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1. 发明授权

US4325483A Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus 失效
标题翻译：用于检测和控制静电颗粒分选装置的液滴形成流的流速的方法
公开(公告)号：US4325483A
公开(公告)日：1982-04-20
申请号：US68231
申请日：1979-08-20
申请人： Igino Lombardo , Donald E. Barry , W. Peter Hansen
发明人： Igino Lombardo , Donald E. Barry , W. Peter Hansen
IPC分类号： G01N15/14 , B07C5/342
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/149 , Y10S209/906
摘要： A novel method is disclosed for detecting and controlling the flow rate of a perturbed, droplet-forming stream in an electrostatic particle sorting apparatus. Detection apparatus is located at two points along the stream, at a first particle sensing point for sensing the presence of particles within a core portion of the stream, and at a second downstream point, preferably the stream breakpoint, for sensing light scatter and extinction characteristics which are proportional to the surface characteristics of the sheath portion of the stream. Changes in phase shift, pulse width, duty cycle, pulse area, or breakpoint location are detected by analyzing these sheath surface-related characteristics. An error signal is produced in response to such changes which drives an electromechanical fluid flow regulator to increase or decrease the fluid flow rate in a direction which tends to minimize the error signal. The flow rate is thus maintained at a reference flow rate setting.
摘要翻译：公开了一种用于检测和控制静电颗粒分选装置中扰动的液滴形成流的流速的新方法。检测装置位于沿着流的两个点处，在用于感测流的核心部分内的颗粒的存在的第一颗粒感测点处，以及在第二下游点，优选地，流断点处，用于感测光散射和消光特性其与流的护套部分的表面特性成比例。通过分析这些鞘表面相关特征来检测相移，脉冲宽度，占空比，脉冲区域或断点位置的变化。响应于这样的变化而产生误差信号，这些变化驱动机电流体流量调节器以使倾向于最小化误差信号的方向增加或减小流体流速。因此，流速保持在参考流量设置。

2. 发明授权

US4318483A Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system 失效
标题翻译：使用相对可移动的流表面感测系统的静电颗粒分选系统的自动相对液滴充电时间延迟系统
公开(公告)号：US4318483A
公开(公告)日：1982-03-09
申请号：US68259
申请日：1979-08-20
申请人： Igino Lombardo , Donald E. Barry
发明人： Igino Lombardo , Donald E. Barry
IPC分类号： G01N15/14 , B07C5/342
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/149 , Y10S209/906
摘要： A novel method and apparatus for automatically setting the time delay for relatively charging droplets in an electrostatic particle sorting system is disclosed. By utilizing a movable sheath sensing means for sensing the light scatter and extinction of this stream, the flow rate and distance to breakpoint are automatically measured and used to calculate and set the timing delay circuitry. This insures that droplet charging at the breakpoint will occur synchronously to produce selective relative charging of those droplets containing particles to be sorted.
摘要翻译：公开了一种用于在静电颗粒分选系统中自动设置相对充电液滴的时间延迟的新型方法和装置。通过利用用于感测该光的光散射和消光的可移动护套感测装置，自动测量流速和断点距离，并用于计算和设置定时延迟电路。这确保在断点处的液滴充电将同步发生，以产生包含待分选颗粒的那些液滴的选择性相对充电。

