专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

CA1340798C DISUBSTITUTED PYRIDINES 未知
公开(公告)号：CA1340798C
公开(公告)日：1999-10-26
申请号：CA588502
申请日：1989-01-18
申请人： ANGERBAUER ROLF , FEY PETER , HUEBSCH WALTER , SCHMIDT DELF , PETZINNA DIETER , PHILIPPS THOMAS , THOMAS GUENTER , BISCHOFF HILMAR
发明人： ANGERBAUER ROLF , FEY PETER , HUBSCH WALTER , SCHMIDT DELF , PETZINNA DIETER , PHILIPPS THOMAS , THOMAS GUENTER , BISCHOFF HILMAR
IPC分类号： C07D333/24 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P3/06 , A61P9/10 , C07D211/90 , C07D213/30 , C07D213/42 , C07D213/48 , C07D213/55 , C07D213/65 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D213/89 , C07D307/54 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07F7/08 , C07F7/18 , C07D405/02 , C07D413/06
摘要： New substituted pyridines can be prepared by reduction of pyridines which are substituted by a ketone radical, and subsequent hydrolysis, cyclization or hydrogenation. The new compounds can be used as active compounds in medicaments, particularly for inhibiting HMG-CoA reductase, for inhibiting cholesterol biosynthesis or for the treatment of hyperlipoproteinaemia, lipoproteinaemia or arteriosclerosis.

2. 发明专利

SK279675B6 TRISUBSTITUTED BIPHENYLS, PROCESS FOR THEIR PREPARATION, MEDICAMENTS THEM CONTAINING AND THEIR USE 未知
公开(公告)号：SK279675B6
公开(公告)日：1999-02-11
申请号：SK116993
申请日：1993-10-22
申请人： DRESSEL JURGEN , FEY PETER , HANKO RUDOLF , HUBSCH WALTER , KRAMER THOMAS , MULLER ULRICH E. , MULLER-GLIEMANN MATTHIAS , BEUCK MARTIN , KAZDA STANISLAV , WOHLFEIL STEFAN , KNORR ANDREAS , STASCH JOHANNES-PETER , ZAISS SIEGFRIED
发明人： DRESSEL JURGEN , FEY PETER , HANKO RUDOLF , HUBSCH WALTER , KRAMER THOMAS , MULLER ULRICH E , MULLER-GLIEMANN MATTHIAS , BEUCK MARTIN , KAZDA STANISLAV , WOHLFEIL STEFAN , KNORR ANDREAS , STASCH JOHANNES-PETER , ZAISS SIEGFRIED
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61P9/10 , A61P9/12 , C07D213/79 , C07D401/10 , C07D213/64
摘要： Trisubstituted biphenyls of the general formula (I), the substituents whereof have their meaning stated in the Description; a process for their preparation, their use in medicaments, especially as blood pressure-decreasing agents or antiatherosclerotic agents. Said compounds are prepared in the reaction of corresponding pyridones with biphenylmethylhalogen compounds.

3. 发明专利

SK279433B6 SUBSTITUTED BIPHENYLPYRIDINONES, METHOD OF THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THEM CONTAINING AND THEIR USE 未知
公开(公告)号：SK279433B6
公开(公告)日：1998-11-04
申请号：SK338092
申请日：1992-11-12
申请人： MULLER-GLIEMANN MATTHIAS , BEUCK MARTIN , KAZDA STANISLAV , STASCH JOHANNES-PETER , KNORR ANDREAS , WOHLFEIL STEFAN , HUBSCH WALTER , DRESSEL JURGEN , FEY PETER , HANKO RUDOLF , KRAMER THOMAS , MULLER ULRICH E. , ZAISS SIEGFRIED
发明人： MULLER-GLIEMANN MATTHIAS , BEUCK MARTIN , KAZDA STANISLAV , STASCH JOHANNES-PETER , KNORR ANDREAS , WOHLFEIL STEFAN , HUBSCH WALTER , DRESSEL JURGEN , FEY PETER , HANKO RUDOLF , KRAMER THOMAS , MULLER ULRICH E , ZAISS SIEGFRIED
IPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/41 , A61K31/4433 , A61K31/455 , A61P9/10 , A61P9/12 , C07D213/64 , C07D213/79 , C07D213/80 , C07D401/10 , C07D401/14 , C07D409/14
摘要： Substituted biphenylpyridones of the general formula (I) in which particular substituents have the stated meanings. These compounds can be prepared by alkylation of pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active ingredients in pharmaceutical compositions, especially in pharmaceutical compositions which lower blood pressure and have antiatherosclerotic effects.

