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1. 发明专利

JP2012179388A Device, system and method to treat heart failure 有权
标题翻译：装置，系统和治疗心脏失败的方法
公开(公告)号：JP2012179388A
公开(公告)日：2012-09-20
申请号：JP2012115258
申请日：2012-05-21
申请人： Dc Devices Inc , ディーシーディヴァイシーズインコーポレイテッド
发明人： MCNAMARA EDWARD , CELERMAJER DAVID , FORCUCCI STEPHEN , SUGIMOTO HIROATSU
IPC分类号： A61F2/24 , A61F2/06 , A61M39/00
CPC分类号： A61F2/24 , A61B17/0057 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61F2/2493 , A61F2250/0029
摘要： PROBLEM TO BE SOLVED: To provide several unique intracardiac pressure vents, placement catheters, methods of placement and methods of treating heart failure.SOLUTION: The intracardiac pressure vents allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms but also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombus or other embolic material from entering the arterial circulation. Deployment of the interatrial pressure vent preferably occurs in a series of steps comprising first advancing the placement catheter through a septal opening, second deploying a first flange, third retracting the placement catheter to position the first flange against a septal wall, and fourth deploying a second flange on the other side of the septal wall from the first flange.
摘要翻译：要解决的问题：提供几种独特的心内压力通气口，放置导管，放置方法和治疗心力衰竭的方法。解决方案：心内压力通气口允许从左心房到右心房的足够的流量，以缓解左心房压升高和导致患者症状，但也限制从右心房向左心房的流量，以最小化血栓或其他栓塞物质进入动脉循环。室间压力通气孔的部署优选地在一系列步骤中进行，包括首先使置放导管穿过间隔开口，第二部署第一凸缘，第三部分缩回放置导管以将第一凸缘定位在隔壁上，以及第四部署第二凸缘法兰在第一法兰的隔壁另一侧。版权所有（C）2012，JPO＆INPIT

2. 发明申请

WO2014150106A1 DEVICES AND METHODS FOR RETRIEVABLE INTRA-ATRIAL IMPLANTS 审中-公开
标题翻译：用于可逆的内切植入物的装置和方法
公开(公告)号：WO2014150106A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/022240
申请日：2014-03-10
申请人： DC DEVICES, INC.
发明人： SUGIMOTO, Hiroatsu , FORCUCCI, Stephen, J. , MCNAMARA, Edward, I , FINCH, Matthew, J. , MAGNIN, Christopher
IPC分类号： A61F2/24
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61B2017/00867 , A61B2090/3966 , A61F2/2451 , A61F2/2493 , A61F2/856
摘要： Devices and methods to enhance the implantation, retreivability, or repositionability are provided. Embodiments of devices include pivotable sections providing the ability to maintain the device's engagement with a delivery system during implantation where the deliver system approaches an opening of the septum at an angle. Embodiments of devices also include configurations that allow for improved retrieval into a delivery system in the event that a malfunction or a problem with the patients physiology is detected.
摘要翻译：提供了增强植入，回溯性或重新定位性的装置和方法。装置的实施例包括可枢转部分，其提供在植入期间保持装置与输送系统的接合的能力，其中输送系统以一定角度接近隔膜的开口。设备的实施例还包括在检测到患者生理学的故障或问题的情况下允许改进对输送系统的检索的配置。

3. 发明申请

WO2012109557A2 APPARATUS AND METHODS TO CREATE AND MAINTAIN AN INTRA-ATRIAL PRESSURE RELIEF OPENING 审中-公开
标题翻译：装置和方法来创建和维持内部压力消除开启
公开(公告)号：WO2012109557A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024680
申请日：2012-02-10
申请人： DC DEVICES, INC. , CELERMAJER, David , MCNAMARA, Edward, I. , SUTHERLAND, Michael, W. , SUGIMOTO, Hiroatsu
发明人： CELERMAJER, David , MCNAMARA, Edward, I. , SUTHERLAND, Michael, W. , SUGIMOTO, Hiroatsu
IPC分类号： A61M29/02 , A61M25/088 , A61M25/10
CPC分类号： A61B17/0057 , A61B6/12 , A61B6/503 , A61B8/0841 , A61B8/0883 , A61B17/32 , A61B17/320016 , A61B17/32002 , A61B17/32053 , A61B17/3478 , A61B18/1492 , A61B18/24 , A61B2017/00247 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/22044 , A61B2017/320004 , A61B2017/320008 , A61B2017/320064 , A61B2017/3488 , A61B2018/0022 , A61B2018/00351 , A61B2018/00577 , A61B2018/046 , A61B2018/1467 , A61M25/0068 , A61M25/0662 , A61M25/1002 , A61M29/02 , A61M2025/0039 , A61M2025/0681 , A61M2025/09008 , A61M2025/105 , A61M2025/1086 , A61M2025/1088 , A61N7/022
摘要： The present disclosure relates to a method and a device for treating heart failure by normalizing elevated blood pressure in the left and right atria of a heart of a mammal. The present disclosure includes methods for creating and maintaining an opening in the atrial septum. Tools for making an opening and enlarging the opening are also disclosed. Use of the techniques and tools described herein prolongs the patency of an intra-atrial pressure relief opening.
摘要翻译：本公开内容涉及通过使哺乳动物心脏的左心房和右心房升高的血压正常化来治疗心力衰竭的方法和装置。本公开包括用于在房间隔中创建和维持开口的方法。还公开了用于打开和扩大开口的工具。使用本文所述的技术和工具延长了心房内压力释放开口的通畅。

