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1. 发明申请

US20120286072A1 FORCE AMPLIFYING DRIVER SYSTEM AND JETTING DISPENSER AND METHOD OF DISPENSING FLUID 有权
标题翻译：强制驱动系统和喷射分配器和分配流体的方法
公开(公告)号：US20120286072A1
公开(公告)日：2012-11-15
申请号：US13511058
申请日：2010-12-07
申请人： Laurence B. Saidman , Edward C. Taylor
发明人： Laurence B. Saidman , Edward C. Taylor
IPC分类号： B05B1/30
CPC分类号： B05B1/306 , B05B1/3053 , B05C5/0225 , B05C5/0237 , B05C5/0291
摘要： A force amplifying driver system including an actuator (12) with a powered actuating member (22) mounted for movement along a first distance “X”. A driven member (46) mounted for movement along a second distance or working distance “Y” which is less than the first distance “X”. The powered actuating member (24) is movable through a gap “Z” before being mechanically coupled with the driven member (46) and subsequently moves with the driven member (46) along the second distance “Y”. Energy is transferred from the powered actuating member (24) to the driven member (46) along the second or working distance “Y”. The force amplifying driver system may be used for actuating a fluid jetting dispenser (14).
摘要翻译：一种力放大驱动器系统，包括具有安装成沿着第一距离X移动的动力驱动构件（22）的致动器（12）。被驱动构件（46）安装成沿着第二距离或工作距离Y移动，所述第二距离或工作距离Y小于第一距离X.动力致动构件（24）在与被驱动构件（46）机械联接之前可移动通过间隙Z，并随后沿着第二距离Y与从动构件（46）一起移动。能量从动力致动构件（24）沿着第二或工作距离Y到被驱动构件（46）。力放大驱动器系统可以用于致动流体喷射分配器（14）。

2. 发明授权

US6161722A Liquid dispensing device and methods utilizing a magnetically coupled valve stem 失效
标题翻译：液体分配装置和利用磁耦合阀杆的方法
公开(公告)号：US6161722A
公开(公告)日：2000-12-19
申请号：US182151
申请日：1998-10-29
申请人： Sidney K. Sooudi , Edward C. Taylor
发明人： Sidney K. Sooudi , Edward C. Taylor
IPC分类号： B05D1/26 , B05B1/30 , B05C5/00 , B05C5/02 , F16K31/08 , F16K31/122 , G01F11/00
CPC分类号： F16K31/086 , B05C5/0237 , B05C5/0279
摘要： A liquid dispensing device including a body generally having an actuator cavity and a liquid passage. A valve seat element is connected to the body and a valve stem is mounted for movement within the body with respect to the valve seat element. Inner and outer magnetic elements are disposed around the periphery of the valve stem to couple the valve stem to the valve actuator. The inner magnetic element is connected to the valve stem for movement with the valve stem within the body. The outer magnetic element is connected with an actuator and is slidable within the body in response to, for example, pressurized air being applied against the actuator. The magnetic elements couple the valve stem to the actuator and eliminate the need for a dynamic seal between the valve stem and body.
摘要翻译：一种液体分配装置，包括通常具有致动器空腔和液体通道的主体。阀座元件连接到主体，并且安装阀杆以相对于阀座元件在主体内移动。内部和外部磁性元件设置在阀杆的周边周围以将阀杆连接到阀致动器。内部磁性元件连接到阀杆，用于与阀杆在体内移动。外磁性元件与致动器连接，并且响应于例如对致动器施加的加压空气而在主体内滑动。磁性元件将阀杆连接到致动器，并且不需要阀杆和阀体之间的动态密封。

