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1. 发明申请

US20110243968A1 THERAPEUTIC APPLICATIONS OF P53 ISOFORMS IN REGENERATIVE MEDICINE, AGING AND CANCER 有权
标题翻译： P53认证在再生医学，老化和癌症中的应用
公开(公告)号：US20110243968A1
公开(公告)日：2011-10-06
申请号：US12742250
申请日：2008-10-21
申请人： Curtis C. Harris , Kaori Fujita , Izumi Horikawa , Borivoj Vojtesek , Jean-Christophe Bourdon , David P. Lane
发明人： Curtis C. Harris , Kaori Fujita , Izumi Horikawa , Borivoj Vojtesek , Jean-Christophe Bourdon , David P. Lane
IPC分类号： A61K31/713 , C12N5/071 , C12N5/09 , A61K31/7088 , C12N15/85 , A61K48/00 , C07H21/02 , A61P43/00 , A61P35/00 , A61P37/06
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K48/00 , C07K14/4746 , C12N5/0652 , C12N15/1135 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/141 , C12N2310/531
摘要： The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
摘要翻译：本发明提供使用p53肿瘤抑制蛋白的同种型调节细胞衰老和细胞增殖的方法和组合物。通过调节细胞衰老和增殖，本发明的方法和组合物用于抑制癌细胞生长或产生用于组织再生的细胞群体。

2. 发明授权

US07502997B2 Ensuring completeness when publishing to a content management system 有权
标题翻译：确保在发布到内容管理系统时的完整性
公开(公告)号：US07502997B2
公开(公告)日：2009-03-10
申请号：US10306563
申请日：2002-11-27
申请人： Gregory S Reid , Timothy Ringo , David P Lane , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester
发明人： Gregory S Reid , Timothy Ringo , David P Lane , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester
IPC分类号： G06F17/00
CPC分类号： G06F17/30899
摘要： New functions for a contact center system include: testing user's comprehension of informational messages with a quiz; capturing insight of superior users having a KPI score above a threshold by having those users submit information on why they perform so well; dynamically ordering solutions to issues by re-ranking the solutions periodically based on recency and frequency; integrating information for use by a contact center representative while online with a customer and information for use when not online; storing content items in a telecommunications industry taxonomy; directing user feedback on a content item to the proper owner/manager of that content; communicating solution information using a solutions taxonomy; displaying a dual information system having a CRM application as well as reference material that is context-appropriate; enforcing completion of a group of templates when creating a content item to be published; ensuring a group of templates for a content item are complete before publishing them; and searching within a contact center system portal using a continuum of search functions.
摘要翻译：联络中心系统的新功能包括：通过测验测试用户对信息消息的理解; 通过让这些用户提交关于他们为什么表现如此出色的信息，获取KPI得分高于阈值的上级用户的洞察力; 通过基于新近度和频率周期性地重新排列解决方案来动态地排序问题的解决方案; 集成信息供联络中心代表在线与客户联系以供在线使用时使用; 将内容项目存储在电信行业分类中; 将内容项目的用户反馈引导到该内容的正确的所有者/管理者; 使用解决方案分类法传达解决方案信息; 显示具有CRM应用程序的双重信息系统以及适合上下文的参考资料; 在创建要发布的内容项时强制完成一组模板; 确保一组内容项目的模板在发布之前已经完成; 并使用连续的搜索功能在联络中心系统门户中进行搜索。