4. 发明申请

WO2012163799A1 CHIRAL SYNTHESIS OF N-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-6-METHOXYPHENYL}-1-[2,3-DIHYDROXY-PROPYL]CYCLOPROPANESULFONAMIDES 审中-公开
标题翻译： N- {3,4-二氟-2 - [（2-氟-4-碘苯基）氨基] -6-甲氧基苯基} -1- [2,3-二羟基丙基]环丙烷磺酰胺的合成
公开(公告)号：WO2012163799A1
公开(公告)日：2012-12-06
申请号：PCT/EP2012/059717
申请日：2012-05-24
申请人： BAYER INTELLECTUAL PROPERTY GMBH , FEY, Peter , MAYER, Agathe, Christine
发明人： FEY, Peter , MAYER, Agathe, Christine
IPC分类号： C07C303/38 , C07C303/40 , C07C309/82 , C07C311/28
CPC分类号： C07C303/38 , C07B2200/07 , C07C303/40 , C07C309/71 , C07C2601/02 , C07D303/34 , C07D309/12 , C07D317/18 , C07D317/24 , C07F7/1856 , C07C311/28
摘要： The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2- fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy- propyl]cyclopropanesulfonamide.
摘要翻译：本发明涉及制备N- {3,4-二氟-2 - [（2-氟-4-碘苯基）氨基] -6-5甲氧基苯基的（S） - 和（R） - 对映异构体的新型对映选择性方法对于新型中间体化合物，以及所述新型中间体化合物用于制备所述（S） - 和（R） - 对映异构体的用途，所述N-（3） - （2,3-二羟基 - 丙基）环丙烷磺酰胺， 4-二氟-2 - [（2-氟-4-碘苯基）氨基] -6-甲氧基苯基} -1- [2,3-二羟基 - 丙基]环丙烷磺酰胺。

5. 发明申请

WO0076996A2 METHOD FOR THE ENANTIOMER SEPARATION OF CIS-8-BENZYL-7,9-DIOXO-2,8-DIAZABICYCLO[4.3.0]NONANE 审中-公开
标题翻译：方法光学CIS-8-苄基-7,9-二氧代-2,8-二氮杂二环[4.3.0]壬烷的拆分
公开(公告)号：WO0076996A2
公开(公告)日：2000-12-21
申请号：PCT/EP0005116
申请日：2000-06-05
申请人： BAYER AG , FEY PETER
发明人： FEY PETER
IPC分类号： C07D471/04 , C07H9/04
CPC分类号： C07D471/04 , C07H9/04
摘要： The invention relates to a method for the enantiomer separation of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane (also described below as cis-6-benzyl-5,7-dioxooctahydropyrrolo[3,4-b]pyridine or dioxopyrrolopiperidine). The invention also relates to a method for producing (1S, 6R)- and (1R, 6S)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the above method. The invention further relates to the (-)-2,3:4,6-di-O-isopropylidene-2-keto-L- gulonic acid salts of (1S, 6R)- and (1R, 6S)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane and to a method for producing the same. Finally, the invention relates to a method for the enantiomer enrichment of (1S, 6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]-nonane.
摘要翻译：本发明涉及一种用于顺式-8-苄基-7,9-二氧代-2,8-二氮杂二环[4.3.0]的对映异构体的分离壬烷（在下文中也被称作顺式-6-苄基-5,7- dioxooctahydropyrrolo [3- ，4-b]吡啶或下文Dioxopyrrolopiperidin）。在另一个方面，本发明涉及一种用于（1S，6R）的制备 - 和（1R，6S）-8-苄基-7,9-二氧代-2,8-二氮杂二环[4.3.0]壬烷，使用上述流程。此外，本发明涉及（ - ） - 2,3：4,6-二-O-异丙叉基-2-酮-L-gulonsäuresalze（1S，6R） - 和（1R，6S）-8-苄基-7-， 9二氧代-2,8-二氮杂二环[4.3.0]壬烷和它们的制备过程。此外，本发明涉及一种用于对映体富集的处理（1S，6R）-8-苄基-7,9-二氧代-2,8-二氮杂二环[4.3.0]壬烷。