3. 发明授权

US6123302A Liquid dispensing device and methods utilizing a uniaxial mounting 失效
标题翻译：液体分配装置和利用单轴安装的方法
公开(公告)号：US6123302A
公开(公告)日：2000-09-26
申请号：US183518
申请日：1998-10-30
申请人： Edward C. Taylor
发明人： Edward C. Taylor
IPC分类号： B05B15/06 , B05C5/02 , B65B59/04 , A47B96/06
CPC分类号： B05B15/061 , B05C5/02 , B65B59/04
摘要： A uniaxial mounting for dispensing apparatus includes one or more uniaxial connecting portions on a dispenser and at least one support member having at least one complementary uniaxial mounting portion. The uniaxial mounting portions may include projections and generally complementary channels allowing rapid installation, removal and replacement of the dispenser. The support member may include a locking pivot for further adjustment capability. When dispensing heated liquids, a thermal insulator is incorporated to reduce heat conduction between the dispenser and the support member. The uniaxial mounting may have an alignment guide to ensure proper positioning of the dispenser along the axis of engagement between the uniaxial connecting portions.
摘要翻译：用于分配装置的单轴安装包括分配器上的一个或多个单轴连接部分和具有至少一个互补单轴安装部分的至少一个支撑构件。单轴安装部分可以包括突起和通常互补的通道，允许分配器的快速安装，移除和更换。支撑构件可以包括用于进一步调节能力的锁定枢轴。当分配加热的液体时，结合了绝热体以减少分配器和支撑构件之间的热传导。单轴安装件可以具有对准引导件，以确保分配器沿着单轴连接部分之间的接合轴线的适当定位。

4. 发明授权

US06066732A Process for the preparation of pyrrolo[2,3-d]pyrimidines 失效
标题翻译：制备吡咯并[2,3-d]嘧啶的方法
公开(公告)号：US06066732A
公开(公告)日：2000-05-23
申请号：US138354
申请日：1998-08-21
申请人： Edward C. Taylor , Bin Liu
发明人： Edward C. Taylor , Bin Liu
IPC分类号： C07D487/04 , C07D239/47 , C07D239/48
CPC分类号： C07D487/04
摘要： 4(3H)-X-7H-Pyrrolo[2,3-d]pyrimidines in which X is .dbd.O or .dbd.NH are prepared by treating a 6-amino-4(3H)-X-pyrimidine with a unsubstituted or substituted 1-nitroalk-1-ene to yield a 6-amino-4(3H)-X-pyrimidine which is substituted in the 5-position by a 1-nitroalk-2-yl group; (ii) converting the 5-(1-nitroalk-2-yl)-6-amino-4(3H)-X-pyrimidine to the corresponding 5-(1-oxoalk-2-yl)-6-amino-4(3H)-X-pyr-imidine; and (iii) removing the elements of water from the 5-(1-oxoalk-2-yl)-6-amino-4(3H)-X-pyrimidine to effect cyclization. A typical embodiment involves treating 2,6-diamino-4(3H)-pyrimidone with 1-nitro-4-(4-ethoxycarbonylphenyl)-1-butene to yield 1 -nitro-2-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-4-(4-ethoxy-carbonylphenyl)butane which is then treated sequentially with base and acid, without isolation of the intermediate aldehyde, to form 4-[2-(2-amino-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid, a valuable known chemical intermediate for the preparation of N-[4-{2-(2-hydroxy-4-amino-7H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl}benzoyl]glutamic acid.
摘要翻译：通过用未取代的或取代的1位的6-氨基-4（3H） - 嘧啶处理制备X（= O或= NH）的4（3H） - 7H-吡咯并[2,3-d] - 硝基-1-烯，得到6-位氨基-4（3H） - 嘧啶，其在5-位被1-硝基烷基-2-基取代; （ii）将5-（1-硝基烷基-2-基）-6-氨基-4（3H） - 嘧啶转化成相应的5-（1-氧代-2-基）-6-氨基-4（ 3H）-X-吡啶亚胺; 和（iii）从5-（1-氧代-2-基）-6-氨基-4（3H）-X-嘧啶中除去水元素以进行环化。典型的实施方案涉及用1-硝基-4-（4-乙氧基羰基苯基）-1-丁烯处理2,6-二氨基-4（3H） - 嘧啶酮，得到1-硝基-2-（2,6-二氨基-4 3H） - 氧代嘧啶-5-基）-4-（4-乙氧基 - 羰基苯基）丁烷，然后用碱和酸依次处理，而不分离中间体醛，形成4- [2-（2-氨基-4 （3H） - 氧代-7H-吡咯并[2,3-d]嘧啶-5-基）乙基]苯甲酸是一种有价值的已知化学中间体，用于制备N- [4- {2-（2-羟基-4 - 氨基-7H-吡咯并[2,3-d] - 嘧啶-5-基）乙基}苯甲酰基]谷氨酸。

