专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20140073778A9 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：包含羟基烷基淀粉和细胞毒素的方法及其制备方法
公开(公告)号：US20140073778A9
公开(公告)日：2014-03-13
申请号：US13809074
申请日：2011-07-11
申请人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken
发明人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken
IPC分类号： C08B31/10
CPC分类号： C08B31/10 , A61K47/61 , C08B31/12 , C08L3/08
摘要： The present invention relates to hydroxyalkyl starch conjugates, a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent and the cytotoxic agent comprising at least one tertiary hydroxyl group, wherein the hydroxyalkyl starch is linked via said tertiary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
摘要翻译：本发明涉及羟烷基淀粉共轭物，其制备方法，包含羟烷基淀粉衍生物和细胞毒性剂的羟烷基淀粉缀合物和包含至少一个叔羟基的细胞毒性剂，其中羟烷基淀粉通过所述第三级羟基对细胞毒性剂。根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，以及 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

2. 发明申请

US20130184454A1 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：包含羟基烷基淀粉和细胞毒素的方法及其制备方法
公开(公告)号：US20130184454A1
公开(公告)日：2013-07-18
申请号：US13809074
申请日：2011-07-11
申请人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken
发明人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken
IPC分类号： C08B31/10
CPC分类号： C08B31/10 , A61K47/61 , C08B31/12 , C08L3/08
摘要： The present invention relates to hydroxyalkyl starch conjugates, a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent and the cytotoxic agent comprising at least one tertiary hydroxyl group, wherein the hydroxyalkyl starch is linked via said tertiary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
摘要翻译：本发明涉及羟烷基淀粉共轭物，其制备方法，包含羟烷基淀粉衍生物和细胞毒性剂的羟烷基淀粉缀合物和包含至少一个叔羟基的细胞毒性剂，其中羟烷基淀粉通过所述第三级羟基对细胞毒性剂。根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，以及 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

3. 发明申请

US20130184237A1 NITRIC OXIDE DELIVERING HYDROXYALKYL STARCH DERIVATIVES 审中-公开
标题翻译：氮氧化物递送羟基烷基淀粉衍生物
公开(公告)号：US20130184237A1
公开(公告)日：2013-07-18
申请号：US13809199
申请日：2011-07-11
申请人： Martin Schimmel , Dominik Heckmann , Cornelius Jungheinrich
发明人： Martin Schimmel , Dominik Heckmann , Cornelius Jungheinrich
IPC分类号： C08B31/12 , A61K47/48
CPC分类号： C08B31/125 , A61K47/61 , C08L3/08
摘要： The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
摘要翻译：本发明涉及一氧化氮递送羟烷基淀粉衍生物，其制备方法以及这些羟烷基淀粉衍生物的具体用途。

4. 发明申请

US20140073779A9 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：包含羟基烷基淀粉和细胞毒素的方法及其制备方法
公开(公告)号：US20140073779A9
公开(公告)日：2014-03-13
申请号：US13809081
申请日：2011-07-11
申请人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken , Saswata Lahiri , Nitin Gupta , Sunil Sanghani , Azim Abul , Hemant Kumar Singh , Sandeep Grewal , Sandeep Kaur
发明人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken , Saswata Lahiri , Nitin Gupta , Sunil Sanghani , Azim Abul , Hemant Kumar Singh , Sandeep Grewal , Sandeep Kaur
IPC分类号： C08B31/10
CPC分类号： A61K47/4823 , A61K47/36 , A61K47/61 , C08B31/10
摘要： The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
摘要翻译：本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，所述细胞毒性剂包含至少一个仲羟基，其中所述羟烷基淀粉通过所述仲羟基对细胞毒性剂。根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

5. 发明申请

US20130184455A1 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：包含羟基烷基淀粉和细胞毒素的方法及其制备方法
公开(公告)号：US20130184455A1
公开(公告)日：2013-07-18
申请号：US13809081
申请日：2011-07-11
申请人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken , Saswata Lahiri , Nitin Gupta , Sunil Sanghani , Azim Abul , Hemant Kumar Singh , Sandeep Grewal , Sandeep Kaur
发明人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken , Saswata Lahiri , Nitin Gupta , Sunil Sanghani , Azim Abul , Hemant Kumar Singh , Sandeep Grewal , Sandeep Kaur
IPC分类号： C08B31/10
CPC分类号： A61K47/36 , A61K47/61 , C08B31/10
摘要： The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
摘要翻译：本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，所述细胞毒性剂包含至少一个仲羟基，其中所述羟烷基淀粉通过所述仲羟基对细胞毒性剂。根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

6. 发明申请

US20140088298A9 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：包含羟基烷基淀粉和细胞毒素的方法及其制备方法
公开(公告)号：US20140088298A9
公开(公告)日：2014-03-27
申请号：US13809194
申请日：2011-07-11
申请人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken , Saswata Lahiri , Nitin Gupta , Sunil Sanghani , Azim Abul , Hemant Kumar Singh , Sandeep Grewal , Sandeep Kaur
发明人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken , Saswata Lahiri , Nitin Gupta , Sunil Sanghani , Azim Abul , Hemant Kumar Singh , Sandeep Grewal , Sandeep Kaur
IPC分类号： A61K47/36
CPC分类号： A61K47/4823 , A61K47/36 , A61K47/61 , C08B31/10
摘要： The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
摘要翻译：本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟基 - 烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，细胞毒性剂包含至少一个仲羟基，其中羟烷基淀粉连接通过所述仲羟基与细胞毒性剂接触。根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

