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1. 发明专利

CA1338441C EXPRESSION OF IMMUNOLOGICALLY ACTIVE PROTEINS OF HUMAN .BETA.-LYMPHO TROPIC VIRUS 未知
公开(公告)号：CA1338441C
公开(公告)日：1996-07-09
申请号：CA568355
申请日：1988-06-01
申请人： CHANG NANCY T , CHANG TSE WEN , FUNG MICHAEL SEK CHUNG , FUNG MING CHIU , GALLO ROBERT C , WONG STAAL FLOSSIE
发明人： CHANG NANCY T , CHANG TSE WEN , FUNG MICHAEL SEK-CHUNG , FUNG MING-CHIU , GALLO ROBERT C , WONG-STAAL FLOSSIE
IPC分类号： G01N33/569 , A61K31/00 , A61K39/00 , A61K39/12 , A61K39/245 , A61P31/00 , A61P31/12 , C07K14/00 , C07K14/03 , C12N1/21 , C12N15/09 , C12P21/00 , C12P21/02 , C12Q1/70 , C12R1/19 , C12R1/92 , C12N15/38 , C07K17/00 , C12N15/56 , C12N15/62
摘要： Recombinant proteins of human B-lymphotrophic virus (HBLV) which are immunoreactive with antibodies against HBLV are disclosed. Regions of the HBLV genome which encode the proteins are also disclosed. The proteins can be expressed in prokaryotic or eukaryotic expression systems. The proteins can be used in assays for the detection of antibodies against HBLV in biological fluid and they can be used as immunogens to stimulate an immune response to HBLV.

2. 发明申请

WO2004073725A1 ACTIVE INGREDIENTS PREPARATION AND SINGLE COMPOUND PURIFICATION FROM TRADITIONAL CHINESE HERBAL MEDICINE FRUCTUS TRICHOSANTHIS AND USES THEREOF 审中-公开
标题翻译：活性成分制剂和单一化学纯化来自中国传统中草药的纤维化学物质及其用途
公开(公告)号：WO2004073725A1
公开(公告)日：2004-09-02
申请号：PCT/CN2004/000139
申请日：2004-02-23
申请人： THE CHINESE UNIVERSITY OF HONG KONG , FUNG, Ming Chiu , XING, Hong Tao
发明人： FUNG, Ming Chiu , XING, Hong Tao
IPC分类号： A61K35/78
CPC分类号： A61K36/428
摘要： Disclosed are an extract from traditional Chinese herbal medicine Trichosanthes with the activity of increasing globin gene expression and a composition comprising the extract. A method for preparing the extract and use thereof in treating disorders related to globing gene expression are also provided.
摘要翻译：公开了具有增加珠蛋白基因表达活性的中草药中草药提取物和包含提取物的组合物。还提供了一种制备提取物及其用于治疗与球状基因表达相关的疾病的方法。

3. 发明申请

WO1989005349A1 METHOD OF COMBATING VIRAL INFECTIONS 审中-公开
标题翻译：组合病毒感染的方法
公开(公告)号：WO1989005349A1
公开(公告)日：1989-06-15
申请号：PCT/AU1988000474
申请日：1988-12-09
申请人： THE AUSTRALIAN NATIONAL UNIVERSITY , HAHN, Jeffrey, Robert , HAPEL, Andrew, John , FUNG, Ming-Chiu
发明人： THE AUSTRALIAN NATIONAL UNIVERSITY
IPC分类号： C12N15/00
CPC分类号： C12N15/86 , A61K35/18 , A61K35/28 , A61K38/00 , A61K48/00 , C07K14/005 , C12N2740/16043 , C12N2740/16222
摘要： A method for combating viral infection in a human or animal patient, comprises administering to the patient histocompatible blood cells or bone marrow stem cells which have been transformed with a nucleotide sequence coding for a protein or polypeptide which, on expression by the cells will reduce the rate at which the superinfecting virus particles can enter the cells. The nucleotide sequence may be a sequence or gene coding for all or an immunologically-active portion of a HIV envelope protein such as gp160, gp120 or gp41.
摘要翻译：一种在人或动物患者中对抗病毒感染的方法，包括向所述患者施用已经用编码蛋白质或多肽的核苷酸序列转化的组织相容性血细胞或骨髓干细胞，所述核苷酸序列在细胞表达时将会减少超级病毒颗粒可以进入细胞的速率。核苷酸序列可以是编码HIV包膜蛋白例如gp160，gp120或gp41的全部或免疫活性部分的序列或基因。