5. 发明授权

US5254687A Process for the preparation of pyrrolo[2,3-d]pyrimidines 失效
标题翻译：制备吡咯并[2,3-d]嘧啶的方法
公开(公告)号：US5254687A
公开(公告)日：1993-10-19
申请号：US802192
申请日：1991-12-04
申请人： Edward C. Taylor , Hemantkumar H. Patel
发明人： Edward C. Taylor , Hemantkumar H. Patel
IPC分类号： C07D307/68 , C07D487/04
CPC分类号： C07D487/04 , C07D307/68
摘要： 5-Substituted pyrrolo[2,3-d]pyrimidines are prepared from a nucleophile of the formula R.sup.2 -C(.dbd.NH)NH.sub.2 and a 2-amino-5-substituted-furan carrying a cyano or carboxy group in the 4-position. A typical example is the preparation of ethyl 4-(2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-5-yl)ethyl}benzoate, an intermediate for the preparation of the known N-[4-{2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-5-yl)ethyl}benzoyl]-L-glutamic acid, by allowing guanidine and ethyl 4-[2-(2-amino-3-cyanofur-4-yl)ethyl]benzoate to react under mild conditions.

6. 发明授权

US4882333A N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives 失效
标题翻译： N-（5,6,7,8-四氢吡啶并[2,3-d]嘧啶-6-基 - 烷酰基） - 谷氨酸衍生物
公开(公告)号：US4882333A
公开(公告)日：1989-11-21
申请号：US198201
申请日：1988-05-25
申请人： Chuan Shih , Edward C. Taylor
发明人： Chuan Shih , Edward C. Taylor
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： N-alkanoylglutamic acid derivatives in which the alkanoyl group is substituted with the 2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-6-yl or 2,4-diamino-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl group are antineoplastic agents. Typical embodiments are N-[6-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)hexanoyl]-L-glutamic acid and N-[4-{-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl ethyl}cyclohex-1-yl]-L-glutamic acid.
摘要翻译：其中链烷酰基被2-氨基-4-羟基-5,6,7,8-四氢吡啶并[2,3-d]嘧啶-6-基或2,4-二氨基 - 嘧啶-6-基取代的N-烷酰基谷氨酸衍生物， 5,6,7,8-四氢吡啶并[2,3-d]嘧啶-6-基是抗肿瘤剂。典型的实施方案是N- [6-（2-氨基-4-羟基-5,6,7,8-四氢吡啶并[2,3-d]嘧啶-6-基）己酰基] -L-谷氨酸和N- [ 4 - { - （2-氨基-4-羟基-5,6,7,8-四氢吡啶并[2,3-d]嘧啶-6-基乙基}环己-1-基] -L-谷氨酸。

7. 发明授权

US4871746A N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzo yl]glutamic acid derivatives as neoplastic growth inhibitors 失效
标题翻译： N- [N-（四氢吡啶并[2,3-D]嘧啶基甲基） - 氨基甲基苯甲酰基]谷氨酸衍生物作为肿瘤生长抑制剂
公开(公告)号：US4871746A
公开(公告)日：1989-10-03
申请号：US200136
申请日：1988-05-31
申请人： Edward C. Taylor , James M. Hamby , Chuan Shih
发明人： Edward C. Taylor , James M. Hamby , Chuan Shih
IPC分类号： A61K31/505 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： N-[N-(Tetrahydropyrido[2,3-d]pyrimidinylmethyl) aminomethylbenzoyl]glutamic acid derivatives are antineoplastic agents with an effect on one or more enzymes which utilize metabolic derivatives of folic acid. The compounds can be prepared by allowing a protected aminomethylbenzoylglutamic acid derivative to react with 2-amino-4-hydroxy-6-formylpyrido[2,3-d]pyrimidine, reducing the intermediate Schiff base, and subjecting the intermediate to catalytic hydrogenation. A typical embodiment is (S,S) N-[N-(2-amino-4-hydroxy-5,6,7,8- tetrahydropyrido-[2,3-d]pyrimidin-6-ylmethyl)-4-aminomethylbenzoyl]-glutamic acid.

