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1. 发明专利

CA2032734A1 BENZOXAZINE DERIVATIVE AND BENZOTHIAZINE DERIVATIVE AND HERBICIDE COMPRISING THE SAME AS ACTIVE INGREDIENT 未知
公开(公告)号：CA2032734A1
公开(公告)日：1991-06-23
申请号：CA2032734
申请日：1990-12-19
申请人： KAWAGUCHI NAOKO , FUKAMI HARUKAZU , NIWATA SHINJIRO , SAGO RYUICHI , FUJITA FUMIO
发明人： KAWAGUCHI NAOKO , FUKAMI HARUKAZU , NIWATA SHINJIRO , SAGO RYUICHI , FUJITA FUMIO
IPC分类号： A01N43/84 , C07D265/36 , C07D279/16 , C07D413/12 , C07D417/12
摘要： BENZOXAZINE DERIVATIVE AND BENZOTHIAZINE DERIVATIVE AND HERBICIDE COMPRISING THE SAME AS ACTIVE INGREDIENT A benzoxazine derivative and a benzothiazine derivative having the formula (I): (I) wherein A is N or a CH group; B is O, S, an SO group or an SO2 group; W is O, S, a CR4R5 group or an NR4 group wherein R4 and R5 are each independently a hydrogen atom, a CN group or an NO2 group; X, Y and Z are each independently a hydrogen atom, a halogen atom or a lower haloalkyl group having 1 to 3 carbon atoms; R1 is a hydrogen atom, a lower alkyl group having 1 to 5 carbon atoms, a lower alkenyl group having 2 to 5 carbon atoms, a lower alkynyl group having 2 to 5 carbon atoms, a lower hydroxyalkyl group having 1 to 5 carbon atoms or a lower haloalkyl group having 1 to 3 carbon atoms; and R2 and R3 are each independently a hydrogen atom, a lower alkyl group having 1 to 5 carbon atoms or an aryl group having 6 to 10 carbon atoms and a herbicidal composition containing the compound of the formula (I) as an active ingredient.

2. 发明专利

CA1287051C PHENYLPIPERAZINE DERIVATIVES AND THEIR ACID ADDITION SALTS 未知
公开(公告)号：CA1287051C
公开(公告)日：1991-07-30
申请号：CA479278
申请日：1985-04-16
申请人： FUKAMI HARUKAZU
发明人： FUKAMI HARUKAZU , KIKUMOTO RYOJI , NAKAO KENICHIRO , NITTA ISSEI , INOUE SHINYA
IPC分类号： C07D239/96 , C07D285/32 , C07D491/04 , C07D491/056 , C07D513/04 , C07D403/06 , C07D417/06
摘要： TITLE OF THE INVENTION: PHENYLPIPERAZINE DERIVATIVES AND THEIR ACID ADDITION SALTS A phenylpiperazine derivative according to the present invention has the following general formula ¢I!: ¢I! wherein R1, R2 and R3 are independently hydrogen or alkoxy group having 1 to 3 carbon atoms, or R1 and R2 or R2 and R3 together with carbon atoms to which they are attached form -O(CH2)mO- wherein m is an integer of 1 to 3, or either R1 or R2 is amine residue selected from the group consisting of NH2, -NHSO2CH3, -NHCOCH3 and -NHCONH2 and the other is hydrogen or alkoxy group of 1 to 3 carbon atoms and R3 is hydrogen; R4 and R5 are independently hydrogen or alkyl group of 1 to 3 carbon atoms; Y is -CO- or -SO2- provided that at least one of R1 and R2 is not hydrogen when Y is -CO-; and n is an integer of 2 to 4. An acid addition salt of the phenylpiperazine derivative having the general formula ¢I! is included in the present invention. The phenylpiperazine derivative as well as its acid addition salt according to the present invention have the ability to reduce the blood pressure.

