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1. 发明申请

WO2012106299A1 PHARMACEUTICAL COMPOSITIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF 审中-公开
标题翻译：细胞模拟物的药物组合物及其使用方法
公开(公告)号：WO2012106299A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023258
申请日：2012-01-31
申请人： CELGENE CORPORATION , LAI, Mei , ETTER, Jeffrey, B. , TUTINO, Anthony
发明人： LAI, Mei , ETTER, Jeffrey, B. , TUTINO, Anthony
IPC分类号： A61K9/19 , A61K31/706 , A61K47/00
CPC分类号： A61K31/706 , A61K9/0019
摘要： The present disclosure provides pharmaceutical compositions comprising cytidine analogs for parenteral administration. Also provided are methods of preparing the compositions and methods of treating diseases and disorders using the compositions provided herein.
摘要翻译：本公开提供了包含用于肠胃外给药的胞苷类似物的药物组合物。还提供了使用本文提供的组合物制备治疗疾病和病症的组合物和方法的方法。

2. 发明申请

WO2012125674A1 LASER WELDING OF DISC TO CLOSE NEEDLE END 审中-公开
标题翻译：光盘激光焊接关闭针头
公开(公告)号：WO2012125674A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028992
申请日：2012-03-14
申请人： MEDICAL INSTRUMENT DEVELOPMENT LABORATORIES, INC. , CHEN, David, E-bin , ETTER, Jeffrey, Wayne
发明人： CHEN, David, E-bin , ETTER, Jeffrey, Wayne
IPC分类号： A61B17/20 , A61B17/32 , A61M1/00 , A61M5/178
CPC分类号： B23K26/324 , A61F9/00763 , B23K26/22 , B23K26/242 , B23K26/28 , B23K26/38
摘要： A cutting apparatus has a handle and a hollow needle having a first end connected to the handle and a second end. The needle outer diameter is about 0.04 inch or less. An end cap is formed from a blank material. Preferably, at least one bridge is formed between the end cap and the blank material. The end cap is welded to the second end to enclose the needle and then the bridge is cut. The end cap has substantially flat inner and outer surfaces. The needle has a port and a hollow cutter that slides within the needle. The cutter has a first end connected to a drive, and a second end having a cutting edge. An outer cutter diameter is less than the needle inner diameter. The drive reciprocates the cutter within the needle to perform a cut.
摘要翻译：切割装置具有手柄和中空针，其具有连接到手柄的第一端和第二端。针外径约为0.04英寸或更小。端盖由坯料形成。优选地，在端盖和坯料之间形成至少一个桥。端盖焊接到第二端以封闭针，然后切割桥。端盖具有基本平坦的内表面和外表面。针头有一个端口和一个在针内滑动的中空切割器。切割器具有连接到驱动器的第一端和具有切割边缘的第二端。外切刀直径小于针内径。驱动器使切割器在针内往复运动以进行切割。

3. 发明申请

WO2006071554A3 IMPROVED APPARATUS FOR DELIVERY OF OCULAR IMPLANTS 审中-公开
标题翻译：改进的用于输送OCURAR IMPLANTS的装置
公开(公告)号：WO2006071554A3
公开(公告)日：2006-10-05
申请号：PCT/US2005045491
申请日：2005-12-14
申请人： ALLERGAN INC , WEBER DAVID A , KANE INGRID , REHAL MIKE , LATHROP III ROBERT L , APTEKAREV KENNY , ETTER JEFFREY , GERONDALE SCOTT , BHAGAT RAHUL , DAVIS SHAWN
发明人： WEBER DAVID A , KANE INGRID , REHAL MIKE , LATHROP III ROBERT L , APTEKAREV KENNY , ETTER JEFFREY , GERONDALE SCOTT , BHAGAT RAHUL , DAVIS SHAWN
IPC分类号： A61F2/16 , A61F9/00
CPC分类号： A61F2/167 , A61F9/0017 , A61F9/007
摘要： An apparatus (400) and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator (460) produces proportional movement of a linkage (600) causing the implant or microimplant to be ejected through a cannula (430) disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：一种装置（400）和用于输送眼部植入物或微量植入物的方法。该装置符合人体工程学设计以便于使用，并且致动器（460）的简单手动按压产生联动装置（600）的成比例的运动，使得植入物或微型植入物通过设置在期望位置处的套管（430）眼。提供小尺寸插管用于自密封输送方法。

