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1. 发明申请

WO2012085017A3 DEDICATED CARTRIDGE 审中-公开
标题翻译：专用盒
公开(公告)号：WO2012085017A3
公开(公告)日：2012-12-20
申请号：PCT/EP2011073498
申请日：2011-12-21
申请人： SANOFI AVENTIS DEUTSCHLAND , SENIOR JAMES , DAVIES JAMES ALEXANDER
发明人： SENIOR JAMES , DAVIES JAMES ALEXANDER
IPC分类号： A61M5/24
CPC分类号： A61M5/31 , A61M5/24 , A61M5/347 , A61M2005/2411 , A61M2005/2414 , A61M2005/2437 , A61M2005/2444 , A61M2205/6045
摘要： A cartridge assembly for use with a drug delivery device is specified. The cartridge assembly comprises a cartridge (120, 200, 400, 600, 700, 800, 900)with a retention cap (210, 410, 610, 710, 810, 910)and a cartridge holder (104, 300, 500, 650, 750, 850, 950). According to one aspect,the cartridge (120, 200, 400, 600, 700, 800, 900) and the cartridge holder (104, 300, 500, 650, 750, 850, 950) may be configured to be fixed to each other in a predetermined position According to another aspect, the retention cap (210, 410, 610, 710, 810, 910) comprises at least one coding feature (214, 414, 612, 712, 912) configured to affix said cartridge (120, 200, 400, 600,700, 800, 900) to said cartridge holder (104, 300, 500, 650, 750, 850, 950) in the predetermined position by the mating of said coding feature (214, 414, 612, 712, 912) with a corresponding coding feature (310, 512, 660, 670, 762, 960) on the cartridge holder (104, 300, 500, 650, 750, 850, 950).
摘要翻译：规定了与药物输送装置一起使用的药筒组件。盒组件包括具有保持盖（210,410,610,710,810,910）和盒保持器（104,300,500,650,900）的盒（120,200,400,600,700,800,900），750,850,950）。根据一个方面，盒（120,200,400,600,700,800,900）和盒保持器（104,300,500,650,750,850,950）可以被配置为彼此固定根据另一方面，保持盖（210,410,610,710,810,910）包括至少一个编码特征（214,414,612,712,912），其被配置为将所述盒（120，通过所述编码特征（214,414,612,712,912）的配合将所述盒保持器（104,300,500,650,750,850,950）中的所述编码特征（200,400,600,700,800,900）放置在所述预定位置）具有在盒保持器（104,300,500,650,750,850,950）上的对应编码特征（310,512,660,670,762,960）。

2. 发明申请

WO2012146680A1 JOINING TECHNOLOGY OF A DISPENSE INTERFACE 审中-公开
标题翻译：混合接口的接合技术
公开(公告)号：WO2012146680A1
公开(公告)日：2012-11-01
申请号：PCT/EP2012/057696
申请日：2012-04-26
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , HOLTWICK, Marc , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel
发明人： HOLTWICK, Marc , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel
IPC分类号： A61M5/19 , A61M5/50 , A61M5/31
CPC分类号： B65D11/20 , A61M5/19 , A61M5/20 , A61M5/31546 , A61M5/344 , A61M5/345 , A61M5/50 , A61M2005/2407 , A61M2005/2474 , A61M2005/2496 , A61M2005/3128 , A61M2205/273
摘要： The present invention inter alia relates to an apparatus and a method. The apparatus comprises a body part and a cover part, wherein the body part and the cover part are configured to at least partially form a fluid channel between a surface of the body part and a surface of the cover part. The surfaces of the body part and the cover part may be facing surfaces. The method comprises manufacturing the apparatus according to the present invention.
摘要翻译：本发明尤其涉及一种装置和方法。该装置包括主体部分和盖部分，其中主体部分和盖部分构造成至少部分地在主体部分的表面和盖部分的表面之间形成流体通道。主体部分和盖部分的表面可以是面对的表面。该方法包括制造根据本发明的装置。

