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1. 发明公开

EP2108656A1 Antigenic protein fragments of streptococcus pneumoniae 审中-公开
标题翻译： Antigene Proteinfragmente des Streptococcus pneumoniae
公开(公告)号：EP2108656A1
公开(公告)日：2009-10-14
申请号：EP08425177.6
申请日：2008-03-19
申请人： Beninati, Concetta , Felici, Franco , Universita Degli Studi di Siena
发明人： Oggioni, Marco , Pozzi, Gianni , Ricci, Susanna
IPC分类号： C07K14/315 , A61K39/09 , C12N15/31 , C12Q1/04
CPC分类号： C07K16/1275 , A61K39/00 , C07K14/3156
摘要： Antigenic protein fragments of Streptococcus pneumoniae to be used for the preparation of a medicament for the prevention and the treatment of bacterial infections and a method for the detection thereof, and related compositions using said epitopes, are disclosed.
摘要翻译：公开了用于制备用于预防和治疗细菌感染的药物的肺炎链球菌的抗原性蛋白质片段及其检测方法，以及使用所述表位的相关组合物。

2. 发明公开

EP2265633A2 ANTIGENIC PROTEIN FRAGMENTS OF STREPTOCOCCUS PNEUMONIAE 有权
标题翻译：抗原蛋白抗原结合蛋白
公开(公告)号：EP2265633A2
公开(公告)日：2010-12-29
申请号：EP09723240.9
申请日：2009-03-17
申请人： Beninati, Concetta , Felici, Franco , Universita Degli Studi di Siena
发明人： OGGIONI, Marco , POZZI, Gianni , RICCI, Susanna
IPC分类号： C07K14/315 , A61K39/09 , C12N15/31 , C12Q1/04
CPC分类号： C07K16/1275 , A61K39/00 , C07K14/3156
摘要： Antigenic protein fragments of Streptococcus pneumoniae to be used for the preparation of a medicament for the prevention and the treatment of bacterial infections and a method for the detection thereof, and related compositions using said epitopes, are disclosed.

3. 发明公开

EP2044103A2 PEPTIDES THAT MIMIC NON-HUMAN CROSS-REACTIVE PROTECTIVE EPITOPES OF THE GROUP B MENINGOCOCCAL CAPSULAR POLYSACCHARIDE 有权
标题翻译：肽模仿脑膜炎球菌荚膜组B多糖非人交叉反应SCHUTZEPITOPE
公开(公告)号：EP2044103A2
公开(公告)日：2009-04-08
申请号：EP07804929.3
申请日：2007-06-12
申请人： Teti, Giuseppe , Felici, Franco
发明人： FELICI, Franco Dept. of Pathology & Experimental Microbiology
IPC分类号： C07K7/06
CPC分类号： A61K39/095 , A61K2039/53
摘要： Peptides that mimic the antigenic features of non human-cross-reactive protective epitopes of the MenB CP and nucleic acids encoding the peptide mimetics are disclosed. Antibodies elicited by these peptides do not bind to polysialic acid in host tissue and thus provide a safe and efficacious method for the treatment and/or prevention of Meningitis B.

4. 发明授权

EP2044103B1 PEPTIDES THAT MIMIC NON-HUMAN CROSS-REACTIVE PROTECTIVE EPITOPES OF THE GROUP B MENINGOCOCCAL CAPSULAR POLYSACCHARIDE 有权
标题翻译：肽模仿脑膜炎球菌荚膜组B多糖非人交叉反应SCHUTZEPITOPE
公开(公告)号：EP2044103B1
公开(公告)日：2014-04-23
申请号：EP07804929.3
申请日：2007-06-12
申请人： Teti, Giuseppe , Felici, Franco
发明人： FELICI, Franco
IPC分类号： C07K7/06
CPC分类号： A61K39/095 , A61K2039/53