4. 发明申请

WO2006071554A2 IMPROVED APPARATUS FOR DELIVERY OF OCULAR IMPLANTS 审中-公开
标题翻译：改进的用于输送OCURAR IMPLANTS的装置
公开(公告)号：WO2006071554A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/045491
申请日：2005-12-14
申请人： ALLERGAN, INC. , WEBER, David, A. , KANE, Ingrid , REHAL, Mike , LATHROP, III, Robert, L. , APTEKAREV, Kenny , ETTER, Jeffrey , GERONDALE, Scott , BHAGAT, Rahul , DAVIS, Shawn
发明人： WEBER, David, A. , KANE, Ingrid , REHAL, Mike , LATHROP, III, Robert, L. , APTEKAREV, Kenny , ETTER, Jeffrey , GERONDALE, Scott , BHAGAT, Rahul , DAVIS, Shawn
IPC分类号： A61F2/16 , A61F9/00
CPC分类号： A61F2/167 , A61F9/0017 , A61F9/007
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

5. 发明申请

WO2008028193A3 COLON-TARGETED ORAL FORMULATIONS OF CYTIDINE ANALOGS 审中-公开
标题翻译： CYONDINE类似物的结肠靶向口服制剂
公开(公告)号：WO2008028193A3
公开(公告)日：2008-12-04
申请号：PCT/US2007077557
申请日：2007-09-04
申请人： PHARMION CORP , ETTER JEFFREY B
发明人： ETTER JEFFREY B
IPC分类号： A61K31/7068 , A61K9/00 , A61P43/00
CPC分类号： A61K31/7068 , A61K9/2846 , A61K9/2886 , A61K9/4891
摘要： The present invention provides an oral formulation of a cytidine analog, including, 5-azacytidine, for delivery to the lower gastrointestinal tract, including, the large intestine; methods to treat diseases associated with abnormal cell proliferation by treatment with the oral formulations of the present invention; and methods to increase the bioavailability of a cytidine analog upon administration to a patient by providing an oral formulation of the present invention.
摘要翻译：本发明提供了胞苷类似物（包括5-氮杂胞苷）的口服制剂，用于递送至下胃肠道，包括大肠; 通过用本发明的口服制剂治疗来治疗与异常细胞增殖有关的疾病的方法; 以及通过提供本发明的口服制剂来增加胞苷类似物在给予患者时的生物利用度的方法。

6. 发明申请

WO2004026106A3 METHODS AND APPARATUS FOR DELIVERY OF OCULAR IMPLANTS 审中-公开
标题翻译：用于输送眼部植入物的方法和装置
公开(公告)号：WO2004026106A3
公开(公告)日：2004-07-29
申请号：PCT/US0329518
申请日：2003-09-18
申请人： ALLERGAN INC , WEBER DAVID , KANE INGRID , REHAL MIKE , LATHROP ROBERT L III , APTEKAREV KENNY , ETTER JEFFREY
发明人： WEBER DAVID , KANE INGRID , REHAL MIKE , LATHROP ROBERT L III , APTEKAREV KENNY , ETTER JEFFREY
IPC分类号： A61B17/00 , A61F2/14 , A61F2/16 , A61F9/00 , A61F9/007 , A61M37/00
CPC分类号： A61M37/0069 , A61F2/167 , A61F9/0017
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

7. 发明申请

WO2004026106A2 METHODS AND APPARATUS FOR DELIVERY OF OCULAR IMPLANTS 审中-公开
标题翻译：用于递送眼睛植入物的方法和设备
公开(公告)号：WO2004026106A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/029518
申请日：2003-09-18
申请人： OCULEX PHARMACEUTICALS, INC. , WEBER, David , KANE, Ingrid , REHAL, Mike , LATHROP, Robert, L., III , APTEKAREV, Kenny , ETTER, Jeffrey
发明人： WEBER, David , KANE, Ingrid , REHAL, Mike , LATHROP, Robert, L., III , APTEKAREV, Kenny , ETTER, Jeffrey
IPC分类号： A61B
CPC分类号： A61M37/0069 , A61F2/167 , A61F9/0017
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于递送眼植入物或微植入物的装置和方法。该设备符合人体工程学设计以易于使用，并且致动器的简单手动压下产生连杆的成比例移动，导致植入物或微植入物通过设置在眼睛期望位置的套管射出。小号插管提供自动密封的交付方式。

