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1. 发明授权

US07229468B2 Medical device and method for temperature control and treatment of the eye and surrounding tissues 有权
标题翻译：用于温度控制和治疗眼睛和周围组织的医疗装置和方法
公开(公告)号：US07229468B2
公开(公告)日：2007-06-12
申请号：US11285690
申请日：2005-11-22
申请人： Edward K. Wong, Jr. , Timothy L. Lee , Markus D. Wong
发明人： Edward K. Wong, Jr. , Timothy L. Lee , Markus D. Wong
IPC分类号： A61F7/00
CPC分类号： A61F9/0017 , A61B3/165 , A61B5/145 , A61B5/14539 , A61B5/14546 , A61B5/417 , A61B5/6821 , A61B2017/00088 , A61B2090/064 , A61F7/12 , A61F9/007 , A61F2007/0004 , A61F2007/0054 , A61F2007/0056
摘要： The invention provides a medical device having a thermister for temperature measurement, irrigation/aspiration ports for fluid exchange and application of therapeutic modalities, a pressure manometer for pressure measurement, and an external system for control of temperature, pressure, and flow rate. When applied to the eye and orbit, this device can be used in hypothermia or hyperthermia applications, the control of intraocular pressure (IOP), and the application of treatment modalities. Methods of using the device in treating patients suffering from central retinal artery occlusion, anterior optic nerve disease, pathology of the choroid and retina including the macula, inflammation of the eye including the vitreous and anterior segment, glaucoma, inflammation and/or infections of the anterior and/or posterior segment of the eye, treatment before/during/after surgery of the eye, and the application of treatment modalities through a semi-permeable membrane are described.
摘要翻译：本发明提供一种具有用于温度测量的热敏电阻器，用于流体交换的灌注/抽吸端口和治疗方式的应用的医疗装置，用于压力测量的压力计压力计，以及用于控制温度，压力和流量的外部系统。当应用于眼睛和轨道时，该装置可用于低温或高热应用，眼压控制（IOP）以及治疗方式的应用。使用该装置治疗患有视网膜中央动脉闭塞，前视神经疾病，脉络膜和包括黄斑的视网膜病变的患者的方法，包括玻璃体和前段的眼睛炎症，青光眼，炎症和/或感染描述眼睛的前部和/或后部部分，眼睛手术之前/期间/之后的治疗以及通过半透膜施加治疗方式。

2. 发明授权

US4980552A High resolution PET scanner using rotating ring array of enlarged detectors having successively offset collimation apertures 失效
标题翻译：高分辨率PET扫描仪，使用具有连续偏移准直孔的放大检测器的旋转环阵列
公开(公告)号：US4980552A
公开(公告)日：1990-12-25
申请号：US368707
申请日：1989-06-20
申请人： Zang-Hee Cho , Monte S. Buchsbaum , William E. Bunny , Richard M. Friedenberg , Edward K. Wong, Jr.
发明人： Zang-Hee Cho , Monte S. Buchsbaum , William E. Bunny , Richard M. Friedenberg , Edward K. Wong, Jr.
IPC分类号： A61B6/03 , G01T1/161 , G01T1/164 , G01T1/29
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1644
摘要： A greatly reduced number of scintillation cyrstal/PMT gamma ray detectors are employed in a ring array about a PET image volume. Because of the relatively small number of such detectors, the complexity and expense of associated electronic signal processing channels is greatly reduced (even if each such channel is provided with sophisticated time of flight capabilities). Similarly, because relatively fewer crystals are employed, it becomes possible to use much larger and faster response time scintillation crystals so as to greatly increase gamma ray detection efficiency and scatter rejection while also permitting the electronic circuits to better reject random events and to provide effective time of flight image data filtering. By providing successively offset collimation apertures for each successive detector of the ring array and by rotating the array 360 degrees through a large number of successive view angle positions, it is nevertheless possible to acquire extremely high resolution image data with a greatly reduced system cost. A multiple aperture embodiment provides improved sensitivity by using associated light collimators and photodiodes in conjunction with slow coincidence steering circuits.
摘要翻译：在围绕PET图像体积的环阵列中使用大量减少数量的闪烁晶体/ PMTγ射线检测器。由于这种检测器数量相对较少，相关电子信号处理通道的复杂性和费用大大降低（即使每个这样的信道都具有复杂的飞行时间）。类似地，由于使用相对较少的晶体，所以可以使用更大更快的响应时间闪烁晶体，从而大大增加伽马射线检测效率和散射抑制，同时还允许电子电路更好地拒绝随机事件并提供有效时间的飞行图像数据过滤。通过为环阵列的每个连续检测器提供连续的偏移准直孔，并且通过大量连续的视角位置使阵列360度旋转，仍然可以以大大降低的系统成本获得极高分辨率的图像数据。多孔实施例通过使用相关的光准直仪和光电二极管结合缓慢的重合转向电路来提供改进的灵敏度。

