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1. 发明申请

US20080176288A1 Recombinant Production of Polyanionic Polymers, and Uses Thereof 审中-公开
标题翻译：聚阴离子聚合物的重组生产及其用途
公开(公告)号：US20080176288A1
公开(公告)日：2008-07-24
申请号：US11928737
申请日：2007-10-30
申请人： David W. Leung , Philip A. Bergman , Alan Lofquist , Gregory E. Pietz , Christopher K. Tompkins , David W. Waggoner
发明人： David W. Leung , Philip A. Bergman , Alan Lofquist , Gregory E. Pietz , Christopher K. Tompkins , David W. Waggoner
IPC分类号： C12P21/00 , C07K1/00 , C07K16/00 , C12N15/64
CPC分类号： C07K7/06 , A61K47/645 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.
摘要翻译：聚阴离子聚合物可以改善与其结合的药物的生物活性和水溶性。本发明的方法提供可以容易地操作的重组生产的聚阴离子聚合物的单分散制剂，例如延长的。活性部分可以化学或重组连接到聚阴离子聚合物以增加其生物半衰期和/或溶解度。本发明还提供了将聚阴离子聚合物缀合物或融合蛋白递送至特定细胞类型或组织的方法。

2. 发明授权

US07199238B2 LPAAT-β inhibitors and uses thereof 失效
公开(公告)号：US07199238B2
公开(公告)日：2007-04-03
申请号：US11224340
申请日：2005-09-12
申请人： Lynn Bonham , Baoqing Gong , Robert E Finney , David M Hollenback , J. Peter Klein , David W Leung , Scott A Shaffer , Norina M Tang , John Tulinsky , Thayer H White
发明人： Lynn Bonham , Baoqing Gong , Robert E Finney , David M Hollenback , J. Peter Klein , David W Leung , Scott A Shaffer , Norina M Tang , John Tulinsky , Thayer H White
IPC分类号： C07D251/52 , C07D251/38 , A61K31/53 , A61P35/00
CPC分类号： C07D251/70 , C07D251/50 , C07D251/52 , C07D251/54 , C07D251/58
摘要： The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity.

3. 发明授权

US5688763A Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein 失效
标题翻译：用于合成生长激素受体和生长激素结合蛋白的组合物和方法
公开(公告)号：US5688763A
公开(公告)日：1997-11-18
申请号：US248832
申请日：1994-05-25
申请人： R. Glenn Hammonds, Jr. , David W. Leung , Steven A. Spencer , William I. Wood , Peter Cameron Colosi
发明人： R. Glenn Hammonds, Jr. , David W. Leung , Steven A. Spencer , William I. Wood , Peter Cameron Colosi
IPC分类号： A61K38/00 , C07K14/71 , G01N33/74 , A61K38/27 , A61K38/17 , A61K38/18 , C07K14/72
CPC分类号： C07K14/71 , G01N33/74 , A61K38/00
摘要： Growth hormone receptor and growth hormone binding protein are purified enabling amino acid sequence and DNA isolates coding for growth hormone receptor and growth hormone binding protein and methods of obtaining such DNA are provided, together with expression systems for recombinant production of growth hormone receptor and growth hormone binding protein. Therapeutically useful forms of the growth hormone receptor and growth hormone binding protein and anti-receptor antibodies are described.
摘要翻译：纯化生长激素受体和生长激素结合蛋白，使氨基酸序列和编码生长激素受体和生长激素结合蛋白的DNA分离物和获得此类DNA的方法与生物激素受体和生长激素重组生产的表达系统一起提供结合蛋白。描述了生长激素受体和生长激素结合蛋白和抗受体抗体的治疗上有用的形式。

4. 发明授权

US07135314B1 Human phosphatidic acid phosphatase 失效
标题翻译：人磷脂酸磷酸酶
公开(公告)号：US07135314B1
公开(公告)日：2006-11-14
申请号：US08842827
申请日：1997-04-17
申请人： David W. Leung , Christopher K. Tompkins
发明人： David W. Leung , Christopher K. Tompkins
IPC分类号： C12N9/16 , C12N15/55 , C12P7/64
CPC分类号： C12P13/001 , C12N9/16 , C12P7/6463 , C12P7/6481 , C12P13/02
摘要： This invention relates to a biotechnology invention concerning human phosphatidic acid phosphatase. More particularly, this invention relates to three variants of human phosphatidic acid phosphatase namely PAP-α(1 and 2), PAP-β and PAP-γ and uses thereof.
摘要翻译：本发明涉及涉及人类磷脂酸磷酸酶的生物技术发明。更具体地说，本发明涉及人磷脂酸磷酸酶的三种变体，即PAP-α（1和2），PAP-β和PAP-γ及其用途。

