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1. 发明申请

WO2014118782A2 METHODS AND SYSTEMS FOR REDUCING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT 审中-公开
标题翻译：用于减少受试者的一个机构的神经活动的方法和系统
公开(公告)号：WO2014118782A2
公开(公告)日：2014-08-07
申请号：PCT/IL2014/050109
申请日：2014-01-30
申请人： DIGMA MEDICAL LTD.
发明人： BEN-OREN, Ilan , HERSCHKOVITZ, Avia , WOLF, Tamir , YANIV, Irit
CPC分类号： A61B18/24 , A61B2018/00202 , A61B2018/00273 , A61B2018/00434 , A61B2018/00494 , A61B2018/00577 , A61B2018/00773 , A61B2018/00982 , A61B2018/20359 , A61B2018/2272
摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.
摘要翻译：根据一些实施方案，本公开提供了用于选择性地减少，阻断或抑制受试者器官中的至少一部分神经活性的方法和系统。在优选实施方案中，所述方法和系统用于选择性阻断需要其的受试者的十二指肠中的至少一部分神经活性。根据一些实施例，通过使用激光辐射发生选择性阻塞。根据一些实施例，选择性阻塞包括对位于目标区域内的感觉神经的至少部分造成损伤，同时保持围绕感觉神经的组织的功能活动。根据一些实施例，感觉神经包括被配置为传送由通过十二指肠的食物触发的信号的神经元，例如但不限于神经激素信号。

2. 发明申请

WO2018033910A1 APPARATUS AND METHOD FOR NERVE ABLATION IN THE WALL OF THE GASTOINTESTINAL TRACT 审中-公开
标题翻译：用于在胃肠道内壁神经消融的装置和方法
公开(公告)号：WO2018033910A1
公开(公告)日：2018-02-22
申请号：PCT/IL2017/050898
申请日：2017-08-14
申请人： DIGMA MEDICAL LTD.
发明人： SHAMAY, Yonatan , BEHAR, Boaz , BEN OREN, Ilan
IPC分类号： A61M25/10 , A61B18/28 , A61B18/22 , A61B18/18 , A61B18/24 , A61B6/00
摘要： Catheter for real-time evaluation of duodenal ablation, the catheter including an expandable member configured to stretch the duodenal wall and to generate a fixed distance between a center of the catheter and the duodenal wall; a laser transmitting element coupled with the catheter body and configured to transmit a first laser beam and a second laser beam; wherein the first laser beam is configured to cause ablative damage in a region of the duodenal wall as a result of its impingement thereon, and wherein the second laser beam is configured to detect modifications in the region of the duodenal wall resulting from the impingement of the first laser beam thereon.
摘要翻译：用于十二指肠消融的实时评估的导管，所述导管包括可扩张构件，所述可扩张构件被配置为拉伸十二指肠壁并且在所述导管的中心与所述十二指肠壁之间产生固定距离; 激光发射元件，其与所述导管主体耦合并且被配置为发射第一激光束和第二激光束; 其中所述第一激光束被配置为由于其冲击而在所述十二指肠壁的区域中引起烧蚀损伤，并且其中所述第二激光束被配置为检测由于所述第二激光束撞击所述十二指肠壁而引起的所述十二指肠壁区域中的改变第一个激光束在其上。

3. 发明授权

US09993297B2 Methods and systems for reducing neural activity in an organ of a subject 有权
公开(公告)号：US09993297B2
公开(公告)日：2018-06-12
申请号：US14763514
申请日：2014-01-30
申请人： DIGMA MEDICAL LTD.
发明人： Ilan Ben-Oren , Avia Herschkovitz , Tamir Wolf , Irit Yaniv
IPC分类号： A61B18/24 , A61B18/00 , A61B18/22 , A61B18/20
CPC分类号： A61B18/24 , A61B2018/00202 , A61B2018/00273 , A61B2018/00434 , A61B2018/00494 , A61B2018/00577 , A61B2018/00773 , A61B2018/00982 , A61B2018/20359 , A61B2018/2272
摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

