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1. 发明申请

WO2006107191A1 A METHOD OF DYEING A SUBSTRATE WITH A REACTIVE DYESTUFF IN SUPERCRITICAL OR NEAR SUPERCRITICAL CARBON DIOXIDE 审中-公开
标题翻译：在超临界二氧化碳或超临界二氧化碳中对基质进行反应性染色的方法
公开(公告)号：WO2006107191A1
公开(公告)日：2006-10-12
申请号：PCT/NL2005/050031
申请日：2005-11-04
申请人： FEYECON DEVELOPMENT & IMPLEMENTATION B.V. , FERNANDEZ CID, Maria, Vanesa , WITKAMP, Geert, Jan , WOERLEE, Geert, Feye , VEUGELERS, Wilhelmus, Johannes, Theodorus
发明人： FERNANDEZ CID, Maria, Vanesa , WITKAMP, Geert, Jan , WOERLEE, Geert, Feye , VEUGELERS, Wilhelmus, Johannes, Theodorus
IPC分类号： D06P1/94 , D06P1/384
CPC分类号： D06P1/384 , D06P1/94 , Y10S8/918 , Y10S8/92
摘要： The present invention relates to a method of dyeing a substrate with a reactive dyestuff in supercritical or near supercritical carbon dioxide, said substrate being selected from the group consisting of cellulose fibres; modified cellulose fibres; protein fibres; synthetic fibres and any combination thereof, wherein the method comprises dyeing said substrate by contacting the substrate with supercritical or near supercritical carbon dioxide containing a reactive dyestuff and one or more acids in a concentration of at least 0.05 mol.%, calculated on the molar amount of reactive dyestuff that is used in the dyeing method, said reactive dyestuff being a chromophore derivative containing a chromophoric residue and a reactive group, said reactive group comprising a cyclic or heterocyclic aromatic residue that will be protonated under the conditions employed during the contacting, such protonation resulting in enhanced reactivity of the reactive dyestuff towards the plurality of reactive groups contained in the substrate.
摘要翻译：本发明涉及在超临界或近超临界二氧化碳中用活性染料染色底物的方法，所述底物选自纤维素纤维; 改性纤维素纤维; 蛋白纤维; 合成纤维及其任何组合，其中所述方法包括通过使底物与含有活性染料的超临界或近超临界二氧化碳和一种或多种浓度为至少0.05mol。％的酸的摩尔量在染色方法中使用的活性染料，所述活性染料是含有发色残基和反应性基团的发色团衍生物，所述反应性基团包含环状或杂环芳族残基，其将在接触期间使用的条件下质子化，质子化导致活性染料对基材中包含的多个反应性基团的反应性增强。

