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1. 发明申请

US20110232636A1 VALVED HOLDING CHAMBER AND MASK THEREFOR 审中-公开
标题翻译：阀门和阀门
公开(公告)号：US20110232636A1
公开(公告)日：2011-09-29
申请号：US13132428
申请日：2008-12-18
申请人： Dirk Von Hollen , Jonathan Stanley Harold Denyer , Eric Lieberman
发明人： Dirk Von Hollen , Jonathan Stanley Harold Denyer , Eric Lieberman
IPC分类号： A61M16/10 , A61M16/00 , G10K5/00
CPC分类号： A61M15/0086 , A61M15/009 , A61M16/208 , A61M2205/43 , A61M2205/581
摘要： Various embodiments of a valved holding chamber and a mask for a respiratory drug delivery apparatus each having an exhalation valve element having two portions which, based on the movement thereof, encourages proper use of the device. Also, a valved holding chamber having an MDI adapter having a rigid outer portion and a flexible inner portion structured to receive and hold an outlet of an MDI. In addition, a mouthpiece assembly for a valved holding chamber that includes a main body portion and a mouthpiece portion having a plurality of legs for supporting the valved holding chamber in a first orientation and preventing it from freely rolling.
摘要翻译：具有用于呼吸药物输送装置的带阀的保持室和掩模的各种实施方式，每个呼吸药物输送装置具有呼气阀元件，该呼气阀元件具有两部分，该部分基于其运动，鼓励适当使用该装置。此外，具有MDI适配器的带阀的保持室具有刚性外部部分和柔性内部部分，该内部部分构造成容纳和保持MDI的出口。另外，一种用于阀门保持室的接口组件，其包括主体部分和接口部分，其具有多个腿部，用于以第一取向支撑阀门保持室并防止其自由滚动。

2. 发明授权

US07748385B2 Valved holding chamber for use with an aerosol medication delivery system 失效
标题翻译：用于气溶胶药物输送系统的带阀门的保持室
公开(公告)号：US07748385B2
公开(公告)日：2010-07-06
申请号：US10848213
申请日：2004-05-18
申请人： Eric Lieberman , Dirk Von Hollen
发明人： Eric Lieberman , Dirk Von Hollen
IPC分类号： A61M16/20 , A62B18/10
CPC分类号： A61M15/0086 , A61M15/0016 , A61M15/0018 , Y10T137/2544 , Y10T137/7842 , Y10T137/7882 , Y10T137/7895
摘要： The present invention pertains to a valved holding chamber suitable for use in an aerosol medication delivery system. The valved holding chamber includes a housing and a mouthpiece coupled to the housing. A one-way valve assembly is coupled to the housing, the mouthpiece, or both so that fluid flows in a first direction from the housing to the mouthpiece passes through the valve assembly but does not pass back into the housing. The valve assembly includes a conical flange disposed such that the conical flange tapers in the first direction to smooth the fluid flow in the first direction toward the patient. In a further embodiment, the mouthpiece includes an exhaust port defined in a conical collar portion of the mouthpiece, and an exhaust valve element is disposed over the exhaust port to provide a one-way flow of fluid from within the mouthpiece to ambient atmosphere via the exhaust port.
摘要翻译：本发明涉及一种适用于气溶胶药物输送系统的带阀的保持室。带阀的保持室包括壳体和连接到壳体的接口管。单向阀组件联接到壳体，接口管或两者，使得流体沿着第一方向从壳体流到嘴部件通过阀组件，但不会返回到壳体中。阀组件包括锥形凸缘，该圆锥形凸缘被设置成使得锥形凸缘在第一方向上逐渐变细，以使朝向患者的第一方向的流体流动平滑。在进一步的实施例中，吸嘴包括限定在接口管的锥形套环部分中的排气口，并且排气阀元件设置在排气口上方，以通过经由管嘴从嘴内向内部空气提供单向流体流排气口。