4. 发明申请

WO2011093941A4 DEVICES AND SYSTEMS FOR TREATING HEART FAILURE 审中-公开
标题翻译：用于治疗心脏病的装置和系统
公开(公告)号：WO2011093941A4
公开(公告)日：2011-08-04
申请号：PCT/US2010/058110
申请日：2010-11-24
申请人： DC DEVICES, INC. , FINCH, Matthew, J. , McNAMARA, Edward , FORCUCCI, Stephen, J. , SUGIMOTO, Hiroatsu
发明人： FINCH, Matthew, J. , McNAMARA, Edward , FORCUCCI, Stephen, J. , SUGIMOTO, Hiroatsu
IPC分类号： A61M25/01 , A61B17/34 , A61F2/84 , A61F2/24 , A61L31/04
摘要： The present disclosure relates to devices and methods for implanting a prosthesis into a heart of a mammal, such as a person. The disclosure includes a prosthesis that acts as a pressure vent between the left and right atria of the heart. The disclosure also includes a mounting tool for mounting the prosthesis onto a loading tool, the loading tool useful for loading the prosthesis onto a device for delivering the prosthesis into the patient's heart. Control devices and methods for using these devices are also disclosed. The intracardiac pressure vents disclosed allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms. The devices also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombi or other embolic material from entering arterial circulation.
摘要翻译：本公开涉及用于将假体植入哺乳动物（例如人）的心脏中的装置和方法。本公开内容包括充当心脏左心房和右心房之间的压力通气孔的假体。本公开还包括用于将假体安装到加载工具上的安装工具，加载工具用于将假体装载到用于将假体输送到患者心脏中的装置上。还公开了使用这些设备的控制设备和方法。所公开的心内压力通风口允许从左心房到右心房的足够流量以缓解升高的左心房压力并导致患者症状。这些装置还限制从右心房流到左心房的流量，从而将血栓或其他栓塞材料进入动脉循环的可能性降至最低。

5. 发明申请

WO2013096965A1 METHODS AND DEVICES FOR INTRA-ATRIAL DEVICES HAVING SELECTABLE FLOW RATES 审中-公开
标题翻译：具有可选择流量速率的内部装置的方法和装置
公开(公告)号：WO2013096965A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/071588
申请日：2012-12-24
申请人： DC DEVICES, INC.
发明人： MCNAMARA, Edward , SUTHERLAND, Michael, W. , FINCH, Matthew, J. , FORCUCCI, Stephen, J. , MITZEL, John
IPC分类号： A61F2/06 , A61F2/02 , A61M29/00 , A61L27/58
CPC分类号： A61M27/002 , A61B2017/00247 , A61B2017/00575 , A61B2017/00584 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/2493
摘要： Devices and methods for treating heart disease by normalizing elevated blood pressure in the left and right atria of a heart of a mammal are disclosed. The devices are adapted to permit fluid flow across the membrane in which the device is implanted at first rate, and at a second rate, wherein a difference between the first rate and the second rate is not solely dependent upon variations in blood pressure differential across the membrane due to the heart's pumping cycle. Devices may include an adjustable hydraulic diameter and/or a removable and/or replaceable shunt portion. Devices may include absorbable materials, the absorption of which directly or indirectly causes alterations of the fluid flow capacities the devices.
摘要翻译：公开了通过使哺乳动物的心脏的左心房和右心房升高的血压正常化来治疗心脏病的装置和方法。这些装置适于允许流体以第一速率流过穿过装置的膜的流体，并且以第二速率流动，其中第一速率和第二速率之间的差异不仅仅取决于跨越的血压差的变化由于心脏的泵送周期，膜。设备可以包括可调节的液压直径和/或可拆卸和/或可更换的分路部分。设备可以包括可吸收材料，其吸收直接或间接地导致设备的流体流动能力的改变。