4. 发明申请

US20220211437A1 METHODS AND SYSTEMS FOR REDUCING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT 有权
公开(公告)号：US20220211437A1
公开(公告)日：2022-07-07
申请号：US17703204
申请日：2022-03-24
申请人： DIGMA MEDICAL LTD.
发明人： Ilan BEN-OREN , Avia HERSCHKOVITZ , Tamir WOLF , Irit YANIV
IPC分类号： A61B18/24
摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

5. 发明申请

WO2015159296A1 METHODS AND SYSTEMS FOR BLOCKING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT, PREFERABLY IN THE SMALL INTESTINE OR THE DUODENUM 审中-公开
标题翻译：用于阻塞一个主体的机器中的神经活动的方法和系统，优选地在小型内部或者DUODENUM
公开(公告)号：WO2015159296A1
公开(公告)日：2015-10-22
申请号：PCT/IL2015/050410
申请日：2015-04-16
申请人： DIGMA MEDICAL LTD.
发明人： BEN OREN, Ilan , YANIV, Irit , WOLF, Tamir , HERSCHKOVITZ, Avia
IPC分类号： A61B18/18 , A61B6/00
CPC分类号： A61B18/22 , A61B1/012 , A61B5/0066 , A61B5/0086 , A61B5/015 , A61B5/026 , A61B5/055 , A61B5/1076 , A61B5/4255 , A61B6/00 , A61B8/085 , A61B8/12 , A61B8/445 , A61B18/02 , A61B18/26 , A61B2018/00029 , A61B2018/00273 , A61B2018/00285 , A61B2018/00434 , A61B2018/00494 , A61B2018/00577 , A61B2018/00589 , A61B2018/00601 , A61B2018/00702 , A61B2018/00714 , A61B2018/00744 , A61B2018/00779 , A61B2018/00785 , A61B2018/00809 , A61B2018/00904 , A61B2018/00982 , A61B2018/0212 , A61B2018/20359 , A61B2018/2261 , A61B2018/2266 , A61B2018/2277 , A61B2018/2283 , A61B2090/061 , A61B2090/3735 , A61B2090/378 , A61B2218/001 , A61B2505/05 , A61M25/10 , A61M2025/1013 , A61N5/0603 , A61N5/062 , A61N5/0625 , A61N7/00 , A61N2005/063 , A61N2005/0659 , A61N2007/003 , A61N2007/0043
摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.
摘要翻译：根据一些实施方案，本公开提供了用于选择性地减少，阻断或抑制受试者器官中的至少一部分神经活性的方法和系统。在优选实施方案中，所述方法和系统用于选择性阻断需要其的受试者的十二指肠中的至少一部分神经活性。根据一些实施例，通过使用激光辐射发生选择性阻塞。根据一些实施例，通过使用超声能量发生选择性阻塞。根据一些实施例，选择性阻塞包括对位于目标区域内的感觉神经的至少部分造成损伤，同时通过屏蔽激光辐射的作用来保持围绕感觉神经的组织的功能活动。根据一些实施例，感觉神经包括被配置为传送由通过十二指肠的食物触发的信号的神经元，例如但不限于神经激素信号。

6. 发明申请

WO2014118782A3 METHODS AND SYSTEMS FOR REDUCING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT 审中-公开
标题翻译：用于降低受试者的器官中的神经活动的方法和系统
公开(公告)号：WO2014118782A3
公开(公告)日：2014-10-02
申请号：PCT/IL2014050109
申请日：2014-01-30
申请人： DIGMA MEDICAL LTD
发明人： BEN-OREN ILAN , HERSCHKOVITZ AVIA , WOLF TAMIR , YANIV IRIT
IPC分类号： A61N1/18 , A61N5/067
CPC分类号： A61B18/24 , A61B2018/00202 , A61B2018/00273 , A61B2018/00434 , A61B2018/00494 , A61B2018/00577 , A61B2018/00773 , A61B2018/00982 , A61B2018/20359 , A61B2018/2272
摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.
摘要翻译：根据一些实施方案，本公开提供了用于选择性地减少，阻断或抑制受试者器官中的至少部分神经活性的方法和系统。在优选实施方案中，所述方法和系统用于选择性阻断有需要的受试者的十二指肠中的至少部分神经活性。根据一些实施例，选择性阻挡通过使用激光辐射而发生。根据一些实施例，选择性阻挡包括对位于目标区域内的至少一部分感觉神经造成损害，同时保持感觉神经周围组织的功能活性。根据一些实施例，感觉神经包括被配置成传送由食物通过十二指肠触发的信号的神经元，例如但不限于神经激素信号。

