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1. 发明申请

US20070099276A1 Retrovirus-like particles and retroviral vaccines 审中-公开
标题翻译：逆转录病毒样颗粒和逆转录病毒疫苗
公开(公告)号：US20070099276A1
公开(公告)日：2007-05-03
申请号：US11413614
申请日：2006-04-27
申请人： David Ott , Dexter Poon , Robert Gorelick
发明人： David Ott , Dexter Poon , Robert Gorelick
IPC分类号： C12P19/34 , C12N5/06 , C12N5/16
CPC分类号： C12N7/00 , A61K39/12 , A61K39/21 , A61K2039/5258 , C07K14/005 , C12N2740/16023 , C12N2740/16222 , C12N2740/16234
摘要： The invention relates to retrovirus-like particles having an altered nucleocapsid domain that inhibits packaging of genomic RNA into the retrovirus-like particle, and a protease having reduced enzymatic activity. The invention also provides nucleic acid constructs that encode the retrovirus-like particles. Also provided are immunological compositions, vaccines, and DNA vaccines containing the retrovirus-like particles and nucleic acid constructs that can be used to immunize a mammal against infection by a retrovirus. Methods to produce retrovirus-like particles are also provided.
摘要翻译：本发明涉及具有改变的核衣壳结构域的逆转录病毒样颗粒，其抑制将基因组RNA包装到逆转录病毒样颗粒中，以及具有降低的酶活性的蛋白酶。本发明还提供编码逆转录病毒样颗粒的核酸构建体。还提供了免疫组合物，疫苗和含有逆转录病毒样颗粒的DNA疫苗和可用于免疫哺乳动物免受逆转录病毒感染的核酸构建体。还提供了产生逆转录病毒样颗粒的方法。

2. 发明申请

US20050260250A1 Medicinal products incorporating bound organosulfur groups 有权
标题翻译：结合有机硫基团的药用产品
公开(公告)号：US20050260250A1
公开(公告)日：2005-11-24
申请号：US11137747
申请日：2005-05-24
申请人： David Ott
发明人： David Ott
IPC分类号： A23J1/00 , A23L1/221 , A23L1/30 , A23L1/305 , A61K36/8962 , A61K38/16 , A61K47/00 , C12P11/00 , A61K35/78
CPC分类号： A61K31/255 , A23L27/105 , A23L33/105 , A23L33/17 , A23L33/175 , A61K36/8962
摘要： Nutraceutical and dietary supplement formulations for delivering bioavailable thiols to a host, comprising certain organosulfur radicals, such as the allyl mercapto radical, bound to larger molecules such as proteins, resulting in the formation in the host's body of various allium-related compounds such as allicin. The formulations are produced by treating an ingestible material comprising a cysteine-containing protein with a thiol, disulfide, mixed disulfide, thiosufinate or mixed thiosulfinate so as to cause thiol residues to become disulfide bonded to cysteines contained in the protein.
摘要翻译：将生物可利用的硫醇递送到宿主的营养和膳食补充剂制剂，其包含某些有机硫自由基，例如烯丙基巯基，与大分子如蛋白质结合，导致宿主体内形成各种与鎓相关的化合物如大蒜素。通过用硫醇，二硫化物，混合二硫化物，硫代硫酸盐或混合的硫代亚磺酸盐处理包含含半胱氨酸的蛋白质的可摄入物质以使硫醇残基与蛋白质中包含的半胱氨酸二硫键结合来制备配方。

3. 发明授权

US09650432B2 Rodent combinatorial antibody libraries 有权
公开(公告)号：US09650432B2
公开(公告)日：2017-05-16
申请号：US13574782
申请日：2011-01-28
申请人： Josef Prassler , David Ott , Stefanie Thiel , Yvonne Stark , Ute Keck , Thomas Pietzonka , Hilmar Ebersbach
发明人： Josef Prassler , David Ott , Stefanie Thiel , Yvonne Stark , Ute Keck , Thomas Pietzonka , Hilmar Ebersbach
IPC分类号： C07K16/00 , C07K16/22
CPC分类号： C07K16/005 , C07K16/00 , C07K16/22 , C07K16/243 , C07K2317/20 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , C07K2317/94 , G01N33/6854
摘要： The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.

