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1. 发明授权

US5534529A Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses 失效
标题翻译：具有抗高血胆固醇活性的取代的芳族酰胺和脲衍生物及其制备及其治疗用途
公开(公告)号：US5534529A
公开(公告)日：1996-07-09
申请号：US267124
申请日：1994-06-28
申请人： Akira Yoshida , Koza Oda , Sadao Ishihara , Takashi Kasai , Fujio Saito , Hiroyuki Koike , Teiichiro Koga , Eiichi Kitazawa , Hiroshi Kogen , Ichiro Hayakawa
发明人： Akira Yoshida , Koza Oda , Sadao Ishihara , Takashi Kasai , Fujio Saito , Hiroyuki Koike , Teiichiro Koga , Eiichi Kitazawa , Hiroshi Kogen , Ichiro Hayakawa
IPC分类号： A61K31/165 , A61K31/00 , A61K31/16 , A61K31/167 , A61K31/17 , A61K31/215 , A61K31/235 , A61K31/265 , A61K31/335 , A61K31/35 , A61K31/352 , A61K31/41 , A61K31/415 , A61K31/535 , A61P3/06 , A61P9/10 , A61P43/00 , C07C233/07 , C07C233/11 , C07C233/25 , C07C233/26 , C07C235/38 , C07C235/48 , C07C237/06 , C07C237/40 , C07C275/18 , C07C275/28 , C07C275/34 , C07C323/39 , C07D233/12 , C07D233/56 , C07D233/58 , C07D233/60 , C07D235/08 , C07D235/12 , C07D311/82 , C07D311/90 , C07D313/12 , C07D405/12 , C07D413/12 , C07D521/00 , C07F9/09 , C12N9/99 , A61K31/24 , C07C275/30 , C07D513/04
CPC分类号： C07D231/12 , C07C233/25 , C07C233/26 , C07C235/48 , C07D233/56 , C07D249/08 , C07D311/90 , C07D313/12 , C07D405/12
摘要： Compounds of formula (I) are provided: ##STR1## wherein: R.sup.1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are hydrogen or various organic groups; and pharmaceutically acceptable salts thereof; as well as methods for the preparation of such compounds and their use in the treatment and prophylaxis of hypercholesteremia and arteriosclerosis.
摘要翻译：提供式（I）化合物：其中：R 1表示烷基; （II），（III），（IV）或（V）的基团：其中基团R 2 ，R3，R4和R5是氢或各种有机基团; 及其药学上可接受的盐; 以及制备这些化合物的方法及其在治疗和预防高胆固醇血症和动脉硬化中的用途。

2. 发明授权

US4871762A Lipid peroxide lowering 1,3-benzoxathiole derivative compositions and method of use therefor 失效
标题翻译：降低脂肪的过氧化1,3-苯并硫草衍生物组合物及其用途
公开(公告)号：US4871762A
公开(公告)日：1989-10-03
申请号：US139180
申请日：1987-12-24
申请人： Takao Yoshioka , Eiichi Kitazawa , Mitsuo Yamazaki , Yoshio Iizuka
发明人： Takao Yoshioka , Eiichi Kitazawa , Mitsuo Yamazaki , Yoshio Iizuka
IPC分类号： A61K31/39 , A61K31/695 , A61P3/06 , A61P7/02 , A61P9/00 , A61P37/08 , C07D327/04 , C07F7/18
CPC分类号： C07C323/00 , C07D327/04 , C07F7/1856
摘要： Compounds formula (I): ##STR1## in which: R.sup.1 represents a hydrogen atom, an alkyl group, a substituted alkyl group, a C.sub.2 -C.sub.6 alkenyl group, an aryl group, a substituted aryl group or an alkoxycarbonyl group wherein the alkoxy part has from 1 to 6 carbon atoms; R.sup.2 represenets a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a C.sub.3 or C.sub.4 alkenyl group; R.sup.3 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group; R.sup.4 represents a hydroxy group, a C.sub.1 -C.sub.21 aliphatic acyloxy group or a carbocyclic aryl carboxylic aryloxy group; R.sup.5 represents a C.sub.1 -C.sub.12 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a hydroxy group, a C.sub.1 -C.sub.7 aliphatic acyloxy group or a carbocyclic aryl carboxylic acyloxy group; R.sup.6 represents a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a C.sub.1 -C.sub.6 alkoxy group; and n is 0, 1, or 2;and pharmaceutically acceptable salts thereof are valuable in the treatment of circulatory disorders and allergies.

