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1. 发明专利

AU1104913B KEYLESS LOCK AND LABEL 未知
公开(公告)号：AU1104913B
公开(公告)日：1914-03-24
申请号：AU1104913
申请日：1913-10-28
申请人： EDWARD MACDONALD , ALBERT FLIGHT , WILLIAM CONNOR , LOUIS LEVY AARONS
发明人： EDWARD MACDONALD ALBERT FLIGHT WILLIAM CONNOR LOUIS LEW AARONS

2. 发明专利

AU11049B1 KEYLESS LOCK AND LABEL 未知
公开(公告)号：AU11049B1
公开(公告)日：1914-03-24
申请号：AU1104913
申请日：1913-10-28
申请人： EDWARD MACDONALD , ALBERT FLIGHT , WILLIAM CONNOR , LOUIS LEVY AARONS
发明人： EDWARD MACDONALD ALBERT FLIGHT WILLIAM CONNOR LOUIS LEW AARONS

3. 发明授权

US08840532B2 Strap adjuster and keeper and method of strap control 有权
标题翻译：皮带调节器和保持器以及皮带控制方法
公开(公告)号：US08840532B2
公开(公告)日：2014-09-23
申请号：US13194522
申请日：2011-07-29
申请人： Randal Hetrick , Jordan Edward Macdonald , Stephanie Russo
发明人： Randal Hetrick , Jordan Edward Macdonald , Stephanie Russo
IPC分类号： A63B71/00 , A44B11/25 , A63B21/16 , A63B21/00 , A63B21/068
CPC分类号： A63B21/068 , A44B11/2557 , A63B21/0557 , A63B21/1636 , A63B21/4035 , A63B21/4043 , A63B2225/09 , Y10T24/4086
摘要： A method of strap control and an apparatus including a combined strap-length adjuster and strap keeper is disclosed for use with strap-length adjuster comprising two rings. The strap-length adjuster includes openings that permit the attachment of a tether to the strap keeper. The arrangement allows the tether to not interfere with the positioning or movement of the straps, and maintains the straps close to the strap-length adjuster and prevents slippage of the strap through the strap-length adjuster.
摘要翻译：公开了一种带式控制的方法和包括组合带长度调节器和带式保持器的设备，用于包括两个环的带长度调节器。带长度调节器包括允许将系绳附接到绑带保持器的开口。该布置允许系绳不干扰带的定位或移动，并且将带子保持靠近带长度调节器并且防止带穿过带长度调节器的滑动。

4. 发明授权

US07647239B2 Methods and systems for smoothing of the assumed long-term discount rate for pension plans and actuarial valuations 有权
标题翻译：用于平衡养老金计划和精算估值的假定长期贴现率的方法和系统
公开(公告)号：US07647239B2
公开(公告)日：2010-01-12
申请号：US10938449
申请日：2004-09-10
申请人： Edward Macdonald
发明人： Edward Macdonald
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q40/00 , G06Q40/04 , G06Q40/06 , G06Q40/08 , G06Q40/10
摘要： Methods and computer systems provide for the determination of employer liabilities and resulting contributions to pension plans by utilizing a smoothed discount rate in place of an assumed long-term discount rate. A compounded expected cumulative return on market value over a period of time that is based on the assumed long-term discount rate is found. A compounded actual return on market value over the chosen look-back period is also found. An adjusted expected rate of return over a future period of time remaining in an assumed period of time is then found based on the compounded expected return and the compounded actual return. The smoothed discount rate to be used in place of the assumed long-term discount rate is then based on the adjusted expected return.
摘要翻译：方法和计算机系统通过利用平滑的贴现率代替假设的长期贴现率来确定雇主负债的确定和养老金计划的结果。发现在一段时间内，基于假定的长期贴现率的复合预期市场价值累计回报率。还找到了在所选择的追溯期内复合实际的市场价值回报率。然后根据复合预期收益和复合实际收益，确定在假设期间剩余时间内的调整后预期回报率。然后根据经调整的预期收益，用于代替假设长期贴现率的平滑贴现率。