4. 发明申请

US20140181794A1 SYSTEM AND METHOD FOR CORRECT EXECUTION OF SOFTWARE 有权
标题翻译：用于软件更正执行的系统和方法
公开(公告)号：US20140181794A1
公开(公告)日：2014-06-26
申请号：US13722158
申请日：2012-12-20
申请人： David GRAWROCK , David OTT , Corey MALONE , Jesse WALKER
发明人： David GRAWROCK , David OTT , Corey MALONE , Jesse WALKER
IPC分类号： G06F9/44
CPC分类号： G06F11/3636 , G06F8/70 , G06F11/36 , G06F11/3616
摘要： In an embodiment a software application may include a “baseline trace” indicating proper application execution. The baseline trace may include counts for various types of instructions (e.g., how many times each of a LR instruction and a MV instruction occurs during an execution of code). The finished application includes the baseline trace. Upon execution the application randomly selects which of the various types of instructions to count during execution (e.g., LR or MV instruction) to produce a “real time trace”. The application executes and produces the real-time trace. The baseline trace is then compared to the real-time trace, which is specific to the randomly chosen type of instruction. If the traces are within a pre-determined range of each other the user has a level of assurance the software is operating correctly. Other embodiments are described herein.
摘要翻译：在一个实施例中，软件应用可以包括指示正确应用执行的“基线迹线”。基线迹线可以包括各种类型的指令的计数（例如，在执行代码期间，LR指令和MV指令的每一个发生多少次）。完成的应用程序包括基线轨迹。一旦执行，应用程序随机选择在执行期间计数各种类型的指令（例如，LR或MV指令）以产生“实时跟踪”。应用程序执行并产生实时跟踪。然后将基线轨迹与随机选择的指令类型特有的实时跟踪进行比较。如果迹线在彼此的预定范围内，则用户具有软件正确操作的保证级别。本文描述了其它实施例。

5. 发明申请

US20130030157A1 Rodent Combinatorial Antibody Libraries 有权
标题翻译：啮齿动物组合抗体库
公开(公告)号：US20130030157A1
公开(公告)日：2013-01-31
申请号：US13574782
申请日：2011-01-28
申请人： Josef Prassler , David Ott , Stefanie Thiel , Yvonne Stark , Ute Keck , Thomas Pietzonka , Hilmar Ebersbach
发明人： Josef Prassler , David Ott , Stefanie Thiel , Yvonne Stark , Ute Keck , Thomas Pietzonka , Hilmar Ebersbach
IPC分类号： C40B40/10 , C12N15/63 , C07K16/46 , C12N5/10 , C40B30/04 , C07K16/00 , C40B40/06 , C12N1/21
CPC分类号： C07K16/005 , C07K16/00 , C07K16/22 , C07K16/243 , C07K2317/20 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , C07K2317/94 , G01N33/6854
摘要： The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.
摘要翻译：本发明提供合成的啮齿动物抗体文库，例如小鼠或大鼠抗体文库，以及与这些文库结合使用的多肽，核酸，载体，宿主细胞和方法。本发明还提供从这些文库和这种抗体的变体分离的抗体。

