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1. 发明申请

US20090048430A1 Site specific protein modification 审中-公开
标题翻译：位点特异性蛋白质修饰
公开(公告)号：US20090048430A1
公开(公告)日：2009-02-19
申请号：US11987006
申请日：2007-11-26
申请人： Homme W. Hellinga , James J. Smith , David W. Conrad
发明人： Homme W. Hellinga , James J. Smith , David W. Conrad
IPC分类号： C07K1/00
CPC分类号： C07K1/13
摘要： The present invention relates, in general, to protein modifications and, in particular, to a method of effecting site-specific labeling of proteins with covalently coupled reporter groups. The invention further relates to a method of effecting orientation-specific immobilization of proteins on a solid surface. The invention also relates to products produced by such methods.
摘要翻译：本发明一般涉及蛋白质修饰，尤其涉及用共价偶联的报告基团对蛋白质进行位点特异性标记的方法。本发明还涉及一种在固体表面上实现蛋白质取向特异性固定化的方法。本发明还涉及通过这些方法生产的产品。

2. 发明授权

US06977180B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06977180B2
公开(公告)日：2005-12-20
申请号：US10229286
申请日：2002-08-28
申请人： Homme W. Hellinga , David W. Conrad , David E. Benson
发明人： Homme W. Hellinga , David W. Conrad , David E. Benson
IPC分类号： G01N27/327 , C12Q1/02 , G01N27/416 , G01N33/543
CPC分类号： G01N33/54306 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/66 , Y10S436/806 , Y10S436/815
摘要： The present invention relates, in general, to biosensors and, in particular, to bioelectronic sensors comprising a macromolecule immobilized on an electrode surface so that a redox cofactor that is site-specifically attached to the surface of the macromolecule is between the macromolecule and electrode surface ligand-mediated conformational changes alter the geometry of interaction between the redox cofactor and the electrode surface resulting in a change in electronic coupling between the cofactor and electrode.
摘要翻译：本发明一般涉及生物传感器，特别涉及包含固定在电极表面上的大分子的生物电子传感器，使得与高分子表面位置特异性连接的氧化还原辅因子位于大分子与电极表面之间配体介导的构象变化改变了氧化还原辅因子和电极表面之间的相互作用的几何形状，导致辅因子和电极之间的电子耦合的变化。

3. 发明授权

US06781264B1 Integral field cup and front end shield for an electric brake motor 有权
标题翻译：用于电动制动电机的积分球杯和前端护罩
公开(公告)号：US06781264B1
公开(公告)日：2004-08-24
申请号：US09847147
申请日：2001-05-02
申请人： David W. Conrad , David Reynolds
发明人： David W. Conrad , David Reynolds
IPC分类号： H02K07102
CPC分类号： H02K7/1025
摘要： The present invention provides for a system and method for integrating an electric motor with an electromagnetic brake. An integral field cup and front end shield is employed to function as both a brake field cup and a motor end shield. The integral field cup and front end shield houses a bearing assembly for the motor and an electromagnetic coil for the brake. Moreover, the integral field cup and front end shield operatively encloses the opposite drive end of the motor. In addition, an internal fan is positioned at the opposite drive end of the motor outside the brake and is operable to cool both the brake and the motor.
摘要翻译：本发明提供一种用于将电动机与电磁制动器集成的系统和方法。采用整体的场杯和前端罩用作制动场杯和马达端罩两者。一体式场杯和前端防护罩包含用于电动机的轴承组件和用于制动器的电磁线圈。此外，整体场杯和前端罩可操作地包围电动机的相对驱动端。此外，内部风扇位于制动器外部的电机的相对驱动端，并且可操作以冷却制动器和电动机。

4. 发明授权

US06194184B1 Compounds labeled with cyanate or thiocyanate metal complexes for detection by infrared spectroscopy 失效
标题翻译：用氰酸盐或硫氰酸盐金属配合物标记的化合物用红外光谱法检测
公开(公告)号：US06194184B1
公开(公告)日：2001-02-27
申请号：US09294139
申请日：1999-04-20
申请人： David W. Conrad , Charles H. Patterson, Jr.
发明人： David W. Conrad , Charles H. Patterson, Jr.
IPC分类号： C12N999
CPC分类号： G01N33/58 , C07F15/0066
摘要： A labeled compound detectable by IR spectroscopy contains at least one histidine residue bound to a cyanate or thiocyanate metal complex that has an IR absorption band within the spectral region of 2399-1900 cm−1. An assay reagent for simultaneously detecting or determining a plurality of different analytes in a sample is made up of a plurality of different labeled compounds, each being independently distinguishable from the others by absorbing energy in a different and distinguishable region in the range of 2300 to 1900 cm−1.
摘要翻译：通过IR光谱检测的标记化合物含有至少一个与氰酸酯或硫氰酸酯金属络合物结合的组氨酸残基，其具有在2399-1900cm -1的光谱区内的IR吸收带。用于同时检测或确定样品中多种不同分析物的测定试剂由多种不同的标记化合物组成，每种化合物通过在2300至1900范围内的不同和可区分的区域中吸收能量而独立地区别于其它化合物 cm-1。