3. 发明申请

WO2012059458A1 MEDICATED MODULE FOR ADMINISTERING FIXED DOSE 审中-公开
标题翻译：用于管理固定剂量的药物模块
公开(公告)号：WO2012059458A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069107
申请日：2011-10-31
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , DAVIES, James, Alexander , MOORE, David
发明人： DAVIES, James, Alexander , MOORE, David
IPC分类号： A61M5/20 , A61M5/24 , A61M5/32
CPC分类号： A61M5/283 , A61M5/2033 , A61M5/2066 , A61M5/2425 , A61M5/2448 , A61M5/2466 , A61M5/31596 , A61M5/326 , A61M5/3294 , A61M2005/1787 , A61M2005/247 , A61M2005/31516 , A61M2005/3247 , A61M2005/3267
摘要： A medicated module (260) attachable to a drug delivery device. The medicated module comprises a housing configured for attachment to a drug delivery device. The drug delivery device comprises a first medicament. A movable reservoir (250) is contained within the housing. A pre-determined volume of a second medicament is contained within the reservoir. An injection needle (230) is configured within the housing and the needle arrangement is arranged in fluid communication with the movable reservoir. A spring (210) can drive a piston (270) of the movable reservoir (250) to dispense the drugs.
摘要翻译：可附接到药物输送装置的药物模块（260）。药物模块包括构造成附接到药物递送装置的壳体。药物递送装置包括第一药物。可动容器（250）容纳在壳体内。第二药物的预定体积被包含在储存器内。注射针（230）构造在壳体内，并且针装置布置成与可移动储存器流体连通。弹簧（210）可以驱动可移动储存器（250）的活塞（270）以分配药物。

4. 发明申请

WO2012059457A1 MEDICATED MODULE FOR ADMINISTERING FIXED DOSE 审中-公开
标题翻译：用于管理固定剂量的药物模块
公开(公告)号：WO2012059457A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069106
申请日：2011-10-31
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , DAVIES, James Alexander , DRAPER, Paul Richard , WIMPENNY, Steven
发明人： DAVIES, James Alexander , DRAPER, Paul Richard , WIMPENNY, Steven
IPC分类号： A61M5/20 , A61M5/24 , A61M5/32
CPC分类号： A61M5/283 , A61M5/2033 , A61M5/2066 , A61M5/2425 , A61M5/2448 , A61M5/2466 , A61M5/31596 , A61M5/326 , A61M5/3294 , A61M2005/1787 , A61M2005/247 , A61M2005/31516 , A61M2005/3247 , A61M2005/3267
摘要： A medicated module attachable to a drug delivery device. The medicated module comprises a housing (120) configured for attachment to a drug delivery device. The drug delivery device comprises a first medicament. A collapsible reservoir (124) is contained within the housing. A pre-determined volume of a second medicament is contained within the reservoir. A needle arrangement (166) is configured within the housing and the needle arrangement is arranged in fluid communication with the collapsible reservoir. A needle shroud (450) is configured, such that, during an injection step, the shroud acts on the reservoir to inject the second medicament.
摘要翻译：可附接到药物输送装置的药物模块。药物模块包括构造成附接到药物递送装置的壳体（120）。药物递送装置包括第一药物。可收缩的储存器（124）容纳在壳体内。第二药物的预定体积被包含在储存器内。针布置（166）构造在壳体内，并且针布置与可折叠储存器流体连通地布置。针罩（450）构造成使得在注射步骤期间，护罩作用在储存器上以注射第二药剂。

