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1. 发明申请

US20170178047A1 Quality Assurance Systems and Methods Associated Therewith 审中-公开
公开(公告)号：US20170178047A1
公开(公告)日：2017-06-22
申请号：US14974472
申请日：2015-12-18
申请人： Steve Schroeder , Robert Christopher Pirotte , Eric Becker , John Nienhuis , Andy Centeno
发明人： Steve Schroeder , Robert Christopher Pirotte , Eric Becker , John Nienhuis , Andy Centeno
IPC分类号： G06Q10/06
CPC分类号： G06Q10/06395
摘要： A new and improved quality assurance system and associated methods are disclosed that allow for data collected and input electronically via tablets or mobile computing devices in real-time. The input data is collated to allow for review against established product rules that will drastically decrease the time it takes for manufacturers to release batches of quality approved products.

2. 发明授权

US08221999B2 Protein production 有权
标题翻译：蛋白质生产
公开(公告)号：US08221999B2
公开(公告)日：2012-07-17
申请号：US12040198
申请日：2008-02-29
申请人： Hitto Kaufmann , Lore Florin , Eric Becker , Monilola Olayioye , Angelika Hausser , Tim Fugmann
发明人： Hitto Kaufmann , Lore Florin , Eric Becker , Monilola Olayioye , Angelika Hausser , Tim Fugmann
IPC分类号： C12P21/06
CPC分类号： C12N15/63 , C07K14/435 , C07K14/47 , C07K14/4702 , C07K16/00 , C07K2319/036 , C12N15/67 , C12N15/85 , C12P21/00 , C12Q1/68 , G01N33/68
摘要： The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport.
摘要翻译：本发明涉及蛋白质生产和细胞培养技术领域。 CERT被确定为体内PKD底物的新颖。通过PKD在丝氨酸132上的磷酸化降低了CERT对高尔基体膜上的脂质靶磷脂酰肌醇4-磷酸的亲和力，降低了神经酰胺转移活性，鉴定了PKD作为脂质体内平衡的调节剂。本发明显示CERT又对于PKD激活和PKD依赖蛋白质运送到质膜的关键。因此，PKD和CERT的相互依存关系是维持高尔基体膜完整性和分泌转运的关键。

3. 发明申请

US20110281301A1 THE SECRETORY CAPACITY IN HOST CELLS 审中-公开
标题翻译：宿主细胞中的秘密能力
公开(公告)号：US20110281301A1
公开(公告)日：2011-11-17
申请号：US12742299
申请日：2008-10-06
申请人： Hitto Kaufmann , Eric Becker , Lore Florin , Barbara Enenkel , Kerstin Sautter , Rebecca Bischoff
发明人： Hitto Kaufmann , Eric Becker , Lore Florin , Barbara Enenkel , Kerstin Sautter , Rebecca Bischoff
IPC分类号： C12P21/00 , C12N5/10 , C12N15/85
CPC分类号： C12N5/0018 , C07K16/00 , C12N2501/48 , C12N2501/60 , C12N2510/02
摘要： The invention concerns the field of protein production and cell culture technology. It describes a method of producing a heterologous protein of interest in a cell comprising a. Increasing the expression or activity of a secretion enhancing gene, and b. Increasing the expression or activity of an anti-apoptotic gene, and c. Effecting the expression of said protein of interest, whereby the secretion enhancing gene is a gene encoding a protein whose expression or activity is induced during one of the following cellular processes: plasma-cell differentiation, unfolded protein response (UPR), endoplasmic reticulum overload response (EOR).
摘要翻译：本发明涉及蛋白质生产和细胞培养技术领域。它描述了在包含a的细胞中产生感兴趣的异源蛋白质的方法。增加分泌增强基因的表达或活性，b。增加抗凋亡基因的表达或活性，c。影响所述目的蛋白质的表达，由此分泌增强基因是编码在以下细胞过程之一期间诱导其表达或活性的蛋白质的基因：血浆细胞分化，展开的蛋白质应答（UPR），内质网过载反应（EOR）。

