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1. 发明授权

US5959146A Tricyclic compounds 失效
标题翻译：三环化合物
公开(公告)号：US5959146A
公开(公告)日：1999-09-28
申请号：US764863
申请日：1996-12-13
申请人： Francis Brion , Bernadette Chappert , Christian Diolez , Christian Marie , Alain Mazurie , Michel Middendorp , Didier Pronine , Edmond Toromanoff
发明人： Francis Brion , Bernadette Chappert , Christian Diolez , Christian Marie , Alain Mazurie , Michel Middendorp , Didier Pronine , Edmond Toromanoff
IPC分类号： C07D317/70 , C07C45/56 , C07C45/63 , C07C49/747 , C07C49/753 , C07C49/755 , C07C233/32 , C07C305/18 , C07C309/73 , C07C323/41 , C07D209/48 , C07D317/72 , C07C233/05
CPC分类号： C07D209/48 , C07C309/73 , C07C45/56 , C07C45/63 , C07C49/747 , C07C49/755 , C07C2103/30 , Y02P20/55
摘要： Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.
摘要翻译：本说明书中定义的式I的新型三环化合物，其制备方法及其用于制备光学活性或外消旋的秋水仙碱和硫代秋水仙碱衍生物的用途。

2. 发明授权

US4024172A Preparation of prostanoic acid derivatives 失效
标题翻译：前列腺酸衍生物的制备
公开(公告)号：US4024172A
公开(公告)日：1977-05-17
申请号：US176234
申请日：1971-08-30
申请人： Jacques Martel , Jean Buendia , Edmond Toromanoff
发明人： Jacques Martel , Jean Buendia , Edmond Toromanoff
IPC分类号： C07C61/06 , C07C69/74 , C07C405/00 , C07D303/42 , C07D309/12 , C07D521/00 , C07C177/00
CPC分类号： C07D231/12 , C07C405/00 , C07D233/56 , C07D249/08 , C07D303/42 , C07D309/12
摘要： A novel process for the preparation of derivatives of prostanoic acids of the prostaglandin A.sub.2 (PGA.sub.2) group of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and lower alkyl, n is a whole number of 2, 3 or 4 and m is a whole number of 3, 4 or 5 and to novel intermediates produced in the said process.
摘要翻译：用于制备式IMA的前列腺素A2（PGA2）组的前列腺酸衍生物的新方法，其中R选自氢和低级烷基，n是整数2,3或 4和m是3,4或5的整数，以及在所述方法中生产的新型中间体。

3. 发明授权

US5705704A Tricyclic compounds 失效
公开(公告)号：US5705704A
公开(公告)日：1998-01-06
申请号：US609679
申请日：1996-03-01
申请人： Francis Brion , Bernadette Chappert , Christian Diolez , Christian Marie , Alain Mazurie , Michel Middendorp , Didier Pronine , Edmond Toromanoff
发明人： Francis Brion , Bernadette Chappert , Christian Diolez , Christian Marie , Alain Mazurie , Michel Middendorp , Didier Pronine , Edmond Toromanoff
IPC分类号： C07D317/70 , C07C45/56 , C07C45/63 , C07C49/747 , C07C49/753 , C07C49/755 , C07C233/32 , C07C305/18 , C07C309/73 , C07C323/41 , C07D209/48 , C07D317/72 , C07C49/307 , C07F5/04
CPC分类号： C07D209/48 , C07C309/73 , C07C45/56 , C07C45/63 , C07C49/747 , C07C49/755 , C07C2103/30 , Y02P20/55
摘要： Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.

4. 再颁专利

USRE29587E Cyclopentanone derivatives 失效
标题翻译：环戊酮衍生物
公开(公告)号：USRE29587E
公开(公告)日：1978-03-21
申请号：US704846
申请日：1976-07-13
申请人： Jacques Martel , Edmond Toromanoff , Jean Buendia
发明人： Jacques Martel , Edmond Toromanoff , Jean Buendia
IPC分类号： C07C405/00
CPC分类号： C07C405/00
摘要： Novel prostanoic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 7 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen and carbalkoxy of 1 to 7 alkyl carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, carboxy and carbalkoxy of 1 to 7 alkyl carbon atoms, R.sub.3 is selected from the group consisting of hydrogen and .alpha.-tetrahydropyranyl .Iadd.and at least one of R.sub.1, R.sub.2 and R.sub.3 is other than hydrogen.Iaddend., m is 3, 4 or 5 and n is 2, 3 or 4 with the proviso that when R.sub.1 is carbalkoxy, R is alkyl of 1 to 7 carbon atoms, R.sub.2 is hydrogen and R.sub.3 is .alpha.-tetrahydropyranyl; when R.sub.2 is carbalkoxy, R is alkyl of 1 to 7 carbon atoms, R.sub.1 is hydrogen and R.sub.3 is .alpha.-tetrahydropyranyl and when R.sub.2 is carboxy, R and R.sub.1 are hydrogen and R.sub.3 is .alpha.-tetrahydropyranyl, which possess the physiological activity of prostaglandins .[. , and salts thereof when R, R.sub.1, R.sub.2 and R.sub.3 are hydrogen, with non-toxic, pharmaceutically acceptable bases.]. and their preparation.

5. 发明授权

US3932420A Process for the preparation of glaziovine 失效
标题翻译：制备glaziovine的方法
公开(公告)号：US3932420A
公开(公告)日：1976-01-13
申请号：US444554
申请日：1974-02-21
申请人： Julien Warnant , Andre Farcilli , Italo Medici , Edmond Toromanoff
发明人： Julien Warnant , Andre Farcilli , Italo Medici , Edmond Toromanoff
IPC分类号： C07D217/20 , C07D221/18 , C07D221/20 , C07D217/12
CPC分类号： C07D221/20 , C07D217/20
摘要： Process for the preparation of glaziovine by treating N-methyl bromococlaurine in an inert organic solvent with a tin hydride tri-substituted with organic radicals in the presence of a free radical promoter.
摘要翻译：通过在惰性有机溶剂中用自由基促进剂存在下用有机基团三取代的氢化锡处理N-甲基溴代牛磺酸来制备格列酮的方法。

6. 发明授权

US06268520B1 Tricyclic compounds 失效
标题翻译：三环化合物
公开(公告)号：US06268520B1
公开(公告)日：2001-07-31
申请号：US09286057
申请日：1999-04-05
申请人： Francis Brion , Bernadette Chappert , Christian Diolez , Christian Marie , Alain Mazurie , Michel Middendorp , Didier Pronine , Edmond Toromanoff
发明人： Francis Brion , Bernadette Chappert , Christian Diolez , Christian Marie , Alain Mazurie , Michel Middendorp , Didier Pronine , Edmond Toromanoff
IPC分类号： C07C30963
CPC分类号： C07D209/48 , C07C45/56 , C07C45/63 , C07C49/747 , C07C49/755 , C07C309/73 , C07C2603/30 , Y02P20/55
摘要： Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.
摘要翻译：本说明书中定义的式I的新型三环化合物，其制备方法及其用于制备光学活性或外消旋的秋水仙碱和硫代秋水仙碱衍生物的用途。

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