6. 发明授权

US09232448B2 Methods and apparatus for neighbor discovery of base stations in a communication system 有权
标题翻译：通信系统中基站邻居发现的方法和装置
公开(公告)号：US09232448B2
公开(公告)日：2016-01-05
申请号：US12136495
申请日：2008-06-10
申请人： Peerapol Tinnakornsrisuphap , Rajat Prakash , Fatih Ulupinar , David Ott
发明人： Peerapol Tinnakornsrisuphap , Rajat Prakash , Fatih Ulupinar , David Ott
IPC分类号： H04W4/00 , H04W36/00 , H04W8/00 , H04W92/20
CPC分类号： H04W36/0083 , H04W8/005 , H04W92/20
摘要： An automated neighbor discovery by a base station with the assistance of an access terminal are disclosed. An exemplary method includes receiving a first message from an access terminal based on detecting an identification signal by the access terminal from the first base station in a communication system. Determination whether the first base station is a known base station is then made. If the first base station is not known, a second message is transmitted to the access terminal requesting a network identification of the first base station. A third message from the access terminal is received in response to the second message including the requested network identification. A request for identification data is sent by the second base station to the first base station via a network link based on the network identification. Corresponding apparatus and other exemplary methods are also disclosed.
摘要翻译：公开了一种基站在接入终端协助下的自动邻居发现。一种示例性方法包括：基于在通信系统中从第一基站检测接入终端的识别信号，从接入终端接收第一消息。然后确定第一基站是否是已知的基站。如果第一基站不知道，则向接入终端发送第二消息，请求第一基站的网络标识。响应于包括所请求的网络标识的第二消息，接收到来自接入终端的第三消息。基于网络识别，第二基站通过网络链路向第一基站发送对识别数据的请求。还公开了相应的装置和其它示例性方法。

7. 发明申请

US20070275876A1 Method to increase the bioavailability of cysteine 有权
标题翻译：增加半胱氨酸生物利用度的方法
公开(公告)号：US20070275876A1
公开(公告)日：2007-11-29
申请号：US11805637
申请日：2007-05-23
申请人： David Ott
发明人： David Ott
IPC分类号： A61K38/17 , A61K31/095
CPC分类号： A61K31/095
摘要： A method for increasing the bioavailability of cysteine within an animal by reducing extracellular cysteine disulfide molecules to produce extracellular cysteine molecules. A membrane permeable thiol molecule that forms a membrane permeable disulfide molecule after becoming oxidized participates in thiol-disulfide exchange reactions on both sides of the cellular membrane, crossing the membrane randomly via simple diffusion. The membrane permeable disulfide, within or upon entering the highly reductive environment of a cell, becomes reduced to form a membrane permeable thiol molecule. the membrane permeable thiol can then diffuse to the exterior of the cell, where it is available to reduce another cystine molecule. This process can continue cycling, producing net cumulative increase in the concentration of extracellular cysteine. This is beneficial for providing cysteine as a nutrient to cells that require cysteine for nourishment.
摘要翻译：通过减少细胞外半胱氨酸二硫化物分子以产生细胞外半胱氨酸分子来增加动物体内半胱氨酸的生物利用度的方法。在氧化后形成膜可渗透的二硫化物分子的膜可渗透硫醇分子参与细胞膜两侧的硫醇二硫交换反应，通过简单的扩散随机穿过膜。在进入细胞的高度还原环境之内或之后，膜可渗透的二硫化物减少以形成膜可渗透的硫醇分子。膜可渗透的硫醇然后可以扩散到细胞的外部，其中可用于减少另一个胱氨酸分子。该过程可以继续循环，产生细胞外半胱氨酸浓度的净累积增加。这有利于提供半胱氨酸作为需要半胱氨酸营养的细胞的营养物质。

