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1. 发明申请

WO2007105161A2 APPLICATOR, USE OF THE APPLICATOR AND METHOD FOR TOPICALLY ADMINISTERING A LIQUID BY MEANS OF THE APPLICATOR 审中-公开
标题翻译：施用者，施用者的用途以及通过施用者用于局部施用液体的方法
公开(公告)号：WO2007105161A2
公开(公告)日：2007-09-20
申请号：PCT/IB2007/050794
申请日：2007-03-09
申请人： SANTOSOLVE AS , EGE, Thorfinn , ROSENGREN, Oscar , MALM, Christian , AXELSSON, Robert
发明人： EGE, Thorfinn , ROSENGREN, Oscar , MALM, Christian , AXELSSON, Robert
CPC分类号： A45D34/041
摘要： An applicator is adapted for applying a liquid from a source of liquid (2) to the skin of an individual subject. The applicator comprises a housing (8) delimiting a chamber (10), and a roller (13) rotatably mounted in the housing with an adhesion side (14) extending into the chamber and a transfer side (15) extending out of the chamber. A pipe (16) is attached to the housing, at least one first - and one second through hole (22, 23; 26), which are formed in the wall (24) of the pipe, is connecting the pipe to the source of liquid and to the chamber, respectively, said through holes are axially and angularly displaced in relation to each other, a slider (27) is arranged for sliding between a first - and second position in the pipe, a recess (29) is formed in the slider, and this recess is communicating with the source of liquid in the first position of the slider via the at least one first through hole and with the chamber in the second position of the slider via the at least one second through hole. The applicator is suitable for administering accurate and reproducible doses of easy-flowing cosmetic or medical formulation to the skin of e.g. a human being.
摘要翻译：涂敷器适用于将来自液体源（2）的液体施加到个体受试者的皮肤上。施用器包括限定腔室（10）的壳体（8）和可旋转地安装在壳体中的辊子（13），其具有延伸到腔室中的粘附侧（14）和延伸出腔室的传送侧（15）。管（16）连接到外壳上，形成在管壁（24）中的至少一个第一和一个第二通孔（22,23,26）将管连接到液体和腔室中，所述通孔彼此轴向和角度地移位，滑块（27）布置成在管道中的第一位置和第二位置之间滑动，凹部（29）形成在所述滑块通过所述至少一个第一通孔与所述滑块的第一位置中的液体源连通，并且所述腔室在所述滑块的第二位置中经由所述至少一个第二通孔与所述液体源连通。该涂药器适用于将精确和可再现剂量的易流动化妆品或药物制剂施用于例如皮肤上。一个人。

2. 发明申请

WO2004084920A3 ANTI-INFLAMMATORY TREATMENT BASED ON STRONTIUM COMPOUNDS 审中-公开
标题翻译：基于锶化合物的抗炎治疗
公开(公告)号：WO2004084920A3
公开(公告)日：2004-12-29
申请号：PCT/GB2004001369
申请日：2004-03-29
申请人： SANTOSOLVE AS , JELLUM EGIL , FAGERLUND BJOERN JARL , KJOELBERG CLAS MAGNE , KLAVENESS JO , EGE THORFINN , COCKBAIN JULIAN
发明人： JELLUM EGIL , FAGERLUND BJOERN JARL , KJOELBERG CLAS MAGNE , KLAVENESS JO , EGE THORFINN
IPC分类号： A61K31/10 , A61K31/28 , A61K33/24 , A61P29/00
CPC分类号： A61K31/10 , A61K31/28 , A61K33/24 , A61K2300/00
摘要： The invention provides a method of treatment of a human or non-human animal subject to combat inflammation arising from a condition associated with pain or a condition not associated with pain, said method comprising administering to said subject an effective amount of a physiologically tolerable strontium compound.

3. 发明申请

WO2004084920A2 ANTI-INFLAMMATORY TREATMENT 审中-公开
标题翻译：抗炎治疗
公开(公告)号：WO2004084920A2
公开(公告)日：2004-10-07
申请号：PCT/GB2004/001369
申请日：2004-03-29
申请人： SANTOSOLVE AS , COCKBAIN, Julian , JELLUM, Egil , FAGERLUND, Bjørn, Jarl , KJØLBERG, Clas, Magne , KLAVENESS, Jo , EGE, Thorfinn
发明人： JELLUM, Egil , FAGERLUND, Bjørn, Jarl , KJØLBERG, Clas, Magne , KLAVENESS, Jo , EGE, Thorfinn
IPC分类号： A61K33/24
CPC分类号： A61K31/10 , A61K31/28 , A61K33/24 , A61K2300/00
摘要： The invention provides a method of treatment of a human or non-human animal subject to combat inflammation arising from a condition associated with pain or a condition not associated with pain, said method comprising administering to said subject an effective amount of a physiologically tolerable strontium compound.
摘要翻译：本发明提供了治疗由与疼痛或与疼痛无关的病症引起的病症引起的战斗性炎症的人或非人类动物的方法，所述方法包括向所述受试者施用有效量的生理上可耐受的锶化合物。

