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1. 发明专利

CA61234A METHOD OF TANNING 未知
公开(公告)号：CA61234A
公开(公告)日：1898-09-23
申请号：CA61234D
申请日：1898-05-09
申请人： DIZER WALTER M , DIZER SILAS C , EASTON DOUGLAS M , DIZER MARSHALL C
发明人： EASTON DOUGLAS M

2. 发明申请

WO2009056862A2 PROSTATE CANCER SUSCEPTIBILITY SCREENING 审中-公开
标题翻译：前列腺癌可疑筛查
公开(公告)号：WO2009056862A2
公开(公告)日：2009-05-07
申请号：PCT/GB2008/003711
申请日：2008-10-31
申请人： CANCER RESEARCH TECHNOLOGY LTD , EELES, Rosalind , EASTON, Douglas , NEAL, David, Austin , GILES, Graham
发明人： EELES, Rosalind , EASTON, Douglas , NEAL, David, Austin , GILES, Graham
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136
摘要： A panel of prostate cancer susceptibility markers allows screening to identify individuals at high risk of developing prostate cancer. Such individuals can be offered closer clinical follow up and management to ensure timely diagnosis and intervention. A number of the single nucleotide polymorphisms (SNP's) have been found to be linked to sites/genes that are expected to play functional/causative roles in prostate cancer. The most highly associated SNP (rs 10993994) is 2bp upstream of the transcriptional start site of the MSMB gene. The MSMB gene encodes PSP94 which is an immunoglobulin binding factor that is produced by prostate epithelial cells and secreted into the seminal fluid. It has been reported that loss of PSP94 is associated with tumour recurrence in patients following prostatectomy. The second most significant association is for the SNP rs2735839 which is located between the kallikrein 2 and 3 genes. These genes have also been linked to prostate cancer and proposed as possible screening markers. Further SNPs are significantly associated with prostate cancer susceptibility if individuals.
摘要翻译：一组前列腺癌易感性标记物允许筛选鉴定发生前列腺癌的高风险患者。这些个人可以提供更加紧密的临床随访和管理，以确保及时诊断和干预。已经发现许多单核苷酸多态性（SNP）与预期在前列腺癌中发挥功能/致病作用的位点/基因相关联。最高度相关的SNP（rs 10993994）是MSMB基因转录起始位点上游的2bp。 MSMB基因编码PSP94，其是由前列腺上皮细胞产生并分泌到精液中的免疫球蛋白结合因子。据报道，前列腺切除术后患者的PSP94损失与肿瘤复发有关。第二个最重要的关联是位于激肽释放酶2和3基因之间的SNP rs2735839。这些基因也与前列腺癌相关，并提出可能的筛选标记。如果个体，进一步的SNP与前列腺癌易感性显着相关。

3. 发明申请

WO2009056862A3 PROSTATE CANCER SUSCEPTIBILITY SCREENING 审中-公开
标题翻译：前列腺癌敏感性筛查
公开(公告)号：WO2009056862A3
公开(公告)日：2009-07-23
申请号：PCT/GB2008003711
申请日：2008-10-31
申请人： CANCER REC TECH LTD , EELES ROSALIND , EASTON DOUGLAS , NEAL DAVID AUSTIN , GILES GRAHAM
发明人： EELES ROSALIND , EASTON DOUGLAS , NEAL DAVID AUSTIN , GILES GRAHAM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136
摘要： A panel of prostate cancer susceptibility markers allows screening to identify individuals at high risk of developing prostate cancer. Such individuals can be offered closer clinical follow up and management to ensure timely diagnosis and intervention. A number of the single nucleotide polymorphisms (SNP's) have been found to be linked to sites/genes that are expected to play functional/causative roles in prostate cancer. The most highly associated SNP (rs 10993994) is 2bp upstream of the transcriptional start site of the MSMB gene. The MSMB gene encodes PSP94 which is an immunoglobulin binding factor that is produced by prostate epithelial cells and secreted into the seminal fluid. It has been reported that loss of PSP94 is associated with tumour recurrence in patients following prostatectomy. The second most significant association is for the SNP rs2735839 which is located between the kallikrein 2 and 3 genes. These genes have also been linked to prostate cancer and proposed as possible screening markers. Further SNPs are significantly associated with prostate cancer susceptibility if individuals.
摘要翻译：一组前列腺癌易感性标记物允许筛选以鉴定处于发展前列腺癌的高风险中的个体。可以提供更密切的临床随访和管理，以确保及时诊断和干预。已经发现许多单核苷酸多态性（SNP）与预期在前列腺癌中发挥功能/致病作用的位点/基因有关。最高度相关的SNP（rs 10993994）位于MSMB基因转录起始位点上游2bp处。 MSMB基因编码PSP94，它是由前列腺上皮细胞产生并分泌到精液中的免疫球蛋白结合因子。据报道，PSP94的丢失与前列腺切除术后患者的肿瘤复发有关。第二个最重要的关联是位于激肽释放酶2和3基因之间的SNP rs2735839。这些基因也与前列腺癌有关，并被提议作为可能的筛查标记。进一步的SNP与前列腺癌易感性如果个体有显着相关性。

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