3. 发明授权

US4318481A Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter 失效
标题翻译：在静电流分选机中自动设定充电脉冲相位的方法
公开(公告)号：US4318481A
公开(公告)日：1982-03-09
申请号：US68234
申请日：1979-08-20
申请人： Igino Lombardo , Donald E. Barry
发明人： Igino Lombardo , Donald E. Barry
IPC分类号： G01N15/14 , B07C5/342
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/149 , Y10S209/906
摘要： In order to initiate the charging of droplets at a specific point in time with respect to the formation of those droplets in an electrostatic flow sorting system, the charge phase of the system of the present invention is continuously and automatically adjusted by droplet break point monitoring. The charge phase is therefore flow rate and fluid velocity independent. The break point is monitored by a light source which is focused onto the jet stream at the droplet formation break point, or close to it, and the modulation of light caused by the scatter induced by the sheath stream portion as it passes the focused beam of light is detected via the use of a suitable electro-optical detector. From the output of the electro-optical detector, after appropriate signal conditioning, an electrical wave form is obtained which shape depends upon the shape of the fluid column passing the focus beam. Using this conditioned detector output, the charge pulse phase is automatically controlled to occur at a set point in time with respect to a transition point on the waveform thus obtained. Additionally, in order to compensate for large flow rate variations, the focused beam detector can be automatically repositioned to track with the breakpoint. The correct phase of the charge pulse will accordingly continue to be derived from the breakpoint electrical waveform. Alternatively, by monitoring the jet stream at points above or below the breakpoint, the phase adjustment is possible, however, somewhat fluid velocity dependent.
摘要翻译：为了在静电流分选系统中相对于形成这些液滴的特定时间点开始液滴的充电，本发明的系统的充电阶段通过液滴断点监控连续自动调节。因此，充电阶段是流速和流体速度无关。断点由在源于液滴形成断裂点或靠近喷射流的聚焦到射流上的光源监测，并且由鞘流部分引起的散射引起的光的调制，当它穿过聚焦束通过使用合适的电光检测器检测光。从电光检测器的输出，在适当的信号调节之后，获得电波形式，其形状取决于通过聚焦光束的流体柱的形状。使用该调节的检测器输出，充电脉冲相位被自动控制在相对于如此获得的波形上的转变点的设定时间点发生。另外，为了补偿大的流量变化，聚焦光束检测器可以被自动重新定位以跟踪断点。因此，充电脉冲的正确相位将继续从断点电波形导出。或者，通过在断点上方或下方的点监测喷射流，相位调整是可能的，然而，稍微流体速度依赖。

4. 发明授权

US06605223B2 Blood component preparation (BCP) device and method of use thereof 失效
公开(公告)号：US06605223B2
公开(公告)日：2003-08-12
申请号：US10008605
申请日：2001-10-22
申请人： Glen Jorgensen , Donald E. Barry
发明人： Glen Jorgensen , Donald E. Barry
IPC分类号： B04B502
CPC分类号： B04B13/00 , A61M1/3633 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/12 , B01D17/0217 , B01D17/10 , B01D21/262 , B01D2221/10 , B04B5/0421 , B04B5/0428 , B04B9/14 , B04B2005/0478 , B04B2009/143
摘要： An automated blood separation method and apparatus is described that allows for the separation of multiple units of blood simultaneously. The method and apparatus reliably and quickly separates blood into its components. An auto-balancing feature within the apparatus automatically preferably compensates for the changing state of imbalance, thereby eliminating the need for additional balancing steps during the separation process. The apparatus has a rotor into which a plurality of cassettes can be inserted. The cassettes have a number of sections for the containment of the whole blood and for the separated blood components, which are contained in disposable bags. The rotor is placed into a centrifuge assembly, and the blood components are then separated and transferred to the bags in the individual sections of the cassettes. Means for including secondary separation devices such as filters is included. The manufacturing information regarding the lot identities used and the conditions under which each unit was processed is also included.

5. 发明授权

US4318482A Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system 失效
标题翻译：用于测量静电颗粒分选系统中扰动喷射流体的速度的方法
公开(公告)号：US4318482A
公开(公告)日：1982-03-09
申请号：US68235
申请日：1979-08-20
申请人： Donald E. Barry , Igino Lombardo
发明人： Donald E. Barry , Igino Lombardo
IPC分类号： G01N15/14 , B07C5/342
CPC分类号： G01N15/1404 , G01N2015/1406 , G01N2015/149 , Y10S209/906
摘要： A method for the measurement of fluid velocity and fluid flow rate is described which may be applied to a system in which fluid is caused to exit through an orifice to form a free jet. Optical as well as fluidic properties of the jetting fluids are used to determine the mean velocity of the jet between its point of exit from the orifice and at least a preselected detection point. From the mean velocity determination, the fluid flow rate may also be determined. A marker signal perturbation is applied to the jetting fluid at the orifice, and is detected downstream at a stream sensing point which is located a preselected distance from that orifice.
摘要翻译：描述了用于测量流体速度和流体流速的方法，其可以应用于其中使流体通过孔排出以形成自由射流的系统。喷射流体的光学以及流体特性用于确定射流在其从孔口的出口点与至少预选的检测点之间的平均速度。从平均速度确定可以确定流体流速。标记信号扰动被施加到孔口处的喷射流体，并且在距离该孔口预选距离的流感测点处向下游检测。

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