专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100254937A1 METHODS OF USING INTERLEUKIN-1 RECEPTOR ANTAGONIST AS A MYELOPROTECTIVE AGENT 有权
标题翻译：使用白介素-1受体拮抗剂作为助保护剂的方法
公开(公告)号：US20100254937A1
公开(公告)日：2010-10-07
申请号：US12740264
申请日：2007-11-14
申请人： Wei Han , Jing Zhang , Di Xiang , Shunying Zhu
发明人： Wei Han , Jing Zhang , Di Xiang , Shunying Zhu
IPC分类号： A61K38/17 , A61K33/24 , A61K38/18
CPC分类号： A61K45/06 , A61K31/255 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/675 , A61K31/704 , A61K33/24 , A61K38/193 , A61K38/20 , A61K2300/00
摘要： The present invention relates to uses of interleukin-1 receptor antagonist (IL-1Ra) in promoting bone marrow regeneration, increasing peripheral white blood cells, and increasing platelet levels in subjects if administered prior to treatment with chemotherapeutic agents. Thus, particular embodiments of the invention are directed to uses of IL-1Ra as an adjuvant or ancillary therapy to alleviate the hematopoietic toxicities associated with chemotherapy.
摘要翻译：本发明涉及白介素-1受体拮抗剂（IL-1Ra）在促进骨髓再生中的用途，增加外周白细胞，以及在用化学治疗剂治疗前给予受试者血小板水平增加。因此，本发明的具体实施方案涉及IL-1Ra用作佐剂或辅助治疗以减轻与化学疗法相关的造血毒性。

2. 发明授权

US09339528B2 Methods for treating epithelium trauma of the intestinal mucosa using interleukin-1 receptor antagonist 有权
标题翻译：使用白细胞介素-1受体拮抗剂治疗肠粘膜上皮创伤的方法
公开(公告)号：US09339528B2
公开(公告)日：2016-05-17
申请号：US13504114
申请日：2010-10-26
申请人： Wei Han , Di Xiang , Zhenqian Wu
发明人： Wei Han , Di Xiang , Zhenqian Wu
IPC分类号： A61K38/20 , A61K38/17 , C07K14/54
CPC分类号： A61K38/2006 , A61K38/1709 , C07K14/54
摘要： The invention provides a use of the interleukin-1 receptor antagonist protein for preparing a medicament for preventing or treating epithelium trauma of the intestinal mucosa, wherein the protein is selected from: (a) a protein having an amino acid sequence as shown in SEQ ID NO: 1; (b) a protein which has a sequence having at least 70% homology with the amino acid sequence in the (a) and has the effect of preventing or treating epithelium trauma of the intestinal mucosa. The invention also provides a pharmaceutical composition comprising the protein (a) or (b) as the active component.
摘要翻译：本发明提供白细胞介素-1受体拮抗剂蛋白质用于制备用于预防或治疗肠粘膜上皮创伤的药物的用途，其中所述蛋白质选自：（a）具有SEQ ID NO：1所示氨基酸序列的蛋白质 NO：1; （b）具有与（a）中的氨基酸序列具有至少70％同源性的序列的蛋白质，并具有预防或治疗肠粘膜上皮创伤的作用。本发明还提供了包含蛋白质（a）或（b）作为活性组分的药物组合物。

3. 发明申请

US20120322723A1 USE OF INTERLEUKIN-1 RECEPTOR ANTAGONIST FOR PREPARING MEDICAMENT FOR PREVENTING OR TREATING EPITHELIUM TRAUMA OF INTESTINAL MUCOSA 有权
标题翻译：使用INTERLEUKIN-1受体拮抗剂制备药物以预防或治疗肠胃粘膜上皮细胞
公开(公告)号：US20120322723A1
公开(公告)日：2012-12-20
申请号：US13504114
申请日：2010-10-26
申请人： Wei Han , Di Xiang , Zhenqian Wu
发明人： Wei Han , Di Xiang , Zhenqian Wu
IPC分类号： A61K38/19 , A61P1/12 , A61P3/00 , A61P1/00
CPC分类号： A61K38/2006 , A61K38/1709 , C07K14/54
摘要： The invention provides a use of the interleukin-1 receptor antagonist protein for preparing a medicament for preventing or treating epithelium trauma of the intestinal mucosa, wherein the protein is selected from: (a) a protein having an amino acid sequence as shown in SEQ ID NO: 1; (b) a protein which has a sequence having at least 70% homology with the amino acid sequence in the (a) and has the effect of preventing or treating epithelium trauma of the intestinal mucosa. The invention also provides a pharmaceutical composition comprising the protein (a) or (b) as the active component.
摘要翻译：本发明提供白细胞介素-1受体拮抗剂蛋白质用于制备用于预防或治疗肠粘膜上皮创伤的药物的用途，其中所述蛋白质选自：（a）具有SEQ ID NO：1所示氨基酸序列的蛋白质 NO：1; （b）具有与（a）中的氨基酸序列具有至少70％同源性的序列的蛋白质，并具有预防或治疗肠粘膜上皮创伤的作用。本发明还提供了包含蛋白质（a）或（b）作为活性组分的药物组合物。