8. 发明授权

US4818819A Process for the preparation of fused pyridine compounds 失效
标题翻译：稠合吡啶化合物的制备方法
公开(公告)号：US4818819A
公开(公告)日：1989-04-04
申请号：US922511
申请日：1986-10-20
申请人： Edward C. Taylor , George S. K. Wong
发明人： Edward C. Taylor , George S. K. Wong
IPC分类号： B01J23/44 , C07B61/00 , C07D471/04
CPC分类号： C07D471/04
摘要： 2-Amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-en-1-yl]pyrido[2,3,-d]pyrimidines and 2-amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-yn-1-yl]pyrido[2,3-d]pyrimidines are prepared through the reaction of a haloaromatic compound and an unsaturated compound in the presence of a palladium catalyst. The products are chemical intermediates for the preparation of antineoplastic agents.A typical embodiment is the reaction of a protected 2-amino-4-hydroxy-6-ethynylpyrido[2,3-d]pyrimidine and an ester of 4-iodobenzoic acid.
摘要翻译： 2-氨基-4-羟基-6- [2-（4-羧基苯基）烷-1-烯-1-基]吡啶并[2,3-d]吡啶和2-氨基-4-羟基-6- 通过卤代芳族化合物和不饱和化合物在钯催化剂存在下反应来制备[2-（4-羧基苯基）烷-1-炔-1-基]吡啶并[2,3-d]吡啶亚胺。该产品是用于制备抗肿瘤药物的化学中间体。典型的实施方案是受保护的2-氨基-4-羟基-6-乙炔基吡啶并[2,3-d]嘧啶与4-碘苯甲酸的酯的反应。

9. 发明授权

US4695658A Aryl carboxylate process 失效
标题翻译：芳基羧酸酯工艺
公开(公告)号：US4695658A
公开(公告)日：1987-09-22
申请号：US589257
申请日：1984-03-12
申请人： Edward C. Taylor , Alan H. Katz , Randy A. Bull , Lance R. Byers , Richard A. Brown
发明人： Edward C. Taylor , Alan H. Katz , Randy A. Bull , Lance R. Byers , Richard A. Brown
IPC分类号： C07C37/02 , B01J23/00 , B01J31/00 , C07B31/00 , C07B41/02 , C07B41/12 , C07B61/00 , C07C27/00 , C07C37/00 , C07C37/01 , C07C37/055 , C07C39/00 , C07C39/06 , C07C67/00 , C07C69/017 , C07F5/00 , C07C39/10 , C07C69/76
CPC分类号： C07F5/00 , C07C37/01 , C07C37/0555 , C07C67/00
摘要： A process for replacing an aromatic carbon-thallium bond with a carbon-oxygen bond. The process is particularly suitable for producing specific aromatic isomers by thallating an aromatic compound and replacing the thallium with a carboxylate group which can be further hydrolyzed if desired to form an aromatic hydroxyl compound.
摘要翻译：用碳 - 氧键代替芳族碳 - 铊键的方法。该方法特别适用于通过使芳族化合物松弛并用羧酸酯基团代替铊来生产特定的芳族异构体，如果需要，可以进一步水解形成芳族羟基化合物。

10. 发明授权

US4552967A Process for the synthesis of intermediates in the preparation of diaminopyridines 失效
标题翻译：在制备二氨基吡啶的过程中合成中间体
公开(公告)号：US4552967A
公开(公告)日：1985-11-12
申请号：US570144
申请日：1984-01-12
申请人： James M. Greene , Edward R. Lavagnino , Andrew J. Pike , Edward C. Taylor
发明人： James M. Greene , Edward R. Lavagnino , Andrew J. Pike , Edward C. Taylor
IPC分类号： C07D213/73 , C07D213/61
CPC分类号： C07D213/73
摘要： The present invention relates to a process for preparing aminonitropyridines comprising reacting an alkoxynitropyridine with ammonium acetate.
摘要翻译：本发明涉及一种制备氨基硝基吡啶的方法，包括使烷氧基硝基吡啶与乙酸铵反应。

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