5. 发明申请

WO2009141455A1 IMMUNOGENIC POLYPEPTIDES THAT MIMIC THE SURFACE POLYSACCHARIDE O-ANTIGEN FROM SEROTYPE 2A SHIGELLA FLEXNERI, METHOD FOR OBTAINING THE SAME, AND THEIR USE IN VACCINE AND DIAGNOSTIC COMPOSITIONS 审中-公开
标题翻译：来自SEROTYPE 2A SHIGELLA FLEXNERI的表面多糖O-抗原的微生物多肽，其获得方法及其在疫苗和诊断组合物中的用途
公开(公告)号：WO2009141455A1
公开(公告)日：2009-11-26
申请号：PCT/EP2009/056325
申请日：2009-05-25
申请人： INSTITUT PASTEUR , MULARD, Laurence , PHALIPON, Armelle , VULLIEZ-LE NORMAND, Brigitte , THEILLET, François-Xavier , BENTLEY, Graham , SAUL, Frederick , DELEPIERRE, Murielle , FELICI, Franco
发明人： MULARD, Laurence , PHALIPON, Armelle , VULLIEZ-LE NORMAND, Brigitte , THEILLET, François-Xavier , BENTLEY, Graham , SAUL, Frederick , DELEPIERRE, Murielle , FELICI, Franco
IPC分类号： C07K11/00 , C07K14/00 , A61K39/112 , A61P31/04
CPC分类号： G01N33/56916 , A61K39/00 , A61K2039/53 , C07K14/25 , C07K16/1228 , C07K2317/34 , C07K2317/55 , G01N2333/25 , G01N2400/50 , Y02A50/476
摘要： The present invention is directed to purified immunogenic polypeptides comprising an epitope unit recognized by a protective monoclonal antibody having a high affinity and a high specificity for the O-antigen from serotype 2a Shigella flexneri. The invention also concerns the use of said purified immunogenic polypeptides for the preparation of vaccine against serotype 2a S. flexneri infection and for the preparation of diagnostic compositions for the detection of serotype 2a S. flexneri infection. Finally, the present invention comprises high-resolution crystal structures of said natural O-antigen, or functional fragments thereof, possibly synthetic, and the mimetic peptide, in complex with a protective monoclonal antibody, or functional fragments thereof, and to methods for selecting immunogenic polypeptides for the preparation of new candidate vaccinal compositions based on said crystals.
摘要翻译：本发明涉及纯化的免疫原性多肽，其包含由对来自血清型2a志贺氏菌志贺氏菌的O-抗原具有高亲和力和高特异性的保护性单克隆抗体识别的表位单元。本发明还涉及所述纯化的免疫原性多肽用于制备针对血清型2a柔毛病感染的疫苗的用途，以及用于制备用于检测血清型2a柔毛病感染的诊断组合物。最后，本发明包括与保护性单克隆抗体或其功能片段复合的所述天然O-抗原或其功能片段（可能是合成的）和模拟肽的高分辨率晶体结构，以及选择免疫原性的方法用于制备基于所述晶体的新候选疫苗组合物的多肽。

6. 发明申请

WO1994026886A2 PROCESS FOR THE PREPARATION OF IMMUNOGENS OR DIAGNOSTIC REAGENTS, AND IMMUNOGENS OR DIAGNOSTIC REAGENTS THEREBY OBTAINABLE 审中-公开
标题翻译：制备免疫原或诊断试剂的方法，以及可获得的免疫原或诊断试剂
公开(公告)号：WO1994026886A2
公开(公告)日：1994-11-24
申请号：PCT/IT1994000054
申请日：1994-05-05
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , FELICI, Franco , LUZZAGO, Alessandra , NICOSIA, Alfredo , MONACI, Paolo , CORTESE, Riccardo
发明人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.
IPC分类号： C12N15/10
CPC分类号： C40B40/02 , A61K39/00 , C07K14/005 , C07K14/4713 , C07K16/32 , C07K2319/40 , C07K2319/735 , C12N15/1037 , C12N2730/10122 , C12N2770/24222 , Y10S436/811
摘要： A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the diseases, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of an antagonist of the antigen-antibody reactions for treatment of the disease induced by said antigen; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.
摘要翻译：一种制备模拟抗原或疾病特异性的致病生物的免疫原或诊断试剂的方法，其基本特征在于以下操作：鉴定与该疾病特异性的抗原或致病生物反应的至少一种抗体; 构建在衣壳寡肽的表面上显示的噬菌体文库，其由使用遗传操作技术引入到编码噬菌体衣壳蛋白的基因中的随机序列寡核苷酸插入物表达（例如使用为本发明目的而设计的质粒，遗传地图如图所示）; 选择在所述抗体识别的衣壳抗原寡肽的表面上显示的噬菌体; 任选使用所选择的噬菌体和/或其片段和/或其衍生物用于制备用于特定病原体的诊断试剂盒，或一般用于包括已知或未知的所谓自身免疫性疾病典型的免疫学疾病的疾病病因和/或发病机制; 任选使用所选择的噬菌体和/或其片段和/或其衍生物用于制备用于治疗由所述抗原诱导的疾病的抗原 - 抗体反应的拮抗剂; 任选使用所选择的噬菌体和/或其片段和/或其衍生物以诱导对化合物和/或天然或合成制剂的过敏和/或过敏现象的耐受性; 通过所选择的噬菌体和/或其片段和/或其衍生物任选地免疫生物体; 并且可选地验证在免疫生物体的血清中存在识别上述对该疾病特异性的抗原或生物体的抗体。