3. 发明授权

US07418403B2 Content feedback in a multiple-owner content management system 有权
标题翻译：多所有者内容管理系统中的内容反馈
公开(公告)号：US07418403B2
公开(公告)日：2008-08-26
申请号：US10306025
申请日：2002-11-27
申请人： Gregory S Reid , Timothy Ringo , David P Lane , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester , Claudia Staubitz , Kevin Adams , Lesley Pickering , Paul Ritchie
发明人： Gregory S Reid , Timothy Ringo , David P Lane , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester , Claudia Staubitz , Kevin Adams , Lesley Pickering , Paul Ritchie
IPC分类号： G06Q30/00
CPC分类号： G06Q10/06398 , G06Q10/063 , G06Q10/06393 , G06Q10/10 , G06Q30/0601 , G06Q30/0641 , G06Q50/184
摘要： New functions for a contact center system include: testing user's comprehension of informational messages with a quiz; capturing insight of superior users having a KPI score above a threshold by having those users submit information on why they perform so well; dynamically ordering solutions to issues by re-ranking the solutions periodically based on recency and frequency; integrating information for use by a contact center representative while online with a customer and information for use when not online; storing content items in a telecommunications industry taxonomy; directing user feedback on a content item to the proper owner/manager of that content; communicating solution information using a solutions taxonomy; displaying a dual information system having a CRM application as well as reference material that is context-appropriate; enforcing completion of a group of templates when creating a content item to be published; ensuring a group of templates for a content item are complete before publishing them; and searching within a contact center system portal using a continuum of search functions.
摘要翻译：联络中心系统的新功能包括：通过测验测试用户对信息消息的理解; 通过让这些用户提交关于他们为什么表现如此出色的信息，获取KPI得分高于阈值的上级用户的洞察力; 通过基于新近度和频率周期性地重新排列解决方案来动态地排序问题的解决方案; 集成信息供联络中心代表在线与客户联系以供在线使用时使用; 将内容项目存储在电信行业分类中; 将内容项目的用户反馈引导到该内容的正确的所有者/管理者; 使用解决方案分类法传达解决方案信息; 显示具有CRM应用程序的双重信息系统以及适合上下文的参考资料; 在创建要发布的内容项时强制完成一组模板; 确保一组内容项目的模板在发布之前已经完成; 并使用连续的搜索功能在联络中心系统门户中进行搜索。

4. 发明授权

US07062505B2 Content management system for the telecommunications industry 有权
标题翻译：电讯业内容管理系统
公开(公告)号：US07062505B2
公开(公告)日：2006-06-13
申请号：US10305835
申请日：2002-11-27
申请人： David P Lane , Gregory S Reid , Timothy Ringo , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester , Claudia Staubitz , Kevin Adams , Lesley Pickering , Paul Ritchie
发明人： David P Lane , Gregory S Reid , Timothy Ringo , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester , Claudia Staubitz , Kevin Adams , Lesley Pickering , Paul Ritchie
IPC分类号： G06F17/00
CPC分类号： G06Q30/02 , Y10S707/99931 , Y10S707/99933 , Y10S707/99943
摘要： New functions for a contact center system include: testing user's comprehension of informational messages with a quiz; capturing insight of superior users having a KPI score above a threshold by having those users submit information on why they perform so well; dynamically ordering solutions to issues by re-ranking the solutions periodically based on recency and frequency; integrating information for use by a contact center representative while online with a customer and information for use when not online; storing content items in a telecommunications industry taxonomy; directing user feedback on a content item to the proper owner/manager of that content; communicating solution information using a solutions taxonomy; displaying a dual information system having a CRM application as well as reference material that is context-appropriate; enforcing completion of a group of templates when creating a content item to be published; ensuring a group of templates for a content item are complete before publishing them; and searching within a contact center system portal using a continuum of search functions.
摘要翻译：联络中心系统的新功能包括：通过测验测试用户对信息消息的理解; 通过让这些用户提交关于他们为什么表现如此出色的信息，获取KPI得分高于阈值的上级用户的洞察力; 通过基于新近度和频率周期性地重新排列解决方案来动态地排序问题的解决方案; 集成信息供联络中心代表在线与客户联系以供在线使用时使用; 将内容项目存储在电信行业分类中; 将内容项目的用户反馈引导到该内容的正确的所有者/管理者; 使用解决方案分类法传达解决方案信息; 显示具有CRM应用程序的双重信息系统以及适合上下文的参考资料; 在创建要发布的内容项时强制完成一组模板; 确保一组内容项目的模板在发布之前已经完成; 并使用连续的搜索功能在联络中心系统门户中进行搜索。