3. 发明申请

WO2006019186A1 SKIN CARE PRODUCTS, AS WELL AS FOODS AND BEVERAGES CONTAINING 6-O-PUFA ASCORBIC ESTERS 审中-公开
标题翻译：皮肤护理产品，如含有6-O-PUFA抗坏血酸的食品和饮料
公开(公告)号：WO2006019186A1
公开(公告)日：2006-02-23
申请号：PCT/JP2005/015383
申请日：2005-08-18
申请人： SUNTORY LIMITED , FUKAMI, Harukazu , KAWASHIMA, Hiroshi , ONO, Yoshiko
发明人： FUKAMI, Harukazu , KAWASHIMA, Hiroshi , ONO, Yoshiko
IPC分类号： A61K8/67
CPC分类号： A61K8/676 , A23L33/12 , A23L33/15 , A61Q5/00 , A61Q17/04 , A61Q19/00
摘要： Skin care products which contain as a vitamin C component 6-O-PUFA ascorbates represented by general formula (I): RCO-A (I)where RCO- is an acyl group derived from a polyunsaturated fatty acid, and A is a residue of ascorbic acid that binds by -O- derived from the hydroxyl group in ascorbic acid. The products show improved transfer of ascorbic acid to tissues or cells, allow the functions of ascorbic acid to be exhibited efficiently, and also have the potential to show the functions of PUFAs. Also provided are foods and beverages that contain 6-O-PUFA ascorbates represented by general formula (I).
摘要翻译：含有通式（I）表示的维生素C成分6-O-PUFA抗坏血酸盐的护肤品：RCO-A（I），其中RCO-为衍生自多不饱和脂肪酸的酰基，A为在抗坏血酸中与由羟基衍生的-O-结合的抗坏血酸。产品显示改善抗坏血酸转移至组织或细胞，使抗坏血酸的功能得到有效展现，并具有显示PUFA功能的潜力。还提供含有由通式（I）表示的6-O-PUFA抗坏血酸盐的食品和饮料。

4. 发明专利

CA2048114A1 BENZOXAZINE DERIVATIVE AND HERBICIDE CONTAINING SAME AS AN ACTIVE INGREDIENT 未知
公开(公告)号：CA2048114A1
公开(公告)日：1992-04-05
申请号：CA2048114
申请日：1991-07-30
申请人： KAWAGUCHI NAOKO , FUKAMI HARUKAZU , SAGO RYUICHI , IGAI KEITARO
发明人： KAWAGUCHI NAOKO , FUKAMI HARUKAZU , SAGO RYUICHI , IGAI KEITARO
IPC分类号： A01N43/84 , C07D265/36 , C07D413/12
摘要： BENZOXAZINE DERIVATIVE AND HERBICIDE CONTAINING SAME AS AN ACTIVE INGREDIENT A benzoxazine derivative having the formula (I) and a salt thereof: ... (I) wherein A represents N or a CY group, where Y represents a hydrogen atom or a halogen atom; X represents a halogen atom; Z represents an oxygen atom or sulfur atom; R1 represents a hydrogen atom, a lower alkyl group which may be also substituted, where the substituent may be either one of a halogen atom, a lower alkoxy group or an aryl group, a lower alkenyl group, a lower alkynyl group or an aliphatic acyl group; R represents a hydrogen atom or a lower alkyl group; R3 represents a carboxyl group which may be esterified or amidated, an aliphatic acyl group which may be also substituted, where the substituent may be either one of a halogen atom, a diazo group or a hydroxyl group which may be also acylated, a lower alkoxythiocarbonyl group, a C(=NR4)R5 group, where R4 represents a hydroxyl group, a lower alkoxy group, a lower alkenyloxy group, a lower alkynyloxy group, an amino group, a lower alkylamino group or an alkoxycarbonylalkyloxy group, R5 represents a lower alkyl group, a C(OR6)2R7 group, where R6 represents a lower alkyl group or a group for forming an alkylen group with two R6,s, R7 represents a lower alkyl group or a C(R8)2OH group, where R8 represents a lower alkyl group and a herbicide containing the same as an effective ingredient.

