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1. 发明申请

US20060052433A1 Compound 有权
标题翻译：复合
公开(公告)号：US20060052433A1
公开(公告)日：2006-03-09
申请号：US10489559
申请日：2002-08-30
申请人： Kristian Berg , Diem Thuy Tran , Pal Selbo
发明人： Kristian Berg , Diem Thuy Tran , Pal Selbo
IPC分类号： C07D487/22 , A61K31/409
CPC分类号： A61K41/008
摘要： The present invention provides photosensitizing agents obtained by reducing a single double bond in the porphyrin macrocycle of a sulphonated meso-tetraphenylporphyrin, preferably a disulphonated meso-tetraphenylporphyrin such as TPPS2a. The resulting sulphonated meso-tetraphenyl chlorins include compounds of formula (I) (wherein X is —SO3H; n, p, q and r are each independently 0 or 1; and the sum of n, p, q and r is an integer from 1 to 4, preferably at least 2, e.g. 2 or 4) isomers and isomer mixtures thereof. The compounds of the invention and their pharmaceutically acceptable salts find particular use as photosensitizing agents in the photochemical internalization of molecules and in photodynamic therapy.
摘要翻译：本发明提供通过还原磺化内消旋 - 四苯基卟啉，优选二磺酸内消旋 - 四苯基卟啉如TPPS 2a的卟啉大环中的单一双键获得的光敏剂。所得到的磺化内消旋 - 四苯基二氢卟酚包括式（I）化合物（其中X是-SO 3 H; n，p，q和r各自独立地为0或1;并且n， p，q和r是1至4的整数，优选至少2个，例如2或4个异构体及其异构体混合物。本发明的化合物及其药学上可接受的盐在分子的光化学内化和光动力学治疗中特别用作光敏剂

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