7. 发明申请

WO2010028096A3 PEPTIDES PRESENTING AN EPITOPE OF AN A DOMAIN OF FACTOR H BINDING PROTEIN 审中-公开
公开(公告)号：WO2010028096A3
公开(公告)日：2010-03-11
申请号：PCT/US2009/055795
申请日：2009-09-02
申请人： CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND , BEERNINK, Peter , FELICI, Franco , GRANOFF, Dan M. , NOVARTIS VACCINES AND DIAGNOSTICS, SRL. , UNIVERSITÀ DEGLI STUDI DEL MOLISE
发明人： BEERNINK, Peter , FELICI, Franco , GRANOFF, Dan M.
IPC分类号： C07K7/06 , A61K38/08 , A61K39/095
摘要： Polypeptides that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis , and methods of use, are provided.

8. 发明申请

WO2009115509A2 ANTIGENIC PROTEIN FRAGMENTS OF STREPTOCOCCUS PNEUMONIAE 审中-公开
标题翻译：抗原蛋白抗原蛋白片段
公开(公告)号：WO2009115509A2
公开(公告)日：2009-09-24
申请号：PCT/EP2009/053121
申请日：2009-03-17
申请人： BENINATI, Concetta , FELICI, Franco , UNIVERSITA DEGLI STUDI DI SIENA , OGGIONI, Marco , POZZI, Gianni , RICCI, Susanna
发明人： BENINATI, Concetta , FELICI, Franco , OGGIONI, Marco , POZZI, Gianni , RICCI, Susanna
IPC分类号： C07K14/315 , A61K39/09 , C12N15/31 , C12Q1/04
CPC分类号： C07K16/1275 , A61K39/00 , C07K14/3156
摘要： Antigenic protein fragments of Streptococcus pneumoniae to be used for the preparation of a medicament for the prevention and the treatment of bacterial infections and a method for the detection thereof, and related compositions using said epitopes, are disclosed.
摘要翻译：公开了用于制备用于预防和治疗细菌感染的药物的肺炎链球菌的抗原性蛋白质片段及其检测方法，以及使用所述表位的相关组合物。

9. 发明申请

WO2007144771A3 PEPTIDES THAT MIMIC NON-HUMAN CROSS-REACTIVE PROTECTIVE EPITOPES OF THE GROUP B MENINGOCOCCAL CAPSULAR POLYSACCHARIDE 审中-公开
标题翻译：本组B型肉毒杆菌多糖的MIMIC非人类交叉反应性保护性抗原肽
公开(公告)号：WO2007144771A3
公开(公告)日：2008-05-22
申请号：PCT/IB2007002668
申请日：2007-06-12
申请人： TETI GIUSEPPE , FELICI FRANCO
发明人： FELICI FRANCO
IPC分类号： C07K7/06 , A61K39/095
CPC分类号： A61K39/095 , A61K2039/53
摘要： Peptides that mimic the antigenic features of non human-cross-reactive protective epitopes of the MenB CP and nucleic acids encoding the peptide mimetics are disclosed. Antibodies elicited by these peptides do not bind to polysialic acid in host tissue and thus provide a safe and efficacious method for the treatment and/or prevention of Meningitis B.
摘要翻译：公开了模拟MenB CP的非人交叉反应性保护性表位的抗原特征和编码肽模拟物的核酸的肽。由这些肽引发的抗体不与宿主组织中的聚唾液酸结合，因此提供了治疗和/或预防脑膜炎B的安全有效的方法。

10. 发明申请

WO2003011903A3 IDENTIFICATION OF SPECIFIC TUMOR ANTIGENS BY MEANS OF THE SELECTION OF CDNA LIBRARIES WITH SERA 审中-公开
公开(公告)号：WO2003011903A3
公开(公告)日：2003-02-13
申请号：PCT/IT2002/000490
申请日：2002-07-25
申请人： KENTON S.R.L. , FELICI, Franco , MINENKOVA, Olga
发明人： FELICI, Franco , MINENKOVA, Olga
IPC分类号： C07K14/47
摘要： A method is described for the identification of specific tumour antigens by means of the selection of CND display libraries by using sera, characterised in that said selection is accomplished with the phage display technique, and in particular said selection is accomplished by means of the SEREX technique (serological analysis of autologous tumor antigens through the expression of recombinant cDNA). The method according to the invention described herein advantageously combines the SEREX approach with the potency of the phage display technique defined above, at the same time avoiding the drawbacks characteristic of the SEREX technique. The so identified antigens are useful for the preparation of medicaments for the treatment of tumors.

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