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1. 发明申请

US20120176130A1 Detection of J-Coupling Using Atomic Magnetometer 有权
标题翻译：使用原子磁强计检测J耦合
公开(公告)号：US20120176130A1
公开(公告)日：2012-07-12
申请号：US13264376
申请日：2010-04-13
申请人： Micah P. Ledbetter , Charles W. Crawford , David E. Wemmer , Alexander Pines , Svenja Knappe , John Kitching , Dmitry Budker
发明人： Micah P. Ledbetter , Charles W. Crawford , David E. Wemmer , Alexander Pines , Svenja Knappe , John Kitching , Dmitry Budker
IPC分类号： G01R33/12
CPC分类号： G01N24/08 , G01N24/087 , G01R33/26 , G01R33/445 , G01R33/46 , G01R33/4608 , G01R33/5605
摘要： An embodiment of a method of detecting a J-coupling includes providing a polarized analyte adjacent to a vapor cell of an atomic magnetometer; and measuring one or more J-coupling parameters using the atomic magnetometer. According to an embodiment, measuring the one or more J-coupling parameters includes detecting a magnetic field created by the polarized analyte as the magnetic field evolves under a J-coupling interaction.
摘要翻译：检测J耦合的方法的实施例包括提供邻近原子磁力计的蒸汽池的极化分析物; 并使用原子磁力计测量一个或多个J耦合参数。根据实施例，测量一个或多个J耦合参数包括当J-耦合相互作用下磁场发生时检测由极化分析物产生的磁场。

2. 发明申请

US20120112749A1 APPARATUS AND METHOD FOR INCREASING SPIN RELAXATION TIMES FOR ALKALI ATOMS IN ALKALI VAPOR CELLS 审中-公开
标题翻译：用于增加阿尔卡利蒸气细胞中碱性物质的松弛松弛时间的装置和方法
公开(公告)号：US20120112749A1
公开(公告)日：2012-05-10
申请号：US13286930
申请日：2011-11-01
申请人： Dmitry Budker , Micah Ledbetter , Todor Karaulanov , Mikhail V. Balabas
发明人： Dmitry Budker , Micah Ledbetter , Todor Karaulanov , Mikhail V. Balabas
IPC分类号： G01R33/00
CPC分类号： G01R33/1284 , G01R33/26 , G01R33/282
摘要： An atomic vapor cell apparatus and method for obtaining spin polarized vapor of alkali atoms with relaxation times in excess of one minute is provided. The interior wall of the vapor cell is coated with an alkene-based material. The preferred coatings are alkenes ranging from C18 to C30 and C20-C24 are particularly preferred. These alkene coating materials, can support approximately 1,000,000 alkali-wall collisions before depolarizing an alkali atom, an improvement by roughly a factor of 100 over traditional alkane-based coatings. Further, the method involves a combination of one or more of the following: the use of a locking device to isolate the atoms in the volume of the vapor cell from the sidearm used as a reservoir for the alkali metal vapor source, careful management of magnetic-field gradients, and the use of the spin-exchange-relaxation-free (SERF) technique for suppressing spin-exchange relaxation.
摘要翻译：提供了一种用于获得超过一分钟的弛豫时间的碱性原子的旋转极化蒸气的原子蒸汽池装置和方法。蒸气室的内壁涂覆有基于烯烃的材料。优选的涂层是从C18到C30的烯烃，特别优选的是C20-C24。这些烯烃涂层材料可以在碱性原子去极化之前支持大约100万个碱壁碰撞，比传统的烷烃基涂料改善约100倍。此外，该方法涉及以下一个或多个的组合：使用锁定装置将蒸气室的体积中的原子与用作碱金属蒸气源的储存器的侧臂隔离，仔细管理磁性 - 场梯度，以及使用自旋交换松弛（SERF）技术来抑制自旋交换弛豫。

