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    • 3. 发明申请
    • SYSTEM FOR RAPID MICROORGANISM IDENTIFICATION AND ANTIMICROBIAL TESTING
    • 快速微生物识别系统和抗微生物测试系统
    • WO2004090089A1
    • 2004-10-21
    • PCT/GB2004/001517
    • 2004-04-08
    • ACOLYTE BIOMEDICA LIMITEDO'HARA, StephenFORREST, GordonHAMMOND, Richard
    • O'HARA, StephenFORREST, GordonHAMMOND, Richard
    • C12M1/24
    • C12Q1/04C12Q1/18
    • Apparatus for microbiological analysis of a patient sample, comprising: a microorganism extractor; a temporary storage facility; a microorganism identifier; an antimicrobial tester; a thermostatically-controlled incubator; a timer; and sample router(s), for routing: patient sample to the microorganism extractor; extracted microorganisms to the temporary storage facility; microorganisms from the temporary storage facility, patient sample or extracted sample to the microorganism identifier; and microorganisms from the temporary storage facility to the antimicrobial tester. The invention allows microorganism identification without prior need for sample culture, thus giving a significant reduction in the time required between taking a sample and identifying an appropriate antimicrobial therapy. Furthermore, where organisms are identified after their extraction, the invention allows a single non-specific technique to be used for specifically identifying different microorganisms, thus simplifying overall analysis. In addition, results of the identification and antimicrobial testing assays can be analysed by a common technique, which again simplifies the overall analysis.
    • 用于患者样品的微生物分析的装置,包括:微生物提取器; 临时存储设施; 微生物标识符; 抗菌试验机; 恒温控制孵化器; 一个计时器 和样品路由器,用于路由:患者样品到微生物提取器; 提取微生物到临时储存设施; 来自临时储存设施的微生物,患者样品或提取的样品到微生物标识符; 以及从临时储存设施到抗微生物测试仪的微生物。 本发明允许在不需要样品培养的情况下进行微生物鉴定,因此显着降低了取样和鉴定合适的抗微生物治疗所需的时间。 此外,在提取生物之后,本发明允许使用单一非特异性技术来特异性鉴定不同的微生物,从而简化了总体分析。 此外,鉴定和抗微生物测试测定的结果可以通过常见技术进行分析,这再次简化了整体分析。
    • 4. 发明申请
    • LATERAL FLOW DEVICE UTILISING PARTICULATE CARRIER
    • 使用颗粒载体的横向流动装置
    • WO0131337A3
    • 2001-09-20
    • PCT/GB0004140
    • 2000-10-27
    • GENOSIS LTDFORREST GORDON COULTER
    • FORREST GORDON COULTER
    • G01N33/53G01N33/543G01N33/545G01N33/553G01N33/558
    • G01N33/54313G01N33/54386G01N33/558
    • A lateral flow device having a porous reaction zone (2, 3) in communication with a porous filter zone (4). The reaction zone (2, 3) contains (i) analyte-specific label and (ii) a particulate carrier having analyte-specific capture reagent immobilised thereon. The filter zone (4) has a smaller pore size than the reaction zone (2, 3). Label not bound to the particulate carrier can thus enter the filter zone (4), unlike label that is bound to the carrier. After applying a sample, lateral flow brings analyte into contact with label and particulate carrier within the reaction zone (2, 3), to form a complex. Free label does not bind to the particulate carrier. During flow from the reaction zone (2, 3) to the filter zone (4), free label migrates into the filter zone (4), whereas particle-analyte-label complex is captured at its entrance (6). This avoids the need to use immobilised antibody to capture an analyte-label complex.
    • 一种具有与多孔过滤区(4)连通的多孔反应区(2,3)的侧流装置。 反应区(2,3)包含(i)分析物特异性标记和(ii)其上固定有分析物特异性捕获试剂的颗粒载体。 过滤区(4)具有比反应区(2,3)更小的孔径。 与颗粒载体结合的标签因此可以进入过滤区(4),不像与载体结合的标签。 应用样品后,侧向流将分析物与反应区(2,3)内的标记物和颗粒载体接触,形成复合物。 自由标签不与颗粒载体结合。 在从反应区(2,3)到过滤区(4)的流动期间,游离标签迁移到过滤区(4)中,而颗粒 - 分析物 - 标签复合物在其入口处被捕获(6)。 这避免了使用固定化抗体捕获分析物标签复合物的需要。