5. 发明授权

US5922552A Compounds labeled with cyanate or thiocyanate metal complexes for detecting by infrared spectroscopy 失效
标题翻译：用氰酸盐或硫氰酸盐金属络合物标记的化合物用红外光谱法检测
公开(公告)号：US5922552A
公开(公告)日：1999-07-13
申请号：US95025
申请日：1998-06-09
申请人： David W. Conrad , Charles H. Patterson, Jr.
发明人： David W. Conrad , Charles H. Patterson, Jr.
IPC分类号： C07D233/54 , C07F15/00 , G01N33/58 , G01N33/53
CPC分类号： G01N33/58 , C07F15/0066
摘要： A labeled compound detectable by IR spectroscopy contains at least one histidine residue bound to a cyanate or thiocyanate metal complex that has an IR absorption band within the spectral region of 2399-1900 cm.sup.-1. An assay reagent for simultaneously detecting or determining a plurality of different analytes in a sample is made up of a plurality of different labeled compounds, each being independently distinguishable from the others by absorbing energy in a different and distinguishable region in the range of 2300 to 1900 cm.sup.-1.
摘要翻译：通过IR光谱检测的标记化合物含有至少一个与氰酸酯或硫氰酸酯金属络合物结合的组氨酸残基，其具有在2399-1900cm -1的光谱区内的IR吸收带。用于同时检测或确定样品中多种不同分析物的测定试剂由多种不同的标记化合物组成，每种化合物通过在2300至1900范围内的不同和可区分的区域中吸收能量而独立地区别于其它化合物 cm-1。

6. 发明授权

US5847019A Photoactivatable polymers for producing patterned biomolecular assemblies 失效
公开(公告)号：US5847019A
公开(公告)日：1998-12-08
申请号：US813144
申请日：1997-03-07
申请人： David W. Conrad , Paul T. Charles, Jr.
发明人： David W. Conrad , Paul T. Charles, Jr.
IPC分类号： C07C247/18 , C07C271/12 , C08F2/46 , C40B40/06 , G01N33/543 , B32B27/08 , C12M1/00 , G01N33/53
CPC分类号： B82Y30/00 , C07C247/18 , C07C271/12 , G01N33/54373 , G01N33/5438 , B01J2219/00529 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , Y10T428/31725
摘要： The presently claimed invention is directed to novel biochips and a method for forming said biochips and novel photoactivatable compounds, 2,6-DOCA, 2-NOCA and LC-ASA Amine.

7. 发明授权

US5824803A Compounds labeled with cyanate or thiocyanate metal complexes for detection by infrared spectroscopy 失效
标题翻译：用氰酸盐或硫氰酸盐金属配合物标记的化合物用红外光谱法检测
公开(公告)号：US5824803A
公开(公告)日：1998-10-20
申请号：US940736
申请日：1997-09-30
申请人： David W. Conrad , Charles H. Patterson, Jr.
发明人： David W. Conrad , Charles H. Patterson, Jr.
IPC分类号： C07D233/54 , C07F15/00 , G01N33/58 , C07F231/12 , C07D231/12 , C07F293/04
CPC分类号： G01N33/58 , C07F15/0066
摘要： A labeled compound detectable by IR spectroscopy contains at least one hidine residue bound to a cyanate or thiocyanate metal complex that has an IR absorption band within the spectral region of 2399-1900 cm.sup.-1. An assay reagent for simultaneously detecting or determining a plurality of different analytes in a sample is made up of a plurality of different labeled compounds, each being independently distinguishable from the others by absorbing energy in a different and distinguishable region in the range of 2300 to 1900 cm.sup.-1.
摘要翻译：通过IR光谱检测的标记化合物含有至少一个与氰酸酯或硫氰酸酯金属络合物结合的组氨酸残基，其具有在2399-1900cm -1的光谱区内的IR吸收带。用于同时检测或确定样品中多种不同分析物的测定试剂由多种不同的标记化合物组成，每种化合物通过在2300至1900范围内的不同和可区分的区域中吸收能量而独立地区别于其它化合物 cm-1。

