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1. 发明申请

WO2008141107A8 COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 审中-公开
公开(公告)号：WO2008141107A8
公开(公告)日：2008-11-20
申请号：PCT/US2008/063114
申请日：2008-05-08
申请人： NITTO DENKO CORPORATION , VAN, Sang , SONG, Yucheng , WANG, Xinghe , HOU, Zheng , FENG, Zhongling , ZHAO, Gang , YU, Lei
发明人： VAN, Sang , SONG, Yucheng , WANG, Xinghe , HOU, Zheng , FENG, Zhongling , ZHAO, Gang , YU, Lei
IPC分类号： A61K47/48 , A61K49/00 , A61K49/12 , A61K49/18 , A61P35/00
摘要： Various compositions that include a hydrophobic compound and a polymer conjugate are described herein. The compositions can include a polymer conjugate, a first hydrophobic drug, and a second hydrophobic drug. The polymer conjugates of the compositions described herein are capable of conjugating to a number of agents, such as imaging agents, targeting agents, stabilizing agents and/or drugs. Additionally, the polymer conjugates described herein can form nanoparticles that effectively solubilize the agent in an aqueous system by dispersing it at a molecular level, thus increasing the functionality and/or bioavailability of the agent. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications, including delivery of an agent to specific parts of the body.

2. 发明申请

WO2008141107A3 COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 审中-公开
标题翻译：包含疏水化合物和聚氨基酸共混物的组合物
公开(公告)号：WO2008141107A3
公开(公告)日：2009-04-23
申请号：PCT/US2008063114
申请日：2008-05-08
申请人： NITTO DENKO CORP , VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
发明人： VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
IPC分类号： A61K47/48 , A61K49/00 , A61K49/12 , A61K49/18 , A61P35/00
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications. The inventors have discovered novel compositions that include a polymer conjugate, a first hydrophobic drug, and a second hydrophobic drug. The polymer conjugates of the compositions described herein are capable of conjugating to a number of agents, such as imaging agents, targeting agents, stabilizing agents and/or drugs. In some embodiments, the polymers and the resulting conjugates preferentially accumulate in certain tissues (e.g. tumor tissues) and/or certain receptors, and thus are useful for delivering drugs (e.g., anticancer drugs) and/or imaging agents to specific parts of the body (e.g., tumors). In some embodiments, the polymers described herein and the resulting conjugates can form nanoparticles that effectively solubilize the drug in an aqueous system by dispersing it at a molecular level, thus increasing the functionality and/or bioavailability of the drug.
摘要翻译：制备包括疏水化合物和聚氨基酸缀合物的各种组合物。本文描述的组合物可用于各种药物，生物分子和成像剂递送应用。发明人已经发现了包括聚合物缀合物，第一疏水性药物和第二疏水性药物的新型组合物。本文所述组合物的聚合物缀合物能够与许多试剂（例如成像剂，靶向剂，稳定剂和/或药物）共轭。在一些实施方案中，聚合物和所得的缀合物优先积聚在某些组织（例如肿瘤组织）和/或某些受体中，因此可用于将药物（例如抗癌药物）和/或成像剂递送至身体的特定部位（例如肿瘤）。在一些实施方案中，本文所述的聚合物和所得的共轭物可以形成纳米颗粒，其通过将其分散在分子水平上来有效地将药物溶解在水性体系中，从而增加药物的功能性和/或生物利用度。

3. 发明申请

WO2008141107A2 COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 审中-公开
标题翻译：包含疏水化合物和聚氨基酸共混物的组合物
公开(公告)号：WO2008141107A2
公开(公告)日：2008-11-20
申请号：PCT/US2008063114
申请日：2008-05-08
申请人： NITTO DENKO CORP , VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
发明人： VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
IPC分类号： A61K47/48 , A61K49/00 , A61K49/12 , A61K49/18 , A61P35/00
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
摘要翻译：制备包括疏水化合物和聚氨基酸缀合物的各种组合物。本文描述的组合物可用于各种药物，生物分子和成像剂递送应用。

4. 发明申请

WO2007067417A1 POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS 审中-公开
标题翻译：聚氨基酸 - 氨基酸共聚物和方法
公开(公告)号：WO2007067417A1
公开(公告)日：2007-06-14
申请号：PCT/US2006/045915
申请日：2006-12-01
申请人： NITTO DENKO CORPORATION , YU, Lei , ZHAO, Gang , VAN, Sang , DAS, Sanjib Kumar , FENG, Zhongling , FU, Xioli , WANG, Xinghe
发明人： YU, Lei , ZHAO, Gang , VAN, Sang , DAS, Sanjib Kumar , FENG, Zhongling , FU, Xioli , WANG, Xinghe
IPC分类号： C08G69/10
CPC分类号： A61K47/42 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K47/56 , A61K47/62 , A61K47/64 , A61K47/645 , A61K49/0041 , A61K49/0056 , A61K49/146 , C08G69/10 , C08G69/48
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general Formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
摘要翻译：制备包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。这些聚合物可用于各种药物，生物分子和成像剂递送应用。

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