专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090214662A1 SURFACE-LAYER PROTEIN COATED MICROSPHERES AND USES THEREOF 有权
标题翻译：表面层蛋白包被微胶囊及其用途
公开(公告)号：US20090214662A1
公开(公告)日：2009-08-27
申请号：US12162011
申请日：2007-01-24
申请人： Erik P.H. de Leeuw , Wuyuan Lu
发明人： Erik P.H. de Leeuw , Wuyuan Lu
IPC分类号： A61K9/14
CPC分类号： A61K31/138 , A61K9/5052 , A61K9/5068 , A61K38/164 , A61K38/1729 , A61K47/32 , A61K47/34 , Y02A50/475 , Y02A50/481
摘要： The invention provides surface-layer protein coated microspheres for delivery of a therapeutic agent to the intestine. These surface-layer protein coated microspheres generally include a core encapsulated by a microsphere which is coated by surface layer protein. The core includes a therapeutic agent, such as a defensin. The invention also includes methods of making and using the surface-layer protein coated microspheres of the invention for administering therapeutic agents to a subject in need thereof. The invention also includes pharmaceutical dosage units that include the surface-layer protein coated microspheres of the invention. The invention further includes various labeled defensins for use in the study of the properties and actions of defensins, and further includes the use of defensins, particularly HD5α in the treatment of inflammatory conditions of the bowel, such as Crohn's disease.
摘要翻译：本发明提供了用于将治疗剂递送至肠的表面层蛋白质包被的微球。这些表面层蛋白质包被的微球通常包括由表面蛋白质包被的微球包裹的核心。核心包括治疗剂，如防御素。本发明还包括制备和使用本发明的表面层蛋白质包被的微球的方法，用于向有需要的受试者施用治疗剂。本发明还包括药物剂量单位，其包括本发明的表面层蛋白质包被的微球。本发明还包括用于研究防御素的性质和作用的各种标记的防御素，并且还包括使用防御素，特别是HD5α在治疗肠道炎症性疾病如克罗恩病中的用途。

IPRDB

热门服务

关于我们

友情链接

联系方式