6. 发明申请

WO2012071075A1 DEVICES AND METHODS FOR CORONARY SINUS PRESSURE RELIEF 审中-公开
标题翻译：冠状动脉压力消除的装置和方法
公开(公告)号：WO2012071075A1
公开(公告)日：2012-05-31
申请号：PCT/US2011/041841
申请日：2011-06-24
申请人： DC DEVICES, INC. , MCNAMARA, Edward
发明人： MCNAMARA, Edward
IPC分类号： A61F2/82 , A61L27/04 , A61F2/24 , A61M25/10
CPC分类号： A61F2/82 , A61B17/0057 , A61B17/221 , A61B18/1492 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61B2017/22035 , A61B2017/2215 , A61B2018/00023 , A61B2018/00351 , A61B2018/144 , A61F2/2403 , A61F2/2412 , A61F2/2418 , A61F2/2493 , A61F2/91 , A61F2002/061 , A61F2002/821 , A61F2220/0008 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2230/0017 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0098 , A61L31/022 , A61M29/02
摘要： A method and devices for relieving pressure in the left atrium of a patient's heart is disclosed. The method includes using an ablative catheter in a minimally invasive procedure to prepare an opening from the coronary sinus into a left atrium of the patient's heart. Once the opening is prepared, the opening may be enlarged by a technique such as expanding a balloon within the opening. A stent is then placed within the coronary sinus of the patient, with a transverse portion expanding within the opening, allowing blood to flow from the left atrium to the coronary sinus and then to the right atrium. Pressure within the left atrium is thus relieved.
摘要翻译：公开了一种用于缓解患者心脏左心房压力的方法和装置。该方法包括在微创程序中使用消融导管以准备从冠状窦到患者心脏的左心房的开口。一旦准备了开口，可以通过诸如在开口内膨胀气球的技术来扩大开口。然后将支架放置在患者的冠状窦内，横向部分在开口内扩张，允许血液从左心房流动到冠状窦，然后到达右心房。因此左心房内的压力得到缓解。

7. 发明申请

WO2011094521A3 DEVICES AND METHODS FOR REDUCING VENOUS PRESSURE 审中-公开
标题翻译：用于降低呼吸压力的装置和方法
公开(公告)号：WO2011094521A3
公开(公告)日：2011-12-29
申请号：PCT/US2011022895
申请日：2011-01-28
申请人： DC DEVICES INC , CELERMAJER DAVID , SUTHERLAND MICHAEL J , MCNAMARA EDWARD
发明人： CELERMAJER DAVID , SUTHERLAND MICHAEL J , MCNAMARA EDWARD
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2250/0029 , A61F2250/0036
摘要： Devices and method are disclosed for reducing pressure in a patient's vena cava and in the right atrium of a patient's heart. A valve is implanted in the inferior vena cava (IFC) between the patient's renal veins and hepatic veins. When pressure in a patient's IFC reaches high levels, i.e., the pressure differential across the valve reaches high levels, the valve automatically closes or begins to close. The closing is caused by the pressure of the patient's blood moving one or more flaps in the valve to a closed or near-closed position. This prevents excessive pressure in the upper or superior vena cava and the right atrium of the patient's heart. The device also includes a pressure relief feature that opens and allows retrograde flow of blood if the pressure differential exceeds a yet higher pressure.
摘要翻译：公开了用于减轻患者的心脏腔内和右心房中的压力的装置和方法。瓣膜植入患者的肾静脉和肝静脉之间的下腔静脉（IFC）。当患者IFC中的压力达到高水平时，即跨过阀门的压差达到高水平时，阀门自动关闭或开始关闭。关闭是由于患者血液中的一个或多个瓣片移动到闭合或接近闭合位置的压力引起的。这可以防止患者心脏的上腔静脉和上腔静脉和右心房的压力过大。该装置还包括压力释放特征，如果压力差超过更高的压力，该压力释放特征将打开并允许血液逆行流动。

