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1. 发明授权

US5833923A Sampling-assay interface system 失效
标题翻译：取样分析界面系统
公开(公告)号：US5833923A
公开(公告)日：1998-11-10
申请号：US577107
申请日：1995-12-22
申请人： Joseph A. McClintock , Mary Ann Childs , Gregory K. Shipman , William P. Trainor , Erick Gray , David Bernstein
发明人： Joseph A. McClintock , Mary Ann Childs , Gregory K. Shipman , William P. Trainor , Erick Gray , David Bernstein
IPC分类号： G01N21/03 , G01N21/76
CPC分类号： G01N21/76 , G01N21/03
摘要： A system and method for performing an assay for target analytes includes a sampling-device holder interface and a quantifier. The sampling device has a sampling portion and a reading portion containing a chemiluminescent reagent. The interface has a sampling-device holder and a light detector. The holder has a housing having an enclosure with a channel and a base plate with an opening. The base plate and the enclosure houses a slidable tray. The tray has a compartment adapted to seat the sampling device and an opening extending through the compartment. The reading portion is aligned with the tray opening. When the tray is closed, the tray opening is also aligned with the base plate opening, exposing the reading portion. Once the sampling portion is exposed to a sample suspected of containing the target analyte, at least one carrier liquid is introduced, if needed, to the sampling portion to transport any target analyte to the reading portion by dispersion. To measure the emitted light, the sampling device is seated into the tray. The tray is then inserted into housing. The light detector, which is connected in close proximity to the reading portion, outputs a signal. This signal is then converted to quantifiable data indicative of the target analyte quantity, using for instance, an ammeter.
摘要翻译：用于对目标分析物进行测定的系统和方法包括采样设备保持器接口和定量器。采样装置具有采样部分和含有化学发光试剂的读取部分。该接口具有取样装置支架和光检测器。保持器具有壳体，其具有带通道的外壳和具有开口的基板。基板和外壳容纳可滑动的托盘。托盘具有适于安置取样装置的隔室和延伸穿过隔间的开口。阅读部分与托盘开口对齐。当托盘关闭时，托盘开口也与基板开口对准，露出读取部分。一旦采样部分暴露于怀疑含有目标分析物的样品，如果需要，将至少一种载体液体引入采样部分，以通过分散体将任何目标分析物输送到读取部分。为了测量发出的光线，采样装置就位于托盘中。然后将托盘插入外壳。连接在阅读部分附近的光检测器输出信号。然后，使用例如电流表将该信号转换成指示目标分析物量的可量化数据。

2. 发明授权

US5766962A Device for collecting and testing samples 失效
标题翻译：收集和测试样品的设备
公开(公告)号：US5766962A
公开(公告)日：1998-06-16
申请号：US577128
申请日：1995-12-22
申请人： Mary Ann Childs , Mohammed A. Chowdhury , David Bernstein , Gregory K. Shipman , Erick Gray
发明人： Mary Ann Childs , Mohammed A. Chowdhury , David Bernstein , Gregory K. Shipman , Erick Gray
IPC分类号： A61B10/00 , B01L3/00 , B01L9/00 , G01N33/543 , G01N33/569 , G01N21/00 , G01N31/22 , G01N33/53
CPC分类号： G01N33/56911 , A61B10/0038 , A61B10/0045 , B01L3/5023 , G01N33/54366 , B01L2300/0816 , B01L2300/0825 , B01L2400/0406 , B01L2400/0633 , B01L2400/0683 , B01L3/5029 , B01L9/52 , Y10S435/81 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： Improved devices for collecting and analyzing samples of aqueous solutions, body fluids, sewage or fecal matter to be used in detecting microbes and microbial byproducts. A device in accordance with the invention comprises a body including an internal channel having an entryway, a solute chamber connected to the entryway, a solute-adding mechanism operatively connected to the solute chamber, a window in the body that allows viewing of a portion of the channel, and an aperture in the body that opens to the channel; a bendable tang connected to the body; and a sample collection unit attached to the tang.
摘要翻译：用于收集和分析用于检测微生物和微生物副产物的水溶液，体液，污水或粪便物质样品的改进装置。根据本发明的装置包括主体，其包括具有入口通道的内部通道，连接到入口的溶质室，可操作地连接到溶质室的溶质添加机构，身体中允许观察部分通道和在通道中开口的体内的孔; 可弯曲的脚连接到身体; 和一个附在脚上的样本收集单元。

3. 发明授权

US10987527B1 Nasal air filtration device 有权
公开(公告)号：US10987527B1
公开(公告)日：2021-04-27
申请号：US16239636
申请日：2019-01-04
申请人： Erick Gray
发明人： Erick Gray
IPC分类号： A62B23/06 , A62B7/10 , A62B18/02
摘要： A nasal air filtration device for filtering air inhaled by a user is disclosed. The nasal air filtration device includes a pair of nostril tubes including a filter at one end and an ionic plate at other end. Each of the nostril tubes includes a cup having a plurality of openings. The nasal air filtration device includes a base tube coupled to the nostril tubes. The base tube includes an exhaust channel. The base tube includes a first housing having a battery and a second housing having a fan. In order to filter the air inhaled by a user, the nostril tubes are placed inside nostrils of the user. When the user inhales, the fan is operated to draw the air into the base tube, and the air is made to pass through the filter and the ionic plate provided at the nostril tubes into the nostrils via the openings. When the user exhales, the air is released into the atmosphere through the exhaust channel via the nostril tubes.

