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1. 发明授权

US08916548B2 5-alkynyl-pyrimidines 有权
标题翻译： 5-炔基 - 嘧啶
公开(公告)号：US08916548B2
公开(公告)日：2014-12-23
申请号：US13055949
申请日：2009-07-28
申请人： Tobias Wunberg , Ralph Brueckner , Dirk Kessler , Oliver Kraemer , Darryl McConnell , Siegfried Schneider , Lars van der Veen
发明人： Tobias Wunberg , Ralph Brueckner , Dirk Kessler , Oliver Kraemer , Darryl McConnell , Siegfried Schneider , Lars van der Veen
IPC分类号： C07D239/48 , C07D401/04 , C07D403/06
CPC分类号： C07D401/06 , C07D239/48 , C07D401/04 , C07D403/06 , C07D403/14 , C07D409/06 , C07D413/14
摘要： The present invention encompasses compounds of general Formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中R 1至R 4如权利要求1所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，以及其用于制备具有上述药物的药物的用途，上述属性。

2. 发明授权

US08304556B2 Thiazolyl-dihydro-indazoles 有权
标题翻译：噻唑基 - 二氢 - 吲唑
公开(公告)号：US08304556B2
公开(公告)日：2012-11-06
申请号：US13347797
申请日：2012-01-11
申请人： Darryl McConnell , Maria Impagnatiello , Dirk Kessler , Oliver Kraemer , Siegfried Schneider , Lars Van Der Veen , Ulrike Weyer-Czernilofsky , Tobias Wunberg
发明人： Darryl McConnell , Maria Impagnatiello , Dirk Kessler , Oliver Kraemer , Siegfried Schneider , Lars Van Der Veen , Ulrike Weyer-Czernilofsky , Tobias Wunberg
IPC分类号： A61K31/429 , C07D513/04
CPC分类号： C07D513/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，以及其用于制备具有上述特征的药物的用途，上述属性。

3. 发明申请

US20120108567A1 Thiazolyl-Dihydro-Indazoles 有权
标题翻译：噻唑基 - 二氢 - 吲唑
公开(公告)号：US20120108567A1
公开(公告)日：2012-05-03
申请号：US13347797
申请日：2012-01-11
申请人： Darryl McCONNELL , Maria IMPAGNATIELLO , Dirk KESSLER , Oliver KRAEMER , Siegfried SCHNEIDER , Lars VAN DER VEEN , Ulrike WEYER-CZERNILOFSKY , Tobias WUNBERG
发明人： Darryl McCONNELL , Maria IMPAGNATIELLO , Dirk KESSLER , Oliver KRAEMER , Siegfried SCHNEIDER , Lars VAN DER VEEN , Ulrike WEYER-CZERNILOFSKY , Tobias WUNBERG
IPC分类号： A61K31/4439 , A61K31/5377 , A61P35/00 , A61K31/4709 , A61K31/496 , C07D513/04 , A61K31/4545
CPC分类号： C07D513/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，以及其用于制备具有上述特征的药物的用途，上述属性。

4. 发明授权

US08060596B1 Methods and systems for normalizing data loss prevention categorization information 有权
标题翻译：规范化数据丢失防范分类信息的方法和系统
公开(公告)号：US08060596B1
公开(公告)日：2011-11-15
申请号：US12415329
申请日：2009-03-31
申请人： Bruce Wootton , Richard Dandliker , Aleksey Tsibulya , Oskar Bruening , Dirk Kessler
发明人： Bruce Wootton , Richard Dandliker , Aleksey Tsibulya , Oskar Bruening , Dirk Kessler
IPC分类号： G06F15/173 , G06F15/16 , G06F17/00 , H04L9/32
CPC分类号： G06F21/6218
摘要： A computer-implemented method for normalizing data-loss-prevention categorization information, at least a portion of the method being performed by a computing system comprising at least one processor, may identify a data object at a first time. The method may apply a first version of a set of data-loss-prevention rules to the data object to determine a set of categorizations of the data object. The method may distinguish a set of content-based categorizations in the set of categorizations from a set of context-based categorizations in the set of categorizations. The method may apply, based on the set of categorizations, a first data-loss-prevention policy to the data object. The method may identify the data object at a second time, and apply, based on the set of content-based categorizations, a second data-loss-prevention policy to the data object. Various other methods, systems, and computer-readable media are also disclosed.
摘要翻译：一种用于对数据丢失防范分类信息进行归一化的计算机实现的方法，所述方法的至少一部分由包括至少一个处理器的计算系统执行，可以在第一时间识别数据对象。该方法可以将一组数据丢失预防规则的第一版本应用于数据对象以确定数据对象的一组分类。该方法可以将该组分类中的一组基于内容的分类与一组分类中的基于上下文的分类集合区分开。该方法可以基于该集合分类应用针对数据对象的第一数据丢失预防策略。该方法可以在第二时间识别数据对象，并且基于一组基于内容的分类将数据丢失预防策略应用于数据对象。还公开了各种其它方法，系统和计算机可读介质。