3. 发明申请

US20110025323A1 OPTICAL ATOMIC MAGNETOMETER 有权
标题翻译：光学原子磁光计
公开(公告)号：US20110025323A1
公开(公告)日：2011-02-03
申请号：US12675685
申请日：2008-09-04
申请人： Dmitry Budker , James Higbie , Eric P. Corsini
发明人： Dmitry Budker , James Higbie , Eric P. Corsini
IPC分类号： G01R33/26
CPC分类号： G01R33/26
摘要： An optical atomic magnetometers is provided operating on the principles of nonlinear magneto-optical rotation. An atomic vapor is optically pumped using linearly polarized modulated light. The vapor is then probed using a non-modulated linearly polarized light beam. The resulting modulation in polarization angle of the probe light is detected and used in a feedback loop to induce self-oscillation at the resonant frequency.
摘要翻译：提供了基于非线性磁光旋转原理的光学原子磁强计。使用线性偏振调制光将原子蒸汽光泵浦。然后使用非调制线性偏振光束探测蒸汽。在探测光的偏振角中产生的调制被检测并用于反馈回路以在谐振频率处引起自振荡。

4. 发明申请

US20100264917A1 DETECTION OF MAGNETIC RESONANCE SIGNALS USING A MAGNETORESISTIVE SENSOR 有权
标题翻译：使用磁传感器检测磁共振信号
公开(公告)号：US20100264917A1
公开(公告)日：2010-10-21
申请号：US12753306
申请日：2010-04-02
申请人： Dmitry Budker , Alexander Pines , Shoujun Xu , Christian Hilty , Micah P. Ledbetter , Louis S. Bouchard
发明人： Dmitry Budker , Alexander Pines , Shoujun Xu , Christian Hilty , Micah P. Ledbetter , Louis S. Bouchard
IPC分类号： G01R33/44 , G01R33/02
CPC分类号： G01R33/093 , B82Y25/00 , E03F3/046 , G01N24/08 , G01R33/302 , G01R33/307 , G01R33/323 , G01R33/36 , G01R33/44 , G01R33/50 , G01R33/5602 , G01R33/56375
摘要： A method and apparatus are described wherein a micro sample of a fluidic material may be assayed without sample contamination using NMR techniques, in combination with magnetoresistive sensors. The fluidic material to be assayed is first subject to pre-polarization, in one embodiment, by passage through a magnetic field. The magnetization of the fluidic material is then subject to an encoding process, in one embodiment an rf-induced inversion by passage through an adiabatic fast-passage module. Thereafter, the changes in magnetization are detected by a pair of solid-state magnetoresistive sensors arranged in gradiometer mode. Miniaturization is afforded by the close spacing of the various modules.
摘要翻译：描述了一种方法和装置，其中可以使用NMR技术结合磁阻传感器来测定流体材料的微样品而不使用样品污染。要测定的流体物质首先经过预极化，在一个实施方案中，通过磁场。然后流体材料的磁化受到编码过程，在一个实施方案中，通过通过绝热快速通道模块的rf诱导的反转。此后，通过以梯度计模式布置的一对固态磁阻传感器来检测磁化的变化。通过各种模块的紧密间隔提供小型化。

5. 发明授权

US08547095B2 Detection of magnetic resonance signals using a magnetoresistive sensor 有权
标题翻译：使用磁阻传感器检测磁共振信号
公开(公告)号：US08547095B2
公开(公告)日：2013-10-01
申请号：US12753306
申请日：2010-04-02
申请人： Dmitry Budker , Alexander Pines , Shoujun Xu , Christian Hilty , Micah P. Ledbetter , Louis S. Bouchard
发明人： Dmitry Budker , Alexander Pines , Shoujun Xu , Christian Hilty , Micah P. Ledbetter , Louis S. Bouchard
IPC分类号： G01V3/00
CPC分类号： G01R33/093 , B82Y25/00 , E03F3/046 , G01N24/08 , G01R33/302 , G01R33/307 , G01R33/323 , G01R33/36 , G01R33/44 , G01R33/50 , G01R33/5602 , G01R33/56375
摘要： A method and apparatus are described wherein a micro sample of a fluidic material may be assayed without sample contamination using NMR techniques, in combination with magnetoresistive sensors. The fluidic material to be assayed is first subject to pre-polarization, in one embodiment, by passage through a magnetic field. The magnetization of the fluidic material is then subject to an encoding process, in one embodiment an rf-induced inversion by passage through an adiabatic fast-passage module. Thereafter, the changes in magnetization are detected by a pair of solid-state magnetoresistive sensors arranged in gradiometer mode. Miniaturization is afforded by the close spacing of the various modules.
摘要翻译：描述了一种方法和装置，其中可以使用NMR技术结合磁阻传感器来测定流体材料的微样品而不使用样品污染。要测定的流体物质首先经过预极化，在一个实施方案中，通过磁场。流体材料的磁化然后进行编码过程，在一个实施方案中，通过通过绝热快速通道模块的rf诱导的反转。此后，通过以梯度计模式布置的一对固态磁阻传感器来检测磁化的变化。通过各种模块的紧密间隔提供小型化。