8. 发明申请

WO2011093941A2 DEVICES AND SYSTEMS FOR TREATING HEART FAILURE 审中-公开
标题翻译：用于治疗心脏衰竭的装置和系统
公开(公告)号：WO2011093941A2
公开(公告)日：2011-08-04
申请号：PCT/US2010058110
申请日：2010-11-24
申请人： DC DEVICES INC , FINCH MATTHEW J , MCNAMARA EDWARD , FORCUCCI STEPHEN J , SUGIMOTO HIROATSU
发明人： FINCH MATTHEW J , MCNAMARA EDWARD , FORCUCCI STEPHEN J , SUGIMOTO HIROATSU
IPC分类号： A61M25/01 , A61B17/34 , A61F2/24 , A61F2/84 , A61L31/04
CPC分类号： A61B17/0057 , A61B6/12 , A61B6/4423 , A61B8/0841 , A61B2017/00252 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00867 , A61B2560/063 , A61F2/2412 , Y10T29/49002 , Y10T29/49005 , Y10T29/53843 , Y10T29/53909 , Y10T29/53913
摘要： The present disclosure relates to devices and methods for implanting a prosthesis into a heart of a mammal, such as a person. The disclosure includes a prosthesis that acts as a pressure vent between the left and right atria of the heart. The disclosure also includes a mounting tool for mounting the prosthesis onto a loading tool, the loading tool useful for loading the prosthesis onto a device for delivering the prosthesis into the patient's heart. Control devices and methods for using these devices are also disclosed. The intracardiac pressure vents disclosed allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms. The devices also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombi or other embolic material from entering arterial circulation.
摘要翻译：本公开涉及用于将假体植入哺乳动物（例如人）的心脏中的装置和方法。该公开内容包括用作心脏左心房和右心房之间的压力通气口的假体。本公开还包括用于将假体安装到装载工具上的安装工具，所述装载工具可用于将假体装载到用于将假体递送到患者心脏的装置上。还公开了用于使用这些装置的控制装置和方法。所公开的心内压力通风口允许从左心房到右心房的足够的流动，以缓解升高的左心房压力和导致的患者症状。这些装置还限制从右心房到左心房的流量，以最小化血栓或其他栓塞物质进入动脉循环的可能性。

9. 发明申请

WO2010129089A4 DEVICES, SYSTEMS AND METHODS TO TREAT HEART FAILURE 审中-公开
标题翻译：装置，系统和治疗心脏衰竭的方法
公开(公告)号：WO2010129089A4
公开(公告)日：2011-03-10
申请号：PCT/US2010026574
申请日：2010-03-08
申请人： DC DEVICES INC , MCNAMARA EDWARD , CELERMAJER DAVID , FORCUCCI STEPHEN , SUGIMOTO HIROATSU
发明人： MCNAMARA EDWARD , CELERMAJER DAVID , FORCUCCI STEPHEN , SUGIMOTO HIROATSU
IPC分类号： A61F2/06
CPC分类号： A61F2/24 , A61B17/0057 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61F2/2493 , A61F2250/0029
摘要： Several unique intracardiac pressure vents, placement catheters, methods of placement and methods of treating heart failure are presented. The intracardiac pressure vents presented allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms but also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombus or other embolic material from entering the arterial circulation. Deployment of the interatrial pressure vent preferably occurs in a series of steps comprising first advancing the placement catheter through the septal opening, second deploying a first flange, third retracting the placement catheter to position the first flange against the septal wall, and fourth deploying a second flange on the other side of the septal wall from the first flange.
摘要翻译：提出了几种独特的心内压力通气口，放置导管，放置方法和治疗心力衰竭的方法。所提供的心内压力通风口允许从左心房到右心房的足够的流量以缓解升高的左心房压力并导致患者症状，但也限制从右心房到左心房的流量，以使血栓或其他栓塞的可能性最小化材料进入动脉循环。室间压力通气孔的部署优选在一系列步骤中进行，包括首先使置放导管穿过间隔开口，第二部署第一凸缘，第三部分缩回放置导管以将第一凸缘定位在隔壁上，以及第四部分第二部分法兰在第一法兰的隔壁另一侧。

10. 发明授权

US09649480B2 Devices and methods of treating or ameliorating diastolic heart failure through pulmonary valve intervention 有权
公开(公告)号：US09649480B2
公开(公告)日：2017-05-16
申请号：US13937177
申请日：2013-07-08
申请人： DC Devices, Inc.
发明人： Hiroatsu Sugimoto , Christopher J. Magnin
IPC分类号： A61M27/00 , A61F2/24 , A61F2/90 , A61F2/06
CPC分类号： A61M27/002 , A61F2/2436 , A61F2/2445 , A61F2/90 , A61F2002/068
摘要： The present teachings provide a device and methods of making and use thereof. Specifically, one aspect of the present teachings provides a device for restricting blood flow entering the lung after each right bean systole. Certain embodiments of the present teachings provide a device that prevents a complete closure of the pulmonary valve leaflets so that a certain amount of blood is allowed to flow from the pulmonary artery to the right ventricle at the end of a right ventricle systole. Other embodiments of the present teachings provide a device that restricts the amount of blood outflowing from the right ventricle to the pulmonary artery. In addition, the present teachings also provide a delivery system for implanting such a device approximately to or at the pulmonary valve.

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