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1. 发明授权

US10201625B2 Radiolabelled octreotate analogues as PET tracers 有权
公开(公告)号：US10201625B2
公开(公告)日：2019-02-12
申请号：US14002168
申请日：2012-03-01
申请人： Sajinker Kaur Luthra , Julius Leyton , Eric Ofori Aboagye , Lisa Iddon , Bard Indrevoll , Matthias Eberhard Glaser , Alan Cuthbertson
发明人： Sajinker Kaur Luthra , Julius Leyton , Eric Ofori Aboagye , Lisa Iddon , Bard Indrevoll , Matthias Eberhard Glaser , Alan Cuthbertson
IPC分类号： A61K51/00 , A61M36/14 , A61K51/08 , C07B59/00
摘要： Novel radiotracer(s) for Positron Emission Tomography (PET) imaging are described. Novel radiotracer(s) for Positron Emission Tomography (PET) imaging of neuorendocrine tumors are described. Specifically the present invention describes novel [18F]Fluoroethyltriazol-[Tyr3]Octreotate analogs; in particular those that target somatostatin receptors found on the cell surface of gastroenteropancreatic neuorendocrine tumors. The present invention also describes intermediate(s), precursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).

2. 发明申请

US20130295010A1 HER2 BINDING PEPTIDES LABELLED WITH A 18F - CONTAINING ORGANOSILICON COMPOUND 审中-公开
标题翻译：标有18F含有机硅氧烷化合物的HER2结合肽
公开(公告)号：US20130295010A1
公开(公告)日：2013-11-07
申请号：US13996142
申请日：2011-12-19
申请人： Duncan Hiscock , Bard Indrevoll , Peter Iveson , Matthias Eberhard Glaser , Rajiv Bhalla , Anthony Wilson
发明人： Duncan Hiscock , Bard Indrevoll , Peter Iveson , Matthias Eberhard Glaser , Rajiv Bhalla , Anthony Wilson
IPC分类号： A61K51/08 , C07K14/31
CPC分类号： A61K51/088 , C07K14/31
摘要： Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
摘要翻译：包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。

3. 发明授权

US08148575B2 Radiofluorinated compounds and their preparation 失效
标题翻译：放射性氟化合物及其制备方法
公开(公告)号：US08148575B2
公开(公告)日：2012-04-03
申请号：US12297347
申请日：2007-04-20
申请人： Erik Arstad , Matthias Eberhard Glaser
发明人： Erik Arstad , Matthias Eberhard Glaser
IPC分类号： C07C337/00
CPC分类号： A61K51/087 , A61K51/088 , C07B59/008 , C07C215/08 , C07C215/14 , C07C271/28 , C07C331/28 , C07D205/04 , C07K1/13 , C07K14/47
摘要： The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.
摘要翻译：本发明提供了含有伯氨基的生物分子如蛋白质和肽，特别是肽的[18 F] - 氟化方法。本发明还提供用于该方法的试剂，特别是用于制备的18F标记的假基团以及可用于制备[18 F] - 标记的假体基团的未标记的中间体。也可用作用作放射性药物的[18F]标记化合物，专门用于正电子发射断层扫描（PET）。

4. 发明申请

US20110189089A1 RADIOFLUORINATION 有权
标题翻译：无线电辐射
公开(公告)号：US20110189089A1
公开(公告)日：2011-08-04
申请号：US13119468
申请日：2009-10-20
申请人： Robert James Domett Nairne , Erik Arstad , Matthias Eberhard Glaser
发明人： Robert James Domett Nairne , Erik Arstad , Matthias Eberhard Glaser
IPC分类号： A61K51/04 , C07C209/42 , C07D471/04 , C07C231/02 , B01J19/00
CPC分类号： C07B59/001
摘要： The present invention relates to 18F radio-chemistry and in particular to a method for synthesising radiofluorinated amides and amines. The method of the invention has particular application in the radiosynthesis of a variety of 18F-labelled positron emission tomography (PET) tracers.
摘要翻译：本发明涉及18F放射化学，特别涉及一种合成放射性氟化酰胺和胺的方法。本发明的方法在各种18F标记的正电子发射断层扫描（PET）示踪剂的放射合成中具有特别的应用。