5. 发明申请

WO2012059455A1 MEDICATED MODULE HAVING A COLLAPSIBLE FEATURE 审中-公开
标题翻译：具有可折叠功能的药物模块
公开(公告)号：WO2012059455A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069102
申请日：2011-10-31
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , DAVIES, James Alexander , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel Thomas
发明人： DAVIES, James Alexander , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel Thomas
IPC分类号： A61M5/24 , A61M5/32
CPC分类号： A61M5/31596 , A61M5/2425 , A61M5/2429 , A61M5/2448 , A61M5/2466 , A61M5/3146 , A61M5/3294 , A61M5/347 , A61M5/50 , A61M5/5086 , A61M2005/1787 , A61M2005/3247
摘要： A system and method for priming a medicated module during attachment of the medicated module to a drug delivery device. The drug delivery device has a drug reservoir holding a first medicament. The medicated module includes an upper retention feature (208) and a lower retention feature (210), wherein the upper retention feature is axially moveable relative to the lower retention feature. The medicated module also includes an engagement needle (204) and an output needle (206), wherein the output needle is in fluid communication with the engagement needle. The module also includes a collapsible reservoir (212) holding a second medicament, wherein the reservoir feature is operably connected to the upper retention feature. During attachment to the drug delivery device, (i) the upper retention feature moves axially relative to the lower retention feature, (ii) the collapsible feature collapses, and (iii) the engagement needle and the output needle are primed with the second medicament.
摘要翻译：一种用于在将药物模块附接到药物递送装置的过程中灌注药物模块的系统和方法。药物递送装置具有容纳第一药物的药物储存器。所述药物模块包括上部保持部件（208）和下部保持部件（210），其中所述上部保持部件相对于所述下部保持部件可轴向移动。所述药物模块还包括接合针（204）和输出针（206），其中所述输出针与所述接合针流体连通。模块还包括容纳第二药剂的可收缩储存器（212），其中储存器特征可操作地连接到上保留特征。在连接到药物输送装置期间，（i）上部保持部件相对于下部保持部件轴向移动，（ii）可折叠特征塌陷，和（iii）接合针和输出针头被第二药剂引导。

6. 发明申请

WO2012059454A1 MEDICATED MODULE FOR A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于药物递送装置的药物模块
公开(公告)号：WO2012059454A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069101
申请日：2011-10-31
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , DAVIES, James Alexander , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel Thomas
发明人： DAVIES, James Alexander , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel Thomas
IPC分类号： A61M5/24 , A61M5/20 , A61M5/32
CPC分类号： A61M5/31596 , A61M5/2033 , A61M5/2425 , A61M5/2448 , A61M5/2459 , A61M5/2466 , A61M5/31525 , A61M5/31533 , A61M5/3294 , A61M5/3298 , A61M5/5086 , A61M2005/1787 , A61M2005/2462 , A61M2005/3128 , A61M2005/3247
摘要： A system for dispensing a non-user settable dose of one medicament and a user-settable dose of a primary medicament. The system includes a medicated module attachable to a drug delivery device, the drug delivery device having a drug reservoir holding a first medicament. The medicated module includes a first needle (206), a second needle (208), a collapsible feature (210) holding a second medicament, a biasing feature (214) operably connected to the collapsible feature, and a valve system (216) having a closed position and an open position. During dispense, the valve system transitions from the closed position to the open position, and the biasing feature compresses the collapsible feature to force the second medicament to flow from the collapsible feature to the second needle.
摘要翻译：一种用于分配非用户可设定剂量的一种药物和用户可设定剂量的初级药物的系统。该系统包括可附接到药物递送装置的药物模块，药物递送装置具有容纳第一药物的药物储存器。所述药物模块包括第一针（206），第二针（208），容纳第二药物的可收缩特征（210），可操作地连接到所述可收缩特征的偏压特征（214），以及阀系统（216）关闭位置和打开位置。在分配期间，阀系统从关闭位置转换到打开位置，并且偏压特征压缩可折叠特征以迫使第二药物从可收缩特征流动到第二针。