4. 发明申请

US20090247609A1 SM-PROTEIN BASED SECRETION ENGINEERING 审中-公开
标题翻译：基于SM蛋白的分泌工程
公开(公告)号：US20090247609A1
公开(公告)日：2009-10-01
申请号：US12336612
申请日：2008-12-17
申请人： Hitto KAUFMANN , Eric BECKER , Lore FLORIN , Martin FUSSENEGGER , Ren-Wang PENG , Joey M STUDTS
发明人： Hitto KAUFMANN , Eric BECKER , Lore FLORIN , Martin FUSSENEGGER , Ren-Wang PENG , Joey M STUDTS
IPC分类号： A61K31/7105 , C12P21/00 , C12N15/87 , C12P21/08 , C12N15/00 , C12N5/06 , C07K16/18 , A61K31/7088 , C12Q1/02
CPC分类号： C07K14/705 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12P21/02
摘要： The present invention concerns the field of cell culture technology. It describes a novel method for enhancing the secretory transport of proteins in eukaryotic cells by heterologous expression of Munc18c, Sly1 or other members of the SM protein family. This method is particularly useful for the generation of optimized host cell systems with enhanced production capacity for the expression and manufacture of recombinant protein products.
摘要翻译：本发明涉及细胞培养技术领域。它描述了通过异源表达Munc18c，Sly1或SM蛋白家族的其他成员来增强真核细胞中蛋白质分泌转运的新方法。该方法对于产生具有增强的生产能力的优化的宿主细胞系统特别有用，用于表达和制造重组蛋白质产物。

5. 发明申请

US20090018099A1 PROTEIN PRODUCTION 审中-公开
标题翻译：蛋白质生产
公开(公告)号：US20090018099A1
公开(公告)日：2009-01-15
申请号：US12184626
申请日：2008-08-01
申请人： Hitto Kaufmann , Lore Florin , Eric Becker , Monilola Olayioye , Angelika Hausser , Tim Fugmann
发明人： Hitto Kaufmann , Lore Florin , Eric Becker , Monilola Olayioye , Angelika Hausser , Tim Fugmann
IPC分类号： A61K31/7105 , C12Q1/68 , C12N5/00 , A61P35/00
CPC分类号： C07K14/4702 , C07K16/00 , C07K2319/036 , C12N15/67 , C12N15/85
摘要： The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport.
摘要翻译：本发明涉及蛋白质生产和细胞培养技术领域。 CERT被确定为体内PKD底物的新颖。通过PKD在丝氨酸132上的磷酸化降低了CERT对高尔基体膜上的脂质靶磷脂酰肌醇4-磷酸的亲和力，降低了神经酰胺转移活性，鉴定了PKD作为脂质体内平衡的调节剂。本发明显示CERT又对于PKD激活和PKD依赖蛋白质运送到质膜的关键。因此，PKD和CERT的相互依存关系是维持高尔基体膜完整性和分泌转运的关键。

6. 发明授权

US07276947B2 Delay circuit with reset-based forward path static delay 有权
标题翻译：具有基于复位的正向路径静态延迟的延迟电路
公开(公告)号：US07276947B2
公开(公告)日：2007-10-02
申请号：US11493872
申请日：2006-07-26
申请人： Eric Becker , Tyler Gomm , Ross Dermott
发明人： Eric Becker , Tyler Gomm , Ross Dermott
IPC分类号： H03L7/00
CPC分类号： H03L7/0814 , G11C7/22 , G11C7/222
摘要： A delay locked loop circuit and method of operating the same. The delay locked loop circuit comprises a forward delay path having a variable delay portion and a static delay portion, wherein the static delay portion includes a static delay element, a feedback path for generating a feedback signal responsive to an output signal, and a phase detector for comparing the phase of an input signal and the phase of the feedback signal and for generating a variable control signal for controlling the amount of delay provided by the variable delay portion, wherein the static delay element is activated in response to a static control signal indicative of the variable delay portion being unable to lock the output signal to the input signal. Because of the rules governing Abstracts, this Abstract should not be used to construe the claims.
摘要翻译：延迟锁定环电路及其操作方法。所述延迟锁定环电路包括具有可变延迟部分和静态延迟部分的前向延迟路径，其中所述静态延迟部分包括静态延迟元件，用于产生响应于输出信号的反馈信号的反馈路径，以及相位检测器用于比较输入信号的相位和反馈信号的相位，并用于产生用于控制由可变延迟部分提供的延迟量的可变控制信号，其中静态延迟元件响应于指示的静态控制信号而被激活的可变延迟部分不能将输出信号锁定到输入信号。由于摘要规则，本摘要不应用于解释权利要求。