3. 发明授权

US5827855A Hexahydronaphthalene ester derivatives their preparation and their therapeutic uses 失效
标题翻译：六氢萘酯衍生物的制备及其治疗用途
公开(公告)号：US5827855A
公开(公告)日：1998-10-27
申请号：US579840
申请日：1995-12-28
申请人： Hiroshi Kogen , Sadao Ishihara , Teiichiro Koga , Eiichi Kitazawa , Nobufusa Serizawa , Kiyoshi Hamano
发明人： Hiroshi Kogen , Sadao Ishihara , Teiichiro Koga , Eiichi Kitazawa , Nobufusa Serizawa , Kiyoshi Hamano
IPC分类号： A61K31/22 , A61K31/35 , A61K31/365 , A61K31/366 , A61P3/06 , C07C69/03 , C07C69/24 , C07C69/33 , C07C69/67 , C07C69/675 , C07C69/732 , C07C69/734 , C07D309/30 , C12N9/02 , C12P7/62 , C12P17/06 , C12R1/01 , C12R1/465 , C12R1/785 , A01N43/42 , C07C67/74
CPC分类号： C07C69/33 , C07C69/675 , C07C69/732 , C07D309/30 , C12N9/0093 , C12P17/06 , C12P7/62 , Y02P20/55
摘要： Compounds of formula (I): ##STR1## wherein R.sup.1 represents a group of formula (II) or (III): ##STR2## R.sup.2 is alkyl, alkenyl or alkynyl; R.sup.3 and R.sup.4 are each hydrogen, alkyl, alkenyl or alkynyl; R.sup.5 is hydrogen or a carboxy-protecting group; R.sup.a is a group of formula --OR.sup.6 ; R.sup.6 is hydrogen; R.sup.6a and R.sup.6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arysulfonyl, and their salts and esters. Such compounds inhibit the synthesis of cholesterol, and can be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.
摘要翻译：（I）的化合物：其中R 1表示式（II）或（III）的基团：其中R 2是烷基，烯基或炔基; R3和R4各自为氢，烷基，烯基或炔基; R5是氢或羧基保护基; Ra是式-OR6的一组; R6是氢; R6a和R6b各自为氢，羟基保护基，烷基，烷磺酰基，卤代烷磺酰基或芳磺酰基，以及它们的盐和酯。这些化合物抑制胆固醇的合成，并可用于治疗和预防高胆固醇血症和各种心脏疾病。

4. 发明申请

US20100024394A1 TROUBLE DIAGNOSIS DEVICE FOR EXHAUST GAS PURIFICATION SYSTEM AND TROUBLE DIAGNOSIS METHOD FOR EXHAUST GAS PURIFICATION SYSTEM 审中-公开
标题翻译：用于排气净化系统的故障诊断装置和排气净化系统的故障诊断方法
公开(公告)号：US20100024394A1
公开(公告)日：2010-02-04
申请号：US12525401
申请日：2008-01-25
申请人： Eiichi Kitazawa
发明人： Eiichi Kitazawa
IPC分类号： F01N11/00 , F01N3/10
CPC分类号： F01N11/002 , B01D53/9495 , B01D2257/404 , B01D2258/012 , F01N3/206 , F01N3/2066 , F01N3/208 , F01N11/007 , F01N2550/02 , F01N2610/14 , F01N2900/0411 , F01N2900/0418 , F01N2900/14 , F01N2900/1621 , Y02C20/10 , Y02T10/24 , Y02T10/47
摘要： There are provided a trouble diagnosis device and a trouble diagnosis method for an exhaust gas purification system in which the presence or absence of a trouble of the exhaust gas purification system such as abnormality of a control system for the exhaust gas purification system, catalyst deterioration or the like can be determined with high precision, and the reliability of the exhaust gas purification system can be enhanced.The device includes upstream-side NOx flow rate calculating means, downstream-side NOx flow rate calculating means, reduction condition determining means for determining whether at least one condition for performing normal reduction of NOx is satisfied, upstream-side NOx flow amount calculating means for integrating the upstream-side NOx flow amount to calculate the amount of NOx passing through the upstream side of the catalyst within a predetermined time when the condition concerned is determined to be satisfied, downstream-side NOx amount calculating means for integrating the downstream-side NOx flow amount to calculate the amount of NOx passing through the downstream side of the catalyst within a predetermined time when the condition concerned is determined to be satisfied, and trouble determining means for comparing the upstream-side NOx amount and the downstream-side NOx amount to determine whether the exhaust gas purification system operates normally.
摘要翻译：提供了一种排气净化系统的故障诊断装置和故障诊断方法，其中有无排气净化系统的故障，例如排气净化系统的控制系统的异常，催化剂劣化或可以高精度地确定，能够提高排气净化系统的可靠性。该装置包括上游侧NOx流量计算装置，下游侧NOx流量计算装置，用于确定是否满足用于执行正常NOx还原的至少一个条件的还原条件确定装置，上游侧NOx流量计算装置，整合上游侧NOx流量，在确定满足有关条件的规定时间内，计算通过催化剂上游侧的NOx量，下游侧NOx量计算单元，其将下游侧NOx 在确定满足有关条件的规定时间内，计算经过催化剂下游侧的NOx的量的流量;以及将上游侧NOx量与下游侧NOx量进行比较的故障判定单元，确定废气净化系统是否正常运行。