4. 发明申请

WO2005001094A1 TRANSGENIC PLANT PRODUCTS COMPRISING HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：包含人粒细胞集落刺激因子的转基因植物产品及其制备方法
公开(公告)号：WO2005001094A1
公开(公告)日：2005-01-06
申请号：PCT/CN2004/000425
申请日：2004-04-29
申请人： THE CHINESE UNIVERSITY OF HONG KONG , SUN, Samuel, Sai, Ming , FUNG, Ming, Chiu , LAM, Hon, Ming
发明人： SUN, Samuel, Sai, Ming , FUNG, Ming, Chiu , LAM, Hon, Ming
IPC分类号： C12N15/27
CPC分类号： C12N15/8257
摘要： Abstract The present invention is to provide a recombinant construct for transforming a plant comprising a DNA sequence encoding a recombinant human cytokine and a promoter capable of directing the expression of the recombinant human cytokine in the plant. The present invention is also to provide a method for constructing a transgenic plant, comprising the steps of transforming a plant cell with a recombinant construct of the invention, and regenerating the transgenic plant from the plant cell to produce recombinant human cytokine, for example, human granulocyte colony stimulating factor (hG-CSF), in seeds of the transgenic plant. The plant production method of the invention thus has a promising potential to mass-produce some of the most expensive biopharmaceuticals of restricted availability in a much cheaper way, which has high economic value for disease therapy, diagnosis and prevention, and is more accessible to the less affluent countries.
摘要翻译：摘要本发明提供用于转化植物的重组构建体，其包含编码重组人细胞因子的DNA序列和能够指导重组人细胞因子在植物中表达的启动子。本发明还提供一种用于构建转基因植物的方法，其包括以下步骤：用本发明的重组构建体转化植物细胞，并从植物细胞再生转基因植物以产生重组人细胞因子，例如人粒细胞集落刺激因子（hG-CSF），在转基因植物的种子中。因此，本发明的植物生产方法具有很大的潜力，可以以更便宜的方式批量生产一些最昂贵的限制性可用性的生物药物，其具有用于疾病治疗，诊断和预防的高经济价值，并且更容易获得不太富裕的国家。

5. 发明申请

WO1985002863A1 CLONING OF cDNA AND EXPRESSION OF MURINE-INTERLEUKIN-3 审中-公开
标题翻译： cDNA克隆及其表达的研究
公开(公告)号：WO1985002863A1
公开(公告)日：1985-07-04
申请号：PCT/AU1984000272
申请日：1984-12-24
申请人： THE AUSTRALIAN NATIONAL UNIVERSITY , BIOTECHNOLOGY AUSTRALIA PTY. LTD. , YOUNG, Ian, Gordon , HAPEL, Andrew, John , JOHNSON, Rosemary, Anne , YMER, Sanie , COHEN, Donna, Ruth , CAMPBELL, Hugh, Douglas , CLARK, Susan, Joy , STIRZACKER, Sally, Clare , FUNG, Ming-Chiu
发明人： THE AUSTRALIAN NATIONAL UNIVERSITY , BIOTECHNOLOGY AUSTRALIA PTY. LTD.
IPC分类号： C12N15/00
CPC分类号： C07K14/5403 , A61K38/00
摘要： Messenger RNA for murine interleukin-3 is isolated and used to clone c-DNA for this protein. The c-DNA is used as a probe, inter alia, to identify the gene for murine interleukin-3. Also c-DNA for murine interleukin-3 is cloned into a prokaryotic host and expression of biologically active murine interleukin-3 is obtained.
摘要翻译：分离用于鼠白细胞介素-3的信使RNA，并用于克隆该蛋白质的c-DNA。 c-DNA用作探针，特别是用于鉴定鼠白细胞介素-3的基因。还将小鼠白细胞介素-3的c-DNA克隆到原核宿主中，并获得生物活性的鼠白细胞介素-3的表达。

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