7. 发明授权

US07171659B2 System and method for configurable software provisioning 有权
标题翻译：可配置软件配置的系统和方法
公开(公告)号：US07171659B2
公开(公告)日：2007-01-30
申请号：US10102153
申请日：2002-03-19
申请人： Brian Eric Becker , Michael Robert Hanson , Alain Jules Mayer , Michael Todd Schroepfer
发明人： Brian Eric Becker , Michael Robert Hanson , Alain Jules Mayer , Michael Todd Schroepfer
IPC分类号： G06F9/44 , G06F15/16
CPC分类号： H04L67/34 , H04L29/06 , H04L67/306 , H04L69/329
摘要： A system and method for the automated provisioning of software applications onto one or more computers. The provisioning system uses a model of the application, which describes the application in terms of its software features and the actions to manipulate the application. The model preferably describes this information in a general way, such that it is independent of any environmental characteristics associated with the computers. The provisioning system also receives as input a set of references to selected ones of the computers onto which the application is to be provisioned.
摘要翻译：一种用于将软件应用程序自动提供到一个或多个计算机上的系统和方法。配置系统使用应用程序模型，它根据其软件功能和操作应用程序的操作来描述应用程序。该模型优选以一般方式描述该信息，使得其独立于与计算机相关联的任何环境特性。供应系统还接收作为输入的一组对要应用应用程序所要供应的计算机的引用。

8. 发明申请

US20060038597A1 Delay circuit with reset-based forward path static delay 有权
公开(公告)号：US20060038597A1
公开(公告)日：2006-02-23
申请号：US10922326
申请日：2004-08-20
申请人： Eric Becker , Tyler Gomm , Ross Dermott
发明人： Eric Becker , Tyler Gomm , Ross Dermott
IPC分类号： H03L7/06
CPC分类号： H03L7/0814 , G11C7/22 , G11C7/222
摘要： A delay locked loop circuit and method of operating the same. The delay locked loop circuit comprises a forward delay path having a variable delay portion and a static delay portion, wherein the static delay portion includes a static delay element, a feedback path for generating a feedback signal responsive to an output signal, and a phase detector for comparing the phase of an input signal and the phase of the feedback signal and for generating a variable control signal for controlling the amount of delay provided by the variable delay portion, wherein the static delay element is activated in response to a static control signal indicative of the variable delay portion being unable to lock the output signal to the input signal. Because of the rules governing Abstracts, this Abstract should not be used to construe the claims.

9. 发明申请

US20200372433A1 Quality Assurance Systems and Methods Associated Therewith 审中-公开
公开(公告)号：US20200372433A1
公开(公告)日：2020-11-26
申请号：US16989600
申请日：2020-08-10
申请人： Steve Schroeder , Robert Christopher Pirotte , Eric Becker , John Nienhuis , Andy Centeno
发明人： Steve Schroeder , Robert Christopher Pirotte , Eric Becker , John Nienhuis , Andy Centeno
IPC分类号： G06Q10/06
摘要： A new and improved quality assurance system and associated methods are disclosed that allow for data collected and input electronically via tablets or mobile computing devices in real-time. The input data is collated to allow for review against established product rules that will drastically decrease the time it takes for manufacturers to release batches of quality approved products.

10. 发明授权

US09340592B2 CHO/CERT cell lines 有权
标题翻译： CHO / CERT细胞系
公开(公告)号：US09340592B2
公开(公告)日：2016-05-17
申请号：US13318509
申请日：2010-05-04
申请人： Lore Florin , Eric Becker , Hitto Kaufmann
发明人： Lore Florin , Eric Becker , Hitto Kaufmann
IPC分类号： C12N15/85 , C12N15/63 , A61K31/711 , C12P21/08 , C07K14/47
CPC分类号： C07K14/47
摘要： The invention concerns the field of cell culture technology. The invention describes production host cell lines comprising vector constructs comprising a CERT S132 A expression cassette. Those cell lines have improved growth characteristics and high CERT S132A expression levels. The invention especially concerns two cell lines deposited with the DSMZ under the number DSM ACC2989 (CHO/CERT 2.20) and DSM AC-C2990 (CHO/CERT 2.41). The invention further concerns a method of generating such preferred production host cells and a method of producing proteins using the two cell lines deposited with the DSMZ under the number DSM ACC2989 (CHO/CERT 2.20) and DSM ACC2990 (CHO/CERT 2.41).
摘要翻译：本发明涉及细胞培养技术领域。本发明描述了包含载体构建体的生产宿主细胞系，其包含CERT S132A表达盒。这些细胞系具有改善的生长特性和较高的CERT S132A表达水平。本发明特别涉及以DSM ACC2989（CHO / CERT 2.20）和DSM AC-C2990（CHO / CERT 2.41）存放于DSMZ的两种细胞系。本发明还涉及产生这种优选的生产宿主细胞的方法，以及使用保藏在帝斯曼数据DSM ACC2989（CHO / CERT 2.20）和DSM ACC2990（CHO / CERT 2.41）上的DSMZ的两种细胞系产生蛋白质的方法。

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