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1. 发明申请

WO2011080631A2 HIGH INTENSITY FOCUSED ULTRASOUND TRANSDUCER OPTIMIZATION 审中-公开
标题翻译：高强度聚焦超声换能器优化
公开(公告)号：WO2011080631A2
公开(公告)日：2011-07-07
申请号：PCT/IB2010/055640
申请日：2010-12-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , RADULESCU, Emil, G. , EHNHOLM, Gosta, Jakob , ERKAMP, Ramon, Q. , KOSKELA, I., A., Julius , SOKKA, Shunmugavelu, D. , VAHALA, Erkki, T. , KOHLER, Max, Oskar
发明人： RADULESCU, Emil, G. , EHNHOLM, Gosta, Jakob , ERKAMP, Ramon, Q. , KOSKELA, I., A., Julius , SOKKA, Shunmugavelu, D. , VAHALA, Erkki, T. , KOHLER, Max, Oskar
IPC分类号： A61N7/00 , A61N7/02 , A61B19/00
CPC分类号： A61N7/02 , A61B2034/104 , A61B2034/105 , A61B2090/374 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095
摘要： When planning magnetic resonance (MR) guided high intensity focused ultrasonic (HIFU) therapy, HIFU transducer element parameters are optimized as a function of 3D MR data describing a size, shape, and position of a region of interest (ROI) (146) and any obstructions (144) between the HIFU transducer elements and the ROI (146). Transducer element phases and amplitudes are adjusted to maximize HIFU radiation delivery to the ROI (146) while minimizing delivery to the obstruction (144). Additionally or alternatively, transducer elements are selectively deactivated if the obstruction (144) is positioned between the ROI (146) and a given transducer element.
摘要翻译：当规划磁共振（MR）引导的高强度聚焦超声波（HIFU）疗法时，HIFU换能器元件参数根据3D MR数据进行优化，所述3D MR数据描述区域的大小，形状和位置兴趣（ROI）（146）以及HIFU换能器元件和ROI（146）之间的任何障碍物（144）。传感器元件的相位和幅度被调整以最大化HIFU辐射传送到ROI（146），同时最小化传送到障碍物（144）。另外或可选地，如果障碍物（144）位于ROI（146）和给定换能器元件之间，则选择性地停用换能器元件。

2. 发明申请

WO2012117328A1 CALCULATING THE SPEED OF ULTRASOUND IN AT LEAST TWO TISSUE TYPES 审中-公开
标题翻译：以最小二组织计算超声波速度
公开(公告)号：WO2012117328A1
公开(公告)日：2012-09-07
申请号：PCT/IB2012/050886
申请日：2012-02-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MOUGENOT, Charles , EHNHOLM, Gosta Jakob , KOSKELA, Ilpo Asko Julius , KÖHLER, Max Oskar
发明人： MOUGENOT, Charles , EHNHOLM, Gosta Jakob , KOSKELA, Ilpo Asko Julius , KÖHLER, Max Oskar
IPC分类号： A61B8/08 , A61N7/02 , G01H5/00 , A61B5/107 , A61B5/055 , A61B6/00
CPC分类号： A61B8/08 , A61B5/055 , A61B5/1075 , A61B6/50 , A61B6/5247 , A61B8/0825 , A61B8/0858 , A61B8/406 , A61B8/4494 , A61B8/585 , A61B2562/0204 , A61B2562/046 , A61N7/02 , A61N2007/0078 , A61N2007/0095 , G01H5/00 , G06F19/00
摘要： A medical apparatus (400) comprising an ultrasound transmitter (444, 602) and receiver (446, 604) system (600) for acquiring ultrasound data (476) descriptive of the speed of ultrasound (304, 306) along at least two paths (606, 1114). The medical apparatus further comprises a medical imaging system (402) for acquiring medical image data (468) and a memory (464) containing instructions (490, 492, 494, 496, 498, 500, 502, 504) that causes the processor to acquire (100, 200) the medical image data. The instructions further cause the processor to acquire (102, 202) the ultrasound data. The instructions further cause the processor to segment (104, 204) the medical image data into at least two tissue types (434, 436, 610, 612, 708, 710). The instructions further causes the processor to determine (106, 206) at least two distances corresponding to the at least two paths in the subject. The instructions further cause the processor to calculate (108, 208) the speed of ultrasound in the at least two tissue types.
摘要翻译：一种包括超声波发射器（444,602）和接收器（446,604）系统（600）的医疗设备（400），该系统（600）用于采集描述沿着至少两条路径的超声波（304,306）的速度的超声波数据（476） 606，1114）。医疗设备还包括用于获取医学图像数据（468）的医疗成像系统（402）和包含指令（490,492,494,496,498,500,2005,504）的存储器（464），所述指令使处理器获取（100,200）医学图像数据。该指令还使处理器获取超声数据（102,202）。指令还使处理器将医学图像数据（104,204）分割为至少两种组织类型（434,436,610,612,708,710）。指令还使得处理器确定（106,206）与被摄体中的至少两条路径相对应的至少两个距离。该指令还使得处理器在至少两种组织类型中计算（108,208）超声波的速度。