7. 发明申请

WO2011117284A1 MEDICATED MODULE WITH USER SELECTION 审中-公开
标题翻译：具有用户选择的药物模块
公开(公告)号：WO2011117284A1
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054422
申请日：2011-03-23
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , CROSS, John David , BOYD, Malcolm Stanley , YOUNG, Alasdair George , REKAYA, Naceur , DAVIES, James Alexander , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel Thomas , BILTON, Simon Lewis
发明人： CROSS, John David , BOYD, Malcolm Stanley , YOUNG, Alasdair George , REKAYA, Naceur , DAVIES, James Alexander , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel Thomas , BILTON, Simon Lewis
IPC分类号： A61M5/28 , A61M5/32 , A61M5/24
CPC分类号： A61M5/2448 , A61M5/2466 , A61M5/3146 , A61M5/31525 , A61M5/31533 , A61M5/326 , A61M5/3272 , A61M5/3294 , A61M5/347 , A61M2005/1787 , A61M2005/3247 , A61M2005/3267 , A61M2205/583
摘要： A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle (3). The medicated module (4) is user selectable so that it will deliver a priming dose of a primary medicament or both the primary and secondary medicaments. The module (4) also contains a needle guard (42) that locks after dose delivery. The needle guard (42) prevents accidental needle sticks before and after an injection. A locking collar (66) rotates during use as an inner protrusion (12) follows three paths (14, 15, 16) of a track (13) located on the outer surface of a body housing (10). When the inner facing protrusion (12) is in the third path (16), it encounters a hard stop and a rotational bias that locks the guard (42) from further retraction and thus covers the sharp distal end of the needle (3).
摘要翻译：公开了一种用于共同递送至少两种药物的注射系统的药物组件（4），其中包含主要药物的主要递送装置接受含有单剂量次级药物的药物组件（4），并且其中两种药物被递送通过空心针（3）。药物模块（4）是用户可选择的，使得其将递送初始剂量的初级药物或主要和次要药物两者。模块（4）还包含在剂量递送之后锁定的针护罩（42）。针罩（42）防止注射前后的意外针刺。锁定环（66）在使用期间作为内部突起（12）沿着位于主体外壳（10）的外表面上的轨道（13）的三个路径（14,15,16）进行旋转。当内面突起（12）处于第三路径（16）中时，遇到硬停止和旋转偏压，其将防护件（42）锁定进一步缩回，从而覆盖针（3）的尖锐远端。

8. 发明申请

WO2011095486A1 MEDICATED MODULE WITH LOCKABLE NEEDLE GUARD 审中-公开
标题翻译：具有可锁定针头保护的药物模块
公开(公告)号：WO2011095486A1
公开(公告)日：2011-08-11
申请号：PCT/EP2011/051405
申请日：2011-02-01
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BOYD, Malcolm, Stanley , DAVIES, James, Alexander , DE SAUSMAREZ LINTELL, Daniel, Thomas
发明人： BOYD, Malcolm, Stanley , DAVIES, James, Alexander , DE SAUSMAREZ LINTELL, Daniel, Thomas
IPC分类号： A61M5/28 , A61M5/32 , A61M5/24
CPC分类号： A61M5/284 , A61M5/2448 , A61M5/2466 , A61M5/288 , A61M5/3146 , A61M5/31525 , A61M5/3155 , A61M5/326 , A61M5/3294 , A61M5/347 , A61M2005/1787 , A61M2005/3132 , A61M2005/3247 , A61M2005/3267 , A61M2205/583
摘要： A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device (7) containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament and where both medicaments are delivered through a single hollow needle (3). The medicated module (4) is configured so that it will first deliver both the primary and secondary medicaments and then, if needed, a dose(s) of additional primary medicament. The module (4) also contains a needle guard (22) that locks the first dose delivery, but can be manually overridden by a user to perform a second or subsequent injection of primary medicament.
摘要翻译：公开了一种用于共同递送至少两种药物的注射系统的药物模块（4），其中包含主要药物的主要递送装置（7）接受含有单剂量次级药物的药物模块（4）药物通过单个空心针（3）递送。药物组合体（4）被配置成首先递送主要和次要药物，然后如果需要，递送另外的初级药物的剂量。模块（4）还包含锁定第一剂量递送的针护罩（22），但是可以由用户手动覆盖以执行第二次或随后的初级药物的注射。