3. 发明申请

US20070023043A1 Actuator for a metered dose inhaler 审中-公开
标题翻译：计量吸入器的执行机构
公开(公告)号：US20070023043A1
公开(公告)日：2007-02-01
申请号：US11529089
申请日：2006-09-28
申请人： Dirk Von Hollen , Eric Lieberman , Jeffrey Paine , Matthew Paine
发明人： Dirk Von Hollen , Eric Lieberman , Jeffrey Paine , Matthew Paine
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M15/0068 , A61M15/009
摘要： A metered dose inhaler is provided which includes a canister fitted in an actuator body. A metered dose of medication is delivered by compressing the canister in the actuator body. The metered dose inhaler includes an actuator that either fully (automatic) or partially (user-assisted) actuates the metered dose inhaler in order to deliver medication to the user.
摘要翻译：提供了一种计量剂量吸入器，其包括安装在致动器主体中的罐。通过压缩致动器主体中的罐来递送计量剂量的药物。计量剂量吸入器包括完全（自动）或部分（用户辅助的）致动计量剂量吸入器的致动器，以向用户输送药物。

4. 发明申请

US20060137681A1 Actuator for a metered dose inhaler 审中-公开
标题翻译：计量吸入器的执行机构
公开(公告)号：US20060137681A1
公开(公告)日：2006-06-29
申请号：US11315559
申请日：2005-12-22
申请人： Dirk Von Hollen , Eric Lieberman , Jeffrey Paine , Matthew Paine
发明人： Dirk Von Hollen , Eric Lieberman , Jeffrey Paine , Matthew Paine
IPC分类号： A61M11/00 , A61M16/00
CPC分类号： A61M15/0091 , A61M15/0068 , A61M15/009
摘要： A metered dose inhaler is provided which includes a canister fitted in an actuator body. A metered dose of medication is delivered by compressing the canister in the actuator body. The metered dose inhaler includes an actuator that either fully (automatic) or partially (user-assisted) actuates the metered dose inhaler in order to deliver medication to the user.
摘要翻译：提供了一种计量剂量吸入器，其包括安装在致动器主体中的罐。通过压缩致动器主体中的罐来递送计量剂量的药物。计量剂量吸入器包括完全（自动）或部分（用户辅助的）致动计量剂量吸入器的致动器，以向用户输送药物。

5. 发明申请

US20060201501A1 Nebulizing drug delivery device with interlock detection and temperature protection 失效
标题翻译：雾化药物输送装置具有互锁检测和温度保护
公开(公告)号：US20060201501A1
公开(公告)日：2006-09-14
申请号：US11367486
申请日：2006-03-03
申请人： Mark Morrison , Eric Lieberman
发明人： Mark Morrison , Eric Lieberman
IPC分类号： A61M16/00 , A61M15/00
CPC分类号： A61M15/0085 , A61M11/001 , A61M11/002 , A61M11/005
摘要： The present invention provides a nebulizing device with a housing that includes a mouthpiece module., an intermediate module, and a base module. An aerosol generator is in communication with a fluid. A barrier is disposed between the fluid and a drug solution provided within the housing. A signal transmitter and a signal receiver are carried by the housing. The signal is either initiated or terminated when one of the modules is separated or misaligned from the other modules. The device further includes a variable volume resilient structure disposed in communication with the fluid to provide volumetric relief in the event that the fluid expands.
摘要翻译：本发明提供一种具有壳体的雾化装置，该壳体包括一个接口模块，一个中间模块和一个基本模块。气溶胶发生器与流体连通。在流体和设置在壳体内的药物溶液之间设置屏障。信号发送器和信号接收器由外壳承载。当其中一个模块与其他模块分离或未对准时，信号被启动或终止。该装置还包括与流体连通地设置的可变体积弹性结构，以在流体膨胀的情况下提供体积浮雕。