3. 发明申请

WO2011080631A3 HIGH INTENSITY FOCUSED ULTRASOUND TRANSDUCER OPTIMIZATION 审中-公开
标题翻译：高强度聚焦超声波传感器优化
公开(公告)号：WO2011080631A3
公开(公告)日：2011-11-10
申请号：PCT/IB2010055640
申请日：2010-12-07
申请人： KONINKL PHILIPS ELECTRONICS NV , RADULESCU EMIL G , EHNHOLM GOSTA JAKOB , ERKAMP RAMON Q , KOSKELA I A JULIUS , SOKKA SHUNMUGAVELU D , VAHALA ERKKI T , KOHLER MAX OSKAR
发明人： RADULESCU EMIL G , EHNHOLM GOSTA JAKOB , ERKAMP RAMON Q , KOSKELA I A JULIUS , SOKKA SHUNMUGAVELU D , VAHALA ERKKI T , KOHLER MAX OSKAR
IPC分类号： A61N7/00 , A61B19/00 , A61N7/02
CPC分类号： A61N7/02 , A61B2034/104 , A61B2034/105 , A61B2090/374 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095
摘要： When planning magnetic resonance (MR) guided high intensity focused ultrasonic (HIFU) therapy, HIFU transducer element parameters are optimized as a function of 3D MR data describing a size, shape, and position of a region of interest (ROI) (146) and any obstructions (144) between the HIFU transducer elements and the ROI (146). Transducer element phases and amplitudes are adjusted to maximize HIFU radiation delivery to the ROI (146) while minimizing delivery to the obstruction (144). Additionally or alternatively, transducer elements are selectively deactivated if the obstruction (144) is positioned between the ROI (146) and a given transducer element.
摘要翻译：当计划磁共振（MR）引导的高强度聚焦超声（HIFU）治疗时，HIFU换能器元件参数被优化为描述感兴趣区域（ROI）（146）的尺寸，形状和位置的3D MR数据的函数，并且 HIFU换能器元件和ROI（146）之间的任何障碍物（144）。调节传感器元件相位和振幅以最大化HIFU辐射传递到ROI（146），同时最小化到障碍物的传递（144）。另外或替代地，如果障碍物（144）位于ROI（146）和给定的换能器元件之间，则换能器元件被选择性地停用。