4. 发明申请

US20110236305A1 METHODS FOR PROTECTING AND REGENERATING BONE MARROW USING CXCR3 AGONISTS AND ANTAGONISTS 审中-公开
标题翻译：使用CXCR3激动剂和拮抗剂保护和再生骨髓瘤的方法
公开(公告)号：US20110236305A1
公开(公告)日：2011-09-29
申请号：US13075824
申请日：2011-03-30
申请人： Wei Han , Huili Lu , Di Xiang
发明人： Wei Han , Huili Lu , Di Xiang
IPC分类号： A61K51/00 , A61K31/513 , A61K39/395 , A61K31/66 , A61K38/19 , A61P35/00
CPC分类号： A61K31/255 , A61K31/00 , A61K31/437 , A61K31/505 , A61K31/519 , A61K31/675 , A61K31/704 , A61K33/24 , A61K38/193 , A61K38/2006 , A61K38/2073 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： CXCR3 agonists, including natural CXCR3 ligands, promote bone marrow regeneration, increase peripheral white blood cells, and increase survival if administered prior to treatment of a subject with chemotherapy or radiotherapy. Similar effects are obtained by administering an CXCR3 antagonists following chemotherapy radiotherapy. Compositions and methods are presented for the treatment of cancer and bone marrow diseases.
摘要翻译： CXCR3激动剂，包括天然CXCR3配体，促进骨髓再生，增加外周白细胞，如果在化疗或放疗治疗受试者之前进行治疗，则可增加其存活率。通过在化疗放疗后施用CXCR3拮抗剂可获得类似的作用。提供了治疗癌症和骨髓疾病的组合物和方法。

5. 发明申请

US20100080756A1 METHODS FOR PROTECTING AND REGENERATING BONE MARROW USING CXCR3 AGONISTS AND ANTAGONISTS 有权
标题翻译：使用CXCR3激动剂和拮抗剂保护和再生骨髓瘤的方法
公开(公告)号：US20100080756A1
公开(公告)日：2010-04-01
申请号：US12565300
申请日：2009-09-23
申请人： Wei Han , Huili Lu , Di Xiang
发明人： Wei Han , Huili Lu , Di Xiang
IPC分类号： A61K38/20 , A61K51/00 , A61K33/24 , A61K38/19 , A61K31/704 , A61K31/675 , A61K31/519 , A61K31/505 , A61K31/437 , A61K31/255
CPC分类号： A61K31/255 , A61K31/00 , A61K31/437 , A61K31/505 , A61K31/519 , A61K31/675 , A61K31/704 , A61K33/24 , A61K38/193 , A61K38/2006 , A61K38/2073 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： CXCR3 agonists, including natural CXCR3 ligands, promote bone marrow regeneration, increase peripheral white blood cells, and increase survival if administered prior to treatment of a subject with chemotherapy or radiotherapy. Similar effects are obtained by administering an CXCR3 antagonists following chemotherapy radiotherapy. Compositions and methods are presented for the treatment of cancer and bone marrow diseases.
摘要翻译： CXCR3激动剂，包括天然CXCR3配体，促进骨髓再生，增加外周白细胞，如果在化疗或放疗治疗受试者之前进行治疗，则可增加其存活率。通过在化疗放疗后施用CXCR3拮抗剂可获得类似的作用。提供了治疗癌症和骨髓疾病的组合物和方法。

