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1. 发明专利

FR467543A 未知
公开(公告)号：FR467543A
公开(公告)日：1914-06-13
申请号：FR467543D
申请日：1914-01-21
申请人： PETER ERWIN SCHULTZ
发明人： SCHULTZ PETER ERWIN
IPC分类号： A01B63/28

2. 发明专利

DE373106C 未知
公开(公告)号：DE373106C
公开(公告)日：1923-04-07
申请号：DESC061547
申请日：1921-04-23
申请人： PETER ERWIN SCHULTZ , ERICH STRAZIM
IPC分类号： F26B11/04

3. 发明专利

DE336409C 未知
公开(公告)号：DE336409C
公开(公告)日：1921-04-30
申请号：DE336409D
申请日：1917-12-13
申请人： PETER ERWIN SCHULTZ
IPC分类号： A01B3/50

4. 发明授权

US07351409B2 Tumor antigens and CTL clones isolated by a novel procedure 有权
标题翻译：通过新的方法分离的肿瘤抗原和CTL克隆
公开(公告)号：US07351409B2
公开(公告)日：2008-04-01
申请号：US10753158
申请日：2004-01-07
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
IPC分类号： A01N63/00 , C12N5/08 , A61K39/00 , A61K38/04
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
摘要翻译：本发明涉及细胞毒性T淋巴细胞（CTL）克隆的分离。特别地，本发明涉及对MAGE家族的蛋白质特异的分离的CTL克隆。本发明的CTL克隆已经通过连续的步骤来刺激和测试淋巴细胞来分离，所述抗原呈递细胞提供来自不同表达系统的抗原，例如来自重组耶尔森氏菌，重组沙门氏菌或重组病毒。本发明还涉及被分离的CTL克隆识别的抗原肽以及肽/ HLA复合物。

5. 发明授权

US07041502B2 Isolated peptides which bind to HLA-B18 molecules and uses thereof 失效
公开(公告)号：US07041502B2
公开(公告)日：2006-05-09
申请号：US10164078
申请日：2002-06-05
申请人： Janine Bilsborough , Erwin Schultz , Christophe Panichelli , Thierry Boon , Pierre Van der Bruggen
发明人： Janine Bilsborough , Erwin Schultz , Christophe Panichelli , Thierry Boon , Pierre Van der Bruggen
IPC分类号： C12N5/22 , G01N33/53 , A61K38/00 , C07H21/00
CPC分类号： G01N33/5008 , A61K39/00 , A61K39/0011 , A61K2039/515 , A61K2039/5158 , G01N33/5011 , G01N33/5047 , G01N33/505 , G01N33/5091 , G01N33/68
摘要： A peptide, previously identified as a binding partner of HLA-B44, has now been found to bind to HLA-B18 forming a T cell epitope. The therapeutic and diagnostic ramifications of this are the subject of this invention, as are various products obtained in the course of the development of the invention.

6. 发明申请

US20090169573A1 T-Cell Stimulatory Peptides From The Melanoma-Associated Chondroitin Sulfate Proteoglycan And Their Use 审中-公开
公开(公告)号：US20090169573A1
公开(公告)日：2009-07-02
申请号：US11665903
申请日：2005-10-20
申请人： Erwin Schultz , Gerold Schuler
发明人： Erwin Schultz , Gerold Schuler
IPC分类号： A61K39/00 , C07K7/00 , C12N15/11 , C12N15/00 , C12N5/06 , C12N15/87 , C12Q1/02 , C07K16/18 , A61K35/12 , A61K31/7088 , C12Q1/68
CPC分类号： C07K14/4748
摘要： The present invention relates to melanoma-associated chondroitin sulfate proteoglycan (MCSP) epitopes recognized by T cells, especially by CD4+ T lymphocytes (short T-cells) and CD8+ T cells, on human melanoma cells. In more detail, the present invention relates to novel T-cell stimulatory tumour antigenic peptides corresponding to said epitopes (MCSP peptides); to fusion proteins comprising said MCSP peptides; to the use of said MCSP peptides, fusion proteins or of the full length MCSP protein itself or fragments thereof to induce an immune response, especially a T-cell response; to the use of said MCSP peptides, fusion proteins or full length MCSP protein itself or fragments thereof to prepare immune cells, such as mature dendritic cells (DCs) loaded with anyone of the peptides according to the invention, or peptide-specific T-cell clones, especially CD4+ or CD8+ T cell clones; to the use of said MCSP peptides, fusion proteins or MCSP itself or fragments thereof for research and development on/of a cancer treatment; to the use of said MCSP peptides, fusion proteins or MCSP itself or fragments thereof for preparing a medicament for inducing a T cell response in a patient, preferably for the treatment of cancer, more preferably for the treatment of melanoma, including cutaneous and ocular melanoma, and other MCSP expressing tumours such as breast cancer, notably lobular breast carcinoma, astrocytoma, glioma, glioblastoma, neuroblastoma, sarcoma and certain types of leukaemia; to the use of said MCSP peptides, fusion proteins or full length MCSP protein or fragments thereof for the preparation of a medicament, and a diagnostic agent for the treatment and prophylaxis as well the diagnosis of an immune response against tumours; and to the use of said peptide-specific T-cell clones for diagnosing or treating cancer.

7. 发明授权

US06716809B1 Mage-A3 peptides presented by HLA class molecules 失效
标题翻译：由HLA类分子呈递的Mage-A3肽
公开(公告)号：US06716809B1
公开(公告)日：2004-04-06
申请号：US09396315
申请日：1999-09-15
申请人： Erwin Schultz , Pascal Chaux , Jacques van Snick , Bernard Lethe , Thierry Boon-Fallaur , Pierre van der Bruggan , Vincent Stroobant , Kris Thielemans , Jurgen Corthals , Carlo Heirman
发明人： Erwin Schultz , Pascal Chaux , Jacques van Snick , Bernard Lethe , Thierry Boon-Fallaur , Pierre van der Bruggan , Vincent Stroobant , Kris Thielemans , Jurgen Corthals , Carlo Heirman
IPC分类号： A61K3803
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-A3 gene.
摘要翻译：本发明描述了由MAGE-A3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。肽刺激CD4 + T淋巴细胞的活性和增殖。还提供了用于诊断和治疗以MAGE-A3基因表达为特征的病症的方法和产品。

8. 发明授权

US06710172B1 Tumor antigens and CTL clones isolated by a novel procedure 有权
标题翻译：通过新的方法分离的肿瘤抗原和CTL克隆
公开(公告)号：US06710172B1
公开(公告)日：2004-03-23
申请号：US09806769
申请日：2001-07-30
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
IPC分类号： C07H2104
CPC分类号： C07K14/4748
摘要： The present invention relates to nucleic acid molecules encoding antigenic peptides from MAGE molecules that bind to HLA. An example of the nucleic acid molecules of the present invention is a nucleic acid molecule coding for the peptide GVYDGREHTV (SEQ ID NO: 44), which peptide binds to HLA-A2. The nucleic acid molecules and the encoded antigenic peptides are useful for diagnosing and treating various pathological conditions.
摘要翻译：本发明涉及编码结合HLA的MAGE分子的抗原肽的核酸分子。本发明的核酸分子的实例是编码肽GVYDGREHTV（SEQ ID NO：44）的核酸分子，该肽与HLA-A2结合。核酸分子和编码的抗原肽可用于诊断和治疗各种病理状况。

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