7. 发明申请

US20140073602A9 NITRIC OXIDE DELIVERING HYDROXYALKYL STARCH DERIVATIVES 审中-公开
标题翻译：氮氧化物递送羟基烷基淀粉衍生物
公开(公告)号：US20140073602A9
公开(公告)日：2014-03-13
申请号：US13809199
申请日：2011-07-11
申请人： Martin Schimmel , Dominik Heckmann , Cornelius Jungheinrich
发明人： Martin Schimmel , Dominik Heckmann , Cornelius Jungheinrich
IPC分类号： C08B31/12 , A61K47/48
CPC分类号： C08B31/125 , A61K47/61 , C08L3/08
摘要： The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
摘要翻译：本发明涉及一氧化氮递送羟烷基淀粉衍生物，其制备方法以及这些羟烷基淀粉衍生物的具体用途。

8. 发明申请

US20130217871A1 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：包含羟基烷基淀粉和细胞毒素的方法及其制备方法
公开(公告)号：US20130217871A1
公开(公告)日：2013-08-22
申请号：US13809203
申请日：2011-07-11
申请人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Saswata Lahiri , Nitin Gupta , Vivek Kumar , Mukesh Madan Mudgal
发明人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Saswata Lahiri , Nitin Gupta , Vivek Kumar , Mukesh Madan Mudgal
IPC分类号： C08B31/00
CPC分类号： C08B31/00 , A61K47/61
摘要： The present invention relates to hydroxyalkyl starch conjugates and a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one primary hydroxyl group, wherein the hydroxyalkyl starch is linked via said primary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold and a molar substitution (MS) in the range of from 0.6 to 1.5.
摘要翻译：本发明涉及羟基烷基淀粉共轭物及其制备方法，包含羟烷基淀粉衍生物和细胞毒性剂的羟烷基淀粉缀合物，细胞毒性剂包含至少一个伯羟基，其中羟烷基淀粉通过所述初级羟基对细胞毒性剂。根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，以及 n大于或等于1，其中羟烷基淀粉衍生物的平均分子量（MW）高于肾阈值，摩尔取代度（MS）在0.6至1.5的范围内。

9. 发明申请

US20130211060A1 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：包含羟基烷基淀粉和细胞毒素的方法及其制备方法
公开(公告)号：US20130211060A1
公开(公告)日：2013-08-15
申请号：US13809194
申请日：2011-07-11
申请人： Helmut Knoller , Dominik Heckmann , Frank Hacker , Norbert Zander , Frank Nocken , Saswata Lahiri , Nitin Gupta , Sunil Sanghani , Azim Abul , Hemant Kumar Singh , Sandeep Grewal , Sandeep Kaur
发明人： Helmut Knoller , Dominik Heckmann , Frank Hacker , Norbert Zander , Frank Nocken , Saswata Lahiri , Nitin Gupta , Sunil Sanghani , Azim Abul , Hemant Kumar Singh , Sandeep Grewal , Sandeep Kaur
IPC分类号： A61K47/36
CPC分类号： A61K47/36 , A61K47/61 , C08B31/10
摘要： The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
摘要翻译：本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟基 - 烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，细胞毒性剂包含至少一个仲羟基，其中羟烷基淀粉连接通过所述仲羟基与细胞毒性剂接触。根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

10. 发明申请

US20130178437A1 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：包含羟基烷基淀粉和细胞毒素的方法及其制备方法
公开(公告)号：US20130178437A1
公开(公告)日：2013-07-11
申请号：US13809069
申请日：2011-07-11
申请人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander
发明人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander
IPC分类号： C07H15/24
CPC分类号： C07H15/24 , A61K47/61
摘要： The present invention relates to hydroxyalkyl starch (HAS) conjugates and to a method for preparing the hydroxyalkyl starch (HAS) conjugates, the hydroxyalkyl starch (HAS) conjugates comprising a hydroxyalkyl starch derivative and a cytotoxic agent, said conjugate having a structure according the following formula HAS′(-M)n wherein M is a residue of a cytotoxic agent, the cytotoxic agent comprising a carbonyl group, HAS′ is a residue of the hydroxyalkyl starch derivative comprising at least one functional group X, n is greater than or equal to 1, and wherein the cytotoxic agent is linked via the carbonyl function present in the cytotoxic agent to the functional group X comprised in the hydroxyalkyl starch derivative, wherein the linkage via the carbonyl function is a cleavable linkage, which is capable of being cleaved in vivo so as to release the cytotoxic agent.
摘要翻译：本发明涉及羟烷基淀粉（HAS）缀合物和制备羟烷基淀粉（HAS）偶联物的方法，包含羟烷基淀粉衍生物和细胞毒性剂的羟烷基淀粉（HAS）缀合物，所述缀合物具有下列结构：式（M）n其中M是细胞毒性剂的残基，细胞毒性剂包含羰基，HAS'是包含至少一个官能团X的羟烷基淀粉衍生物的残基，n大于或等于至1，并且其中细胞毒性剂通过存在于细胞毒性剂中的羰基官能团连接到包含在羟烷基淀粉衍生物中的官能团X，其中通过羰基官能团的键可切割键，其能够被切割以释放细胞毒性剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式