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1. 发明专利

AU6045896A Bioreactor for mammalian cell growth and maintenance 未知
公开(公告)号：AU6045896A
公开(公告)日：1996-12-30
申请号：AU6045896
申请日：1996-06-07
申请人： BERNHARD O PALSSON , DOUGLAS ARMSTRONG R , JAMES MALUTA
发明人： PALSSON BERNHARD O , ARMSTRONG R DOUGLAS , MALUTA JAMES
IPC分类号： C12M3/04 , C12M1/36 , C12M3/06
摘要： A bioreactor for the ex vivo maintenance and growth of mammalian cells includes a disposable, self contained cell cassette, a system manager, an incubator unit matable with a plurality of the cassettes and a processor unit. The cell cassette includes a substantially circular cell growth chamber defined between a substantially planar cell bed and a gas permeable, liquid impervious membrane. A media inlet enters the cell growth chamber communicates at a radially central portion of the cell bed. A plurality of media outlets are radially outwardly spaced from the media inlet by a distance sufficient for cell growth to occur between the inlet and the outlets. The outlets are substantially equiangularly circumferentially spaced about the cell growth chamber.

2. 发明专利

GB601212A Improvements relating to the separation of wax from crude wax fractions obtained from petroleum distillates 未知
$Improvements relating to the separation of wax from crude wax fractions obtained from petroleum distillates$
公开(公告)号：GB601212A
公开(公告)日：1948-04-30
申请号：GB354244
申请日：1944-06-25
申请人： STEEL BROTHERS & COMPANY LTD , ALBERT DOUGLAS ARMSTRONG , JAMES MITCHELL , ALEXANDER MUNRO FRASER , WILLIAM HANNAH CHALMERS
IPC分类号： C10G73/36
摘要： Wax is separated from crude wax fractions obtained from petroleum distillates by causing the crude wax fraction at a temperature at which it consists of a liquid fraction and a fraction in a semi-solid and flowable condition to flow continuously through a separating apparatus and separately discharging the liquid and semi-solid fractions from the apparatus. In Fig. 1, a liquid oil-wax mixture is fed from tank 10 by means of pump 11 past flowmeter 14 to a cooler 12, in which the mixture is cooled to a temperature at which it consists of a liquid fraction and a fraction in a semi-solid and flowable condition, about 5 DEG F. below the temperature at which wax first separates being suggested. Compressed air is introduced into the cooler through valve 25 above the liquid level 27 and scraper blades such as 16, rotating on a shaft 22, entrain air in the mixture. The mixture then passes through pipe 28 into the separating vessel 13, where the semi-solid fraction, rendered buoyant by the entrained air, rises to the open top and runs, with the assistance of travelling scoop 35, into receiver 34. The liquid fraction is drawn off through valve 32, perhaps after passage through a filter medium. Alternatively the compressed air may be dispensed with and the cooler 12 filled completely with liquid. In this case a separating vessel as shown in Fig. 3 is used, the semi-solid fraction falling by gravity to the outlet 42 and the liquid fraction being withdrawn through pipe 44. Either fraction obtained by the process may be re-circulated, while the semi-solid fraction may be cooled and sweated. Apparatus for carrying out this sweating step is shown, either combined with or distinct from the separating vessel already referred to.

3. 发明专利

GB303812A Improvements in the purification of the wax residues of petroleum and shale oil distillation and apparatus therefor 未知
公开(公告)号：GB303812A
公开(公告)日：1929-01-08
申请号：GB1818527
申请日：1927-07-08
申请人： DOUGLAS ARMSTRONG , GAVIN CHAPMAN GORDON DOBBIE
IPC分类号： C10G73/36
摘要： 303,812. Steel Bros. & Co., Ltd., (Armstrong, D., and Dobbie, G. C. G.). July 8, 1927. Sweating paraffin. - Sweating apparatus in which a cake of any thickness can be treated comprises a tank 1 provided with a multiplicity of horizontal pipes 12 arranged as a series of closely spaced vertical coils. The bottom of the tank is inclined to form drainage channels C which slope to valved outlet pipes. A false bottom is formed by metal frames covered by expanded metal and wire cloth 10. In operation, water is run in to the level of the cloth 10, and then the wax mixture until the tank is full. Water is passed through the pipes 12 until the wax is more or less solidified, the tank emptied of water, and the temperature of the room, preferably also that of the pipes 12, gradually raised. The sweated cake is melted out by passing steam through pipes 16 in the channels C.