5. 发明申请

US20090311177A1 Radiolabelling Methods 有权
标题翻译：放射性标记方法
公开(公告)号：US20090311177A1
公开(公告)日：2009-12-17
申请号：US11721694
申请日：2005-12-09
申请人： Erik Arstad , Matthias Eberhard Glaser
发明人： Erik Arstad , Matthias Eberhard Glaser
IPC分类号： A61K51/08 , C07K1/13 , C07C247/02 , C07C19/08 , C07K2/00 , C07K5/08 , C07K7/64
CPC分类号： A61K51/088 , A61K51/082 , A61K51/1051
摘要： The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): R*-L2-N3 (II) or, a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.
摘要翻译：本发明涉及放射性诊断和放射治疗剂，包括用放射性核素标记的生物活性载体。它还涉及标记载体的方法和试剂，例如肽，其包括式（I）化合物与式（II）化合物的反应：R * -L2-N3（II）或式（III）化合物）与式（IV）的化合物在Cu（I）催化剂的存在下反应。所得到的标记的缀合物可用作诊断剂，例如作为放射性药物更具体地用于正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）或放射治疗。

6. 发明授权

US4838980A Method and apparatus for introducing and joining diaphragms in slotted walls 失效
标题翻译：用于在开槽壁中引入和连接隔膜的方法和装置
公开(公告)号：US4838980A
公开(公告)日：1989-06-13
申请号：US37082
申请日：1987-04-10
申请人： Eberhard Glaser , Eberhard Beitinger , Manfred Nussbaumer
发明人： Eberhard Glaser , Eberhard Beitinger , Manfred Nussbaumer
IPC分类号： B29C65/00 , B29C65/20 , B29C65/34 , E02D5/18 , E02D5/20 , E02D19/18 , E02D29/16
CPC分类号： E02D29/16 , E02D19/185 , E02D5/18 , E02D5/20 , Y10T156/1788 , Y10T156/1798
摘要： A method and apparatus of introducing and joining diaphragms in slotted walls. The slotted inner connecting pipe of one diaphragm is introduced into the slotted outer connecting pipe of another diaphragm. An apparatus for fusing together the two connecting pipes is placed within the interior of the inner pipe and can move through the latter. The apparatus has a heating device for heating and fusing the two connecting pipes together.
摘要翻译：在开槽壁中引入和连接隔膜的方法和装置。一个隔膜的开槽内连接管被引入到另一隔膜的开槽外连接管中。用于将两个连接管熔接在一起的装置被放置在内管的内部并且可以移动通过内管。该装置具有用于将两个连接管加热和熔合在一起的加热装置。

7. 发明授权

US4690590A Method and apparatus for positioning diaphragms in vertical slotted walls which are supported by a suspension 失效
标题翻译：用于将隔膜定位在由悬挂支撑的垂直开槽壁中的方法和装置
公开(公告)号：US4690590A
公开(公告)日：1987-09-01
申请号：US768420
申请日：1985-08-22
申请人： Manfred Nussbaumer , Eberhard Glaser , Eberhard Beitinger
发明人： Manfred Nussbaumer , Eberhard Glaser , Eberhard Beitinger
IPC分类号： E02D19/18 , E02D5/20
CPC分类号： E02D19/18
摘要： To reduce the shearing resistance at the surfaces of the diaphragm, and to decrease the buoyancy force, both of which greatly hamper the positioning of diaphragms or thin sheets in slotted wall suspensions, air bubbles are introduced at the bottom end of the diaphragm during the positioning process. These air bubbles ascend along the vertical surfaces of the diaphragm.
摘要翻译：为了降低膜片表面的抗剪切性，并且为了降低浮力，两者都极大地妨碍了开槽壁悬浮液中的隔膜或薄片的定位，在定位过程中，在隔膜的底端引入气泡处理。这些气泡沿隔膜的垂直表面上升。