8. 发明申请

WO1991004491A1 METHOD AND APPARATUS FOR DETECTION OF AN ANALYTE 审中-公开
标题翻译：用于检测分析仪的方法和装置
公开(公告)号：WO1991004491A1
公开(公告)日：1991-04-04
申请号：PCT/US1990005317
申请日：1990-09-18
申请人： BIOSTAR MEDICAL PRODUCTS, INC. , MODDEL, Garret, R. , MAUL, Diana, M. , ETTER, Jeffrey, B. , STARZL, Timothy, W.
发明人： BIOSTAR MEDICAL PRODUCTS, INC.
IPC分类号： G01N33/543
CPC分类号： B82Y30/00 , B82Y15/00 , G01N21/211 , G01N21/77 , G01N33/54366 , G01N33/54373 , G01N33/551 , G01N33/552
摘要： A new and useful device is disclosed for use in analyte detection comprising: (a) one or more anti-reflective layers coated on a support; (b) a top layer of material capable of being activated to interact with a receptive material; (c) a layer of receptive material capable of interaction with the analyte of interest. The top layer of material includes, but is not limited to, silicon or a silicon compound. These various materials can be chemically activated to covalently bind or adsorb or attach by whatever mechanism to the analyte of interest in a sample. The device undergoes a visual change in color or intensity if the analyte is present in the sample.
摘要翻译：公开了用于分析物检测的新的有用的装置，包括：（a）涂覆在支撑体上的一个或多个抗反射层; （b）能够被激活以与接受材料相互作用的顶层材料; （c）能够与感兴趣的分析物相互作用的接受材料层。材料的顶层包括但不限于硅或硅化合物。这些各种材料可以被化学活化，以通过任何机制共价结合或吸附或附着到样品中感兴趣的分析物。如果分析物存在于样品中，则该装置在颜色或强度上经历视觉上的变化。

9. 发明申请

WO2017048989A1 DEVICES AND METHODS FOR ANCHORING A SHEATH IN A TISSUE CAVITY 审中-公开
标题翻译：用于锚固组织中的皮肤的装置和方法
公开(公告)号：WO2017048989A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/051985
申请日：2016-09-15
申请人： FONG, Kenton D. , LEE, Jan , ETTER, Jeffrey W.
发明人： FONG, Kenton D. , LEE, Jan , ETTER, Jeffrey W.
IPC分类号： A61B17/00 , A61F2/00 , A61F2/04 , A61F2/848
CPC分类号： A61F5/4408 , A61F5/449
摘要： According to some embodiments of the invention, an anchoring system includes a sleeve having an inner surface defining a first lumen, a first annular sealing mechanism disposed at a proximal end of the sleeve, and a second annular sealing mechanism disposed at a distal end of the sleeve. The anchoring system further includes a pressure tube in fluid connection with an outer surface of the sleeve, a sheath in mechanical connection with the sleeve, the sheath forming a second lumen, the second lumen being in fluid connection with the first lumen, and open-cell foam disposed on the outer surface of the sleeve. Application of negative pressure to the pressure tube causes a seal to form between the first and second annular sealing mechanisms and an inner surface of a tissue cavity. Application of negative pressure to the pressure tube also creates a frictional force that resists displacement of the sleeve.
摘要翻译：根据本发明的一些实施例，锚定系统包括具有限定第一内腔的内表面的套筒，设置在套筒的近端处的第一环形密封机构和设置在套筒的远端处的第二环形密封机构袖。锚固系统还包括与套筒的外表面流体连接的压力管，与套筒机械连接的护套，护套形成第二管腔，第二管腔与第一管腔流体连通，细胞泡沫设置在套筒的外表面上。对压力管施加负压导致在第一和第二环形密封机构与组织腔的内表面之间形成密封。对压力管施加负压也产生抵抗套筒位移的摩擦力。

10. 发明申请

WO2009139888A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF 审中-公开
标题翻译： CYDIDINE类似物的口服制剂及其使用方法
公开(公告)号：WO2009139888A1
公开(公告)日：2009-11-19
申请号：PCT/US2009/002999
申请日：2009-05-14
申请人： CELGENE CORPORATION , ETTER, Jeffrey, B. , LAI, Mei , BACKSTROM, Jay, Thomas
发明人： ETTER, Jeffrey, B. , LAI, Mei , BACKSTROM, Jay, Thomas
IPC分类号： A61K9/20 , A61K9/28 , A61K31/7068
CPC分类号： A61K31/706 , A61K9/2013 , A61K9/2018 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/7068 , A61K47/10
摘要： The present disclosure provides pharmaceutical compositions comprising cytidine analogs for oral administration, wherein the compositions release the cytidine analog substantially in the stomach. Also provided are methods of treating diseases and disorders using the oral formulations provided herein.
摘要翻译：本公开提供了包含用于口服给药的胞苷类似物的药物组合物，其中所述组合物基本上在胃中释放胞苷类似物。还提供了使用本文提供的口服制剂治疗疾病和病症的方法。

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