6. 发明申请

US20080300856A1 System and method for structuring information 审中-公开
标题翻译：用于构建信息的系统和方法
公开(公告)号：US20080300856A1
公开(公告)日：2008-12-04
申请号：US10945428
申请日：2004-09-21
申请人： Randal J. Kirk , Julian P. Kirk , Eric Lieberman
发明人： Randal J. Kirk , Julian P. Kirk , Eric Lieberman
IPC分类号： G06F17/28
CPC分类号： H04M3/51 , B07C3/00 , G06F16/3329 , G06F16/345 , G10L15/26 , H04M2203/2061
摘要： A translational language system and method for structuring irregular, or unstructured, information are provided. The language system comprising at least one compulsory characteristic for defining a particular nuance of an irregular communication; and at least one term or phrase corresponding to the at least one compulsory characteristic for further defining the particular nuance of the irregular communication.
摘要翻译：提供了一种用于构建不规则或非结构化信息的翻译语言系统和方法。所述语言系统包括用于定义不规则通信的特定细微差别的至少一个强制性特征; 以及至少一个与所述至少一个强制特征相对应的术语或短语，用于进一步限定所述不规则通信的特定细微差别。

7. 发明申请

US20060243274A1 Nebulizing drug delivery device with barrier 失效
标题翻译：带屏障的雾化药物输送装置
公开(公告)号：US20060243274A1
公开(公告)日：2006-11-02
申请号：US11367075
申请日：2006-03-03
申请人： Eric Lieberman , Dirk Von Hollen , Alexandru Bucur , Lev Pavlovsky
发明人： Eric Lieberman , Dirk Von Hollen , Alexandru Bucur , Lev Pavlovsky
IPC分类号： A61M11/00
CPC分类号： A61M11/005 , A61M11/001 , A61M11/002 , A61M15/0085
摘要： The present invention provides a drug delivery device that uses an aerosol generator to nebulize a drug solution. The drug delivery device includes differently sized guide tubes and separator walls to provide substantially consistent particles that can be varied in size by using different guide tubes. The drug delivery device also includes a barrier that separates a fluid contained in the device from the drug solution at least a portion of the barrier is formed from Polyetheretherketone. The present invention also has a drug detection device that can detect the volume of drug in the device or whether the barrier has been compromised.
摘要翻译：本发明提供了一种使用气溶胶发生剂来雾化药物溶液的药物递送装置。药物递送装置包括不同尺寸的导管和分离器壁，以提供通过使用不同的导管可以在尺寸上变化的基本一致的颗粒。药物递送装置还包括将包含在装置中的流体与药物溶液隔离的屏障，其中阻挡层的至少一部分由聚醚醚酮形成。本发明还具有可以检测装置中药物的体积或者是否损害了屏障的药物检测装置。

8. 发明申请

US20060201502A1 Nebulizing drug delivery device with increased flow rate 有权
标题翻译：具有增加流速的雾化药物输送装置
公开(公告)号：US20060201502A1
公开(公告)日：2006-09-14
申请号：US11367649
申请日：2006-03-03
申请人： Eric Lieberman , Dirk Von Hollen
发明人： Eric Lieberman , Dirk Von Hollen
IPC分类号： A61M15/00 , A61M16/00
CPC分类号： A61M11/041 , A61M11/001 , A61M11/005 , A61M2205/3653 , A61M2205/8268
摘要： The present invention provides a nebulizing drug delivery system for delivering an aerosolized drug to a user having various features to increase the capacity of the drug delivery device. The drug delivery system includes a heater to increase the viscosity of the drug, a double aerosolizing system to double the capacity of the device, and a valve system to continuously replenish drug to the aerosol generator thereby providing a high speed delivery.
摘要翻译：本发明提供了一种雾化药物递送系统，用于将雾化药物递送给具有各种特征的用户以增加药物递送装置的容量。药物递送系统包括加热器以增加药物的粘度，双雾化系统将装置的容量加倍，以及阀系统，以连续补充药物到气溶胶发生器，从而提供高速输送。