8. 发明授权

US4679965A Method and apparatus for installing panels into recesses in the ground 失效
标题翻译：将面板安装在地面凹槽中的方法和装置
公开(公告)号：US4679965A
公开(公告)日：1987-07-14
申请号：US805873
申请日：1985-12-06
申请人： Eberhard Glaser , Eberhard Beitinger
发明人： Eberhard Glaser , Eberhard Beitinger
IPC分类号： E02D19/18 , E02D5/20
CPC分类号： E02D19/18
摘要： For installing panels consisting of diaphragm portions and reinforcements into recesses in the ground a deflection body is provided which is movable along the opening of the ground recess, the upper surface of the deflection body being curved so that the panels can be inserted into a suspension in the ground recess via the deflection body without discontinuities and without bending the panels over a deflection radius smaller than the smallest possible bending radius of the panels. Welding machines are disposed on the deflection body for joining the panel sections transversely and longitudinally to form a web having a length which corresponds to the depth of the suspension filled recess in the ground.
摘要翻译：为了将由隔膜部分和加强件组成的面板安装在地面上的凹槽中，设置有可沿着接地凹槽的开口移动的偏转体，弯曲体的上表面被弯曲，使得面板可以插入到悬架中通过偏转体的接地凹槽不间断，并且在不小于面板的最小可能弯曲半径的偏转半径上弯曲面板。焊接机设置在偏转体上，用于横向和纵向地连接面板部分，以形成具有对应于地面中的悬浮物填充凹槽的深度的长度的腹板。

9. 发明授权

US08679455B2 Radiolabelling methods 有权
标题翻译：放射性标记方法
公开(公告)号：US08679455B2
公开(公告)日：2014-03-25
申请号：US13158555
申请日：2011-06-13
申请人： Erik Arstad , Matthias Eberhard Glaser
发明人： Erik Arstad , Matthias Eberhard Glaser
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/088 , A61K51/082 , A61K51/1051
摘要： The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods of making such radiodiagnostic and radiotherapeutic agents and the compounds used in such methods. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.
摘要翻译：本发明涉及放射性诊断和放射治疗剂，包括用放射性核素标记的生物活性载体。它还涉及制备这种放射诊断和放射治疗剂的方法以及在这些方法中使用的化合物。所得到的标记的缀合物可用作诊断剂，例如作为放射性药物更具体地用于正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）或放射治疗。

10. 发明申请

US20130343990A1 RADIOLABELLED OCTREOTATE ANALOGUES AS PET TRACERS 审中-公开
标题翻译：作为PET跟踪器的无辐射OCOPEOTATE模拟
公开(公告)号：US20130343990A1
公开(公告)日：2013-12-26
申请号：US14002168
申请日：2012-03-01
申请人： Sajinker Kaur Luthra , Julius Leyton , Eric Ofori Aboagye , Lisa Iddon , Bard Indrevoll , Matthias Eberhard Glaser , Alan Cuthbertson
发明人： Sajinker Kaur Luthra , Julius Leyton , Eric Ofori Aboagye , Lisa Iddon , Bard Indrevoll , Matthias Eberhard Glaser , Alan Cuthbertson
IPC分类号： A61K51/08
CPC分类号： A61K51/08 , A61K51/083 , A61K51/088 , C07B59/002 , C07B59/008
摘要： Novel radiotracer(s) for Positron Emission Tomography (PET) imaging are described. Novel radiotracer(s) for Positron Emission Tomography (PET) imaging of neuorendocrine tumors are described. Specifically the present invention describes novel [18F]Fluoroethyltriazol-[Tyr3]Octreotate analogs; in particular those that target somatostatin receptors found on the cell surface of gastroenteropancreatic neuorendocrine tumors. The present invention also describes intermediate(s), precursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).
摘要翻译：描述了用于正电子发射断层扫描（PET）成像的新型放射性示踪剂。描述了用于神经内分泌肿瘤的正电子发射断层扫描（PET）成像的新型放射性示踪剂。具体地说，本发明描述了新颖的[18 F]氟乙基三唑 - [Tyr 3] Octreotate类似物; 特别是在胃肠胰腺内分泌肿瘤的细胞表面上发现的生长抑素受体的那些。本发明还描述了新型放射性示踪剂的中间体，前体，药物组合物，制备方法和使用方法。

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