7. 发明公开

US20230301810A1 METHODS FOR SHORTENING A DUODENUM OF A SUBJECT 审中-公开
公开(公告)号：US20230301810A1
公开(公告)日：2023-09-28
申请号：US18124376
申请日：2023-03-21
申请人： Digma Medical Ltd.
发明人： Shlomit CHAPPEL-RAM , Avia HERSCHKOVITZ
IPC分类号： A61F5/00
CPC分类号： A61F5/0076
摘要： A method for shortening a duodenum of a subject, the method including: manipulating a first surface of the duodenum wall such that a first portion of the first surface of the duodenum wall is layered onto a second portion of the first surface of the duodenum wall, thereby creating at least one fold in the first surface of the duodenum wall, and securing, utilizing at least one implant, the position of the at least one fold in relation to a surrounding surface of the duodenum wall, thereby shortening the duodenum of the subject.

8. 发明申请

US20210361354A1 APPARATUS AND METHOD FOR NERVE ABLATION IN THE WALL OF THE GASTOINTESTINAL TRACT 有权
公开(公告)号：US20210361354A1
公开(公告)日：2021-11-25
申请号：US17393989
申请日：2021-08-04
申请人： DIGMA MEDICAL LTD.
发明人： Ilan BEN OREN
IPC分类号： A61B18/24 , A61B6/00 , A61B18/20 , A61B5/00 , A61B18/14
摘要： Catheter for real-time evaluation of duodenal ablation, the catheter including an expandable member configured to stretch the duodenal wall and to generate a fixed distance between a center of the catheter and the duodenal wall; a laser transmitting element coupled with the catheter body and configured to transmit a first laser beam and a second laser beam; wherein the first laser beam is configured to cause ablative damage in a region of the duodenal wall as a result of its impingement thereon, and wherein the second laser beam is configured to detect modifications in the region of the duodenal wall resulting from the impingement of the first laser beam thereon.

9. 发明授权

US10925671B2 Methods and systems for reducing neural activity in an organ of a subject 有权
公开(公告)号：US10925671B2
公开(公告)日：2021-02-23
申请号：US16136530
申请日：2018-09-20
申请人： DIGMA MEDICAL LTD.
发明人： Ilan Ben-Oren , Avia Herschkovitz , Tamir Wolf , Irit Yaniv
IPC分类号： A61B18/24 , A61N7/00 , A61B18/20 , A61B18/00 , A61B18/22
摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

10. 发明申请

US20170027645A1 METHODS AND SYSTEMS FOR BLOCKING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT, PREFERABLY IN THE SMALL INTESTINE OR THE DUODENUM 审中-公开
标题翻译：用于阻塞一个主体的机器中的神经活动的方法和系统，优选地在小型内部或者DUODENUM
公开(公告)号：US20170027645A1
公开(公告)日：2017-02-02
申请号：US15303080
申请日：2015-04-16
申请人： DIGMA MEDICAL LTD.
发明人： Ilan BEN OREN , Irit YANIV , Tamir WOLF , Avia HERSCHKOVITZ
IPC分类号： A61B18/22
摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.
摘要翻译：根据一些实施方案，本公开提供了用于选择性地减少，阻断或抑制受试者器官中的至少一部分神经活性的方法和系统。在优选实施方案中，所述方法和系统用于选择性阻断需要其的受试者的十二指肠中的至少一部分神经活性。根据一些实施例，通过使用激光辐射发生选择性阻塞。根据一些实施例，通过使用超声能量发生选择性阻塞。根据一些实施例，选择性阻塞包括对位于目标区域内的感觉神经的至少部分造成伤害，同时通过屏蔽激光辐射的作用来保持围绕感觉神经的组织的功能活动。根据一些实施例，感觉神经包括被配置为传送由通过十二指肠的食物触发的信号的神经元，例如但不限于神经激素信号。

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