6. 发明授权

US08421455B1 Pulsed free induction decay nonlinear magneto-optical rotation apparatus 有权
标题翻译：脉冲自由感衰减非线性磁光旋转装置
公开(公告)号：US08421455B1
公开(公告)日：2013-04-16
申请号：US12567452
申请日：2009-09-25
申请人： David Christian Hovde , Dmitry Budker , James Higbie , Victor Acosta , Micah P. Ledbetter
发明人： David Christian Hovde , Dmitry Budker , James Higbie , Victor Acosta , Micah P. Ledbetter
IPC分类号： G01V3/00 , G01R33/02
CPC分类号： G01R33/26 , G01R33/0206 , G01R33/028
摘要： A magnetometer and concomitant magnetometry method comprising emitting light from a light source, via a pulse generator pulsing light from the light source, directing the pulsed light to an atomic chamber, employing a field sensor in the atomic chamber, and via a signal processing module receiving a signal from the field sensor.
摘要翻译：一种磁力计和伴随的磁力计方法，包括通过来自光源的脉冲发生器脉冲光发射来自光源的光，将脉冲光引导到原子室，在原子室中采用场传感器，以及经由信号处理模块接收来自场传感器的信号。

7. 发明申请

US20070205767A1 ATOMIC MAGNETIC GRADIOMETER FOR ROOM TEMPERATURE HIGH SENSITIVITY MAGNETIC FIELD DETECTION 有权
标题翻译：用于房间温度高灵敏度磁场检测的原子级磁阻计
公开(公告)号：US20070205767A1
公开(公告)日：2007-09-06
申请号：US11563537
申请日：2006-11-27
申请人： Shoujun Xu , Thomas Lowery , Dmitry Budker , Valeriy Yashchuk , David Wemmer , Alexander Pines
发明人： Shoujun Xu , Thomas Lowery , Dmitry Budker , Valeriy Yashchuk , David Wemmer , Alexander Pines
IPC分类号： G01V3/00
CPC分类号： G01R33/26
摘要： A laser-based atomic magnetometer (LBAM) apparatus measures magnetic fields, comprising: a plurality of polarization detector cells to detect magnetic fields; a laser source optically coupled to the polarization detector cells; and a signal detector that measures the laser source after being coupled to the polarization detector cells, which may be alkali cells. A single polarization cell may be used for nuclear magnetic resonance (NMR) by prepolarizing the nuclear spins of an analyte, encoding spectroscopic and/or spatial information, and detecting NMR signals from the analyte with a laser-based atomic magnetometer to form NMR spectra and/or magnetic resonance images (MRI). There is no need of a magnetic field or cryogenics in the detection step, as it is detected through the LBAM.
摘要翻译：基于激光的原子磁强计（LBAM）装置测量磁场，包括：多个检测磁场的偏振检测器单元; 光学耦合到所述偏振检测器单元的激光源; 以及信号检测器，其在耦合到可以是碱电池的偏振检测器单元之后测量激光源。通过对分析物的核自旋进行预极化，编码光谱和/或空间信息，并用基于激光的原子磁强计检测来自分析物的NMR信号，可以将单个极化单元用于核磁共振（NMR），以形成NMR光谱， /或磁共振图像（MRI）。在检测步骤中不需要磁场或低温，因为它通过LBAM检测。

