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    • 6. 发明授权
    • Delay circuit with reset-based forward path static delay
    • 具有基于复位的正向路径静态延迟的延迟电路
    • US07276947B2
    • 2007-10-02
    • US11493872
    • 2006-07-26
    • Eric BeckerTyler GommRoss Dermott
    • Eric BeckerTyler GommRoss Dermott
    • H03L7/00
    • H03L7/0814G11C7/22G11C7/222
    • A delay locked loop circuit and method of operating the same. The delay locked loop circuit comprises a forward delay path having a variable delay portion and a static delay portion, wherein the static delay portion includes a static delay element, a feedback path for generating a feedback signal responsive to an output signal, and a phase detector for comparing the phase of an input signal and the phase of the feedback signal and for generating a variable control signal for controlling the amount of delay provided by the variable delay portion, wherein the static delay element is activated in response to a static control signal indicative of the variable delay portion being unable to lock the output signal to the input signal. Because of the rules governing Abstracts, this Abstract should not be used to construe the claims.
    • 延迟锁定环电路及其操作方法。 所述延迟锁定环电路包括具有可变延迟部分和静态延迟部分的前向延迟路径,其中所述静态延迟部分包括静态延迟元件,用于产生响应于输出信号的反馈信号的反馈路径,以及相位检测器 用于比较输入信号的相位和反馈信号的相位,并用于产生用于控制由可变延迟部分提供的延迟量的可变控制信号,其中静态延迟元件响应于指示的静态控制信号而被激活 的可变延迟部分不能将输出信号锁定到输入信号。 由于摘要规则,本摘要不应用于解释权利要求。
    • 10. 发明授权
    • CHO/CERT cell lines
    • CHO / CERT细胞系
    • US09340592B2
    • 2016-05-17
    • US13318509
    • 2010-05-04
    • Lore FlorinEric BeckerHitto Kaufmann
    • Lore FlorinEric BeckerHitto Kaufmann
    • C12N15/85C12N15/63A61K31/711C12P21/08C07K14/47
    • C07K14/47
    • The invention concerns the field of cell culture technology. The invention describes production host cell lines comprising vector constructs comprising a CERT S132 A expression cassette. Those cell lines have improved growth characteristics and high CERT S132A expression levels. The invention especially concerns two cell lines deposited with the DSMZ under the number DSM ACC2989 (CHO/CERT 2.20) and DSM AC-C2990 (CHO/CERT 2.41). The invention further concerns a method of generating such preferred production host cells and a method of producing proteins using the two cell lines deposited with the DSMZ under the number DSM ACC2989 (CHO/CERT 2.20) and DSM ACC2990 (CHO/CERT 2.41).
    • 本发明涉及细胞培养技术领域。 本发明描述了包含载体构建体的生产宿主细胞系,其包含CERT S132A表达盒。 这些细胞系具有改善的生长特性和较高的CERT S132A表达水平。 本发明特别涉及以DSM ACC2989(CHO / CERT 2.20)和DSM AC-C2990(CHO / CERT 2.41)存放于DSMZ的两种细胞系。 本发明还涉及产生这种优选的生产宿主细胞的方法,以及使用保藏在帝斯曼数据DSM ACC2989(CHO / CERT 2.20)和DSM ACC2990(CHO / CERT 2.41)上的DSMZ的两种细胞系产生蛋白质的方法。