4. 发明专利

GB605936A Improvements relating to the refining of crude wax obtained from mineral oil 未知
公开(公告)号：GB605936A
公开(公告)日：1948-08-04
申请号：GB375244
申请日：1944-02-29
申请人： STEEL BROTHERS & COMPANY LTD , ALBERT DOUGLAS ARMSTRONG , JAMES MITCHELL , ALEXANDER MUNRO FRASER , WILLIAM HANNAH CHALMERS
IPC分类号： C10G73/36
摘要： Crude mineral wax is refined by bringing it to a temperature which is below its melting-point and is such that the mass contains liquid constituents separable by drainage, separating the latter from the solidified material in the mass, and thereafter subjecting the solidified material to sweating by heating it in a drainage vessel while allowing liquefied constituents to drain from the vessel. The preliminary separation may be effected at a temperature, e.g. of 6 DEG F. below the melting-point of the crude wax, either by cooling the liquefied crude wax or by heating the solidified crude wax. This operation may be carried out in the drainage vessel or the material may be brought to the appropriate temperature outside the drainage vessel, the separation being effected therein, or as in the latter, but the separation being effected before the solidified material is charged into the drainage vessel. By any of these methods the drainage vessel may be fully charged before the sweating step. A suitable plant using the first method comprises a drainage and sweating tank 4, provided with temperature regulating pipes 5, a filter 8 and a downwardly inclined base 9, a supply tank 1 and a receiving tank 13 connected to the drainage tank by piping 3 and 21, and a refined wax collecting tank 14. The drainage tank may be housed in a temperature-controlled room. In operation, the filter 8 is first sealed by filling the space between it and the bottom 9 with water, and the tank 4 is then filled with the liquefied crude wax. Cooling fluid is passed through the pipes 5 and the air in the room brought to the same temperature; the filter is then unsealed and the mass allowed to filter, the liquid constituents being drained into the receiving tank 13. A fresh charge is admitted to the tank and the process repeated until the tank is filled with solid wax. The latter is then sweated by passing heating fluid through the pipes 5 and adjusting the air temperature correspondingly. The liquid constituents are also drained into the tank 13 and the refined wax finally melted out by admission of steam for collection in the collecting tank 14. In the second method external coolers are provided, the remainder of the plant and the method of working being as before. In the third method a preferred cooling apparatus comprises a trough of U-shaped cross-section provided with a longitudinally extending rotatable shaft carrying radially arranged blades and the liquefied crude wax is subjected to a churning movement therein. The separated solidified material is then introduced into the drainage vessel and subjected only to the sweating operation as described.

5. 外观设计

USD721619S1 Bicycle pedal cover 有权
公开(公告)号：USD721619S1
公开(公告)日：2015-01-27
申请号：US29470427
申请日：2013-10-21
申请人： Walter Douglas Armstrong
设计人： Walter Douglas Armstrong

6. 发明申请

US20050081206A1 Methods and apparatus for profiling threaded programs 审中-公开
标题翻译：用于剖析线程程序的方法和设备
公开(公告)号：US20050081206A1
公开(公告)日：2005-04-14
申请号：US10684662
申请日：2003-10-14
申请人： Douglas Armstrong , Anthony Nguyen , Paul Petersen , Sanjiv Shah
发明人： Douglas Armstrong , Anthony Nguyen , Paul Petersen , Sanjiv Shah
IPC分类号： G06F9/46
CPC分类号： G06F11/3612
摘要： A method and apparatus for profiling threaded programs is disclosed. The method may include monitoring information exchanged between a processing unit and first and second threads executed by the processing unit, determining a critical path of thread execution and determining a wait time during which the first thread awaits a synchronization event. The method may also include determining whether the wait time affects the critical path of thread execution and indicating that the wait time is of a high priority if the wait time affects the critical path of thread execution, and indicating that the wait time is of a low priority if the wait time does not affect the critical path of thread execution.
摘要翻译：公开了一种用于剖析线程程序的方法和装置。该方法可以包括监视由处理单元与处理单元执行的第一和第二线程之间交换的信息，确定线程执行的关键路径并确定第一线程等待同步事件的等待时间。该方法还可以包括确定等待时间是否影响线程执行的关键路径，并指示如果等待时间影响线程执行的关键路径并且指示等待时间低的等待时间是高优先级的优先级如果等待时间不影响线程执行的关键路径。

