专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5550117A Dipyrido[3,2-B:2 ',3'-E][1,4]Diaqzepines and their use in the treatment of HIV infection 失效
标题翻译：二吡啶并[3,2-B：2'，3'-E] [1,4] Diaqzepines及其在治疗HIV感染中的用途
公开(公告)号：US5550117A
公开(公告)日：1996-08-27
申请号：US366130
申请日：1994-12-29
申请人： Karl D. Hargrave , Ernest Cullen , John R. Proudfoot , Karl G. Grozinger , Kollol Pal , Julian Adams
发明人： Karl D. Hargrave , Ernest Cullen , John R. Proudfoot , Karl G. Grozinger , Kollol Pal , Julian Adams
IPC分类号： C07D471/04 , C07D471/14 , C07D495/14 , C07F9/6561 , A61K31/55 , C07D487/14
CPC分类号： C07D471/04 , C07D471/14 , C07D495/14 , C07F9/6561
摘要： Disclosed are novel dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the treatment of HIV-1 infection. An exemplary species is 6-chloro-11-cyclopropyl-4-methyl-11H-dipyrido[3,2-b:2',3'-e][1,4]diazepine, which has the following chemical structure: ##STR1##
摘要翻译：公开了新的二吡啶并[3,2-b：2'，3'-e] [1,4]二氮杂类及其在治疗HIV-1感染中的用途。示例性物质是6-氯-11-环丙基-4-甲基-11H-二吡啶并[3,2-b：2'，3'-e] [1,4]二氮杂，其具有以下化学结构：

2. 发明授权

US5593979A Pyridobenzo-and pyridiothieno-diazepines useful for the treatment of HIV infection 失效
标题翻译：可用于治疗HIV感染的吡啶并苯并吡啶并噻吩并二氮杂
公开(公告)号：US5593979A
公开(公告)日：1997-01-14
申请号：US366131
申请日：1994-12-29
申请人： Karl D. Hargrave , Ernest Cullen , John R. Proudfoot , Karl G. Grozinger , Kollol Pal , Julian Adams
发明人： Karl D. Hargrave , Ernest Cullen , John R. Proudfoot , Karl G. Grozinger , Kollol Pal , Julian Adams
IPC分类号： C07D471/04 , C07D471/14 , C07D495/14 , C07F9/6561 , A61K31/55
CPC分类号： C07D471/04 , C07D471/14 , C07D495/14 , C07F9/6561
摘要： Disclosed are novel pyrido[2,3-b][1,4]benzodiazepines. These compounds are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection. The compounds are of the class having the structure: ##STR1##
摘要翻译：公开了新的吡啶并[2,3-b] [1,4]苯并二氮杂。这些化合物可用于治疗与艾滋病毒感染相关的AIDS，ARC和相关疾病。具有以下结构的化合物：

