会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 5. 发明申请
    • Taxol-like protein (TALP) and process for preparing the same
    • 紫杉醇样蛋白(TALP)及其制备方法
    • US20010034322A1
    • 2001-10-25
    • US09799409
    • 2001-03-05
    • Byung-Doo Hwang
    • Byung-Doo HwangKyu LimSang-Tae KwakGi-Ryang KweonWan-Hee Yoon
    • C12N009/99A61K038/57
    • C07K14/47A61K38/00Y02A50/473
    • The present invention relates to a novel taxol-like protein (nullTALPnull), a process for preparing the same, and use of the same as anticancer and antiviral agents. TALP is prepared by a process which comprises the steps of homogenizing mammalian tissue, obtaining supernatant after centrifugation, and fractionating the supernatant thus obtained by cation-exchange chromatography and hydroxyapatite chromatography. TALP of the invention promotes tubulin polymerization without GTP, like taxol, and the microtubules thus polymerized are resistant to disassembly caused by Ca2null and cold temperature under 4null C. and highly stabilized. Moreover, TALP of the invention inhibits cell proliferation, regeneration of scraped NIH 3T3 cell, proliferation and in vitro motility of HM7 human colon cancer cell, cell division of fertilized Xenopus oocyte, binding of tau protein to tubulin molecule, and E. coli lysis caused by virus.
    • 本发明涉及一种新型紫杉醇样蛋白(“TALP”),其制备方法,以及其与抗癌和抗病毒剂的用途。 通过包括以下步骤的方法制备TALP,所述方法包括均化哺乳动物组织,离心后获得上清液,并通过阳离子交换层析和羟基磷灰石层析分离上清液。 本发明的TALP促进不含GTP的微管蛋白聚合,如紫杉醇,由此聚合的微管耐受由Ca2 +引起的分解和4℃以下的低温,高度稳定。 此外,本发明的TALP抑制细胞增殖,刮伤的NIH 3T3细胞的再生,HM7人结肠癌细胞的增殖和体外运动,受精的非洲爪蟾卵母细胞的细胞分裂,tau蛋白与微管蛋白分子的结合以及引起的大肠杆菌裂解 病毒。
    • 8. 发明申请
    • Grit Chamber for Wastewater Treatment Plant, Capable of Preventing Sedimentation of Organic Material
    • 污水处理厂污泥室,能防止有机物沉淀
    • US20080041774A1
    • 2008-02-21
    • US11632393
    • 2005-07-21
    • Kyung ParkDoo Hwang
    • Kyung ParkDoo Hwang
    • B01D21/02
    • B01D21/0024B01D21/2444B01D21/2461B01D21/302B01D21/34
    • A grit chamber for a wastewater treatment plant. A vertical floodgate is installed on a partitioning wall and is driven in a vertical direction to be opened downwardly from a top toward a bottom. A floodgate driving motor is coupled to one end of the vertical floodgate to directly drive the vertical floodgate. An inflow amount measurement means functions to stepwisely measure a flow amount of wastewater which passes through a wastewater tank. A control section is connected to the floodgate driving motor and the inflow amount measurement means to control the floodgate driving motor in response to a measurement result of the inflow amount measurement means. A wastewater level is adjusted within a predetermined range through operation of the vertical floodgate to maintain a constant flow velocity of wastewater which passes through a sand sedimentation zone, thereby preventing organic material which is contained in the wastewater and is other than sand, from sedimenting.
    • 污水处理厂的砂砾室。 垂直闸门安装在分隔壁上,并沿垂直方向驱动,从顶部向底部向下打开。 水闸驱动电机连接到垂直闸门的一端,以直接驱动垂直闸门。 流入量测量装置用于逐步测量通过废水箱的废水的流量。 控制部连接到闸门驱动电动机和流入量测量装置,以根据流入量测量装置的测量结果控制闸门驱动电动机。 通过垂直闸门的操作将废水水平调整到预定范围内,以保持通过沙子沉淀区域的废水的恒定流速,从而防止废水中包含的除了沙子之外的有机物质沉淀。