4. 发明申请

WO2010143133A1 MR IMAGING GUIDED ULTRASOUND THERAPY 审中-公开
标题翻译：成像指导超声治疗
公开(公告)号：WO2010143133A1
公开(公告)日：2010-12-16
申请号：PCT/IB2010/052537
申请日：2010-06-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VIRTA, Tero Jouko Valtter , EHNHOLM, Gosta Jakob , IMMONEN, Paavo
发明人： VIRTA, Tero Jouko Valtter , EHNHOLM, Gosta Jakob , IMMONEN, Paavo
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B5/055 , A61B2017/00084 , A61B2090/374 , G01R33/288 , G01R33/4814
摘要： The invention relates to a therapeutic system which comprises: an ultrasound therapy unit (1) arranged to insonify at least a portion of a body (2) of a patient with high intensity ultrasound, wherein the ultrasound therapy unit (1) comprises an ultrasound applicator (10) attached to a patient table (9) carrying the body (2) of the patient, and a MR imaging unit (3) arranged to acquire MR signals from the portion of the body (2) and to reconstruct a MR image from the MR signals, wherein the MR imaging unit (3) comprises a RF receiving antenna (14) for receiving the MR signals. It is an object of the invention to provide a therapeutic system which facilitates a good image quality close to the ultrasound applicator and improves the usability of the therapeutic system. To this end, the invention proposes that the RF receiving antenna (14) is integrally incorporated into the patient table (9).
摘要翻译：本发明涉及一种治疗系统，其包括：超声治疗单元（1），其布置成用高强度超声波对身体（2）的至少一部分进行增强，其中所述超声治疗单元（1）包括超声波施加器（10），其安装在携带患者身体（2）的患者台（9）上，MR成像单元（3）被布置成从身体（2）的部分获取MR信号，并从 MR信号，其中MR成像单元（3）包括用于接收MR信号的RF接收天线（14）。本发明的目的是提供一种治疗系统，其有利于接近超声波施加器的良好图像质量并且提高了治疗系统的可用性。为此，本发明提出将RF接收天线（14）整体并入到患者台（9）中。

5. 发明申请

WO2010140086A1 MR IMAGING GUIDED THERAPY 审中-公开
标题翻译：成像指导治疗
公开(公告)号：WO2010140086A1
公开(公告)日：2010-12-09
申请号：PCT/IB2010/052357
申请日：2010-05-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , RAJU, Balasundara, I. , ANAND, Ajay , EHNHOLM, Gosta, Jakob
发明人： RAJU, Balasundara, I. , ANAND, Ajay , EHNHOLM, Gosta, Jakob
IPC分类号： A61N7/02 , A61N5/067 , A61N1/40
CPC分类号： A61N7/02 , A61B2017/00084 , A61B2090/374
摘要： The invention relates to a therapeutic system comprising: a MR imaging unit arranged to acquire MR signals from a body (10) of a patient positioned in an examination volume, a thermal treatment unit (19, 20) for the deposition of thermal energy within tissue of the body (10). It is an object of the invention to enable continuous temperature monitoring based on MR thermometry even in a situation in which the focus of the thermal treatment is moved. To this end, the invention proposes that the system is arranged to perform the steps of: a) initiating thermal treatment by heating the tissue of the body (10) at the position of a focus within the examination volume, b) selective acquisition of MR signals from a first image plane (24), the position of the focus of the thermal treatment being located within the first image plane (24), c) reconstruction of a thermographic MR image from the MR signals acquired from the first image plane (24), d) computing a baseline thermographic MR image from the temperature distribution within at least one second image plane (25, 26, 27) being different from the first image plane (24), e) moving the focus of the thermal treatment to a new position within the examination volume, f) changing the position and/or orientation of the first image plane (24) corresponding to the new position of the focus of the thermal treatment, g) repeating steps b) and c), wherein the baseline thermographic MR image computed in step d) is used for thermographic image reconstruction in subsequent step c).
摘要翻译：本发明涉及一种治疗系统，包括：MR成像单元，其布置成从位于检查体积中的患者的身体（10）获取MR信号;热处理单元（19,20），用于在组织内沉积热能的身体（10）。本发明的目的是即使在热处理的焦点移动的情况下也能够基于MR测温进行连续温度监测。为此，本发明提出，该系统被设置为执行以下步骤：a）通过在检查体积内的焦点位置加热身体（10）的组织来启动热处理，b）选择性地获取MR 来自第一图像平面（24）的信号，热处理的焦点的位置位于第一图像平面（24）内，c）从从第一图像平面（24）获取的MR信号重建热成像MR图像），d）从与第一图像平面（24）不同的至少一个第二图像平面（25,26,27）内的温度分布计算基线热成像MR图像，e）将热处理的焦点移动到在检查体积内的新位置，f）改变对应于热处理焦点的新位置的第一图像平面（24）的位置和/或取向，g）重复步骤b）和c），其中基线热成像MR图像计算步骤d）中的d用于后续步骤c）中的热成像图像重建。