9. 发明申请

WO2011095478A1 FLEXIBLE RESERVOIR FOR A MEDICATED MODULE 审中-公开
标题翻译：用于药物模块的柔性贮存器
公开(公告)号：WO2011095478A1
公开(公告)日：2011-08-11
申请号：PCT/EP2011/051393
申请日：2011-02-01
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , BOYD, Malcolm Stanley , DAVIES, James Alexander , WALLACE, Andrew Gordon , SANDERS, David
发明人： BOYD, Malcolm Stanley , DAVIES, James Alexander , WALLACE, Andrew Gordon , SANDERS, David
IPC分类号： A61M5/28 , A61M5/32 , A61M5/24
CPC分类号： A61M5/284 , A61M5/2425 , A61M5/2448 , A61M5/282 , A61M5/3146 , A61M5/31525 , A61M5/3155 , A61M5/326 , A61M5/3294 , A61M5/3297 , A61M5/347 , A61M2005/1787 , A61M2005/3267
摘要： A reservoir (31) with at least one flexible section for use in a medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device (7) containing a first medicament accepts a medicated module (4) containing a single dose of a second medicament (2) and where both medicaments are delivered through a single hollow needle (3). The reservoir (31 ) comprises one or more slit valves (44, 45) to allow for delivery of the first and second medicaments. The medicated module (4) also contains a needle guard (22) that engages a housing (43) of the reservoir (31 ) to open the slit valves (44, 45).
摘要翻译：公开了一种具有至少一个柔性部分的储存器（31），用于在用于注射系统的药物模块（4）中共同递送至少两种药物的柔性部分，其中包含第一药物的主要输送装置（7）接受药物模块（4），其含有单剂量的第二药物（2），并且其中两种药物通过单个中空针（3）递送。储存器（31）包括一个或多个狭缝阀（44,45），以允许第一和第二药物的输送。所述药物模块（4）还包含与所述储存器（31）的壳体（43）接合以打开所述狭缝阀（44,45）的针护罩（22）。

10. 发明申请

WO2012146678A1 DISPENSE INTERFACE ASSEMBLY 审中-公开
标题翻译：解决接口组件
公开(公告)号：WO2012146678A1
公开(公告)日：2012-11-01
申请号：PCT/EP2012/057694
申请日：2012-04-26
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , HOLTWICK, Marc , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel
发明人： HOLTWICK, Marc , DAVIES, James Alexander , BILTON, Simon Lewis , MOORE, David , WIMPENNY, Steven , LANGLEY, Christopher Nigel
IPC分类号： A61M5/19 , A61M5/24 , A61M5/31
CPC分类号： A61M5/19 , A61M5/24 , A61M5/3148 , A61M2005/3128
摘要： The invention is related to an apparatus comprising an inner body (2000) of a dispense interface and a manifold (2300), wherein the inner body (2000) comprises a recess (2044) configured to receive a distal needle from a distal end (2002) of the inner body (2000), a first fluid reservoir (2050) and a second fluid reservoir (2054), and wherein the manifold (2300) comprises a filling block (2314) configured to redirect flow, a fluid groove arrangement (2318) configured to provide a fluid connection to the filling block (2314), wherein the inner body (2000) and the manifold (2300) are assembled such that there is formed a channel providing a fluid connection from the first fluid reservoir (2050) and the second fluid reservoir (2054), respectively, via the fluid groove arrangement (2318) and the filling block (2314) to the recess (2044). The invention is further related to a drug delivery device comprising an apparatus of the aforementioned kind.
摘要翻译：本发明涉及一种包括分配界面的内体（2000）和歧管（2300）的装置，其中所述内体（2000）包括构造成从远端接收远端针的凹部（2044）（2002）内部主体（2000），第一流体储存器（2050）和第二流体储存器（2054），并且其中所述歧管（2300）包括构造成重新流动的填充块（2314），流体槽装置，其被配置成提供到所述填充块（2314）的流体连接，其中所述内部主体（2000）和所述歧管（2300）被组装成使得形成有提供来自所述第一流体储存器（2050）的流体连接的通道和第二流体储存器（2054）分别经由流体槽装置（2318）和填充块（2314）到达凹部（2044）。本发明进一步涉及包括上述类型的装置的药物递送装置。

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