7. 发明授权

US6096532A Processor apparatus for use in a system for maintaining and growing biological cells 失效
标题翻译：用于维持和生长生物细胞的系统中的处理器装置
公开(公告)号：US6096532A
公开(公告)日：2000-08-01
申请号：US921847
申请日：1997-09-02
申请人： R. Douglas Armstrong , James Maluta , David W. Roecker
发明人： R. Douglas Armstrong , James Maluta , David W. Roecker
IPC分类号： C12M3/02
CPC分类号： C12M27/16 , C12M23/42 , C12M23/54 , C12M41/00 , C12M41/48
摘要： A processor apparatus is disclosed, for conditioning a portable cassette as part of a process in which biological cells contained within a sterilizable cell growth chamber of the cassette are maintained and grown ex vivo, without exposing the cells to the external environment. The processor apparatus includes a support configured to removably receive the portable cassette and to be movable in a controlled manner, and it further includes a flow control actuator engageable with a media flow path of the portable cassette, which communicates with the cell growth chamber. The processor apparatus further includes a controller that controls the flow control actuator and the support, such that a quantity of growth medium is selectively delivered to the cell growth chamber, such that the cassette is moved in a manner that properly distributes the biological cells throughout the chamber, and such that biological cells are harvested from the cell growth chamber, all without exposing the chamber and the media flow path to the external environment. The processor apparatus also may be configured to retrieve data from, and to store data to, an updatable memory device carried on the portable cassette.
摘要翻译：公开了一种处理器装置，用于调节便携式盒式磁带，作为其中包含在盒的可灭菌细胞生长室内的生物细胞离体维持和生长的过程的一部分，而不将细胞暴露于外部环境。所述处理器装置包括支撑件，其构造成可拆卸地容纳所述便携式盒并可受控地移动，并且还包括可与所述便携式盒的介质流动路径接合的流量控制致动器，所述介质流动路径与所述电池生长室连通。处理器装置还包括控制器，其控制流量控制致动器和支撑件，使得一定量的生长培养基被选择性地递送到细胞生长室，使得盒以适当地分布生物细胞的方式移动并且使得从细胞生长室收获生物细胞，所有这些都不会暴露室和介质流动路径到外部环境。处理器装置还可以被配置为从便携式盒带上携带的可更新存储装置检索数据并将数据存储到其中。

8. 发明授权

US5985653A Incubator apparatus for use in a system for maintaining and growing biological cells 失效
标题翻译：用于维持和生长生物细胞的系统中的孵化器装置
公开(公告)号：US5985653A
公开(公告)日：1999-11-16
申请号：US999593
申请日：1997-06-24
申请人： R. Douglas Armstrong , James Maluta , David W. Roecker
发明人： R. Douglas Armstrong , James Maluta , David W. Roecker
IPC分类号： C12M1/38 , C12M3/00 , C12M3/06 , C12C1/00
CPC分类号： C12M41/00 , C12M23/42 , C12M23/54
摘要： An incubator apparatus is disclosed, for conditioning a portable cassette such that biological cells contained within a cell growth chamber of the cassette are maintained and grown ex vivo, without exposing the cells to the external environment. The incubator apparatus includes first and second receptacles sized and configured to removably receive first and second casings, respectively, of the portable cassette, and it further includes first and second temperature regulators that regulate the temperatures of the respective first and second receptacles to prescribed values. In addition, the incubator apparatus includes a mechanical interface that is engaged by the portable cassette's first and second casings when they are received in their corresponding receptacles, and this mechanical interface controls the transport of growth media and a gas through the cassette's cell growth chamber, without exposing the cell growth chamber to the external environment. The incubator apparatus also is configured to retrieve data from, and to store data to, an updatable memory device carried on the cassette.
摘要翻译：公开了一种用于调节便携式盒的培养器装置，使得包含在盒的细胞生长室内的生物细胞在体外保持和生长，而不将细胞暴露于外部环境。培养箱装置包括第一和第二容器，其尺寸和构造分别可拆卸地容纳便携式盒子的第一和第二壳体，并且还包括将相应的第一和第二容器的温度调节到规定值的第一和第二温度调节器。此外，培养箱装置包括机械接口，当它们被容纳在其相应的容器中时，其被便携式盒的第一和第二壳体接合，并且该机械界面控制生长介质和气体通过盒的细胞生长室的传送，而不会将细胞生长室暴露于外部环境。培养箱装置还被配置为从盒上携带的可更新存储装置检索数据并将数据存储到其中。