5. 发明申请

WO2004085582A3 LIPID-IMPROVING AGENT AND COMPOSITION CONTAINING LIPID-IMPROVIMG AGENT 审中-公开
标题翻译：脂肪改善剂及其组合物，其含有脂质体改良剂
公开(公告)号：WO2004085582A3
公开(公告)日：2004-12-02
申请号：PCT/JP2004004282
申请日：2004-03-26
申请人： SUNTORY LTD , AKIMOTO KENGO , FUKAMI HARUKAZU , GODA TOSHINAO
发明人： AKIMOTO KENGO , FUKAMI HARUKAZU , GODA TOSHINAO
IPC分类号： A23D9/00 , A23L1/30 , A61K31/231 , A61K31/232 , C11C3/08 , C12P7/64
CPC分类号： C12P7/6472 , A23D9/00 , A23L33/115 , A23V2002/00 , A61K31/231 , A61K31/232 , C11C3/08 , A23V2250/5112 , A23V2250/1862
摘要： A lipid-improving agent containing a triglyceride(s) where a poly-unsaturated fatty acid is bonded to 2-position of a triglyceride(s).
摘要翻译：含有甘油三酯的脂质改进剂，其中多不饱和脂肪酸与甘油三酯的2-位结合。

6. 发明申请

WO9933840A2 PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA1-BLOCKING ACTION 审中-公开
标题翻译：具有SEROTONIN-2受体拮抗剂和ALPHA1阻断作用的吡罗昔康和吡咯烷酮化合物
公开(公告)号：WO9933840A2
公开(公告)日：1999-07-08
申请号：PCT/JP9805954
申请日：1998-12-25
申请人： SUNTORY LTD , MIZUNO AKIRA , SHIBATA MAKOTO , KAMEI TOMOE , FUKAMI HARUKAZU , INOMATA NORIO
发明人： MIZUNO AKIRA , SHIBATA MAKOTO , KAMEI TOMOE , FUKAMI HARUKAZU , INOMATA NORIO
IPC分类号： A61K31/54 , A61K31/55 , A61P9/00 , A61P9/02 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P43/00 , C07D207/36 , C07D513/04
CPC分类号： C07D513/04 , C07D207/36
摘要： A pyrrolesulfonamide derivative having formula (I) wherein the ring P represented by alpha is a pyrrole ring having structure beta or psi wherein R represents alkyl, cycloalkyl, cycloalkyl-alkyl or aralkyl; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present and Z1 represents H but, when the bond is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are combined together to represent O or a group NOR1, in which R1 represents H, or alkyl, aralkyl or aryl; stands for 0 or 1; A represents alkylene, alkenylene or alkynylene; and Y represents a group delta in which W represents CH, C= or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C=; B represents a specific divalent group; E1 and E2 each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group. The compound (I) has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is useful as a therapeutic for circulatory diseases such as ischemic heart diseases, cerebrovascular disturbances and peripheral circulatory disturbances.
摘要翻译：具有式（I）的吡咯磺酰胺衍生物，其中由α表示的环P是具有β或psi结构的吡咯环，其中R表示烷基，环烷基，环烷基 - 烷基或芳烷基; 虚线表示存在或不存在键; 当存在键时，Z 2不存在，Z1表示H，但当不存在键时，Z1表示H，Z2表示OH或Z1，Z2组合在一起表示O或NOR1基团，其中R1表示 H或烷基，芳烷基或芳基; 代表0或1; A表示亚烷基，亚烯基或亚炔基; 并且Y表示其中W表示CH，C =或N的组δ; 当W为CH或N时，m代表0或1，当W为C =时，m代表1; B表示特定的二价基团; E1和E2各自独立地表示H或低级烷基; D表示芳族烃基或杂环基。化合物（I）具有强的5-羟色胺-2受体拮抗作用，毒性低，副作用小，作为循环系统疾病如缺血性心脏病，脑血管障碍和周围循环障碍的治疗有用。

