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1. 发明授权

US09066918B2 Methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol 有权
标题翻译：提高次优选化学化合物治疗益处的方法，包括取代的己糖醇如二脱水半乳糖醇和二乙酰二钠半乳糖醇
公开(公告)号：US09066918B2
公开(公告)日：2015-06-30
申请号：US13817096
申请日：2011-08-17
申请人： Dennis M. Brown
发明人： Dennis M. Brown
IPC分类号： A61K31/045 , A61K31/336 , A61K31/44 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/7004 , A61K31/7024 , A61K45/06 , A61K31/047
CPC分类号： A61K31/336 , A61K31/045 , A61K31/047 , A61K31/44 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/7004 , A61K31/7024 , A61K45/06
摘要： The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol.
摘要翻译：本发明描述了通过改善作为单一疗法的功效或减少副作用而改善先前受次优治疗性能限制的治疗剂的治疗功效的方法和组合物。这些方法和组合物特别适用于取代的己醇如二脱水半乳糖醇和二乙酰基二缩水甘油二糖。

2. 发明申请

US20140094346A1 JAWLINE DEVICE 审中-公开
标题翻译： JAWLINE设备
公开(公告)号：US20140094346A1
公开(公告)日：2014-04-03
申请号：US13973581
申请日：2013-08-22
申请人： Ian S. BROWN , Dennis M. Brown
发明人： Ian S. BROWN , Dennis M. Brown
IPC分类号： A63B23/03
CPC分类号： A63B23/032 , A63B21/00043 , A63B21/028 , A63B71/0036 , A63B71/085
摘要： The present invention provides an effective way to strengthen the muscles of the jaw. In general, a device according to the present invention is a device constructed of plastic and resistance rubber to be inserted in the mouth to strengthen the muscles of the jaw to improve the shape of the jawline and increase the strength of the muscles of mastication; wherein the device is dimensioned for placement in the mouth such that a user can repeatedly bite down on the resistance rubber to strengthen the muscles of the jaw. The device can strengthen the temporomandibular joint to reduce the risk of head injury from trauma. The device can be provided with a case to hold and store the device.
摘要翻译：本发明提供了一种加强下颌肌肉的有效方法。通常，根据本发明的装置是由塑料和阻力橡胶构成的装置，其被插入口中以加强颌骨的肌肉以改善下巴的形状并增加咀嚼肌肉的强度; 其中所述装置的尺寸适于放置在口中，使得使用者可以重复地咬住阻力橡胶以加强颚的肌肉。该装置可加强颞下颌关节，减少头部受伤的风险。该设备可以设置有用于保存和存储设备的壳体。

3. 发明申请

US20110312034A1 Recombined Molecules and Preparation Thereof 审中-公开
标题翻译：重组分子及其制备方法
公开(公告)号：US20110312034A1
公开(公告)日：2011-12-22
申请号：US13039055
申请日：2011-03-02
申请人： Dennis M. Brown
发明人： Dennis M. Brown
IPC分类号： C12P19/44 , C12P17/04 , C12P17/18 , C12P19/02 , C12P17/16 , C12P17/10 , C12P19/26
CPC分类号： C07H17/08 , C07H21/04 , C07K1/047 , C07K1/1077 , C07K9/00 , C12P1/00 , C12P7/44 , C12P7/46 , C12P13/04 , C12P17/04 , C12P19/00
摘要： The invention relates to novel molecules and libraries thereof as well as methods for their production. Methods of producing the novel molecules include the cleaving of starting molecules into molecular subunits and the assembly of the subunits into novel recombined molecules.
摘要翻译：本发明涉及新型分子及其文库及其制备方法。生产新分子的方法包括将起始分子切割成分子亚基，并将亚单位组装成新的重组分子。

