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1. 发明授权

US07957793B2 Methods for identifying neuronal spikes 有权
标题翻译：识别神经元尖峰的方法
公开(公告)号：US07957793B2
公开(公告)日：2011-06-07
申请号：US11315808
申请日：2005-12-22
申请人： Erwin B. Montgomery, Jr. , He Huang , John T. Gale
发明人： Erwin B. Montgomery, Jr. , He Huang , John T. Gale
IPC分类号： A61B5/04
CPC分类号： A61B5/04001 , A61B5/7217
摘要： A method for identifying neuronal spikes (extracellular action potentials) is described wherein measured microelectrode readings from tissue are reviewed to identify spikes (successive readings having prolonged rises and/or falls). The frequency of such spikes as a function of their amplitude assumes a bimodal distribution wherein higher amplitude spikes represent neuronal spikes (signal) and lower amplitude spikes represent noise, and thus the higher amplitude spikes can be assumed to be neuronal spikes. Neuronal spikes from the same neuron can then be assumed to have substantially the same waveform shape and period, with the only significant difference between them being the scaling of their amplitudes (i.e., the amplitudes of spikes from the same neuron tend to be proportionate at any given time along their period). Thus, by testing identified neuronal spikes for matching timing and for proportional amplitudes, the neuronal spikes may further be identified as coming from the same or different neurons.
摘要翻译：描述了用于鉴定神经元尖峰（细胞外动作电位）的方法，其中检查来自组织的测量的微电极读数以识别尖峰（具有延长的上升和/或下降的连续读数）。作为其幅度的函数的这种尖峰的频率呈现双峰分布，其中较高幅度尖峰表示神经元尖峰（信号），较低幅度尖峰表示噪声，因此较高幅度尖峰可以被假设为神经元尖峰。然后可以假设来自相同神经元的神经元峰值具有基本上相同的波形形状和周期，它们之间的唯一显着差异是其幅度的缩放（即，来自相同神经元的尖峰的幅度倾向于在任何给定的时间沿他们的时期）。因此，通过测试用于匹配定时和比例幅度的识别的神经元峰值，神经元尖峰可进一步被鉴定为来自相同或不同的神经元。

2. 发明申请

US20090125080A1 INTRAVENTRICULAR ELECTRODES FOR ELECTRICAL STIMULATION OF THE BRAIN 审中-公开
标题翻译：用于电刺激脑的内部电极
公开(公告)号：US20090125080A1
公开(公告)日：2009-05-14
申请号：US11938591
申请日：2007-11-12
申请人： Erwin B. Montgomery, JR.
发明人： Erwin B. Montgomery, JR.
IPC分类号： A61N1/05
CPC分类号： A61N1/0531 , A61N1/0534
摘要： An electrode—preferably an anode (current sink)—is implanted within a ventricle of the brain so that the cerebrospinal fluid therein, which is highly conductive, effectively makes the ventricle a conductive extension of the anode. An opposing electrode (i.e., a cathode) can then be situated within or outside the brain (e.g., extradurally) so that a portion of the brain to be electrically stimulated is situated between the electrodes. The electrodes can then be energized at appropriate frequencies and current/voltage levels to apply the desired stimulation, in a manner similar to preexisting Deep Brain Stimulation (DBS), Extradural Motor Cortex Stimulation (EMCS), and other electrical brain stimulation procedures.
摘要翻译：将电极 - 优选阳极（电流吸收）植入脑的脑室内，使得其中高度导电的脑脊液有效地使得心室成为阳极的导电延伸。然后可以将对置电极（即，阴极）位于脑内或外部（例如，硬膜外），使得被电刺激的脑的一部分位于电极之间。然后可以以适当的频率和电流/电压电平来激励电极，以类似于预先存在的深脑刺激（DBS），外延运动皮层刺激（EMCS）和其他电脑刺激程序的方式施加期望的刺激。

3. 发明申请

US20090043220A1 METHODS AND DEVICES FOR ANALYSIS OF CLUSTERED DATA, IN PARTICULAR ACTION POTENTIALS (I.E. NEURON FIRING SIGNALS IN THE BRAIN) 有权
标题翻译：用于分析数据，特别是动作电位的方法和装置（I.E.NEONON在大脑中发出的信号）
公开(公告)号：US20090043220A1
公开(公告)日：2009-02-12
申请号：US11722229
申请日：2005-12-22
申请人： Erwin B. Montgomery, JR. , He Huang , Amir H. Assadi
发明人： Erwin B. Montgomery, JR. , He Huang , Amir H. Assadi
IPC分类号： A61B5/04
CPC分类号： G06K9/0057
摘要： Methods for clustering of multi-dimensional data allow unsupervised grouping of multi-dimensional data points into clusters having like characteristics. The methods may be usefully applied to extracellular action potentials (neuronal spikes) measured from the brain, whereby spike data may be grouped in accordance with dimensions such as spike period, spike shape, etc., to assist in identification and location of individual neurons and/or regions of the brain.
摘要翻译：用于多维数据聚类的方法允许多维数据点的无监督分组成为具有相似特征的簇。这些方法可能有用地应用于从脑测量的细胞外动作电位（神经元峰值），由此尖峰数据可以根据诸如尖峰周期，尖峰形状等的尺寸进行分组，以帮助识别和定位个体神经元， /或大脑的区域。

4. 发明授权

US07136696B2 Neuron signal analysis system and method 失效
公开(公告)号：US07136696B2
公开(公告)日：2006-11-14
申请号：US10138987
申请日：2002-05-03
申请人： Erwin B. Montgomery, Jr.
发明人： Erwin B. Montgomery, Jr.
IPC分类号： A61B5/04
CPC分类号： A61B5/685 , A61B5/04001
摘要： Electrical signal data from a target location are recorded and collected. A signal analyzer analyzes the signal data and determines whether characteristics of the signal data resemble noise data or whether a departure from noise is present. If the characteristics show a departure from noise, neuronal activity at the target location is indicated.

5. 发明授权

US08150795B2 Methods and devices for analysis of clustered data, in particular action potentials (i.e. neuron firing signals in the brain) 有权
标题翻译：用于分析聚类数据的方法和装置，特别是动作电位（即脑中的神经元激发信号）
公开(公告)号：US08150795B2
公开(公告)日：2012-04-03
申请号：US11722229
申请日：2005-12-22
申请人： Erwin B. Montgomery, Jr. , He Huang , Amir H. Assadi
发明人： Erwin B. Montgomery, Jr. , He Huang , Amir H. Assadi
IPC分类号： G06F15/00 , G06F15/18
CPC分类号： G06K9/0057
摘要： Methods for clustering of multi-dimensional data allow unsupervised grouping of multi-dimensional data points into clusters having like characteristics. The methods may be usefully applied to extracellular action potentials (neuronal spikes) measured from the brain, whereby spike data may be grouped in accordance with dimensions such as spike period, spike shape, etc., to assist in identification and location of individual neurons and/or regions of the brain.
摘要翻译：用于多维数据聚类的方法允许多维数据点的无监督分组成为具有相似特征的簇。这些方法可能有用地应用于从脑测量的细胞外动作电位（神经元峰值），由此尖峰数据可以根据诸如尖峰周期，尖峰形状等的尺寸进行分组，以帮助识别和定位个体神经元， /或大脑的区域。

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