2. 发明申请

WO2006049504A3 A METHOD OF DYEING A SUBSTRATE WITH A REACTIVE DYESTUFF IN SUPERCRITICAL OR NEAR SUPERCRITICAL CARBON DIOXIDE 审中-公开
标题翻译：在超临界二氧化碳或超临界二氧化碳中对基质进行反应性染色的方法
公开(公告)号：WO2006049504A3
公开(公告)日：2006-08-31
申请号：PCT/NL2005050033
申请日：2005-11-04
申请人： FEYECON DEV & IMPLEMENTATION , FERNANDEZ CID MARIA VANESA , VAN SPRONSEN JAAP , VEUGELERS WILHELMUS JOHANNES T , WOERLEE GEERT FEYE
发明人： FERNANDEZ CID MARIA VANESA , VAN SPRONSEN JAAP , VEUGELERS WILHELMUS JOHANNES T , WOERLEE GEERT FEYE
IPC分类号： D06P1/382 , D06M23/10 , D06P1/00 , D06P1/673 , D06P1/94
CPC分类号： D06P1/382 , D06M23/105 , D06P1/0004 , D06P1/67316 , D06P1/94
摘要： The present invention relates to a method of dyeing a substrate selected from the group consisting of cellulose fibres, modified cellulose fibres, protein fibres, synthetic fibres and combinations thereof, wherein the method comprises contacting the substrate with supercritical or near supercritical carbon dioxide containing a reactive dyestuff of the formula (I): wherein Ch represents a chromophoric residue of an aromatic diazo substance or of an anthraquinone substance; Y represents O or NR, in which R represents hydrogen or a C 1 -C 8 alkyl, which is optionally substituted by hydroxy, cyano, chloro, bromo, C 1 -C 5 alkoxy, phenoxy, phenyl or phenoxy C 1 -C 4 -alkoxy; X 1 represents fluorine; X 2 represents fluorine, chlorine, OR 1 or N(R 2 )R 3 ; R 1 represents hydrogen, or a C 1 -C 4 alkyl, which is optionally substituted by hydroxy, cyano, fluorine, chlorine or bromine; R 2 and R 3 independent ly represent hydrogen, P(O)(OH)R 4 or a C 1 -C 3 alkyl which is optionally subst ituted by hydroxy, cyano, fluorine, chlorine or bromine; and R 4 represents hydroxy, fluorine, chlorine or bromine.
摘要翻译：本发明涉及一种染色选自纤维素纤维，改性纤维素纤维，蛋白质纤维，合成纤维及其组合的底物的方法，其中所述方法包括使所述底物与含有反应性的超临界或近临界二氧化碳接触式（I）的染料：其中Ch表示芳族重氮物质或蒽醌物质的发色残基; Y表示O或NR，其中R表示氢或C 1 -C 8烷基，其任选被羟基，氰基，氯，溴，C

3. 发明申请

WO2008033023A3 GRANULATE CONTAINING A PHARMACEUTICALLY ACTIVE SUBSTANCE AND ANEMULSIFIER AND METHOD FOR ITS MANUFACTURE 审中-公开
标题翻译：含有药物活性物质的颗粒和其制造方法及其制造方法
公开(公告)号：WO2008033023A3
公开(公告)日：2008-09-12
申请号：PCT/NL2007050448
申请日：2007-09-14
申请人： ECHO PHARMACEUTICALS BV , PELLIKAAN HUBERT CLEMENS , VERMEULEN PIETER SEBASTIAAN , BENDER JOHANNES CASPAR MATHIAS , FERNANDEZ CID MARIA VANESA
发明人： PELLIKAAN HUBERT CLEMENS , VERMEULEN PIETER SEBASTIAAN , BENDER JOHANNES CASPAR MATHIAS , FERNANDEZ CID MARIA VANESA
IPC分类号： A61K9/00 , A61K9/16
CPC分类号： A61K9/2059 , A61K9/1617 , A61K9/1623 , A61K9/1694 , A61K9/2013 , A61K9/2018
摘要： One aspect of the present invention relates to a granulate having a volume weighted mean diameter of 1-200 m and containing: at least 0.1 wt.% of a pharmaceutically active substance; at least 10 wt.% of emulsifier 0-89.9 wt.% of a water-dispersible saccharide; the combination of the pharmaceutically active substance, the emulsifier and the water-dispersible saccharide together represening at least 60 wt.% of the granulate; wherein the granulate is monophasic or wherein the granulate comprises a dispersed phase containing the pharmaceutically active substance, said dispersed phase having a volume weighted mean diameter of less than 300 nm. Another aspect of the invention relates to a process for the preparation of said granulate containing a pharmaceutically active substance, which process employs.
摘要翻译：本发明的一个方面涉及体积加权平均直径为1-200μm并含有至少0.1wt％的药物活性物质的颗粒; 至少10重量％的乳化剂0-89.9重量％的水分散性糖; 药物活性物质，乳化剂和水分散性糖的组合共同表示至少60重量％的颗粒; 其中所述颗粒是单相的或其中所述颗粒包含含有所述药物活性物质的分散相，所述分散相的体积加权平均直径小于300nm。本发明的另一方面涉及一种制备含有药物活性物质的所述颗粒的方法，该方法使用。