6. 发明授权

US08323635B2 Methods of using interleukin-1 receptor antagonist as a myeloprotective agent 有权
标题翻译：使用白细胞介素-1受体拮抗剂作为骨髓保护剂的方法
公开(公告)号：US08323635B2
公开(公告)日：2012-12-04
申请号：US12740264
申请日：2007-11-14
申请人： Wei Han , Jing Zhang , Di Xiang , Shunying Zhu
发明人： Wei Han , Jing Zhang , Di Xiang , Shunying Zhu
IPC分类号： A61K45/00 , A61K38/18 , A61K38/16 , C07K14/475
CPC分类号： A61K45/06 , A61K31/255 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/675 , A61K31/704 , A61K33/24 , A61K38/193 , A61K38/20 , A61K2300/00
摘要： The present invention relates to uses of interleukin-1 receptor antagonist (IL-1Ra) in promoting bone marrow regeneration, increasing peripheral white blood cells, and increasing platelet levels in subjects if administered prior to treatment with chemotherapeutic agents. Thus, particular embodiments of the invention are directed to uses of IL-1Ra as an adjuvant or ancillary therapy to alleviate the hematopoietic toxicities associated with chemotherapy.
摘要翻译：本发明涉及白介素-1受体拮抗剂（IL-1Ra）在促进骨髓再生中的用途，增加外周白细胞，以及在用化学治疗剂治疗前给予受试者血小板水平增加。因此，本发明的具体实施方案涉及IL-1Ra用作佐剂或辅助治疗以减轻与化学疗法相关的造血毒性。

7. 发明授权

US07943131B2 Methods for protecting and regenerating bone marrow using CXCR3 agonists and antagonists 有权
标题翻译：使用CXCR3激动剂和拮抗剂保护和再生骨髓的方法
公开(公告)号：US07943131B2
公开(公告)日：2011-05-17
申请号：US12565300
申请日：2009-09-23
申请人： Wei Han , Huili Lu , Di Xiang
发明人： Wei Han , Huili Lu , Di Xiang
IPC分类号： A61K39/395 , A61K38/44 , A61K38/17 , A61K38/19
CPC分类号： A61K31/255 , A61K31/00 , A61K31/437 , A61K31/505 , A61K31/519 , A61K31/675 , A61K31/704 , A61K33/24 , A61K38/193 , A61K38/2006 , A61K38/2073 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： CXCR3 agonists, including natural CXCR3 ligands, promote bone marrow regeneration, increase peripheral white blood cells, and increase survival if administered prior to treatment of a subject with chemotherapy or radiotherapy. Similar effects are obtained by administering an CXCR3 antagonists following chemotherapy radiotherapy. Compositions and methods are presented for the treatment of cancer and bone marrow diseases.
摘要翻译： CXCR3激动剂，包括天然CXCR3配体，促进骨髓再生，增加外周白细胞，如果在化疗或放疗治疗受试者之前进行治疗，则可增加其存活率。通过在化疗放疗后施用CXCR3拮抗剂可获得类似的作用。提供了治疗癌症和骨髓疾病的组合物和方法。

8. 发明授权

US4961988A General packing of expanded graphite 失效
标题翻译：膨胀石墨的一般包装
公开(公告)号：US4961988A
公开(公告)日：1990-10-09
申请号：US249981
申请日：1988-09-27
申请人： Di Xiang Zhu
发明人： Di Xiang Zhu
IPC分类号： F16J15/10 , F16J15/20
CPC分类号： F16J15/20 , F16J15/102 , Y10T428/30 , Y10T442/3699
摘要： This invention relates to a general packing of expanded graphite and the process for production thereof. The packing mainly includes vermiform laminae of expanded graphite and auxiliary materials, which is characterized by the embedment of the auxiliary materials into the vermiform graphite laminae, the bonding of the auxiliary materials to the vermiform graphite laminae with organic adhesives. The process for producing of the packing comprises the treatment of graphite with strong acid to produce interlaminar compound followed by transient expansion of treated graphite to become vermiform and the combination of vermiform graphite laminae with the auxiliary materials to produce packing. Wherein the above mentioned vermiform laminae of expanded graphite are bonded to the auxiliary materials with organic adhesives, and the auxiliary materials are embedded between the vermiform laminae of expanded graphite.
摘要翻译：本发明涉及膨胀石墨的一般包装及其生产方法。填料主要包括膨胀石墨和辅助材料的蠕虫层状，其特征在于将辅助材料嵌入蠕虫状石墨层，用有机粘合剂将辅助材料粘合到蠕石状石墨层。填料的生产方法包括用强酸处理石墨以产生层间化合物，随后经处理的石墨瞬时膨胀成蠕形，并将蠕虫状石墨层与辅助材料组合以产生填料。其中上述膨胀石墨的蠕虫状薄片用有机粘合剂粘合到辅助材料上，并且辅助材料嵌入在膨胀石墨的蠕变层之间。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式