5. 发明授权

US06040339A Urea derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use 失效
标题翻译：具有ACAT抑制活性的尿素衍生物及其制备及其治疗和预防用途
公开(公告)号：US06040339A
公开(公告)日：2000-03-21
申请号：US86402
申请日：1998-05-28
申请人： Akira Yoshida , Kozo Oda , Takashi Kasai , Kousei Shimada , Hiroshi Kogen , Ichiro Hayakawa , Sadao Ishihara , Teiichiro Koga , Eiichi Kitazawa , Taro Tokui
发明人： Akira Yoshida , Kozo Oda , Takashi Kasai , Kousei Shimada , Hiroshi Kogen , Ichiro Hayakawa , Sadao Ishihara , Teiichiro Koga , Eiichi Kitazawa , Taro Tokui
IPC分类号： C07C275/28 , A61K31/16 , A61K31/17 , A61K31/18 , A61K31/275 , A61K31/40 , A61K31/445 , A61K31/535 , A61P9/10 , C07C233/08 , C07C235/38 , C07C237/22 , C07C237/42 , C07C237/52 , C07C251/48 , C07C255/01 , C07C255/44 , C07C255/49 , C07C255/57 , C07C255/60 , C07C259/10 , C07C271/12 , C07C271/20 , C07C271/64 , C07C275/24 , C07C275/32 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C311/04 , C07C311/29 , C07C311/32 , C07C311/37 , C07C311/46 , C07C317/18 , C07C317/46 , C07C323/62 , C07D207/02 , C07D211/04 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/88 , C07D231/12 , C07D231/40 , C07D233/54 , C07D239/28 , C07D239/42 , C07D241/20 , C07D241/24 , C07D265/28 , C07D277/30 , C07D277/46 , C07D295/192 , C07D295/215 , C07D317/58 , C07D317/60 , C07D405/12 , C07D521/00 , A61K31/27
CPC分类号： C07D213/75 , C07C235/38 , C07C237/22 , C07C237/42 , C07C237/52 , C07C251/48 , C07C255/44 , C07C255/57 , C07C255/60 , C07C259/10 , C07C271/12 , C07C271/20 , C07C271/64 , C07C275/24 , C07C275/40 , C07C275/42 , C07C311/04 , C07C311/29 , C07C311/46 , C07C317/18 , C07C317/46 , C07C323/62 , C07D213/56 , C07D213/81 , C07D213/82 , C07D213/88 , C07D231/12 , C07D231/40 , C07D233/56 , C07D233/64 , C07D239/28 , C07D239/42 , C07D241/20 , C07D241/24 , C07D249/08 , C07D277/30 , C07D277/46 , C07D295/192 , C07D295/215 , C07D317/58 , C07D317/60 , C07D405/12
摘要： Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R.sup.3 is alkyl; R.sup.4 is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): ##STR2## wherein: A.sup.1 is a single bond, alkylene or alkenylene; A.sup.2 is or alkenylene; A.sup.3 is a single bond, alkyleneor alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or various other groups; R.sup.6 is alkyl or phenyl; R.sup.7 is hydrogen or alkyl; R.sup.8 is alkyl or various other groups; and n is 0 and pharmaceutically acceptable salts thereof have valuable inhibitory activity against acyl-CoA: cholesterol acyl transferase.
摘要翻译：式（I）的化合物：其中：R 1是烷基; R2a，R2b，R2c和R2d相同或不同，各自为氢，任选取代的烷基或各种其他有机基团; R3是烷基; R4是式（II），（III），（IV），（V），（VI），（VII），（VIII）或（IX）的基团：其中：A1是单键，亚烷基或亚烯基; A2是或亚烯基; A3是单键，亚烷基或亚烯基; R5a和R5b相同或不同，各自为氢，烷基或各种其它基团; R6是烷基或苯基; R7是氢或烷基; R8是烷基或各种其它基团; n为0，其药学上可接受的盐对酰基-CoA：胆固醇酰基转移酶具有有价值的抑制活性。