4. 发明申请

WO1991015243A1 DIAGNOSTIC AGENTS 审中-公开
标题翻译：诊断代理
公开(公告)号：WO1991015243A1
公开(公告)日：1991-10-17
申请号：PCT/EP1991000619
申请日：1991-03-30
申请人： COCKBAIN, Julian, Roderick, Michaelson , NYCOMED AS , KLAVENESS, Jo , EGE, Thorfinn , ROCKLAGE, Scott, M.
发明人： COCKBAIN, Julian, Roderick, Michaelson , NYCOMED AS
IPC分类号： A61K49/00
CPC分类号： A61K49/126 , A61K49/085 , A61K49/103 , A61K49/106 , A61K49/16 , A61K49/18 , A61K49/1812 , A61K49/1854 , A61K49/1863 , A61K49/1875 , A61K49/20 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： The use of superparamagnetic particles and of paramagnetic materials (such as lanthanide chelates) as contrast agents in magnetometric analysis, especially imaging, and in particular structural and functional, diagnosis or imaging is described.
摘要翻译：描述了超顺磁性颗粒和顺磁性材料（例如镧系元素螯合物）在磁分析，特别是成像，特别是结构和功能，诊断或成像中的对比剂的用途。

5. 发明申请

WO2007060381A1 STRONTIUM-CONTAINING COMPOSITIONS AND THEIR USE IN METHODS OF COSMETIC TREATMENT 审中-公开
标题翻译：含锶组合物及其在化妆品处理方法中的应用
公开(公告)号：WO2007060381A1
公开(公告)日：2007-05-31
申请号：PCT/GB2006/001138
申请日：2006-03-29
申请人： SANTOSOLVE AS , GOLDING, Louise , KLAVENESS, Jo , EGE, Thorfinn
发明人： KLAVENESS, Jo , EGE, Thorfinn
IPC分类号： A61Q5/00 , A61Q19/00 , A61K8/19 , A61K8/20
CPC分类号： A61K8/19 , A61K8/20 , A61Q19/00
摘要： The present invention provides cosmetic formulations comprising strontium in an amount of up to 2.5% by weight, preferably up to 2.1% by weight, together with a physiologically acceptable carrier or excipient, wherein the strontium is present in the form of strontium chloride, strontium acetate or a hydrate thereof. Such formulations may be used to enhance the cosmetic appearance and/or the personal well-being of a subject, preferably a human subject, when topically applied to the body.
摘要翻译：本发明提供了含有至多2.5重量％，优选至多2.1重量％的锶的化妆品制剂，以及生理上可接受的载体或赋形剂，其中锶以氯化锶，乙酸锶的形式存在或其水合物。当局部施用于身体时，这样的制剂可用于增强受试者，优选人类受试者的美容外观和/或个人幸福感。

6. 发明申请

WO1993005818A1 DIAGNOSTIC AGENTS 审中-公开
标题翻译：诊断代理
公开(公告)号：WO1993005818A1
公开(公告)日：1993-04-01
申请号：PCT/EP1992002254
申请日：1992-09-26
申请人： COCKBAIN, Julian, Roderick, Michaelson , NYCOMED IMAGING AS , KLAVENESS, Jo , EGE, Thorfinn , ROCKLAGE, Scott, M.
发明人： COCKBAIN, Julian, Roderick, Michaelson , NYCOMED IMAGING AS
IPC分类号： A61K49/00
CPC分类号： A61K49/1887 , A61K49/18 , A61K49/1857 , Y10T436/24
摘要： The invention provides the use of a physiologically tolerable, particulate, free or matrix-borne, ferrimagnetic or ferromagnetic material for the manufacture of a diagnostic agent for administration into the gastrointestinal tract, the reproductive tract, the urinary tract, a closed body cavity (e.g. into the synovial fluid or the vasculature) or the musculature for magnetometric imaging of the human or non-human animal body.
摘要翻译：本发明提供了生理上可耐受的，颗粒状的，游离的或基质载体的铁磁性或铁磁材料用于制造用于施用于胃肠道，生殖道，尿道，闭合体腔（例如，进入滑液或脉管系统）或用于人或非人动物体的磁力计成像的肌肉组织。