7. 发明申请

WO9933841B1 PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION 审中-公开
标题翻译：具有SEROTONIN-2受体拮抗剂和ALPHA-1阻断作用的吡咯烷酮和吡咯烷酮化合物
公开(公告)号：WO9933841B1
公开(公告)日：2001-05-25
申请号：PCT/JP9805955
申请日：1998-12-25
申请人： SUNTORY LTD , MIZUNO AKIRA , SHIBATA MAKOTO , KAMEI TOMOE , FUKAMI HARUKAZU , INOMATA NORIO
发明人： MIZUNO AKIRA , SHIBATA MAKOTO , KAMEI TOMOE , FUKAMI HARUKAZU , INOMATA NORIO
IPC分类号： A61K31/54 , A61K31/55 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P43/00 , C07D207/36 , C07D513/04
CPC分类号： C07D513/04 , C07D207/36
摘要： A pyrrolesulfonamide compound having formula (I) wherein the ring P represented by ( alpha ) is a pyrrole ring having structure ( beta ) or ( psi ) wherein A represents alkylene, alkenylene or alkynylene; and Y represents a group ( delta ) in which W represents CH, C= or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C=; B represents a specific divalent group; E1 and E2 each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group; stands for 0 or 1; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present and Z1 represents H but, when the bond is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are combined together to represent O or a group NOR5, in which R5 represents H, or alkyl, aralkyl or aryl; and R represents H, alkyl, cycloalkyl, cycloalkyl-alkyl or aralkyl. The compound (1) has been improved in potency, selectivity to receptors other than serotonin-2 receptors, toxicity, side effects and/or the like over medicines reported to date and equipped with alpha 1-blocking action and serotonin-2 receptor antagonistic action in combination.
摘要翻译：具有式（I）的吡咯磺酰胺化合物，其中由（α）表示的环P是具有结构（β）或（psi）的吡咯环，其中A表示亚烷基，亚烯基或亚炔基; Y表示W表示CH，C =或N的基团（delta）; 当W为CH或N时，m代表0或1，当W为C =时，m代表1; B表示特定的二价基团; E1和E2各自独立地表示H或低级烷基; D表示芳族烃基或杂环基; 代表0或1; 虚线表示存在或不存在键; 当存在键时，Z 2不存在，Z1表示H，但当不存在键时，Z1表示H，Z2表示OH或Z1，Z2组合在一起表示O或NOR5基团，其中R5表示 H或烷基，芳烷基或芳基; R代表H，烷基，环烷基，环烷基 - 烷基或芳烷基。化合物（1）对迄今为止报道的具有α1-阻断作用和5-羟色胺-2受体拮抗作用的药物的效力，对5-羟色胺2受体以外的受体的选择性，毒性，副作用等改善。结合。

8. 发明申请

WO9933841A2 PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION 审中-公开
标题翻译：具有SERONON-2受体拮抗剂和ALPHA-1阻断作用的吡罗昔康和吡咯烷酮化合物
公开(公告)号：WO9933841A2
公开(公告)日：1999-07-08
申请号：PCT/JP9805955
申请日：1998-12-25
申请人： SUNTORY LTD , MIZUNO AKIRA , SHIBATA MAKOTO , KAMEI TOMOE , FUKAMI HARUKAZU , INOMATA NORIO
发明人： MIZUNO AKIRA , SHIBATA MAKOTO , KAMEI TOMOE , FUKAMI HARUKAZU , INOMATA NORIO
IPC分类号： A61K31/54 , A61K31/55 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P43/00 , C07D207/36 , C07D513/04
CPC分类号： C07D513/04 , C07D207/36
摘要： A pyrrolesulfonamide compound having formula (I) wherein the ring P represented by ( alpha ) is a pyrrole ring having structure ( beta ) or ( psi ) wherein A represents alkylene, alkenylene or alkynylene; and Y represents a group ( delta ) in which W represents CH, C= or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C=; B represents a specific divalent group; E1 and E2 each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group; stands for 0 or 1; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present and Z1 represents H but, when the bond is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are combined together to represent O or a group NOR5, in which R5 represents H, or alkyl, aralkyl or aryl; and R represents H, alkyl, cycloalkyl, cycloalkyl-alkyl or aralkyl. The compound (1) has been improved in potency, selectivity to receptors other than serotonin-2 receptors, toxicity, side effects and/or the like over medicines reported to date and equipped with alpha 1-blocking action and serotonin-2 receptor antagonistic action in combination.
摘要翻译：具有式（I）的吡咯磺酰胺化合物，其中由（α）表示的环P是具有结构（β）或（psi）的吡咯环，其中A表示亚烷基，亚烯基或亚炔基; Y表示W（CH），C =或N的基团（delta）; 当W为CH或N时，m代表0或1，当W为C =时，m代表1; B表示特定的二价基团; E1和E2各自独立地表示H或低级烷基; D表示芳族烃基或杂环基; 代表0或1; 虚线表示存在或不存在键; 当存在键时，Z 2不存在，Z1表示H，但当不存在键时，Z1表示H，Z2表示OH或Z1，Z2组合在一起表示O或NOR5基团，其中R5表示 H或烷基，芳烷基或芳基; 且R代表H，烷基，环烷基，环烷基 - 烷基或芳烷基。化合物（1）对迄今为止报道的具有α1-阻断作用和5-羟色胺-2受体拮抗作用的药物的效力，对5-羟色胺2受体以外的受体的选择性，毒性，副作用等改善结合。