3. 发明授权

US4344946A 2,6-Diamino-benzo[1,2-d:5,4-d']bisthiazoles and salts thereof 失效
标题翻译： 2,6-二氨基 - 苯并[1,2-d：5,4-d']二联体及其盐
公开(公告)号：US4344946A
公开(公告)日：1982-08-17
申请号：US182077
申请日：1980-08-28
申请人： Ernest Cullen , Genus Possanza , Patrick B. Stewart
发明人： Ernest Cullen , Genus Possanza , Patrick B. Stewart
IPC分类号： A61K31/425 , A61K31/428 , A61K31/429 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/54 , A61P19/02 , A61P29/00 , C07D513/04 , C07D521/00
CPC分类号： C07D513/04 , Y10S514/825
摘要： Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.1 ', which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 2 carbon atoms;R.sub.2 and R.sub.2 ', which may be identical to or different from each other, are each hydrogen or ##STR2## but other than both hydrogen at the same time, where A is alkylene of 1 to 2 carbon atoms,R.sub.5 is hydrogen, lower alkyl, lower alkylamino-lower alkyl, lower alkoxy-lower alkyl, hydroxycarbonyl-lower alkyl, cycloalkyl of 5 to 8 carbon atoms, lower alkyl-cycloalkyl of 5 to 8 carbon atoms, phenyl or morpholino;R.sub.6 is hydrogen, lower alkyl, lower alkylamino-lower alkyl or lower alkoxy-lower alkyl; orR.sub.5 and R.sub.6, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring, where a 5- or 6-membered ring may comprise an additional sulfur or nitrogen heteroatom, and in the latter case said heterocyclic ring may optionally have one or two lower alkyl substituents, a lower alkoxy-carbonyl, a lower alkoxy-carbonyl-methyl, a hydroxy-lower alkyl, a trifluoroethyl, a cycloalkyl, a lower alkyl-cycloalkyl, a cyclohexylmethyl, a benzyl, a pyridyl, a piperidino, a phenyl, a fluoro-phenyl, a chloro-phenyl, a trifluoromethyl-phenyl, or an acetyl-phenyl substituent attached thereto; andR.sub.3 and R.sub.4, which may be identical to or different from each other, are each hydrogen, chlorine, bromine, lower alkyl, lower alkoxy, lower alkanoyl, hydroxycarbonyl, lower alkoxy-carbonyl, amino-carbonyl, phenyl, trifluoromethyl, nitro, cyano or amino;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as antiarthritics and antirheumatics.
摘要翻译：其中R 1和R 1'可以彼此相同或不同的化合物分别为氢或1至2个碳原子的烷基; R 2和R 2'可以彼此相同或不同，各自为氢或不同于氢，但不是同时为氢，其中A为1至2个碳原子的亚烷基，R5为氢，低级烷基低级烷基氨基 - 低级烷基，低级烷氧基 - 低级烷基，羟基羰基 - 低级烷基，5-8个碳原子的环烷基，5-8个碳原子的低级烷基 - 环烷基，苯基或吗啉代; R6是氢，低级烷基，低级烷基氨基 - 低级烷基或低级烷氧基 - 低级烷基; 或R 5和R 6彼此连接并与它们相连的氮原子形成5-，6-或7-元杂环，其中5-或6-元环可以包含另外的硫或氮杂原子在后一种情况下，所述杂环可任选地具有一个或两个低级烷基取代基，低级烷氧基 - 羰基，低级烷氧基 - 羰基 - 甲基，羟基 - 低级烷基，三氟乙基，环烷基，低级烷基 - 环烷基，环己基甲基，苄基，吡啶基，哌啶子基，苯基，氟 - 苯基，氯 - 苯基，三氟甲基 - 苯基或与其连接的乙酰基 - 苯基取代基; 可以相同或不同的R 3和R 4各自为氢，氯，溴，低级烷基，低级烷氧基，低级烷酰基，羟基羰基，低级烷氧基 - 羰基，氨基 - 羰基，苯基，三氟甲基，硝基，氰基或氨基; 和无毒的，药学上可接受的酸加成盐。化合物以及盐可用作抗关节炎和抗风湿剂。

4. 发明授权

US4021551A 3,6-Bis-(heterocyclic aminoacyl-amino)-acridines and salts thereof 失效
标题翻译： 3,6-双 - （杂环氨酰基 - 氨基） - 吖啶及其盐
公开(公告)号：US4021551A
公开(公告)日：1977-05-03
申请号：US600434
申请日：1975-07-30
申请人： Ernest Cullen , Peter Meindl , Hans Tuppy , Gerhard Bodo
发明人： Ernest Cullen , Peter Meindl , Hans Tuppy , Gerhard Bodo
IPC分类号： C07D219/08 , C07D401/12 , A61K31/54 , C07D413/12 , C07D417/12
CPC分类号： C07D219/08 , Y10S514/889
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3, together with each other and the nitrogen atom to which they are attached, form a saturated or unsaturated heterocyclic ring system which may optionally contain one or more additional heteroatoms, andA is lower alkylene or aryl-lower alkylene, and nontoxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as inducers of the formation of interferon.
摘要翻译：其中R 1是氢或甲基，R 2和R 3彼此以及与它们相连的氮原子形成饱和或不饱和杂环体系，其可以任选地含有一个或多个另外的杂原子，和A是低级亚烷基或芳基 - 低级亚烷基，和无毒的药学上可接受的酸加成盐; 化合物及其盐可用作干扰素形成的诱导剂。

5. 发明授权

US5602113A Pyridobenzo- and pyridiothieno-diazepines useful for the treatment of HIV infection 失效
标题翻译：可用于治疗HIV感染的吡啶并苯并噻唑并噻吩并二氮杂
公开(公告)号：US5602113A
公开(公告)日：1997-02-11
申请号：US365647
申请日：1994-12-29
申请人： Karl D. Hargrave , Ernest Cullen , John R. Proudfoot , Karl G. Grozinger , Kollol Pal , Julian Adams
发明人： Karl D. Hargrave , Ernest Cullen , John R. Proudfoot , Karl G. Grozinger , Kollol Pal , Julian Adams
IPC分类号： C07D471/04 , C07D471/14 , C07D495/14 , C07F9/6561 , A61K31/55
CPC分类号： C07D471/04 , C07D471/14 , C07D495/14 , C07F9/6561
摘要： Disclosed are novel pyrido[2,3,-b][1,5]benzodiazepines. These compounds are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection. ##STR1##
摘要翻译：公开了新的吡啶并[2,3，-b] [1,5]苯并二氮杂。这些化合物可用于治疗与艾滋病毒感染相关的AIDS，ARC和相关疾病。（一）

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式