6. 发明授权

US08359826B2 Trouble diagnosis device and trouble diagnosis method for NOx sensor 有权
标题翻译： NOx传感器故障诊断装置及故障诊断方法
公开(公告)号：US08359826B2
公开(公告)日：2013-01-29
申请号：US12525408
申请日：2008-01-25
申请人： Eiichi Kitazawa
发明人： Eiichi Kitazawa
IPC分类号： F01N11/00 , G01M15/10
CPC分类号： F02D41/222 , F01N3/0807 , F01N11/00 , F01N2560/026 , F01N2900/0416 , F01N2900/14 , F02D41/146 , F02D41/1461 , F02D41/1462 , Y02C20/10 , Y02T10/20 , Y02T10/40 , Y02T10/47
摘要： A trouble diagnosis device and method for an NOx sensor for determining abnormality of an NOx sensor used in an exhaust gas purification system. The device can perform a trouble diagnosis without forcedly creating a diagnosis mode during operation of an internal combustion engine and without deterioration of drivability or fuel consumption. The device detects the time-lapse variation of the exhaust NOx flow rate suitable for diagnosis in a normal operation mode and determines whether the NOx sensor responds with following this variation.
摘要翻译：一种用于确定在废气净化系统中使用的NOx传感器的异常的NOx传感器的故障诊断装置和方法。该装置可以执行故障诊断，而不会在内燃机的运行期间强制建立诊断模式，并且不会降低驾驶性能或燃料消耗。该装置检测适合于正常运行模式下的诊断的排气NOx流量的延时变化，并且确定NOx传感器是否响应该变化。

7. 发明授权

US08161735B2 Clogging determining device for reducing agent passage and clogging determining method for reducing agent passage 有权
标题翻译：用于还原剂通过的堵塞确定装置和用于还原剂通过的堵塞确定方法
公开(公告)号：US08161735B2
公开(公告)日：2012-04-24
申请号：US12527600
申请日：2008-02-18
申请人： Eiichi Kitazawa
发明人： Eiichi Kitazawa
IPC分类号： F01N3/36
CPC分类号： F01N11/00 , B01D2251/2067 , B01D2257/404 , F01N3/2066 , F01N2550/05 , F01N2610/02 , F01N2610/14 , Y02T10/24 , Y02T10/47
摘要： There are provided a clogging determining device for a reducing agent passage and a clogging determining method for a reducing agent passage, which can accurately detect clogging and estimate a clogged place when clogging occurs in any place of a supply line or a return line.The device includes pump driving control element for subjecting the pump to DUTY control so that a pressure value is kept to a predetermined value, driving DUTY determining element for determining whether the driving DUTY of the pump is less than a predetermined threshold value corresponding to the opening degree of the reducing agent injection valve, or not; pressure reduction amount calculating element for calculating a pressure reduction amount by which the pressure value detected by the pressure sensor is reduced within a predetermined time after the pump is stopped and the reducing agent injection valve is fully opened when it is determined that the driving DUTY of the pump is less than the threshold value, and clogging determining element for determining on the basis of the pressure reduction amount calculated by the pressure reduction amount: calculating element whether clogging occurs in the first reducing agent passage or the second reducing agent passage.
摘要翻译：提供了用于还原剂通道的堵塞确定装置和用于还原剂通道的堵塞确定方法，其可以在供应管线或返回管线的任何位置发生堵塞时，准确地检测堵塞并估计堵塞的位置。该装置包括泵驱动控制元件，用于对泵进行DUTY控制，使得压力值保持在预定值，驱动DUTY确定元件，用于确定泵的驱动DUTY是否小于对应于开度的预定阈值还原剂注射阀的程度，不是; 减压量计算单元，用于计算在所述泵停止后的预定时间内所述压力传感器检测到的压力值减小的压力降低量，并且当确定所述还原剂喷射阀被确定为所述泵小于所述阈值，根据由所述减压量计算出的压力降低量确定的堵塞判定要素：计算单元是否在所述第一还原剂通道或所述第二还原剂通路中发生堵塞。