6. 发明申请

WO2007043009A2 RF ANTENNA WITH INTEGRATED ELECTRONICS 审中-公开
标题翻译：射频天线与集成电子
公开(公告)号：WO2007043009A2
公开(公告)日：2007-04-19
申请号：PCT/IB2006/053718
申请日：2006-10-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HAANS, Paulus Cornelius Hendrikus Adrianus , SAES, Marc Paul , EHNHOLM, Gosta Jakob
发明人： HAANS, Paulus Cornelius Hendrikus Adrianus , SAES, Marc Paul , EHNHOLM, Gosta Jakob
IPC分类号： G01R33/54
CPC分类号： G01R33/54 , G01R33/3621 , G01R33/3692
摘要： A radio frequency antenna comprising a resonant pickup circuit (102) arranged to pick up a magnetic resonance signal, an analog-to-digital converter (105) arranged to convert the magnetic resonance signal to digital data, and a frequency converter arranged to convert a primary band of frequencies of the digital data. By upshifting the frequency of the transmitted bit-stream, it is possible to RF-trap the transmission channel (109) by simple high-pass filtering techniques. In case the transmitted bit pattern has frequency components that approach the resonance frequency, an encoding technique like Manchester encoding can be used to eliminate unwanted signals.
摘要翻译：一种射频天线，包括布置成拾取磁共振信号的谐振拾取电路（102），被配置为将磁共振信号转换为数字数据的模数转换器（105），以及频率转换器，数字数据的主频带。通过升高发送的比特流的频率，可以通过简单的高通滤波技术对传输信道（109）进行RF陷阱。在发送的位模式具有接近谐振频率的频率分量的情况下，可以使用像曼彻斯特编码的编码技术来消除不需要的信号。

7. 发明申请

WO2010140125A1 MR IMAGING GUIDED THERAPY 审中-公开
标题翻译：成像指导治疗
公开(公告)号：WO2010140125A1
公开(公告)日：2010-12-09
申请号：PCT/IB2010/052458
申请日：2010-06-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ANAND, Ajay , EHNHOLM, Gosta Jakob , RAJU, Balasundara Iyyavu
发明人： ANAND, Ajay , EHNHOLM, Gosta Jakob , RAJU, Balasundara Iyyavu
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B8/5223 , A61B2017/00084 , A61B2090/374 , A61B2090/378 , A61N2007/0008 , A61N2007/0078
摘要： The invention relates to a therapeutic system which comprises an ultrasound therapy unit (1, 518) arranged to insonify at least a portion of a body (2, 508) of a patient with high intensity ultrasound and a MR imaging unit (3, 500) arranged to acquire MR signals from the portion of the body (2, 508) and to reconstruct a thermographic MR image from the MR signals. It is an object of the invention to enable MR guided high intensity focused ultrasound (HIFU) treatment, in which temperature values within critical anatomic regions containing fat can be monitored. The invention proposes that the therapeutic system further comprises an ultrasound diagnostic unit (5, 518) which is arranged to acquire ultrasound signals from the portion of the body (2, 508) and to derive at least one local temperature value from the ultrasound signals.
摘要翻译：本发明涉及一种包括超声治疗单元（1,518）的治疗系统，所述超声治疗单元布置成使具有高强度超声的患者的身体（2,508）的至少一部分和MR成像单元（3,5500）布置成从身体的部分（2,508）获取MR信号，并从MR信号重构热成像MR图像。本发明的一个目的是实现MR引导的高强度聚焦超声（HIFU）治疗，其中可以监测含有脂肪的关键解剖区域内的温度值。本发明提出，治疗系统还包括超声诊断单元（5,518），其被布置成从身体的部分（2,508）获取超声信号，并从超声信号导出至少一个局部温度值。

