固体组分。该装置还包括分析组件，其包括设置有载体并被配置为保持样品的腔室; X射线源，被配置为在样品设置在腔室中时用X射线辐射照射样品，以及一个或多个X 射线检测器被配置为响应于来自X射线源的照射来检测从样品发射的辐射。

10. 发明申请

US20120275570A1 AUTO GRID MOVING DEVICE FOR DIAGNOSTIC X RAY TABLE 有权
标题翻译：自动网格移动装置，用于诊断X射线表
公开(公告)号：US20120275570A1
公开(公告)日：2012-11-01
申请号：US13436842
申请日：2012-03-31
申请人： Yuqing Li , Fusheng Li , Yingjie Jia , Weining Xi
发明人： Yuqing Li , Fusheng Li , Yingjie Jia , Weining Xi
IPC分类号： G21K1/00
CPC分类号： A61B6/583 , A61B6/0457 , A61B6/4291
摘要： An auto grid moving apparatus for an X ray imaging device is provided. The apparatus includes: a grid; a grid holder on which the grid is disposed; a fixing base; and a double sided timing belt geared with at least two timing wheels at the two ends of the timing belt on the inner side face of the timing belt and geared with the grid holder at the outer side face of the timing belt, wherein one of the timing wheels has a motor disposed thereon, the motor being configured to drive the timing wheel to move the timing belt and to drive the grid holder to move.
摘要翻译：提供了一种用于X射线成像装置的自动格栅移动装置。该装置包括：电网; 栅格架设在其上; 固定底座; 以及双面正时皮带，其在正时皮带的内侧面上的同步皮带的两端处至少两个同步轮，并且与同步皮带的外侧面上的格架保持架相配合，其中，定时轮具有设置在其上的电动机，该电动机构造成驱动正时轮以移动正时带并驱动电网架移动。

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