5. 发明授权

US06973419B1 Method and system for designing an impingement film floatwall panel system 有权
标题翻译：冲击膜浮法面板系统设计方法及系统
公开(公告)号：US06973419B1
公开(公告)日：2005-12-06
申请号：US09517567
申请日：2000-03-02
申请人： Thomas B. Fortin , Gregory E. Chetta , David W. Leung , Duncan C. Meyers , Keith C. Belson , John V. Diaz , Thomas E. Holladay , Scott A. Ladd , Randall G. McKinney , Sergio Rinella , Andreas Sadil , George F. Titterton, III
发明人： Thomas B. Fortin , Gregory E. Chetta , David W. Leung , Duncan C. Meyers , Keith C. Belson , John V. Diaz , Thomas E. Holladay , Scott A. Ladd , Randall G. McKinney , Sergio Rinella , Andreas Sadil , George F. Titterton, III
IPC分类号： F23R3/00 , G06G7/48
CPC分类号： F23R3/002 , F23R2900/00018 , F23R2900/03044 , Y02T50/675 , Y10T477/40
摘要： A method and system for designing an impingement film floatwall panel system for a combustion chamber for a gas turbine engine comprising the steps of creating an impingement film floatwall panel knowledge base of information. The knowledge base has a plurality of design rule signals with respect to a corresponding plurality of parameter signals of associated elements of impingement film floatwall panels for a combustion chamber, wherein the knowledge base comprises at least one data value signal for each one of the plurality of design rule signals. The steps also include entering a desired data value signal for a selected one of the plurality of parameter signals of an associated element of the impingement film floatwall panels and comparing the entered desired data value signal for the selected one of the plurality of parameters with the corresponding at least one data value signal in the knowledge base for the corresponding one of the plurality of design rule signals. If the result of the step of comparing is such that the entered desired data value signal for the selected one of the plurality of parameter signals is determined to have a first predetermined relationship with respect to the corresponding at least one data value signal in the knowledge base for the selected one of the plurality of design rule signals, create signals representative of a geometric representation of the selected one of the plurality of parameter signals of the associated element of the impingement film floatwall panels.
摘要翻译：一种用于设计用于燃气涡轮发动机的燃烧室的冲击膜浮动面板系统的方法和系统，包括以下步骤：创建冲击膜浮体墙板信息的知识库。知识库相对于燃烧室的冲击膜浮动面板的相关元件的相应多个参数信号具有多个设计规则信号，其中知识库包括至少一个数据值信号，用于多个设计规则信号。这些步骤还包括为冲击薄膜浮动面板的相关元件的多个参数信号中选定的一个参数信号输入期望的数据值信号，并将输入的多个参数中所选择的一个参数的期望数据值信号与相应的所述知识库中的所述多个设计规则信号中的相应一个的至少一个数据值信号。如果比较步骤的结果是使得所输入的多个参数信号中所选择的一个参数信号的期望数据值信号被确定为相对于知识库中相应的至少一个数据值信号具有第一预定关系对于所选择的多个设计规则信号中的一个，创建表示冲击膜浮体面板的相关元件的多个参数信号中所选择的一个的几何表示的信号。

6. 发明授权

US06670143B2 Method of screening compounds that inhibit lysophosphatidic acid acyltransferase 失效
标题翻译：筛选抑制溶血磷脂酰基转移酶的化合物的方法
公开(公告)号：US06670143B2
公开(公告)日：2003-12-30
申请号：US09970989
申请日：2001-10-05
申请人： David W. Leung , Daniel Adourel , David Hollenback
发明人： David W. Leung , Daniel Adourel , David Hollenback
IPC分类号： C12Q148
CPC分类号： C12N9/1029
摘要： Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
摘要翻译：多肽例如通过编码cDNA序列的表达获得，其具有酶溶血磷脂酸酰基转移酶（LPAAT）的活性，也称为1-酰基sn-甘油-3-磷酸酰基转移酶。