8. 发明申请

US20090256561A1 INTEGRATED MICROCHIP INCORPORATING ATOMIC MAGNETOMETER AND MICROFLUIDIC CHANNEL FOR NMR AND MRI 有权
标题翻译：集成微型计算机核磁共振和核磁共振成像原理磁光计和微流通道
公开(公告)号：US20090256561A1
公开(公告)日：2009-10-15
申请号：US12367292
申请日：2009-02-06
申请人： Micah P. Ledbetter , Igor M. Savukov , Dmitry Budker , Vishal K. Shah , Svenja Knappe , John Kitching , David J. Michalak , Shoujun Xu , Alexander Pines
发明人： Micah P. Ledbetter , Igor M. Savukov , Dmitry Budker , Vishal K. Shah , Svenja Knappe , John Kitching , David J. Michalak , Shoujun Xu , Alexander Pines
IPC分类号： G01R33/26
CPC分类号： G01R33/26 , G01R33/282
摘要： An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.
摘要翻译：一体化的微流体装置包括碱蒸汽池和微流体通道，其可用于检测核磁共振（NMR）和磁共振成像（MRI）的磁性。可以通过光学偏振和探测小磁场中的自旋进动来测量蒸气室附近的小磁场。这可以用于检测相邻微流体通道中的编码分析物中的磁场。通过在微流体芯片（远程检测模式）上游应用适当的无线电或音频脉冲序列来调节微流体通道中的磁性，以产生检测NMR和MRI的敏感手段。

9. 发明授权

US10914800B2 Magnetic resonance spectrometer 有权
公开(公告)号：US10914800B2
公开(公告)日：2021-02-09
申请号：US15743527
申请日：2016-07-11
申请人： STC.UNM , Victor Acosta , Andrejs Jarmola , Lykourgos Bougas , Dmitry Budker
发明人： Victor Acosta , Andrejs Jarmola , Lykourgos Bougas , Dmitry Budker
IPC分类号： G01R33/32 , G01N24/08 , G01N24/10 , G01R33/30 , G01R33/44 , G01R33/46 , G01R33/60 , C30B33/08 , C30B29/04 , C30B33/12
摘要： Technologies relating to a magnetic resonance spectrometer are disclosed. The magnetic resonance spectrometer may include a doped nanostructured crystal. By nanostructuring the surface of the crystal, the sensor-sample contact area of the crystal can be increased. As a result of the increased sensor-sample contact area, the output fluorescence signal emitted from the crystal is also increased, with corresponding reductions in measurement acquisition time and requisite sample volumes.

10. 发明授权

US07994783B2 Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI 有权
标题翻译：集成微芯片结合原子磁强计和微流体通道用于NMR和MRI
公开(公告)号：US07994783B2
公开(公告)日：2011-08-09
申请号：US12367292
申请日：2009-02-06
申请人： Micah P. Ledbetter , Igor M. Savukov , Dmitry Budker , Vishal K. Shah , Svenja Knappe , John Kitching , David J. Michalak , Shoujun Xu , Alexander Pines
发明人： Micah P. Ledbetter , Igor M. Savukov , Dmitry Budker , Vishal K. Shah , Svenja Knappe , John Kitching , David J. Michalak , Shoujun Xu , Alexander Pines
IPC分类号： G01V3/00
CPC分类号： G01R33/26 , G01R33/282
摘要： An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.
摘要翻译：一体化的微流体装置包括碱蒸汽池和微流体通道，其可用于检测核磁共振（NMR）和磁共振成像（MRI）的磁性。可以通过光学偏振和探测小磁场中的自旋进动来测量蒸气室附近的小磁场。这可以用于检测相邻微流体通道中的编码分析物中的磁场。通过在微流体芯片（远程检测模式）上游应用适当的无线电或音频脉冲序列来调节微流体通道中的磁性，以产生检测NMR和MRI的敏感手段。

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