5. 发明授权

US08572058B2 Presenting linked information in a CRM system 有权
标题翻译：在CRM系统中呈现链接信息
公开(公告)号：US08572058B2
公开(公告)日：2013-10-29
申请号：US10306386
申请日：2002-11-27
申请人： Gregory S Reid , Timothy Ringo , David P Lane , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester , Claudia Staubitz , Kevin Adams , Lesley Pickering , Paul Ritchie
发明人： Gregory S Reid , Timothy Ringo , David P Lane , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester , Claudia Staubitz , Kevin Adams , Lesley Pickering , Paul Ritchie
IPC分类号： G06F17/30
CPC分类号： G06Q30/02
摘要： New functions for a contact center system include: testing user's comprehension of informational messages with a quiz; capturing insight of superior users having a KPI score above a threshold by having those users submit information on why they perform so well; dynamically ordering solutions to issues by re-ranking the solutions periodically based on recency and frequency; integrating information for use by a contact center representative while online with a customer and information for use when not online; storing content items in a telecommunications industry taxonomy; directing user feedback on a content item to the proper owner/manager of that content; communicating solution information using a solutions taxonomy; displaying a dual information system having a CRM application as well as reference material that is context-appropriate; enforcing completion of a group of templates when creating a content item to be published; ensuring a group of templates for a content item are complete before publishing them; and searching within a contact center system portal using a continuum of search functions.
摘要翻译：联络中心系统的新功能包括：通过测验测试用户对信息消息的理解; 通过让这些用户提交关于他们为什么表现如此出色的信息，获取KPI得分高于阈值的上级用户的洞察力; 通过基于新近度和频率周期性地重新排列解决方案来动态地排序问题的解决方案; 集成信息供联络中心代表在线与客户联系以供在线使用时使用; 将内容项目存储在电信行业分类中; 将内容项目的用户反馈引导到该内容的正确的所有者/管理者; 使用解决方案分类法传达解决方案信息; 显示具有CRM应用程序的双重信息系统以及适合上下文的参考资料; 在创建要发布的内容项时强制完成一组模板; 确保一组内容项目的模板在发布之前已经完成; 并使用连续的搜索功能在联络中心系统门户中进行搜索。

6. 发明授权

US08090624B2 Content feedback in a multiple-owner content management system 有权
标题翻译：多所有者内容管理系统中的内容反馈
公开(公告)号：US08090624B2
公开(公告)日：2012-01-03
申请号：US12179429
申请日：2008-07-24
申请人： Gregory S Reid , Timothy Ringo , David P Lane , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester , Claudia Staubitz , Kevin Adams , Lesley Pickering , Paul Ritchie
发明人： Gregory S Reid , Timothy Ringo , David P Lane , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester , Claudia Staubitz , Kevin Adams , Lesley Pickering , Paul Ritchie
IPC分类号： G06Q30/00
CPC分类号： G06Q10/06398 , G06Q10/063 , G06Q10/06393 , G06Q10/10 , G06Q30/0601 , G06Q30/0641 , G06Q50/184
摘要： New functions for a contact center system include: testing user's comprehension of informational messages with a quiz; capturing insight of superior users having a KPI score above a threshold by having those users submit information on why they perform so well; dynamically ordering solutions to issues by re-ranking the solutions periodically based on recency and frequency; integrating information for use by a contact center representative while online with a customer and information for use when not online; storing content items in a telecommunications industry taxonomy; directing user feedback on a content item to the proper owner/manager of that content; communicating solution information using a solutions taxonomy; displaying a dual information system having a CRM application as well as reference material that is context-appropriate; enforcing completion of a group of templates when creating a content item to be published; ensuring a group of templates for a content item are complete before publishing them; and searching within a contact center system portal using a continuum of search functions.
摘要翻译：联络中心系统的新功能包括：通过测验测试用户对信息消息的理解; 通过让这些用户提交关于他们为什么表现如此出色的信息，获取KPI得分高于阈值的上级用户的洞察力; 通过基于新近度和频率周期性地重新排列解决方案来动态地排序问题的解决方案; 集成信息供联络中心代表在线与客户联系以供在线使用时使用; 将内容项目存储在电信行业分类中; 将内容项目的用户反馈引导到该内容的正确的所有者/管理者; 使用解决方案分类法传达解决方案信息; 显示具有CRM应用程序的双重信息系统以及适合上下文的参考资料; 在创建要发布的内容项时强制完成一组模板; 确保一组内容项目的模板在发布之前已经完成; 并使用连续的搜索功能在联络中心系统门户中进行搜索。