3. 发明授权

US08262715B2 Medical device and method for temperature control and treatment of the eye and surrounding tissues via magnetic drug therapy 有权
标题翻译：通过磁药治疗眼睛和周围组织的温度控制和治疗的医疗装置和方法
公开(公告)号：US08262715B2
公开(公告)日：2012-09-11
申请号：US11746621
申请日：2007-05-09
申请人： Edward K. Wong, Jr. , Timothy L. Lee , Markus D. Wong , Michael T. Vu
发明人： Edward K. Wong, Jr. , Timothy L. Lee , Markus D. Wong , Michael T. Vu
IPC分类号： A61F7/00
CPC分类号： A61N1/306 , A61F7/12 , A61F9/007 , A61F2007/0004 , A61F2007/0056
摘要： The invention provides a medical device having a thermostat for temperature measurement, irrigation/aspiration ports for fluid exchange and application of therapeutic modalities, a pressure manometer for pressure measurement, and an external system for control of temperature, pressure, and flow rate. When applied to the eye, eyelid and orbit, this device can be used in hypothermia or hyperthermia applications, the control of intraocular pressure (IOP), and the application of treatment modalities. Methods of using the device in treating patients suffering from central retinal artery occlusion, anterior optic nerve disease, pathology of the choroid and retina including the macula, inflammation of the eye including the vitreous and anterior segment, glaucoma, inflammation and/or infections of the anterior and/or posterior segment of the eye, treatment before/during/after surgery of the eye, and the application of treatment modalities including iontophoresis through a semi-permeable membrane are described.
摘要翻译：本发明提供了一种具有用于温度测量的恒温器，用于流体交换的灌注/抽吸端口和治疗方式的应用的医疗装置，用于压力测量的压力计，以及用于控制温度，压力和流速的外部系统。当应用于眼睛，眼睑和轨道时，该装置可用于低温或高热应用，眼压控制（IOP）以及治疗方式的应用。使用该装置治疗患有视网膜中央动脉闭塞，前视神经疾病，脉络膜和包括黄斑的视网膜病变的患者的方法，包括玻璃体和前段的眼睛炎症，青光眼，炎症和/或感染描述眼睛的前部和/或后部部分，眼睛手术之前/期间/之后的治疗，以及包括通过半透膜的离子电渗疗法的治疗方式的应用。

4. 发明授权

US5023554A Fringe field MRI 失效
标题翻译：边缘场MRI
公开(公告)号：US5023554A
公开(公告)日：1991-06-11
申请号：US354990
申请日：1989-05-22
申请人： Zang-Hee Cho , Edward K. Wong, Jr.
发明人： Zang-Hee Cho , Edward K. Wong, Jr.
IPC分类号： A61B5/055 , G01R33/38 , G01R33/48
CPC分类号： G01R33/3806 , G01R33/3808
摘要： Extremely non-homogenous high but extremely intense high fringe magnetic fields are purposefully (and even advantageously) utilized for magnetic resonance imaging (including localization and spectroscopy) so as to better obtain advantages typically associated with ultra high field MRI. Static magnetic field gradients inherently included in such fringe fields are actively utilized in conjunction with suitable NMR RF nutation pulses so as to achieve volume-selective NMR data acquisition. Special arrangements of static electromagnets, magnetic gradient coils and/or RF coils may be used in conjunction with novel RF/gradient pulse sequences so as to elicit and acquire suitable MRI data.

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