4. 发明申请

WO2006049504A2 A METHOD OF DYEING A SUBSTRATE WITH A REACTIVE DYESTUFF IN SUPERCRITICAL OR NEAR SUPERCRITICAL CARBON DIOXIDE 审中-公开
标题翻译：在超临界二氧化碳或超临界二氧化碳中对基质进行反应性染色的方法
公开(公告)号：WO2006049504A2
公开(公告)日：2006-05-11
申请号：PCT/NL2005/050033
申请日：2005-11-04
申请人： FEYECON DEVELOPMENT & IMPLEMENTATION B.V. , FERNANDEZ CID, Maria Vanesa , VAN SPRONSEN, Jaap , VEUGELERS, Wilhelmus Johannes Theodorus , WOERLEE, Geert Feye
发明人： FERNANDEZ CID, Maria Vanesa , VAN SPRONSEN, Jaap , VEUGELERS, Wilhelmus Johannes Theodorus , WOERLEE, Geert Feye
CPC分类号： D06P1/382 , D06M23/105 , D06P1/0004 , D06P1/67316 , D06P1/94
摘要： ABSTRACT The present invention relates to a method of dyeing a substrate selected from the group consisting of cellulose fibres, modified cellulose fibres, protein fibres, synthet ic 5 fibres and combinat ions thereof, wherein the method comprises contacting the substrate with supercritical or near supercritical carbon dioxide containing a reactive dyestuff of the formula (I): X1 N 10 N Ch Y N X2 wherein Ch represents a chromophoric residue of an aromatic diazo substance or of an 15 anthraquinone substance; Y represents O or NR, in which R represents hydrogen or a C1-C8 alkyl, which is optionally subst ituted by hydroxy, cyano, chloro, bromo, C1-C5 alkoxy, phenoxy, phenyl or phenoxy C1-C4-alkoxy; X1 represents fluorine; 20 X2 represents fluorine, chlorine, OR1 or N(R2)R3; R1 represents hydrogen, or a C1-C4 alkyl, which is optionally substituted by hydroxy, cyano, fluorine, chlorine or bromine; R2 and R3 independent ly represent hydrogen, P(O)(OH)R4 or a C1-C3 alkyl which is optionally subst ituted by hydroxy, cyano, fluorine, chlorine or bromine; and 25 R4 represents hydroxy, fluorine, chlorine or bromine.
摘要翻译：摘要本发明涉及一种染色选自纤维素纤维，改性纤维素纤维，蛋白质纤维，合成纤维5及其组合离子的底物的方法，其中所述方法包括使所述底物与超临界或接近超临界碳含有式（I）的活性染料的二氧化碳：X1 N 10 N Ch YN X2其中Ch表示芳族重氮物质或15种蒽醌物质的发色残基; 氰基，氯，溴，C 1 -C 5烷氧基，苯氧基，苯基或苯氧基C 1 -C 4 - 烷氧基;其中R 1代表氢或C 1 -C 8烷基， X1表示氟; 20 X2表示氟，氯，OR 1或N（R2）R3; R 1表示氢或任选被羟基，氰基，氟，氯或溴取代的C 1 -C 4烷基; R2和R3独立地表示氢，P（O）（OH）R4或任选被羟基，氰基，氟，氯或溴取代的C1-C3烷基; 25R4代表羟基，氟，氯或溴。