9. 发明授权

US5312900A 23K protein with binding specificity for queuine 失效
标题翻译： 23K蛋白具有对奎宁的结合特异性
公开(公告)号：US5312900A
公开(公告)日：1994-05-17
申请号：US681889
申请日：1991-04-08
申请人： R. Douglas Armstrong
发明人： R. Douglas Armstrong
IPC分类号： A61K38/00 , C07K14/47 , C07K15/00 , C07K3/18
CPC分类号： C07K14/47 , A61K38/00 , Y10S530/851
摘要： The invention generally relates to the discovery of a 23 kD protein, designated herein as Queb, that has specific binding affinity for the purine base Queuine. The invention particularly relates to polypeptides having specific binding reactivity with Queuine and methods of using such polypeptides to purify Queuine and Queuine-containing substances. The invention also relates to antibodies having specific reactivity with Queuine or Queb. Methods for determining the presence and concentration of Queuine and Queb are also provided as well as methods for the diagnosis of a pathological disease or prognosis of a patient having a disease associated with Queuine, Queuine-containing substances such as Queuine-tRNA, or Queb. Kits useful for performing the methods of the present invention are also provided.
摘要翻译：本发明通常涉及对嘌呤碱基奎因具有特异性结合亲和力的23kD蛋白质（本文称为Queb）的发现。本发明特别涉及对Queuine具有特异性结合反应性的多肽以及使用这些多肽来净化Queuine和Queuine的物质的方法。本发明还涉及具有与Queuine或Queb具有特异反应性的抗体。还提供了用于确定Queuine和Queb的存在和浓度的方法，以及用于诊断具有与Queuine，Queuine-tRNA或Queb等含奎因的物质相关的疾病的患者的病理疾病或预后的方法。还提供了用于执行本发明的方法的试剂盒。

10. 发明授权

US4374644A Blood cell volume monitoring 失效
标题翻译：血细胞体积监测
公开(公告)号：US4374644A
公开(公告)日：1983-02-22
申请号：US251668
申请日：1981-04-06
申请人： Douglas Armstrong
发明人： Douglas Armstrong
IPC分类号： G01N13/04 , G01N33/487 , G01N27/04 , G01N33/50
CPC分类号： G01N13/04 , G01N33/49
摘要： By subjecting cells, such as red blood cells, to a hypotonic solution or a solution having a lytic agent, the cells will rapidly attain a change in volume and electrical resistance parameters, which change is measured as a function of time, for example, by a Coulter Counter.RTM. particle measuring instrument. The relationship between the change in the cell resistance or cell volume and the time of immersion in the volume changing solution provides a discriminator between a normality, different diseases, and certain inherited differences.
摘要翻译：通过将诸如红细胞的细胞经受低渗溶液或具有溶解剂的溶液，细胞将迅速达到体积和电阻参数的变化，该变化作为时间的函数被测量，例如通过 Coulter Counter TM粒子测量仪器。细胞电阻或细胞体积变化与体积变化溶液浸泡时间之间的关系提供了正常性，不同疾病和某些遗传差异之间的歧视。

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