4. 发明申请

US20110008307A1 Cephalotaxine Alkaloid Compositions and Uses Thereof 审中-公开
标题翻译：头孢噻肟生物碱组合物及其用途
公开(公告)号：US20110008307A1
公开(公告)日：2011-01-13
申请号：US12761251
申请日：2010-04-15
申请人： Dennis M. BROWN
发明人： Dennis M. BROWN
IPC分类号： A61K38/43 , A61K31/55 , A61K31/7064 , A61K31/7076 , A61K38/00 , A61K33/24 , A61P35/00
CPC分类号： A61K45/06 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/55 , A61K31/70 , A61K31/7048 , A61K31/7076 , A61K33/24 , A61K2300/00
摘要： A method of treatment of a host with a cellular proliferative disease, comprising contacting the host with a cephalotaxine and an antiproliferative agent, each in an amount sufficient to modulate said cellular proliferative disease, is described. In some embodiments, the cephalotaxine comprises homoharringtonine (cephalotaxine, 4-methyl-2-hydroxy-2-(4-hydroxy-4-methyl pentyl)butanediocate ester). Antiproliferative agents of the invention comprise alkylating agents, intercalating agents, metal coordination complexes, pyrimidine nucleosides, purine nucleosides, inhibitors of nucleic acid associated enzymes and proteins, and agents affecting structural proteins and cytoplasmic enzymes.
摘要翻译：描述了一种治疗具有细胞增殖性疾病的宿主的方法，包括使宿主与足以调节所述细胞增殖性疾病的量的头孢噻肟和抗增殖剂接触。在一些实施方案中，头孢噻肟含有高粱素（头孢噻肟，4-甲基-2-羟基-2-（4-羟基-4-甲基戊基）丁二酸酯）。本发明的抗增殖剂包括烷化剂，嵌入剂，金属配位络合物，嘧啶核苷，嘌呤核苷，核酸相关酶和蛋白质的抑制剂以及影响结构蛋白和细胞质酶的试剂。

5. 发明申请

US20110003742A1 Naphthalimide Dosing by N-Acetyl Transferase Genotyping 审中-公开
公开(公告)号：US20110003742A1
公开(公告)日：2011-01-06
申请号：US12720515
申请日：2010-03-09
申请人： Dennis M. Brown
发明人： Dennis M. Brown
IPC分类号： A61K38/18 , A61K31/473 , A61P35/00 , C12Q1/68
CPC分类号： A61K31/435 , A61K31/473 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： The present invention provides methods for dosing patients with naphthalimides, including amonafide, amonafide salts, and analogs thereof based on N-acetyl transferase genotyping. The invention also provides methods for dosing the amount of granulocyte colony stimulating factor (GCSF) used in combination with naphthalimide to prevent or modulate leukocytopenia.

6. 发明授权

US5858030A Diesel fuel composition comprising dialkoxy alkanes for increased cetane number 失效
标题翻译：包含二烷氧基烷烃的柴油燃料组合物用于增加十六烷值
公开(公告)号：US5858030A
公开(公告)日：1999-01-12
申请号：US935430
申请日：1997-09-23
申请人： Francis J. Waller , Edward L. Weist, Jr. , Dennis M. Brown , Petrus J. A. Tijm
发明人： Francis J. Waller , Edward L. Weist, Jr. , Dennis M. Brown , Petrus J. A. Tijm
IPC分类号： C10L1/182 , C10L1/02 , C10L1/18 , C10L1/185 , C10L10/12
CPC分类号： C10L1/1852 , C10L1/026 , C10L1/18 , C10L1/1824
摘要： A diesel fuel composition is set forth for an increased cetane number vis-a-vis conventional diesel fuel compositions. The composition generally comprises one or more compounds selected from the dialkoxy alkane (DAAK) chemical family. In a preferred embodiment of the present invention, the diesel fuel composition consists of moderate amounts of dimethoxy propane (DMPP) and dimethoxy ethane (DMET) blended into a conventional diesel fuel.
摘要翻译：阐述柴油燃料组合物相对于常规柴油组合物的增加的十六烷值。组合物通常包含一种或多种选自二烷氧基烷烃（DAAK）化学族的化合物。在本发明的一个优选实施方案中，柴油燃料组合物由适量的二甲氧基丙烷（DMPP）和二甲氧基乙烷（DMET）组成。

7. 再颁专利

USRE35748E Treatments employing drug containing matrices for introduction into cellular lesion areas 失效
公开(公告)号：USRE35748E
公开(公告)日：1998-03-17
申请号：US574498
申请日：1995-12-19
申请人： Edward E. Luck , Dennis M. Brown
发明人： Edward E. Luck , Dennis M. Brown
IPC分类号： A61K47/42 , A61L26/00 , A61K9/00 , A61K9/22 , A61K9/26 , A61K31/28
CPC分类号： A61K47/42 , A61L26/0033 , A61L26/0066 , A61L2300/416 , A61L2300/45 , A61L2300/602
摘要： Treatment of cellular disorders involving abnormal solid cellular growths involves introduction of cytotoxic reagents dispersed in a physiologically acceptable proteinaceous matrix into the solid cellular growth or area of an existing or removed solid cellular growth. Enhanced effectiveness of the drug is observed, with reduced cytotoxic effects on cells distant from the site of introduction. Other drugs may be included to enhance therapeutic gain and reduce adverse affects to normal tissue.