4. 外观设计

USD407825S Octagonal diagnostic test device 失效
公开(公告)号：USD407825S
公开(公告)日：1999-04-06
申请号：US61172
申请日：1996-10-17
申请人： Mary Ann Childs , Thomas He , Greg K. Shipman , William Trainor , Erick Gray , Mohammud Afzal Chowdhury , Joseph A. McClintock , David Bernstein
设计人： Mary Ann Childs , Thomas He , Greg K. Shipman , William Trainor , Erick Gray , Mohammud Afzal Chowdhury , Joseph A. McClintock , David Bernstein

5. 发明授权

US5824268A Rapid self-contained assay format 失效
标题翻译：快速自给自足的检测方式
公开(公告)号：US5824268A
公开(公告)日：1998-10-20
申请号：US950331
申请日：1997-10-14
申请人： David Bernstein , Mary Ann Childs , William Trainor , Majorie Wier , Erick Gray
发明人： David Bernstein , Mary Ann Childs , William Trainor , Majorie Wier , Erick Gray
IPC分类号： G01N30/02 , G01N33/538 , G01N33/543 , G01N33/558
CPC分类号： G01N33/538 , G01N33/54386 , G01N33/558 , G01N30/02 , Y10S435/97
摘要： A test strip, a device incorporating the test strip and a method for use of the test strip within the device detecting an analyte in a solution or bodily fluid are disclosed. The test strip was three zones, a reaction zone coated with a substance that binds the analyte, a sample zone with a region for addition of the sample of solution or fluid, and a detection region zone with a region coated with detection reagent. An absorbent pad underlies the reaction zone. The reaction zone is a small membrane and is physically in contact on its upper surface with both the sample zone and the detection zone. The test strip is incorporated into a device which includes a sample collection/transferring device, a housing for holding the test strip, and a container for holding solvent solutions at both outer ends of the test strip such that the solvent solutions can come into contact with the outer ends of the test strip when pressure is applied to the ends. The method involves placing a sample onto the strip using the sample collection/transferring device, causing solvent solutions to come into contact with the sample and detection membranes, and observing the test results. The resulting orthogonal buffer flow is an improvement over current methods because it reduces the number of steps and the time required for performance of a sequential assay.
摘要翻译：公开了一种测试条，包含测试条的装置以及在装置内使用测试条的方法，其中检测溶液或体液中的分析物。测试条是三个区域，涂覆有结合分析物的物质的反应区域，具有用于添加溶液或流体样品的区域的样品区域以及涂覆有检测试剂的区域的检测区域区域。吸收垫位于反应区的正下方。反应区是一个小膜，并在其上表面物理接触，同时具有样品区和检测区。测试条被结合到包括样品收集/转移装置，用于保持测试条的壳体和用于在测试条的两个外端保持溶剂溶液的容器的装置中，使得溶剂溶液可以与当压力施加到端部时，测试条的外端。该方法包括使用样品收集/转移装置将样品放置在条上，使溶剂溶液与样品和检测膜接触，并观察测试结果。所得到的正交缓冲液流是对现有方法的改进，因为它减少了进行顺序测定所需的步骤数和时间。

6. 发明授权

US5783399A Chemiluminescent assay methods and devices for detecting target analytes 失效
标题翻译：用于检测目标分析物的化学发光测定方法和装置
公开(公告)号：US5783399A
公开(公告)日：1998-07-21
申请号：US560094
申请日：1995-11-17
申请人： Mary Ann Childs , Gregory K. Shipman , William P. Trainor , Erick Gray , David Bernstein
发明人： Mary Ann Childs , Gregory K. Shipman , William P. Trainor , Erick Gray , David Bernstein
IPC分类号： C12Q1/66 , G01N21/76 , G01N33/543 , G01N33/53 , C12Q1/00 , C12Q1/02 , G01N33/554
CPC分类号： C12Q1/66 , G01N21/76 , G01N33/54366 , Y10S435/968
摘要： A method which utilize chemiluminescence for analyte detection and the detection of bacteria on surfaces. The method uses a device comprising a sampling portion made of a first adsorbent material, a container, and a second adsorbent material located within the container. The sampling portion collects analytes from a test sample which includes a surface or volume of a liquid. The second adsorbent material holds one or more chemiluminescent components including luciferase enzyme and cofactors in a dry state. In a preferred embodiment, the sampling portion is swabbed over a suspected contaminated surface. A bacteriolytic solution is then added to the adsorbent and releases ATP from any bacteria present. The ATP diffuses into the second adsorbent and mixes with the reagents therein to produce detectable light.
摘要翻译：利用化学发光进行分析物检测和表面细菌检测的方法。该方法使用包括由位于容器内的第一吸附剂材料，容器和第二吸附材料制成的取样部分的装置。采样部分从包括液体的表面或体积的测试样品中收集分析物。第二吸附材料在干燥状态下保持一种或多种化学发光成分，包括荧光素酶和辅因子。在优选实施例中，采样部分被擦拭在可疑的污染表面上。然后将溶菌溶液加入到吸附剂中并从存在的任何细菌释放ATP。 ATP扩散到第二吸附剂中并与其中的试剂混合以产生可检测的光。

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