8. 发明授权

US5880147A Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use 失效
标题翻译：具有ACAT抑制活性的酰胺衍生物，其制备及其治疗和预防用途
公开(公告)号：US5880147A
公开(公告)日：1999-03-09
申请号：US715589
申请日：1996-09-18
申请人： Akira Yoshida , Kozo Oda , Takashi Kasai , Kousei Shimada , Hiroshi Kogen , Ichiro Hayakawa , Sadao Ishihara , Teiichiro Koga , Eiichi Kitazawa , Taro Tokui
发明人： Akira Yoshida , Kozo Oda , Takashi Kasai , Kousei Shimada , Hiroshi Kogen , Ichiro Hayakawa , Sadao Ishihara , Teiichiro Koga , Eiichi Kitazawa , Taro Tokui
IPC分类号： C07C275/28 , A61K31/16 , A61K31/17 , A61K31/18 , A61K31/275 , A61K31/40 , A61K31/445 , A61K31/535 , A61P9/10 , C07C233/08 , C07C235/38 , C07C237/22 , C07C237/42 , C07C237/52 , C07C251/48 , C07C255/01 , C07C255/44 , C07C255/49 , C07C255/57 , C07C255/60 , C07C259/10 , C07C271/12 , C07C271/20 , C07C271/64 , C07C275/24 , C07C275/32 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C311/04 , C07C311/29 , C07C311/32 , C07C311/37 , C07C311/46 , C07C317/18 , C07C317/46 , C07C323/62 , C07D207/02 , C07D211/04 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/88 , C07D231/12 , C07D231/40 , C07D233/54 , C07D239/28 , C07D239/42 , C07D241/20 , C07D241/24 , C07D265/28 , C07D277/30 , C07D277/46 , C07D295/192 , C07D295/215 , C07D317/58 , C07D317/60 , C07D405/12 , C07D521/00 , A61K31/335 , A61K31/165 , C07C233/05 , C07D319/16
CPC分类号： C07D213/75 , C07C235/38 , C07C237/22 , C07C237/42 , C07C237/52 , C07C251/48 , C07C255/44 , C07C255/57 , C07C255/60 , C07C259/10 , C07C271/12 , C07C271/20 , C07C271/64 , C07C275/24 , C07C275/40 , C07C275/42 , C07C311/04 , C07C311/29 , C07C311/46 , C07C317/18 , C07C317/46 , C07C323/62 , C07D213/56 , C07D213/81 , C07D213/82 , C07D213/88 , C07D231/12 , C07D231/40 , C07D233/56 , C07D233/64 , C07D239/28 , C07D239/42 , C07D241/20 , C07D241/24 , C07D249/08 , C07D277/30 , C07D277/46 , C07D295/192 , C07D295/215 , C07D317/58 , C07D317/60 , C07D405/12
摘要： Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl, --(C.dbd.O)--B.sup.1 (wherein B.sup.1 is hydrogen or alkyl), nitro, --NR.sup.c R.sup.d (wherein R.sup.c is hydrogen or alkyl and Rd is alkyl), hydroxy, protected hydroxy group, alkoxy, cyano, alkylthio, alkylsulfinyl, alkylsulfonyl or halogen;R.sup.3 is alkyl; R.sup.4 is a group of the formula (II) ##STR2## wherein A.sup.1 is a single bond, alkylene or alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or --A.sup.4 R.sup.5.sub.c wherein A is a single bond, alkylene or alkenylene and R.sup.5.sub.c is alkoxy; and n is 0, and pharmaceutically acceptable salts thereof. Such compounds have valuable inhibitory activity against acyl-CoA (cholesterol acyl transferase).
摘要翻译：式（I）的化合物：其中：R 1是烷基; R2a，R2b，R2c和R2d相同或不同，各自为氢，任选取代的烷基， - （C = O）-B1（其中B1为氢或烷基），硝基，-NRcRd（其中Rc为氢或烷基， Rd是烷基），羟基，保护的羟基，烷氧基，氰基，烷硫基，烷基亚磺酰基，烷基磺酰基或卤素; R3是烷基; R4是式（Ⅱ）的基团，其中A1是单键，亚烷基或亚烯基; R5a和R5b相同或不同，各自为氢，烷基或-A4R5c，其中A为单键，亚烷基或亚烯基，R5c为烷氧基; 和n为0，及其药学上可接受的盐。这些化合物对酰基辅酶A（胆固醇酰基转移酶）具有有价值的抑制活性。

