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1. 发明申请

WO1995023137A1 ACETIC ACID AMIDE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：乙酸酰胺衍生物及其制备方法
公开(公告)号：WO1995023137A1
公开(公告)日：1995-08-31
申请号：PCT/HU1995000003
申请日：1995-02-22
申请人： EGIS GYOGYSZERGYAR RT. , REITER, Józsefné , BUDAI, Zoltán , TAKATS, Gáborné , MEZEI, Tibor , BLASKO, Gábor , SIMIG, Gyula , EGYED, András , VIZI, E. Szilveszter , FEKETE, Márton , SZEMERÉDI, Katalin , GYERTYAN, István , GACSALYI, István
发明人： EGIS GYOGYSZERGYAR RT.
IPC分类号： C07D219/10
CPC分类号： C07D401/12 , C07D219/10 , C07D471/04
摘要： The invention relates to new acetic acid derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said acetic acid amide derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new compounds according to the invention can be characterized by general formula (I), wherein R stands for hydrogen and B represents piperazino, 8-azaspiro[4,5]decane-7,9-dion-8-yl or 2-(1,2,4-triazolo[4,3-a]pyridyl-3(2H)-on-2-yl) optionally carrying an aryl, aralkyl or heteroaryl substituent, and possess valuable pharmaceutical properties, they are suitable for the treatment of Alzheimer's disease.
摘要翻译：本发明涉及新的乙酸衍生物，其制备方法，包含其的药物组合物，使用所述乙酸酰胺衍生物用于治疗疾病和制备适用于治疗疾病的药物组合物。根据本发明的新化合物可以由通式（I）表征，其中R代表氢，B代表哌嗪子基，8-氮杂螺[4,5]癸烷-7,9-二酮-8-基或2-（任选带有芳基，芳烷基或杂芳基取代基的1,2,4-三唑并[4,3-a]吡啶基-3（2H） - 酮-2-基），并且具有有价值的药物性质，它们适用于阿尔茨海默氏病。

2. 发明申请

WO2000020005A1 PHARMACEUTICAL COMPOSITIONS CONTAINING AN OPIATE ANALGESIC AND A SYNERGIZING SUBSTANCE 审中-公开
标题翻译：含有可视化的药物和协同物质的药物组合物
公开(公告)号：WO2000020005A1
公开(公告)日：2000-04-13
申请号：PCT/HU1998000090
申请日：1998-10-01
申请人： EGIS GYOGYSZERGYAR RT. , SZÉKELY, József , ANDRASI, Ferenc , MATÉ, Györgyné , HORVATH, Katalin , HORVATH, Edit , HASKANÉ SALAMON, Cecília , ARANYI, Péter , GIGLER, Gábor , FEKETE, Pál , FEKETE, Márton
发明人： EGIS GYOGYSZERGYAR RT.
IPC分类号： A61K31/55
CPC分类号： A61K31/55
摘要： The invention relates to a synergistic analgesic pharmaceutical composition comprising an opiate analgesic agent (component A) and a substance synergizing the analgesic effect of said opiate (component B) in admixture with suitable inert solid or liquid pharmaceutical carriers and/or diluents.
摘要翻译：本发明涉及一种协同镇痛药物组合物，其包含阿片剂止痛剂（组分A）和协同所述阿片剂（组分B）与合适的惰性固体或液体药物载体和/或稀释剂混合的镇痛作用的物质。

3. 发明申请

WO1995031443A1 ACID AMIDE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：酰胺衍生物及其制备方法
公开(公告)号：WO1995031443A1
公开(公告)日：1995-11-23
申请号：PCT/HU1995000015
申请日：1995-05-18
申请人： EGIS GYOGYSZERGYAR RT. , RIVO, Endre , VIZI, E., Szilveszter , MAKARA, Gábor , REITER, József , BLASKO, Gábor , SIMIG, Gyula , GAAL, László , FEKETE, Márton
发明人： EGIS GYOGYSZERGYAR RT.
IPC分类号： C07D241/44
CPC分类号： C07D241/44
摘要： The invention relates to new acid amide derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said acid amide derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new compounds according to the invention can be characterized by formula (I), wherein R represents hydrogen or nitro, R and R stand, independently from each other, for hydrogen, lower alkyl or lower alkenyl optionally carrying a substituent selected from the group consisting of halogen, hydroxy, lower alkoxy, di(lower alkyl)amino, phenyl-lower alkoxycarbonyl and a 5- to 6-membered saturated heteroring containing 1 or 2 nitrogen and/or oxygen atom(s); or R and R form, together with the adjacent nitrogen atom, a 6-membered saturated heterocyclic group containing optionally 1 or 2 additional nitrogen atoms and/or oxygen atom(s), said ring optionally carrying a hydroxy or a hydroxy-lower alkyl group, and possess valuable AMPA and kainate antagonizing properties, so they can be used to advantage in the therapy.
摘要翻译：本发明涉及新的酰胺酰胺衍生物，其制备方法，包含该酰胺衍生物的药物组合物，涉及使用所述酰胺酰胺衍生物用于治疗疾病和用于制备适于治疗疾病的药物组合物。根据本发明的新化合物可以通过式（I）表征，其中R 1表示氢或硝基，R 2和R 3彼此独立地表示氢，低级烷基或低级烯基任选地带有选自卤素，羟基，低级烷氧基，二（低级烷基）氨基，苯基 - 低级烷氧基羰基和含有1或2个氮和/或氧原子的5-至6-元饱和杂环的取代基）; 或R 2和R 3与相邻的氮原子一起形成含有任选1或2个另外的氮原子和/或氧原子的6元饱和杂环基，所述环任选地带有羟基或羟基低级烷基，具有有价值的AMPA和红藻氨酸盐拮抗性，因此可用于治疗。

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