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1. 发明申请

WO2004010935A3 METHODS OF TREATING AND PREVENTING RSV, HMPV, AND PIV USING ANTI-RSV, ANTI-HMPV, AND ANTI-PIV ANTIBODIES 审中-公开
标题翻译：使用抗RSV，抗-HPV和抗PIV抗体治疗和预防RSV，HMPV和PIV的方法
公开(公告)号：WO2004010935A3
公开(公告)日：2004-11-11
申请号：PCT/US0323376
申请日：2003-07-25
申请人： MEDIMMUNE INC , VIRONOVATIVE BV , YOUNG JAMES F , KIENER PETER , OSTERHAUS ALBERTUS D M E , FOUCHIER RONALDUS A M
发明人： YOUNG JAMES F , KIENER PETER , OSTERHAUS ALBERTUS D M E , FOUCHIER RONALDUS A M
IPC分类号： C12N15/09 , A61K39/155 , A61K39/395 , A61P11/00 , A61P31/14 , A61P31/16 , C07K16/10 , A61K39/12 , A61K39/42 , C12N15/00 , C12P19/34 , C12P21/06
CPC分类号： C07K16/1027 , A61K2039/505
摘要： The present invention relates to methods for broad spectrum prevention and treatment of viral respiratory infections. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with respiratory syncytial virus (RSV), parainfluenza virus (PIV), and/or human metapneumovirus (hMPV) infection, the methods comprising administering to a subject an effective amount of one or more anti-RSV-antigen antibodies or antigen-binding fragments thereof, one or more anti-hMPV-antigen antibodies or antigen-binding fragments thereof, and/or one or more anti-PIV-antigen antibodies or antigen-binding fragments thereof. In certain embodiments, a certain serum titer of the anti-RSV-antigen antibodies, andt-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof is achieved in said subject. In certain specific embodiments, the subject is human and, preferably, the anti-RSV-antigen antibody, anti-PIV-antigen antibody, and/or anti-hMPV-antigen antibodies are human or humanized. The present invention relates further to compositions comprising the anti-RSV-antigen antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof. The present invention also relates to detectable or diagnostic compositions comprising the one or more anti-RSV-antigen antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen binding fragments thereof and methods for detecting or diagnosing RSV, PIV, and/or hMPV infection utilizing the compositions.
摘要翻译：本发明涉及广谱预防和治疗病毒性呼吸道感染的方法。特别地，本发明涉及用于预防，治疗或改善与呼吸道合胞病毒（RSV），副流感病毒（PIV）和/或人类偏肺病毒（hMPV）感染相关的症状的方法，所述方法包括向受试者施用有效的一种或多种抗RSV抗原抗体或其抗原结合片段，一种或多种抗hMPV抗原抗体或其抗原结合片段，和/或一种或多种抗PIV-抗原抗体或抗原结合片段。在某些实施方案中，在所述受试者中实现了抗RSV抗原抗体和-TIV-抗原抗体和/或抗-hMPV-抗原抗体或其抗原结合片段的某一血清滴度。在某些具体实施方案中，受试者是人，并且优选抗RSV抗原抗体，抗-PIV抗原抗体和/或抗hMPV-抗原抗体是人或人源化的。本发明还涉及包含抗RSV抗原抗体，抗PIV-抗原抗体和/或抗-hMPV-抗原抗体或其抗原结合片段的组合物。本发明还涉及包含一种或多种抗RSV抗原抗体，抗PIV抗原抗体和/或抗-hMPV-抗原抗体或其抗原结合片段的可检测或诊断组合物和用于检测或诊断RSV的方法，PIV和/或hMPV感染。

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