6. 发明申请

WO2002094807A1 VERFAHREN ZUR SPALTUNG DES METHYL 4-(2-CHLOR-4-FLUORPHENYL)-2-(3,5-DIFLUOR-2-PYRIDINYL)-6-METHYL-1,4-DIHYDRO-5-PYRIMIDINCARBOXYLAT-RACEMATS 审中-公开
标题翻译： METHOD FOR甲基4-（2-氯-4-氟苯基）-2-（3,5-二氟-2-吡啶基）-6-甲基-1,4-二氢-5-嘧啶羧酸乙酯的外消旋物的切割
公开(公告)号：WO2002094807A1
公开(公告)日：2002-11-28
申请号：PCT/EP2002/005339
申请日：2002-05-15
申请人： BAYER AKTIENGESELLSCHAFT , GOLDMANN, Siegfried , FEY, Peter
发明人： GOLDMANN, Siegfried , FEY, Peter
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07B2200/07
摘要： Die Enantiomeren von Methyl 4-(2-chlor-4-fluorphenyl)-2-(3,5-difluor-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrimidincarboxylat lassen sich mit Hilfe von (-)-Camphansäure trennen.
摘要翻译：甲基-4-的对映异构体（2-氯-4-氟苯基）-2-（3,5-二氟-2-吡啶基）-6-甲基-1,4-二氢-5-嘧啶羧酸可以是具有的助剂（ - ）-Camphansäure分开。

7. 发明申请

WO1995019337A1 NOVEL HIGH ENANTIO-SELECTIVE PROCESS FOR PRODUCING PURE ENANTIOMERIC CYCLOPENTANE AND CYCLOPENTENE-'beta'-AMINO ACIDS 审中-公开
标题翻译：新型高对映选择性方法用于生产对映体纯环戊烷和-PENTEN-β-氨基酸
公开(公告)号：WO1995019337A1
公开(公告)日：1995-07-20
申请号：PCT/EP1995000059
申请日：1995-01-09
申请人： BAYER AKTIENGESELLSCHAFT , MITTENDORF, Joachim , AROLD, Hermann , FEY, Peter , MATZKE, Michael , MILITZER, Hans-Christian , MOHRS, Klaus-Helmut
发明人： BAYER AKTIENGESELLSCHAFT
IPC分类号： C07C227/32
CPC分类号： C07C229/48 , C07C69/74 , C07C227/32 , C07C271/24 , C07C2601/08 , Y02P20/55
摘要： The present invention relates to a high enantio-selective process for producing pure enantiomeric cyclopentane and cyclopentene- beta -amino acids of the general formula (I) in which A and L, A and D or E and L, D and E, R , R , T and R have the meanings given in the description. In the process, meso-dicarboxylic acid anhydride is first converted into the enantiomer-free dicarboxylic acid mono-ester via the intermediate, enantiomer-free salt stage by asymmetrical alcoholysis with alcohols and in the presence of equimolar quantities of a chiral amine base in enantiomer-free form, in inert solvents, and then the enantiomer-free amides are produced after NH3 activation, the ester group is separated out in a further step and finally a Hofmann transposition is performed with alkaline or alkaline earth hypochlorites in an aqueous alkaline or alkaline earth hydroxide solution, in solution the free amine function is first blocked with a typical amino-protective group and, after the protected compounds have been isolated in normal conditions, they are separated out by the usual methods, retaining the pure enantiomer.
摘要翻译：本发明涉及一种用于对映体纯环戊烷和-penten-的β的制备高对映选择性方法氨基的通式（I）的酸，其中A和L，A和D或E和L，D和E，R <2>， [R <3>，T和R <1>具有说明书中给出的含义。该方法的特征在于，内消旋 - 二羧酸酐第一通过不对称醇解用的醇并在对映体纯形式，手性胺碱，在惰性溶剂中的等摩尔量的本的存在下转化，经由中间，对映体纯Salztufe到对映体纯的二羧酸单酯，然后激活 NH 3，对映异构纯的酰胺制备，在进一步的步骤中裂解掉酯基，最后用，并经过典型氨基封端从而隔离的保护的化合物的最初进行霍夫曼重排用碱金属或含水的碱金属或碱土金属氢氧化物碱土金属次氯酸盐，在溶液中的游离胺官能团裂解以常规条件，包括接收到相应纯对映体的，通过常规的方法。

8. 发明申请

WO1994014807A1 SUBSTITUTED TRIOLS 审中-公开
标题翻译：取代TRIOLE
公开(公告)号：WO1994014807A1
公开(公告)日：1994-07-07
申请号：PCT/EP1993003459
申请日：1993-12-08
申请人： BAYER AKTIENGESELLSCHAFT , ANGERBAUER, Rolf , FEY, Peter , HÜBSCH, Walter , PHILIPPS, Thomas , BISCHOFF, Hilmar , KRAUSE, Hans-Peter , PETERSEN VON GEHR, Jörg , SCHMIDT, Delf
发明人： BAYER AKTIENGESELLSCHAFT
IPC分类号： C07D471/04
CPC分类号： C07F9/6561 , C07C33/28 , C07C33/36 , C07C33/38 , C07C69/013 , C07D209/12 , C07F9/3211
摘要： Substituted triols of Formula D-R wherein R represents the group of Formulae (a), (b), (c) or (d), can be used as active substances in drugs against hyperproteinemia.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式