5. 发明申请

US20110212861A1 DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS 失效
标题翻译：指导性合成寡糖磷酸酯STEREOISOMERS
公开(公告)号：US20110212861A1
公开(公告)日：2011-09-01
申请号：US13099630
申请日：2011-05-03
申请人： Dieter Heindl , Dirk Kessler , Angelika Roesler , Christoph Seidel , Wilma Thuer
发明人： Dieter Heindl , Dirk Kessler , Angelika Roesler , Christoph Seidel , Wilma Thuer
IPC分类号： C40B40/04 , C07F9/24 , G01N33/68
CPC分类号： G01N33/5308 , C07F9/6552 , C07F9/65586 , Y02P20/55
摘要： The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner.
摘要翻译：使化合物的三价磷原子与试剂反应，形成稳定的磷酸酯模拟物或说明物。具有至少一个含有保护基团的羟基残基的磷原子的亚磷酰胺与该游离羟基反应：在第一个合成循环中，羟基通过可裂解或不可切割的方式与固体支持物连接接头。在进一步的合成循环中，通过从生长的低聚物中切割保护基而产生羟基。这导致形成与叠氮化物反应的亚磷酸三酯。通过选择具有定义的立体定构的合成合成单体，以立体控制的方式制备式1的化合物。

6. 发明授权

US07761118B1 Database programs for handheld devices 有权
标题翻译：手持设备的数据库程序
公开(公告)号：US07761118B1
公开(公告)日：2010-07-20
申请号：US11285859
申请日：2005-11-22
申请人： Dirk Kessler , Lee McIntyre
发明人： Dirk Kessler , Lee McIntyre
IPC分类号： H04M1/00
CPC分类号： G06F17/30569
摘要： Techniques for providing access to databases from handheld devices are disclosed. Techniques can be used to implement a database system. The database system provides a graphical user interface which can be displayed on handheld devices. This allows users of handheld devices to conveniently by interacting with the graphical user interface. As will be appreciated, the user can access the database to perform a variety of operations. Moreover, the user can perform these operations without having to write programs and virtually in real time. Thus, the user can conveniently access the database and be provided with up-to-date information. In addition, the user can be provided with hyperlinks which allow the user to conveniently perform various tasks without having to switch between different operation modes.
摘要翻译：公开了提供从手持设备访问数据库的技术。技术可以用于实现数据库系统。数据库系统提供可在手持设备上显示的图形用户界面。这允许手持设备的用户通过与图形用户界面交互来方便地进行。如将理解的，用户可以访问数据库以执行各种操作。此外，用户可以执行这些操作，而无需实时地编写程序。因此，用户可以方便地访问数据库并提供最新信息。此外，可以为用户提供允许用户方便地执行各种任务而不必在不同操作模式之间切换的超链接。