8. 发明申请

WO2010076685A1 SUSCEPTIBILITY-BASED LOCAL FLOW DETECTION TO CONTROL MR-GUIDED ABLATION USING BALLOON DEVICES 审中-公开
标题翻译：基于可靠性的局部流量检测来控制使用气球装置的MR导向
公开(公告)号：WO2010076685A1
公开(公告)日：2010-07-08
申请号：PCT/IB2009/055301
申请日：2009-11-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KRUEGER, Sascha , EHNHOLM, Gosta, Jakob
发明人： KRUEGER, Sascha , EHNHOLM, Gosta, Jakob
IPC分类号： A61B18/14 , A61B19/00 , G01R33/28
CPC分类号： A61B18/1492 , A61B90/06 , A61B90/36 , A61B2017/00084 , A61B2017/00243 , A61B2017/22067 , A61B2090/374 , A61B2090/3954 , A61N7/022
摘要： An interventional instrument (24) for use in performing an interventional procedure includes: a balloon (30) disposed proximate to a tip of the interventional instrument that inflates and anchors in a lumen of a fluid conduit during the interventional procedure; and one or more susceptibility markers (34) disposed proximate to the tip of the interventional instrument. A magnetic resonance scanner (10) is configured to image at least the tip of the interventional instrument during the interventional procedure using a magnetic resonance imaging sequence in which fluid flow (40) through the fluid conduit past the inflated balloon produces an extended magnetic resonance image artifact (42).
摘要翻译：用于执行介入手术的介入器械（24）包括：靠近介入器械的尖端布置的球囊（30），其在介入手术过程中使流体导管的内腔膨胀并锚固; 以及设置在介入器械的尖端附近的一个或多个敏感性标记（34）。磁共振扫描器（10）被配置为使用磁共振成像序列在介入手术过程中至少对介入器械的尖端进行成像，其中通过流体导管的经过充气气囊的流体流（40）产生延伸的磁共振图像神器（42）。

9. 发明申请

WO2007043009A3 MR RF ANTENNA WITH INTEGRATED ELECTRONICS 审中-公开
标题翻译： MR RF天线与集成电子
公开(公告)号：WO2007043009A3
公开(公告)日：2007-07-05
申请号：PCT/IB2006053718
申请日：2006-10-10
申请人： KONINKL PHILIPS ELECTRONICS NV , HAANS PAULUS CORNELIUS HENDRIK , SAES MARC PAUL , EHNHOLM GOSTA JAKOB
发明人： HAANS PAULUS CORNELIUS HENDRIK , SAES MARC PAUL , EHNHOLM GOSTA JAKOB
IPC分类号： G01R33/54
CPC分类号： G01R33/54 , G01R33/3621 , G01R33/3692
摘要： A radio frequency antenna comprising a resonant pickup circuit (102) arranged to pick up a magnetic resonance signal, an analog-to-digital converter (105) arranged to convert the magnetic resonance signal to digital data, and a frequency converter arranged to convert a primary band of frequencies of the digital data. By upshifting the frequency of the transmitted bit-stream, it is possible to RF-trap the transmission channel (109) by simple high-pass filtering techniques. In case the transmitted bit pattern has frequency components that approach the resonance frequency, an encoding technique like Manchester encoding can be used to eliminate unwanted signals.
摘要翻译：一种射频天线，包括布置成拾取磁共振信号的谐振拾取电路（102），被配置为将磁共振信号转换为数字数据的模数转换器（105），以及频率转换器，数字数据的主频带。通过升高发送的比特流的频率，可以通过简单的高通滤波技术对传输信道（109）进行RF捕获。在发送的位模式具有接近谐振频率的频率分量的情况下，可以使用诸如曼彻斯特编码的编码技术来消除不需要的信号。

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