5. 发明申请

WO2006049503A3 A METHOD OF DYEING A SUBSTRATE WITH A REACTIVE DYESTUFF IN SUPERCRITICAL OR NEAR SUPERCRITICAL CARBON DIOXIDE 审中-公开
公开(公告)号：WO2006049503A3
公开(公告)日：2006-05-11
申请号：PCT/NL2005/050032
申请日：2005-11-04
申请人： FEYECON DEVELOPMENT & IMPLEMENTATION B.V. , FERNANDEZ CID, Maria Vanesa , WITKAMP, Geert Jan , TEESINK-GERSTNER, Kathryn, Nicole , VEUGELERS, Wilhelmus Johannes Theodorus , WOERLEE, Geert Feye
发明人： FERNANDEZ CID, Maria Vanesa , WITKAMP, Geert Jan , TEESINK-GERSTNER, Kathryn, Nicole , VEUGELERS, Wilhelmus Johannes Theodorus , WOERLEE, Geert Feye
IPC分类号： D06P1/94 , D06P1/00 , D06P1/38 , D06P3/66 , D06M23/10 , D06P3/54
摘要： The present invention relates to a method of dyeing a substrate with a reactive dyestuff in supercritical or near supercritical carbon dioxide, said substrate being selected from the group consisting of cellulose fibres, modified cellulose fibres, protein fibres and of synthetic fibres, or any combination thereof, wherein the method comprises the subsequent steps of: pre-treating the substrate by wetting the substrate with a fluid medium containing at least 10 wt.%, preferably at least 40 wt.% of one or more organic hydrogen bond acceptor compounds selected from the group consisting of C1-C6 alkano ls, dimethyl sulfoxide, dimethylformamide, acetone, butan-2-one, dimethyl ether, methyl acetate and ethyl acetate; dyeing the substrate by contacting the pre-treated substrate with supercritical or near supercritical carbon dioxide containing a reactive dyestuff.

6. 发明申请

WO2008033023A2 GRANULATE CONTAINING A PHARMACEUTICALLY ACTIVE SUBSTANCE AND METHOD FOR ITS MANUFACTURE 审中-公开
标题翻译：含有药物活性物质的颗粒及其制造方法
公开(公告)号：WO2008033023A2
公开(公告)日：2008-03-20
申请号：PCT/NL2007/050448
申请日：2007-09-14
申请人： FEYECON DEVELOPMENT & IMPLEMENTATION B.V. , PELLIKAAN, Hubert Clemens , VERMEULEN, Pieter Sebastiaan , BENDER, Johannes Caspar Mathias Elizabeth , FERNANDEZ CID, Maria, Vanesa
发明人： PELLIKAAN, Hubert Clemens , VERMEULEN, Pieter Sebastiaan , BENDER, Johannes Caspar Mathias Elizabeth , FERNANDEZ CID, Maria, Vanesa
CPC分类号： A61K9/2059 , A61K9/1617 , A61K9/1623 , A61K9/1694 , A61K9/2013 , A61K9/2018
摘要： One aspect of the present invention relates to a granulate having a volume weighted mean diameter of 1-200 m and containing: at least 0.1 wt.% of a pharmaceutically active substance; at least 10 wt.% of emulsifier selected from the group consisting of sugar fatty acid esters, mono-glycerides, di-glycerides, diacetyl tartaric acid ester of monoglyceride, diacetyl tartaric acid esters of diglyceride, polyglycerol esters, calcium stearoyl lactylate, sodium stearoyl lactylate and combinations thereof; and 0-89.9 wt.% of a water-dispersible saccharide; the combination of the pharmaceutically active substance, the emulsifier and the water-dispersible saccharide together represening at least 60 wt.% of the granulate; wherein the granulate is monophasic or wherein the granulate comprises a dispersed phase containing the pharmaceutically active substance, said dispersed phase having a volume weighted mean diameter of less than 300 nm. The granulates of the present invention enable the manufacture of transmucosal dosage units that exhibit improved solubility and/or bioavailability of the pharmaceutically active substance. Another aspect of the invention relates to a process for the preparation of a granulate containing a pharmaceutically active substance, which process employs: a pumpable emulsion comprising (i) a continuous phase containing a polar solvent and (ii) a dispersed phase containing an emulsifier and a pharmaceutically active substance; an extractant comprising a supercritical, subcritical or liquefied gas; said solvent being substantially more soluble in the extractant than said emulsifier; the process comprising the successive steps of : a. combining the pumpable emulsion with the extractant under mixing conditions; b. allowing the formation of granules containing the emulsifier and the pharmaceutically active substance; c. collect ing the granules and separating them from the extractant.
摘要翻译：本发明的一个方面涉及体积加权平均直径为1-200μm并含有至少0.1wt％的药物活性物质的颗粒; 至少10重量％的选自糖脂肪酸酯，单甘油酯，二甘油酯，甘油单酯的二乙酰酒石酸酯，甘油二酯的二乙酰酒石酸酯，聚甘油酯，硬脂酰乳酸钙，硬脂酰基硬脂酸钠乳酸盐及其组合; 和0-89.9重量％的水分散性糖; 药物活性物质，乳化剂和水分散性糖的组合共同表示至少60重量％的颗粒; 其中所述颗粒是单相的或其中所述颗粒包含含有所述药物活性物质的分散相，所述分散相的体积加权平均直径小于300nm。本发明的颗粒能够制造显示改善的药物活性物质的溶解度和/或生物利用度的经粘膜剂量单位。本发明的另一方面涉及一种制备含有药物活性物质的颗粒的方法，该方法采用：可泵送乳液，其包含（i）含有极性溶剂的连续相和（ii）含有乳化剂的分散相和药物活性物质; 包括超临界，亚临界或液化气体的萃取剂; 所述溶剂比所述乳化剂在萃取剂中更可溶; 该过程包括以下连续步骤：a。将可泵送乳液与萃取剂在混合条件下结合; 湾允许形成含有乳化剂和药物活性物质的颗粒; C。收集颗粒并将其与萃取剂分离。