5. 发明申请

US20050222230A1 3,4-diarylpyrazoles and their use in the therapy of cancer 失效
标题翻译： 3,4-二芳基吡唑及其在癌症治疗中的应用
公开(公告)号：US20050222230A1
公开(公告)日：2005-10-06
申请号：US10499030
申请日：2002-12-19
申请人： Martin Drysdale , Brian Dymock , Xavier Barril-Alonso , Paul Workman , Laurence Pearl , Chrisostomos Prodromou , Edward Macdonald
发明人： Martin Drysdale , Brian Dymock , Xavier Barril-Alonso , Paul Workman , Laurence Pearl , Chrisostomos Prodromou , Edward Macdonald
IPC分类号： A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/428 , A61K31/506 , A61P35/00 , A61P43/00 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/22 , C07D401/04 , C07D401/10 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/04 , A61K31/4152
CPC分类号： C07D231/12 , A61K31/415 , C07D231/14 , C07D231/16 , C07D401/04 , C07D401/10 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D417/04
摘要： The present invention pertains to the use of certain 3,4-diarylpyrazoles of formula (I), both in vitro and in vivo, to inhibit heat shock protein 90 (HSP90), and in the treatment of conditions mediated by HSP90, including, for example, cancer; wherein: Ar3 is independently: a C5-20aryl group, and is optionally substituted; Ar4 is independently: a C5-20aryl group, and is optionally substituted; R5 is independently: hydrogen; halo; hydroxy; ether; formyl; acyl; carboxy; ester, acyloxy; oxycarbonyloxy; amido; acylamido; aminocarbonyloxy; tetrazolyl; amino; nitro; cyano; azido; sulfhydryl; thioether; sulfonamido; C1-7alkyl; C3-20heterocycyl; or C5-20aryl; R N is independently: —H; C1-7alkyl; C3-20heterocycyl; or, C5-20aryl; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to such compounds, pharmaceutical compositions comprising such compounds, such compounds for medical use, such compounds for use in the treatment of conditions mediated by HSP90, including, for example, cancer, and use of such compounds in the preparation of medicaments for such treatments.
摘要翻译：本发明涉及式（I）的某些3,4-二芳基吡唑（体外和体内）用于抑制热休克蛋白90（HSP90）的用途，以及用于治疗HSP90介导的病症，包括例如癌症; 其中：Ar 3独立地是C 5-20-20芳基，并且是任选被取代的; Ar 4独立地是C 5-20-20芳基，并且是任选被取代的; R 5独立地为氢; 光环; 羟基; 醚; 甲酰基酰基; 羧基; 酯，酰氧基; 氧羰氧基氨基酸酰氨基; 氨基羰基氧基; 四唑基; 氨基; 硝基氰基叠氮巯基硫醚磺酰胺 C 1-7烷基; C 3-20杂环基; 或C 5-20-20芳基; R N 独立地为：-H; C 1-7烷基; C 3-20杂环基; 或C 5-20-20芳基; 和其药学上可接受的盐，溶剂合物，酰胺，酯，醚，化学保护形式及其前药。本发明还涉及这样的化合物，包含这种化合物的药物组合物，用于医疗用途的这种化合物，用于治疗由HSP90介导的病症包括例如癌症的化合物，以及这些化合物在制备药物用于治疗。

6. 发明授权

US3023021A Garden carryall and snow remover 失效
标题翻译：花园落地和除雪机
公开(公告)号：US3023021A
公开(公告)日：1962-02-27
申请号：US82584759
申请日：1959-07-08
申请人： FRICKE GERALD J , EDWARD MACDONALD
发明人： FRICKE GERALD J , EDWARD MACDONALD
IPC分类号： E01H5/02
CPC分类号： E01H5/02

7. 发明申请

US20130029813A1 STRAP ADJUSTER AND KEEPER AND METHOD OF STRAP CONTROL 有权
标题翻译： STRAP调整器和保持器及其控制方法
公开(公告)号：US20130029813A1
公开(公告)日：2013-01-31
申请号：US13194522
申请日：2011-07-29
申请人： Randal Hetrick , Jordan Edward Macdonald , Stephanie Russo
发明人： Randal Hetrick , Jordan Edward Macdonald , Stephanie Russo
IPC分类号： A63B71/00 , A44B11/04
CPC分类号： A63B21/068 , A44B11/2557 , A63B21/0557 , A63B21/1636 , A63B21/4035 , A63B21/4043 , A63B2225/09 , Y10T24/4086
摘要： A method of strap control and an apparatus including a combined strap-length adjuster and strap keeper is disclosed for use with strap-length adjuster comprising two rings. The strap-length adjuster includes openings that permit the attachment of a tether to the strap keeper. The arrangement allows the tether to not interfere with the positioning or movement of the straps, and maintains the straps close to the strap-length adjuster and prevents slippage of the strap through the strap-length adjuster
摘要翻译：公开了一种带式控制的方法和包括组合带长度调节器和带式保持器的设备，用于包括两个环的带长度调节器。带长度调节器包括允许将系绳附接到绑带保持器的开口。该布置允许系绳不干扰带的定位或移动，并且将带子保持靠近带长度调节器并且防止带穿过带长度调节器的滑动

8. 发明申请

US20050015284A1 Methods and systems for smoothing of the assumed long-term discount rate for pension plans and actuarial valuations 有权
标题翻译：用于平衡养老金计划和精算估值的假定长期贴现率的方法和系统
公开(公告)号：US20050015284A1
公开(公告)日：2005-01-20
申请号：US10938449
申请日：2004-09-10
申请人： Edward Macdonald
发明人： Edward Macdonald
IPC分类号： G06Q40/00 , G06F17/60
CPC分类号： G06Q40/02 , G06Q40/00 , G06Q40/04 , G06Q40/06 , G06Q40/08 , G06Q40/10
摘要： Methods and computer systems provide for the determination of employer liabilities and resulting contributions to pension plans by utilizing a smoothed discount rate in place of an assumed long-term discount rate. A compounded expected cumulative return on market value over a period of time that is based on the assumed long-term discount rate is found. A compounded actual return on market value over the chosen look-back period is also found. An adjusted expected rate of return over a future period of time remaining in an assumed period of time is then found based on the compounded expected return and the compounded actual return. The smoothed discount rate to be used in place of the assumed long-term discount rate is then based on the adjusted expected return.
摘要翻译：方法和计算机系统通过利用平滑的贴现率代替假设的长期贴现率来确定雇主负债的确定和养老金计划的结果。发现在一段时间内，基于假定的长期贴现率的复合预期市场价值累计回报率。还找到了在所选择的追溯期内复合实际的市场价值回报率。然后根据复合预期收益和复合实际收益，确定在假设期间剩余时间内的调整后预期回报率。然后根据经调整的预期收益，用于代替假设长期贴现率的平滑贴现率。

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