8. 发明授权

US5597578A TGF-.beta. protein compositions for inhibition of cell proliferation 失效
标题翻译：用于抑制细胞增殖的TGF-β蛋白组合物
公开(公告)号：US5597578A
公开(公告)日：1997-01-28
申请号：US234509
申请日：1994-04-28
申请人： Dennis M. Brown , Edward Luck , Daniel R. Twardzik , Anthony F. Purchio
发明人： Dennis M. Brown , Edward Luck , Daniel R. Twardzik , Anthony F. Purchio
IPC分类号： A61K31/135 , A61K9/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61K47/42 , A61K47/48 , A61P35/00 , C07K14/00 , C07K14/435 , C07K14/495 , C07K14/52 , C07K17/04 , A61K9/10 , A61K38/39
CPC分类号： A61K9/0024 , A61K38/1841 , A61K47/42 , A61K47/48269
摘要： Antiproliferative compositions are provided which are capable of sustained release of an antiproliferative agent, particularly a TGF-.beta., at a site proximal to a target cell. The compositions are effective in inhibiting proliferation of the target cell, particularly when used in combination with a vasoconstrictive agent.
摘要翻译：提供抗增殖组合物，其能够在靶细胞附近的部位持续释放抗增殖剂，特别是TGF-β。所述组合物有效抑制靶细胞的增殖，特别是当与血管收缩剂组合使用时。

9. 发明授权

US5573781A Methods and compositions for the treatment of a host with a cellular proliferative disease 失效
标题翻译：用于治疗具有细胞增殖性疾病的宿主的方法和组合物
公开(公告)号：US5573781A
公开(公告)日：1996-11-12
申请号：US365664
申请日：1994-12-29
申请人： Dennis M. Brown , Richard E. Jones , Richard Maskiewicz , Shawnya K. Michaels
发明人： Dennis M. Brown , Richard E. Jones , Richard Maskiewicz , Shawnya K. Michaels
IPC分类号： A61K9/08 , A61K9/00 , A61K31/135 , A61K31/28 , A61K31/335 , A61K31/34 , A61K31/40 , A61K31/505 , A61K31/70 , A61K33/24 , A61K45/00 , A61K45/06 , A61K47/10 , A61K47/44 , A61P3/06 , A61P35/00 , A61P43/00 , A61K9/14 , A61K9/50 , A61K37/00
CPC分类号： A61K33/24 , A61K47/10 , A61K47/44 , A61K9/0019 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/943
摘要： Methods and compositions are provided for the treatment of a host with a cellular proliferative disease, particularly a neoplasia. In the subject methods, a pharmaceutically acceptable, substantially anhydrous, injectable semi-solid composition which acts as a depot for a cytostatic agent, is administered to a lesion of the disease, particularly intralesionally. The subject compositions comprise a water immiscible, fatty acid ester matrix and a cytostatic agent.
摘要翻译：提供了用于治疗具有细胞增殖性疾病，特别是瘤形成的宿主的方法和组合物。在本发明的方法中，将药用可接受的，基本上无水的可注射的半固体组合物作为细胞生长抑制剂的贮库施用于疾病的病变，特别是病灶内。主题组合物包含与水不混溶的脂肪酸酯基质和细胞生长抑制剂。

10. 发明授权

US09908259B2 Dual loop control of ceramic precursor extrusion batch 有权
公开(公告)号：US09908259B2
公开(公告)日：2018-03-06
申请号：US13126342
申请日：2009-10-30
申请人： Dennis M Brown , Maryam Khanbaghi , Robert John Locker , Wenbin Qiu , Kenneth Charles Sariego , Conor James Walsh
发明人： Dennis M Brown , Maryam Khanbaghi , Robert John Locker , Wenbin Qiu , Kenneth Charles Sariego , Conor James Walsh
IPC分类号： G05B19/02 , B28B3/20 , B28B3/26
CPC分类号： B28B3/201 , B28B3/269
摘要： A control strategy for producing high quality extrudates, including the steps of monitoring the temperature of a ceramic precursor batch by measuring the temperature of the batch material either directly or indirectly by measuring the temperature of a component of the extruder proximate to the die and transmitting the temperature data to an extrusion control system which comprises a master controller (106), at least one slave controller (110) and an optional supervisory controller. The supervisory controller determines batch temperature setpoint (102) in order to achieve the desired temperatures for extruding a certain type of batch material based on real time temperature inputs and stored parameters such as batch composition, process throughput, extruder cooling capacity, and the like. The master controller (106) receives batch temperature setpoint from the supervisory controller, and monitors batch temperature and in turn regulates at least one slave controller (110) which controls the flow of coolant (112) to portions of an extruder (114) in contact with the batch material.

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