8. 发明授权

US5773308A Photoactivatable o-nitrobenzyl polyethylene glycol-silane for the production of patterned biomolecular arrays 失效
标题翻译：用于生产图案化生物分子阵列的可光活化的邻硝基苄基聚乙二醇 - 硅烷
公开(公告)号：US5773308A
公开(公告)日：1998-06-30
申请号：US797325
申请日：1997-02-10
申请人： David W. Conrad , Sara K. Golightley , John C. Bart
发明人： David W. Conrad , Sara K. Golightley , John C. Bart
IPC分类号： C07C271/16 , C07F7/08 , C07F7/12 , C07F7/18 , C08F2/46 , G01N33/543 , C07C261/00 , C07C269/00 , C08J3/28
CPC分类号： C07C271/16 , C07F7/0836 , C07F7/12 , C07F7/1836 , G01N33/54353 , Y02P20/55
摘要： O-nitrobenzyl analogs that include a photoremovable protecting group that resists the nonspecific adsorption of biomolecules and a linking group for attaching the o-nitrobenzyl analog to a substrate are disclosed. Also disclosed are methods for using o-nitrobenzyl analogs for creating patterned arrays of anti-ligands on a substrate so that a plurality of bioassays can be conducted simultaneously. In particular, the compounds disclosed are o-nitrobenzyl-polyethylene glycol-silanes, wherein the silane group serves to attach the compound to a substrate, the polyethylene glycol group resists the nonspecific adsorption of biomolecules. The o-nitrobenzyl group provides a photoactivatable functionality that allows the polyethylene glycol group to be selectively removed upon exposure to UV radiation and be replaced by an anti-ligand.
摘要翻译：公开了包含抗非生物分子的非特异性吸附的可光还原保护基的O-硝基苄基类似物和用于将邻硝基苄基类似物连接到底物的连接基团。还公开了使用邻硝基苄基类似物在基底上产生抗配体阵列的方法，以便同时进行多个生物测定。特别地，所公开的化合物是邻硝基苄基 - 聚乙二醇 - 硅烷，其中硅烷基用于将化合物连接到基底上，聚乙二醇基团抵抗生物分子的非特异性吸附。邻硝基苄基提供可光活化的官能团，其允许在暴露于UV辐射下选择性地除去聚乙二醇基团并被抗配体代替。

9. 发明授权

US5736257A Photoactivatable polymers for producing patterned biomolecular assemblies 失效
标题翻译：用于生产图案化生物分子组件的可光活化聚合物
公开(公告)号：US5736257A
公开(公告)日：1998-04-07
申请号：US428454
申请日：1995-04-25
申请人： David W. Conrad , Paul T. Charles, Jr.
发明人： David W. Conrad , Paul T. Charles, Jr.
IPC分类号： C07C247/18 , C07C271/12 , C08F2/46 , C40B40/06 , G01N33/543 , B32B27/08 , C12M1/00 , G01N33/53
CPC分类号： B82Y30/00 , C07C247/18 , C07C271/12 , G01N33/54373 , G01N33/5438 , B01J2219/00529 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , Y10T428/31725
摘要： The presently claimed invention is directed to novel biochips and a method for forming said biochips and novel photoactivatable compounds, 2,6-DOCA, 2-NOCA and LC-ASA Amine.
摘要翻译：本发明涉及用于形成所述生物芯片和新型可光活化化合物2,6-DOCA，2-NOCA和LC-ASA胺的新型生物芯片和方法。

10. 发明授权

US07100747B1 Integral motor brake manual release mechanism 有权
标题翻译：一体式电机制动手动释放机构
公开(公告)号：US07100747B1
公开(公告)日：2006-09-05
申请号：US09836976
申请日：2001-04-18
申请人： David W. Conrad , Patrick N. Cromer
发明人： David W. Conrad , Patrick N. Cromer
IPC分类号： B60L7/00
CPC分类号： H02K7/1025 , H02K5/20 , H02K7/106 , H02K9/06
摘要： The present invention relates to a manual brake release mechanism for an electromagnetic brake of an electronic motor. The manual brake release mechanism includes a cam and lever assembly operable to move an armature plate away from a friction disk, thereby, disengaging an electromagnetic brake. The cam and lever assembly is coupled to a field cup and provides an even pull over both sides of the armature plate.
摘要翻译：本发明涉及一种用于电子电动机的电磁制动器的手动制动器释放机构。手动制动器释放机构包括凸轮和杠杆组件，其可操作以使衔铁板远离摩擦盘移动，从而分离电磁制动器。凸轮和杠杆组件联接到场杯并且在衔铁板的两侧提供均匀的拉力。

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