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1. 发明授权

US06824981B2 Ultra-sensitive detection systems using alterable peptide tags 失效
标题翻译：使用可变肽标签的超灵敏检测系统
公开(公告)号：US06824981B2
公开(公告)日：2004-11-30
申请号：US09929266
申请日：2001-08-13
申请人： Brian T. Chait , Darin R. Latimer , Paul M. Lizardi , Eric R. Kershnar , Jon S. Morrow , Matthew E. Roth , Martin J. Mattessich , Kevin J. McConnell
发明人： Brian T. Chait , Darin R. Latimer , Paul M. Lizardi , Eric R. Kershnar , Jon S. Morrow , Matthew E. Roth , Martin J. Mattessich , Kevin J. McConnell
IPC分类号： C12Q168
CPC分类号： G01N33/6842 , C07K1/047 , C07K1/1077 , C07K1/13 , C07K7/06 , C07K7/08 , G01N33/6803
摘要： Disclosed are compositions and methods for sensitive detection of one or multiple analytes. In general, the methods involve the use of special label components, referred to as reporter signals, that can be associated with, incorporated into, or otherwise linked to the analytes. In some embodiments, the reporter signals can be altered such that the altered forms of different reporter signals can be distinguished from each other. In some embodiments, sets of reporter signals can be used where two or more of the reporter signals in a set have one or more common properties that allow the reporter signals having the common property to be distinguished and/or separated from other molecules lacking the common property. In other embodiments, sets of reporter signal/analyte conjugates can be used where two or more of the reporter signal/analyte conjugates in a set have one or more common properties that allow the reporter signal/analyte conjugates having the common property to be distinguished and/or separated form other molecules lacking the common property. Reporter signals can also be in conjunction with analytes (such as in mixtures of reporter signals and analytes), where no significant physical association between the reporter signals and analytes occurs; or alone, where no analyte is present.
摘要翻译：公开了用于敏感检测一种或多种分析物的组合物和方法。通常，这些方法涉及使用称为报告信号的特殊标记成分，其可以与分析物相关联，并入或以其它方式连接到分析物上。在一些实施方案中，可以改变报道信号，使得不同报道信号的改变形式可以彼此区分。在一些实施方案中，可以使用一组报告信号，其中一组中的两个或更多个报告基因信号具有一个或多个共同性质，其允许具有共同性质的报道信号被区分和/或与其他分子不相同属性。在其它实施方案中，可以使用组的报告信号/分析物缀合物，其中组中的两个或多个报道信号/分析物缀合物具有一个或多个共同性质，其允许区分具有共同性质的报道信号/分析物缀合物， /或分离形成其他缺乏共同性质的分子。记者信号也可以与分析物（例如报告信号和分析物的混合物）结合，其中报告信号和分析物之间不存在明显的物理结合; 或单独存在，其中不存在分析物。

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