9. 发明申请

WO1997011941A1 QUINAZOLINE DERIVATIVES AND USE THEREOF 审中-公开
标题翻译：喹诺酮衍生物及其用途
公开(公告)号：WO1997011941A1
公开(公告)日：1997-04-03
申请号：PCT/JP1996002830
申请日：1996-09-27
申请人： SUNTORY LIMITED , FUKAMI, Harukazu , ITO, Akiko , NIWATA, Shinjiro , KAKUTANI, Saki , SUMIDA, Motoo , KISO, Yoshinobu
发明人： SUNTORY LIMITED
IPC分类号： C07D239/96
CPC分类号： C07D401/06 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07F9/65128
摘要： Quinazoline derivatives represented by general formula (1) or pharmacologically acceptable salts thereof, and chymase inhibitors and preventives/remedies for cardiac and circulatory diseases caused by abnormal overproduction of AngII, each containing the same as the active ingredient.
摘要翻译：由通式（1）表示的喹唑啉衍生物或其药理学上可接受的盐，以及由AngII异常过量产生引起的心脏和循环系统疾病的胃促胰岛素抑制剂和预防药物/治疗药物，每种含量与活性成分相同。

10. 发明申请

WO2007066779A9 NOVEL LIPASE 审中-公开
标题翻译：新手
公开(公告)号：WO2007066779A9
公开(公告)日：2008-10-23
申请号：PCT/JP2006324598
申请日：2006-12-08
申请人： SUNTORY LTD , NAKAO MASAHIRO , KANAMORI MASAKI , FUKAMI HARUKAZU , KASAI HIROAKI , OCHIAI MISA
发明人： NAKAO MASAHIRO , KANAMORI MASAKI , FUKAMI HARUKAZU , KASAI HIROAKI , OCHIAI MISA
IPC分类号： C12N15/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/20 , C12N15/09 , C12P7/62
CPC分类号： C12N9/20 , C12P7/6409 , C12P7/6436 , C12R1/01
摘要： Disclosed are: a novel lipase which is produced by a bacterium belonging to the genus Tetrasphaera and has a molecular weight of about 32 kDa; and a gene encoding the lipase. The lipase can recognize a middle-chain fatty acid as a substrate. Specifically, disclosed are: a novel lipase which is produced by a bacterium belonging to the genus Tetrasphaera, can recognize a middle-chain or long-chain fatty acid as a substrate, and has a molecular weight of about 40 kDa; and a polynucleotide encoding the lipase. Also disclosed is NITE strain P-154 of a bacterium belonging to the genus Tetrasphaera. The lipase can be used as an immobilized enzyme and is useful in the fields such as the production of a digestant or a flavoring agent, the production of a clinical test reagent, an enzyme for detergent or an oil-and-fat, and the production of an optically active intermediate for the production of an agrichemical/pharmaceutical.
摘要翻译：公开了一种新颖的脂肪酶，其由属于四泽属细菌的细菌产生并具有约32kDa的分子量; 和编码脂肪酶的基因。脂肪酶可以识别中链脂肪酸作为底物。具体地说，公开了：由属于四味属细菌的细菌产生的新型脂肪酶，可以识别中链或长链脂肪酸作为底物，分子量约40kDa; 和编码脂肪酶的多核苷酸。还公开了属于四孢属（Tetrasphaera）属的细菌的NITE菌株P-154。该脂肪酶可以作为固定化酶使用，可用于生产消化剂或调味剂，生产临床试剂，洗涤剂或油脂的酶等，的用于生产农药/药物的光学活性中间体。

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