7. 发明申请

WO2006049503A2 A METHOD OF DYEING A SUBSTRATE WITH A REACTIVE DYESTUFF IN SUPERCRITICAL OR NEAR SUPERCRITICAL CARBON DIOXIDE 审中-公开
标题翻译：在超临界二氧化碳或超临界二氧化碳中对基质进行反应性染色的方法
公开(公告)号：WO2006049503A2
公开(公告)日：2006-05-11
申请号：PCT/NL2005050032
申请日：2005-11-04
申请人： FEYECON DEV & IMPLEMENTATION , FERNANDEZ CID MARIA VANESA , WITKAMP GEERT JAN , TEESINK-GERSTNER KATHRYN NICOL , VEUGELERS WILHELMUS JOHANNES T , WOERLEE GEERT FEYE
发明人： FERNANDEZ CID MARIA VANESA , WITKAMP GEERT JAN , TEESINK-GERSTNER KATHRYN NICOL , VEUGELERS WILHELMUS JOHANNES T , WOERLEE GEERT FEYE
CPC分类号： D06P1/94 , D06M23/105 , D06P1/0004 , D06P1/38 , D06P3/66
摘要： The present invention relates to a method of dyeing a substrate with a reactive dyestuff in supercritical or near supercritical carbon dioxide, said substrate being selected from the group consisting of cellulose fibres, modified cellulose fibres, protein fibres and of synthetic fibres, or any combination thereof, wherein the method comprises the subsequent steps of: pre-treating the substrate by wetting the substrate with a fluid medium containing at least 10 wt.%, preferably at least 40 wt.% of one or more organic hydrogen bond acceptor compounds selected from the group consisting of C1-C6 alkano ls, dimethyl sulfoxide, dimethylformamide, acetone, butan-2-one, dimethyl ether, methyl acetate and ethyl acetate; dyeing the substrate by contacting the pre-treated substrate with supercritical or near supercritical carbon dioxide containing a reactive dyestuff.
摘要翻译：本发明涉及一种在超临界或近超临界二氧化碳中用活性染料染色底物的方法，所述底物选自纤维素纤维，改性纤维素纤维，蛋白质纤维和合成纤维，或其任何组合其中所述方法包括以下步骤：通过用含有至少10重量％，优选至少40重量％的一种或多种有机氢键受体化合物的流体介质润湿衬底来预处理衬底，所述有机氢键受体化合物选自由C 1 -C 6烷醇，二甲基亚砜，二甲基甲酰胺，丙酮，丁-2-酮，二甲醚，乙酸甲酯和乙酸乙酯组成的组; 通过使预处理的基材与含有活性染料的超临界或近超临界二氧化碳接触来染色基底。

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