7. 发明申请

WO2007105161A3 APPLICATOR, USE OF THE APPLICATOR AND METHOD FOR TOPICALLY ADMINISTERING A LIQUID BY MEANS OF THE APPLICATOR 审中-公开
标题翻译：申请人，使用者的使用方法及按申请人方式主要管理液体的方法
公开(公告)号：WO2007105161A3
公开(公告)日：2007-12-13
申请号：PCT/IB2007050794
申请日：2007-03-09
申请人： SANTOSOLVE AS , EGE THORFINN , ROSENGREN OSCAR , MALM CHRISTIAN , AXELSSON ROBERT
发明人： EGE THORFINN , ROSENGREN OSCAR , MALM CHRISTIAN , AXELSSON ROBERT
IPC分类号： A45D34/04
CPC分类号： A45D34/041
摘要： An applicator is adapted for applying a liquid from a source of liquid (2) to the skin of an individual subject. The applicator comprises a housing (8) delimiting a chamber (10), and a roller (13) rotatably mounted in the housing with an adhesion side (14) extending into the chamber and a transfer side (15) extending out of the chamber. A pipe (16) is attached to the housing, at least one first - and one second through hole (22, 23; 26), which are formed in the wall (24) of the pipe, is connecting the pipe to the source of liquid and to the chamber, respectively, said through holes are axially and angularly displaced in relation to each other, a slider (27) is arranged for sliding between a first - and second position in the pipe, a recess (29) is formed in the slider, and this recess is communicating with the source of liquid in the first position of the slider via the at least one first through hole and with the chamber in the second position of the slider via the at least one second through hole. The applicator is suitable for administering accurate and reproducible doses of easy-flowing cosmetic or medical formulation to the skin of e.g. a human being.
摘要翻译：施用器适于将液体从液体源（2）施加到个体受试者的皮肤。施加器包括限定腔室（10）的壳体（8）和可旋转地安装在壳体中的辊（13），其具有延伸到腔室中的粘附侧（14）和延伸出腔室的传送侧（15）。管（16）附接到壳体，形成在管的壁（24）中的至少一个第一和第二通孔（22,23; 26）将管道连接到管液体和腔室，所述通孔相对于彼此轴向和角度地移位，滑块（27）布置成用于在管道中的第一和第二位置之间滑动，凹部（29）形成在所述滑块，并且所述凹部经由所述至少一个第一通孔在所述滑块的所述第一位置中与所述液体源连通，并且所述腔经由所述至少一个第二通孔在所述滑块的第二位置中连通。施用器适合于向例如皮肤的皮肤施用准确和可重复剂量的容易流动的化妆品或医药制剂。一个人。

8. 发明申请

WO1995026205A1 LIPOSOMES 审中-公开
标题翻译：脂质体
公开(公告)号：WO1995026205A1
公开(公告)日：1995-10-05
申请号：PCT/GB1995000689
申请日：1995-03-27
申请人： HOLMES, Michael, John , NYCOMED IMAGING A/S , DAIICHI PHARMACEUTICAL CO., LTD. , KLAVENESS, Jo , BERG, Arne , JACOBSEN, Trond, Vegard , RONGVED, Pål , EGE, Thorfinn , KIKUCHI, Hiroshi , YACHI, Kiyoto
发明人： HOLMES, Michael, John , NYCOMED IMAGING A/S , DAIICHI PHARMACEUTICAL CO., LTD.
IPC分类号： A61K49/00
CPC分类号： A61K49/227 , A61K49/0466 , A61K49/1812
摘要： The invention provides a diagnostic composition for administration to human or animal subjects the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.
摘要翻译：本发明提供了一种用于向人或动物受试者施用包含多层脂质体的组合物，任选地与单层脂质体一起给药的诊断组合物，所述脂质体含有至少一种成像剂并悬浮在含有所述显像剂的水性介质中，其中所述脂质体包含中性磷脂和带电磷脂，脂质体的平均粒径为50-3000nm，填充脂质体内部的任何水相中显像剂的浓度基本上与脂质体的水性介质中的相同暂停。相关的造影剂通常是X射线，MRI或超声造影剂。

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