9. 发明授权

US5104888A Thiazolidine derivatives, their preparation and use 失效
标题翻译：噻唑烷衍生物，其制备和使用
公开(公告)号：US5104888A
公开(公告)日：1992-04-14
申请号：US560466
申请日：1990-07-25
申请人： Takao Yoshioka , Eiichi Kitazawa , Yomoyuki Kurumada , Mitsuo Yamazaki , Kazuo Hasegawa , Takashi Fujita
发明人： Takao Yoshioka , Eiichi Kitazawa , Yomoyuki Kurumada , Mitsuo Yamazaki , Kazuo Hasegawa , Takashi Fujita
IPC分类号： C07D311/22 , C07D311/24 , C07D311/70 , C07D311/72 , C07D405/12 , C07D417/12 , C07D417/14 , C07D495/10
CPC分类号： C07D405/12 , C07D311/22 , C07D311/24 , C07D311/70 , C07D311/72 , C07D417/12 , C07D417/14 , C07D495/10
摘要： Compounds of formula (I): ##STR1## (in which R.sup.1 -R.sup.7 are hydrogen or various organic groups, n is 1-10, Ar is an aromatic group, U is CH.sub.2 or a carbon atom doubly bonded to either one of its adjacent carbons, and W is >CH.sub.2, >C.dbd.O, >CHOH, >C.dbd.NOH or various derivatives thereof) have the ability to lower the levels of blood lipid peroxides and blood sugars and to inhibit the activity of aldose reductase; they may be used therapeutically for these purposes.
摘要翻译：式（I）化合物：其中R 1 -R 7为氢或各种有机基团，n为1-10，Ar为芳族基团，U为CH 2或与两者双键结合的碳原子的相邻碳，W是> CH2，> C = O，> CHOH，> C = NOH或其各种衍生物）具有降低血脂过氧化物和血糖水平并抑制醛糖还原酶活性的能力 ; 它们可以用于治疗这些目的。

10. 发明授权

US4691027A 1,3-benzoxathiole derivatives 失效
标题翻译： 1,3-苯并硫杂衍生物
公开(公告)号：US4691027A
公开(公告)日：1987-09-01
申请号：US716171
申请日：1985-03-26
申请人： Takao Yoshioka , Eiichi Kitazawa , Mitsuo Yamazaki , Yoshio Iizuka
发明人： Takao Yoshioka , Eiichi Kitazawa , Mitsuo Yamazaki , Yoshio Iizuka
IPC分类号： A61K31/39 , A61K31/695 , A61P3/06 , A61P7/02 , A61P9/00 , A61P37/08 , C07D327/04 , C07F7/18 , C07D497/00
CPC分类号： C07C323/00 , C07D327/04 , C07F7/1856
摘要： Compounds formula (I): ##STR1## in which: R.sup.1 represents a hydrogen atom, an alkyl group, a substituted alkyl group, a C.sub.2 -C.sub.6 alkenyl group, an aryl group, a substituted aryl group or an alkoxycarbonyl group wherein the alkoxy part has from 1 to 6 carbon atoms; R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a C.sub.3 or C.sub.4 alkenyl group; R.sup.3 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group; R.sup.4 represents a hydroxy group, a C.sub.1 -C.sub.21 aliphatic acyloxy group or a carbocyclic aryl carboxylic acyloxy group; R.sup.5 represents a C.sub.1 -C.sub.12 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a hydroxy group, a C.sub.1 -C.sub.7 aliphatic acyloxy group or a carbocyclic aryl carboxylic acyloxy group; R.sup.6 represents a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a C.sub.1 -C.sub.6 alkoxy group; and n is 0, 1, or 2; and pharmaceutically acceptable salts thereof are valuable in the treatment of circulatory disorders and allergies.
摘要翻译：化合物式（I）：其中：R 1表示氢原子，烷基，取代的烷基，C 2 -C 6烯基，芳基，取代的芳基或烷氧基羰基，其中烷氧基部分具有1至6个碳原子; R2表示氢原子，C1-C6烷基或C3或C4链烯基; R3表示氢原子或C1-C6烷基; R4代表羟基，C1-C21脂族酰氧基或碳环芳基羧酰氧基; R5表示C1-C12烷基，C1-C6烷氧基，羟基，C1-C7脂族酰氧基或碳环芳基羧酰氧基; R6表示氢原子，C1-C6烷基或C1-C6烷氧基; 并且n为0,1或2; 及其药学上可接受的盐在治疗循环障碍和过敏中是有价值的。

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