9. 发明申请

US20060201500A1 Nebulizing drug delivery device for ventilator 有权
标题翻译：呼吸机雾化药物输送装置
公开(公告)号：US20060201500A1
公开(公告)日：2006-09-14
申请号：US11367856
申请日：2006-03-03
申请人： Dirk Von Hollen , Eric Lieberman
发明人： Dirk Von Hollen , Eric Lieberman
IPC分类号： A61M15/00 , A61M11/00
CPC分类号： A61M15/0085 , A61M11/001 , A61M11/002 , A61M11/005 , A61M16/08 , A61M2205/3653 , A61M2205/8268
摘要： The present invention provides a drug delivery device having a housing that includes a ventilator interface module and a base module removeably coupled to the ventilator interface module. An aerosol generator is disposed in the base module to nebulize a drug solution provided in the housing. The ventilator interface module has an outlet port through which nebulized particles of the drug solution can be communicated to a user, and an inlet port through which the housing receives intake gas. The housing has a flow path defined therein that directs intake gas from the inlet port to the outlet port such that the nebulized drug solution particles formed in the housing are motivated toward the outlet port when the base module is coupled to the ventilator interface module. A seal arrangement substantially seals the inlet port and outlet port from ambient atmosphere when the base module is uncoupled from the ventilator interface module, such that intake gas can be communicated from the inlet port to the outlet port.
摘要翻译：本发明提供一种药物输送装置，其具有壳体，该壳体包括呼吸机接口模块和可移除地联接到呼吸机接口模块的基座模块。气雾发生器设置在基座模块中以使设置在壳体中的药液雾化。呼吸机接口模块具有出口端口，药液的雾化颗粒可以通过该出口连接到使用者，以及入口，外壳接收入口气体。壳体具有限定在其中的流动路径，其将进气从入口端口引导到出口端口，使得当基座模块联接到通气机接口模块时，形成在壳体中的雾化药液颗粒被朝向出口端口驱动。当基座模块与通气机接口模块脱离联接时，密封装置基本上将入口端口和出口端口与环境大气密封，使得进气可以从进口端口连接到出口端口。

10. 发明申请

US20110247616A1 SYSTEM AND METHOD FOR DISPENSING MEDICAMENT INTO A VENTILATOR CIRCUIT 审中-公开
标题翻译：将药物分配到通气电路的系统和方法
公开(公告)号：US20110247616A1
公开(公告)日：2011-10-13
申请号：US13132733
申请日：2009-11-23
申请人： Dirk Von Hollen , Eric Lieberman
发明人： Dirk Von Hollen , Eric Lieberman
IPC分类号： A61M16/10
CPC分类号： A61M16/0816 , A61M15/0026 , A61M15/009 , A61M16/0833 , A61M16/208
摘要： A drug delivery adapter is configured to facilitate the delivery of one or more medicaments to a subject being ventilated by a circuit (not shown). The circuit may be a ventilator circuit, or the like, configured to convey a pressurized flow of breathable gas to the airway of the subject. The ventilator circuit may form a flow path between a pressure generator and the airway of the subject to deliver a pressurized flow of breathable gas from the pressure generator to the airway of the subject. The drug delivery adapter, in particular, is configured to enable the delivery of one or more medicaments into the pressurized flow of breathable gas being conveyed to the subject by the circuit without compromising the integrity of the circuit through the introduction of ambient air. To facilitate this delivery, the drug delivery adapter is configured to dock one or more types of medicament dispenser.
摘要翻译：药物递送适配器被配置为便于将一种或多种药物递送到通过电路（未示出）通风的对象。该电路可以是通气机回路等，其构造成将加压的可呼吸气体流传送到对象的气道。呼吸机回路可以在压力发生器和受试者的气道之间形成流动路径，以将来自压力发生器的加压气流从压力发生器输送到对象的气道。特别地，药物输送适配器构造成能够将一种或多种药物输送到通过电路输送到受试者的加压气流中，而不会通过引入环境空气而损害电路的完整性。为了便于该输送，药物递送适配器被配置成对接一种或多种类型的药物分配器。

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