7. 发明授权

US07395499B2 Enforcing template completion when publishing to a content management system 有权
标题翻译：发布到内容管理系统时，强制模板完成
公开(公告)号：US07395499B2
公开(公告)日：2008-07-01
申请号：US10306026
申请日：2002-11-27
申请人： David P. Lane , Gregory S. Reid , Timothy A. Ringo , Elizabeth H. Lian , Daniel C. Farrell , Craig Fenton , Elise Clarke , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester
发明人： David P. Lane , Gregory S. Reid , Timothy A. Ringo , Elizabeth H. Lian , Daniel C. Farrell , Craig Fenton , Elise Clarke , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester
IPC分类号： G06F17/00
CPC分类号： G06F17/30899
摘要： New functions for a contact center system include: testing user's comprehension of informational messages with a quiz; capturing insight of superior users having a KPI score above a threshold by having those users submit information on why they perform so well; dynamically ordering solutions to issues by re-ranking the solutions periodically based on recency and frequency; integrating information for use by a contact center representative while online with a customer and information for use when not online; storing content items in a telecommunications industry taxonomy; directing user feedback on a content item to the proper owner/manager of that content; communicating solution information using a solutions taxonomy; displaying a dual information system having a CRM application as well as reference material that is context-appropriate; enforcing completion of a group of templates when creating a content item to be published; ensuring a group of templates for a content item are complete before publishing them; and searching within a contact center system portal using a continuum of search functions.
摘要翻译：联络中心系统的新功能包括：通过测验测试用户对信息消息的理解; 通过让这些用户提交关于他们为什么表现如此出色的信息，获取KPI得分高于阈值的上级用户的洞察力; 通过基于新近度和频率周期性地重新排列解决方案来动态地排序问题的解决方案; 集成信息供联络中心代表在线与客户联系以供在线使用时使用; 将内容项目存储在电信行业分类中; 将内容项目的用户反馈引导到该内容的正确的所有者/管理者; 使用解决方案分类法传达解决方案信息; 显示具有CRM应用程序的双重信息系统以及适合上下文的参考资料; 在创建要发布的内容项时强制完成一组模板; 确保一组内容项目的模板在发布之前已经完成; 并使用连续的搜索功能在联络中心系统门户中进行搜索。

8. 发明授权

US07200614B2 Dual information system for contact center users 有权
标题翻译：联络中心用户的双重信息系统
公开(公告)号：US07200614B2
公开(公告)日：2007-04-03
申请号：US10306577
申请日：2002-11-27
申请人： Gregory S Reid , Timothy Ringo , David P Lane , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester
发明人： Gregory S Reid , Timothy Ringo , David P Lane , Elizabeth H Lian , Daniel C Farrell , Craig Fenton , Elise Shearing , Randy Bell , Sevasti Wong , Anthony Lingham , Audrey Forrester
IPC分类号： G06F17/30
CPC分类号： G09B7/00 , Y10S707/99945 , Y10S707/99948
摘要： A dual information system for a representative of a contact center includes a first set of information directed for reference by the representative while the representative is online with a customer and a second set of information directed for reference or capability enhancement by the representative while the representative is offline from customers wherein the second set of information includes information automatically directed to the representative based on the representative's online contact with the customer. One of these sets of information may enhance role-based capabilities of the representative.
摘要翻译：用于联络中心的代表的双重信息系统包括第一组信息，供代理人参考，代表与客户在线，第二组信息指导代表参考或提高能力，而代表为从客户离线，其中第二组信息包括基于代表与客户的在线联系自动指向代表的信息。这些信息之一可以增强代表的基于角色的能力。