7. 发明授权

US07759470B2 Labeling reagent 有权
标题翻译：标记试剂
公开(公告)号：US07759470B2
公开(公告)日：2010-07-20
申请号：US11707399
申请日：2007-02-16
申请人： Dieter Heindl , Frank Bergmann , Hans-Peter Josel , Dirk Kessler , Gunter Lampert , Christian Weilke
发明人： Dieter Heindl , Frank Bergmann , Hans-Peter Josel , Dirk Kessler , Gunter Lampert , Christian Weilke
IPC分类号： C07G3/00 , C07H21/02 , C07H21/04 , C07H19/04 , C12Q1/68
CPC分类号： C07H19/23 , C07H19/04 , C07H21/00 , C07H21/04 , Y02P20/55
摘要： The current invention restates substituted indole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectable group or a linker and a reactive group for post synthesis coupling. These modified nucleosides grant access to a wide application area. These new substituted indole nucleosides can be used as labeling reagents for the facile preparation of e.g. optimized hybridization probes, Taqman-probes, or molecular beacon probes.
摘要翻译：本发明将取代的吲哚核苷作为两个末端以及用于核酸检测，分析和定量的标记的寡核苷酸探针的内部构建块重述。取代基包括接头和可检测的基团或接头以及用于后合成偶联的反应性基团。这些修饰的核苷允许进入广泛的应用领域。这些新的取代的吲哚核苷可以用作标记试剂，用于容易地制备例如优化的杂交探针，Taqman探针或分子信标探针。

8. 发明授权

US07741472B2 Polynucleotide containing a phosphate mimetic 有权
标题翻译：含有磷酸酯模拟物的多核苷酸
公开(公告)号：US07741472B2
公开(公告)日：2010-06-22
申请号：US12121842
申请日：2008-05-16
申请人： Dieter Heindl , Dirk Kessler
发明人： Dieter Heindl , Dirk Kessler
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , Y02P20/55
摘要： The present invention concerns modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P═N-Acc where Acc is an electron acceptor or an electron acceptor substituted with a residue R and R is any organic substituent.
摘要翻译：本发明涉及修饰的寡核苷酸及其制备方法，其中这些寡核苷酸至少含有一个结构P = N-Acc，其中Acc是电子受体或被残基R取代的电子受体，R是任何有机取代基。

9. 发明申请

US20100115614A1 DATA LOSS PROTECTION THROUGH APPLICATION DATA ACCESS CLASSIFICATION 有权
标题翻译：数据丢失保护通过应用数据访问分类
公开(公告)号：US20100115614A1
公开(公告)日：2010-05-06
申请号：US12263319
申请日：2008-10-31
申请人： Ian Barile , Bruce Wootton , Dirk Kessler , Rajesh Upadhyay
发明人： Ian Barile , Bruce Wootton , Dirk Kessler , Rajesh Upadhyay
IPC分类号： G06F21/24
CPC分类号： G06F21/552
摘要： A method and apparatus for classifying behavior of an application based on its data access pattern is described. In one embodiment, the method includes monitoring file access events associated with an application, and determining whether at least one of the file access events indicates the application's attempt to manipulate data of a file. If at least one file access event indicates the application's attempt to manipulate the data within the file, then at least one action is caused to be performed.
摘要翻译：描述了一种基于其数据访问模式来分类应用行为的方法和装置。在一个实施例中，该方法包括监视与应用相关联的文件访问事件，以及确定文件访问事件中的至少一个是否指示应用程序尝试操纵文件的数据。如果至少一个文件访问事件指示应用程序尝试操纵文件中的数据，则至少执行一个操作。

10. 发明申请

US20090005550A1 POLYNUCLEOTIDE CONTAINING A PHOSPHATE MIMETIC 有权
标题翻译：含有磷酸盐物质的多核苷酸
公开(公告)号：US20090005550A1
公开(公告)日：2009-01-01
申请号：US12121842
申请日：2008-05-16
申请人： Dieter Heindl , Dirk Kessler
发明人： Dieter Heindl , Dirk Kessler
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , Y02P20/55
摘要： The present invention concerns modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P═N-Acc where Acc is an electron acceptor or an electron acceptor substituted with a residue R and R is any organic substituent.
摘要翻译：本发明涉及经修饰的寡核苷酸及其生产方法，其中这些寡核苷酸至少含有一个结构P-N-Acc，其中Acc是电子受体或被残基R取代的电子受体，R是任何有机取代基。

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