7. 发明授权

US5756511A Method for treating symptoms of a neurodegenerative condition 失效
标题翻译：治疗神经退行性疾病症状的方法
公开(公告)号：US5756511A
公开(公告)日：1998-05-26
申请号：US416270
申请日：1995-04-03
申请人： James W. West , David W. Leung , J. Peter Klein , Gail E. Underiner , Anil M. Kumar
发明人： James W. West , David W. Leung , J. Peter Klein , Gail E. Underiner , Anil M. Kumar
IPC分类号： A61K31/522 , A01N43/90
CPC分类号： A61K31/522
摘要： A method for treating symptoms of Alzheimer's Disease by administering an effective amount of a compound, racemate, isolated R or S enantionmer, solvate, hydrate or salt having the formula: X--terminal heterocyclic moiety. In the above formula, the terminal heterocyclic moiety is a 3,7-dimethylxanthinyl, 3-methylxanthinyyl or xanthinyl moiety and X is: ##STR1## n is zero or an integer from one to four; and m is an integer from seven to fourteen. For compounds useful in the inventive method, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. w may be an integer from one to twenty and R.sub.5 is preferably an hydroxyl, halo C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. R.sub.3 in compounds useful in the inventive method may be either an hydroxyl group, an oxygen atom, the single bond represented being instead a double bond, or --O--R.sub.4, R.sub.4 being a C.sub.1-6 oxoalkyl.
摘要翻译：通过施用有效量的具有下式的化合物，外消旋物，分离的R或S对映体，溶剂合物，水合物或盐，来治疗阿尔茨海默病症状的方法：在上式中，末端杂环部分为 3,7-二甲基黄烷基，3-甲基黄嘌呤基或xanthinyl部分，X为：n为0或1至4的整数; m为7〜14的整数。对于可用于本发明方法的化合物，R 1和R 2是氢，直链或支链烷基，链烯基或炔基，其长度为至多20个碳原子或 - （CH 2）w R 5。 w可以是从一到二十的整数，R 5优选为羟基，卤代C 1-8烷氧基或取代或未取代的碳环或杂环。可用于本发明方法的化合物中的R 3可以是羟基，氧原子，所表示的单键代替双键，或-O-R4，R4是C1-6氧代烷基。

8. 发明授权

US4857637A Methods and compositions for immunologically modulating growth hormone receptor activity 失效
标题翻译：用于免疫调节生长激素受体活性的方法和组合物
公开(公告)号：US4857637A
公开(公告)日：1989-08-15
申请号：US61942
申请日：1987-06-12
申请人： R. Glenn Hammonds , David W. Leung , David W. Martin, Jr. , Steven A. Spencer , William I. Wood
发明人： R. Glenn Hammonds , David W. Leung , David W. Martin, Jr. , Steven A. Spencer , William I. Wood
IPC分类号： A61K39/00 , C07K14/71 , C07K16/26 , C07K16/28 , C12N15/38
CPC分类号： C07K16/2863 , C07K14/71 , C07K16/26 , A61K39/00 , Y10S530/81 , Y10S930/30
摘要： The activity of growth-associated receptors is modulated in vivo in a controlled and reproducible fashion by immunizing animals against target growth-associated receptors. This is accomplished by the use of immunogens predetermined to induce primarily agonist or antagonist responses. The immunogens include anti-ligand antibodies and receptor derivatives.
摘要翻译：生长相关受体的活性以受控和可重复的方式通过免疫动物抵抗靶生长相关受体而在体内进行调节。这是通过使用预先诱导主要激动剂或拮抗剂反应的免疫原实现的。免疫原包括抗配体抗体和受体衍生物。

9. 发明授权

US07052891B2 Human lysophoshatidic acid acyltransferase gamma-1 polypeptide 失效
标题翻译：人溶血糖酸酰基转移酶γ-1多肽
公开(公告)号：US07052891B2
公开(公告)日：2006-05-30
申请号：US10667494
申请日：2003-09-23
申请人： David W. Leung , Daniel Adourel , David Hollenback
发明人： David W. Leung , Daniel Adourel , David Hollenback
IPC分类号： G12N9/10
CPC分类号： C12N9/1029
摘要： Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
摘要翻译：多肽例如通过编码cDNA序列的表达获得，其具有酶溶血磷脂酸酰基转移酶（LPAAT）的活性，也称为1-酰基sn-甘油-3-磷酸酰基转移酶。

10. 发明授权

US07045327B2 Human lysophosphatidic acid acyltransferase gamma-2 polypeptide 失效
标题翻译：人溶血磷脂酸酰基转移酶γ-2多肽
公开(公告)号：US07045327B2
公开(公告)日：2006-05-16
申请号：US10667462
申请日：2003-09-23
申请人： David W. Leung , Daniel Adourel , David Hollenback
发明人： David W. Leung , Daniel Adourel , David Hollenback
IPC分类号： C12N9/10
CPC分类号： C12N9/1029
摘要： Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
摘要翻译：多肽例如通过编码cDNA序列的表达获得，其具有酶溶血磷脂酸酰基转移酶（LPAAT）的活性，也称为1-酰基sn-甘油-3-磷酸酰基转移酶。

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