9. 发明授权

US06613878B1 PCNA binding substance 失效
标题翻译： PCNA结合物质
公开(公告)号：US06613878B1
公开(公告)日：2003-09-02
申请号：US08945645
申请日：1998-07-31
申请人： Lynne S. Cox , David P. Lane , Emma Warbrick , David M. Glover
发明人： Lynne S. Cox , David P. Lane , Emma Warbrick , David M. Glover
IPC分类号： A61K3808
CPC分类号： C12N9/22 , A61K38/00 , C07K14/4738
摘要： Fragments of Fen1 that interact with PCNA are disclosed, together with the use of such fragments or mimetics of Fen1 in methods of screening for compounds useful in treating disorders in which PCNA is implicated. In particular, substances which have the property of binding to PCNA are disclosed, said substances comprising: (i) a fragment of the Fen1 protein containing a peptide of 89 amino acids from the C-terminal region or an active portion thereof; or, (ii) a fragment of the Fen1 protein containing the sequence motif QGRLDxFF; or, (iii) a functional mimetic of said protein fragments; where “x” is preferably the selected form the amino acids S, D or G.
摘要翻译：公开了与PCNA相互作用的Fen1片段，以及在筛选可用于治疗PCNA所涉及的疾病的化合物的方法中使用Fen1的这种片段或模拟物。特别地，公开了具有与PCNA结合的性质的物质，所述物质包括：（i）含有C末端区域或其活性部分的89个氨基酸的肽的Fen1蛋白的片段; 或（ii）含有序列基序QGRLDxFF的Fen1蛋白的片段; 或（iii）所述蛋白质片段的功能模拟物;其中“x”优选为所选形式的氨基酸S，D或G.

10. 发明申请

US20220267376A1 P53 ACTIVATOR PEPTIDOMIMETIC MACROCYCLES 有权
公开(公告)号：US20220267376A1
公开(公告)日：2022-08-25
申请号：US17618751
申请日：2020-06-16
申请人： Tomi K. SAWYER , Pietro ARONICA , Christopher J. BROWN , Fernando J. FERRER , Charles W. JOHANNES , Srinivasaraghavan KANNAN , David P. LANE , Anthony W. PARTRIDGE , Yaw Sing TAN , Chandra S. VERMA , Tsz Ying YUEN , Merck Sharp & Dohme Corp. , Agency for Science, Technology and Research , MSD International GMBH (Singapore Branch)
发明人： Pietro Aronica , Christopher J. Brown , Fernando J. Ferrer , Charles W. Johannes , Srinivasaraghavan Kannan , David P. Lane , Anthony W. Partridge , Tomi K. Sawyer , Yaw Sing Tan , Chandra S. Verma , Tsz Ying Yuen
IPC分类号： C07K7/08 , A61K45/06 , C07K7/06 , A61P35/00
摘要： Peptidomimetic macrocycles that comprise all-D configuration ?-amino acids and bind mouse double minute 2 (MDM2 aka E3 ubiquitin-protein ligase) and MDMX (aka MDM4) are described. These all-D configuration α-amino acid peptidomimetic macrocycles are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX thereby antagonizing MDM2 and MDMX binding to p53. These peptidomimetic macrocycles may be useful in anticancer therapies, particularly in combination with chemotherapy or radiation therapy.

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