8. 发明申请

US20060269488A1 Personal care and medicinal products incorporating bound organosulfur groups 有权
标题翻译：结合有机硫基的个人护理和药用产品
公开(公告)号：US20060269488A1
公开(公告)日：2006-11-30
申请号：US11441292
申请日：2006-05-24
申请人： David Ott
发明人： David Ott
IPC分类号： A61K8/18
CPC分类号： A61K8/46 , A61K8/97 , A61K9/0014 , A61K47/20 , A61K2800/522 , A61Q11/00 , A61Q17/04
摘要： Personal care products useful for the maintenance of personal appearance and good health and minor treatments that do not require professional health care, as well as products that provide a combination of anti-microbial, anti-oxidant, anti-inflammatory, and anti-aging properties and are suitable for use without a prescription. The products utilize a biomembrane permeable organosulfur compound that can redox cycle between thiol, disulfide, and thiosulfinate forms in response to oxidants and antioxidants inside and outside of cells. Example products include an anti-microbial toothpaste with anti-plaque properties, an anti-inflammatory skin lotion with antioxidant, antimicrobial, and deodorant properties, and an anti-toxin skin lotion with anti-arsenicosis properties.
摘要翻译：用于维护个人外观以及不需要专业保健的良好健康和微小治疗的个人护理产品，以及提供抗微生物，抗氧化，抗炎和抗衰老性能组合的产品适合无处方使用。该产品利用生物膜可渗透的有机硫化合物，其响应于细胞内外的氧化剂和抗氧化剂，可以在硫醇，二硫键和硫代亚磺酸盐形式之间进行氧化还原循环。示例产品包括具有抗斑特性的抗微生物牙膏，具有抗氧化剂，抗微生物和除臭性质的抗炎皮肤洗剂和具有抗砷化学性质的抗毒素皮肤洗剂。

9. 发明授权

US5321344A Control circuit for model railroads 失效
标题翻译：型号铁路控制电路
公开(公告)号：US5321344A
公开(公告)日：1994-06-14
申请号：US877727
申请日：1992-04-04
申请人： Kenneth Ott , David Ott
发明人： Kenneth Ott , David Ott
IPC分类号： A63H19/24 , H02P7/00 , H02P7/74
CPC分类号： A63H19/24 , H02P7/04
摘要： A control circuit for a model railroad utilizes a digital counter to control the modes of motor operation. To select a mode of operation a switch is used to repeatedly ground the base of a transistor circuit, causing pulses to be sent to a counter. By using the switch to hold the base of the transistor to ground, the counter sequencing is locked and prevented from further sequencing until the track power is turned off for a defined minimum amount of time. Release of this switched ground places the circuit under track control where short power interrupts cause the counter to sequence to the next count and therefore to sequence the modes of motor operation.
摘要翻译：用于模型铁路的控制电路利用数字计数器来控制电机操作的模式。为了选择一种操作模式，开关用于重复接地晶体管电路的基极，使脉冲发送到计数器。通过使用开关将晶体管的基极保持接地，计数器排序被锁定并防止进一步排序，直到轨道功率关闭达定义的最小时间量。释放这个开关地面使电路处于跟踪控制状态，短电源中断使计数器顺序到下一个计数，因此对电机运行模式进行排序。

10. 发明授权

US4553719A Vehicle lifting system and method 失效
标题翻译：车辆起重系统及方法
公开(公告)号：US4553719A
公开(公告)日：1985-11-19
申请号：US717644
申请日：1985-04-01
申请人： David Ott
发明人： David Ott
IPC分类号： B64D9/00
CPC分类号： B64D9/00 , Y10S294/904
摘要： An improved carrying assembly is provided for using with, and controlled from, a helicopter to seize and lift immobilized vehicles from freeways and other limited access highways. The carrying assembly may be composed of an integrated and framework having four selectively adjustable vertical leg members, each horizontally positionable one to another, for seizing and supporting the vehicle at appropriate points on its chassis whereby the carrying assembly can engage vehicles of many different sizes and configurations. Control and actuation of each of the different segments of the framework is preferably achieved from within the helicopter, whereby the vehicle targeted from removal can be directly approached from overhead, and whereby the vehicle can be securely seized and lifted without assistance from personnel on the ground.
摘要翻译：提供一种改进的携带组件，用于与直升机一起使用并由其控制，以从高速公路和其他有限的进入高速公路中抓取和提升固定的车辆。承载组件可以由具有四个可选择性调节的垂直腿部构件的整体框架和框架组成，每个水平位置可彼此水平定位，用于在其底盘上的适当点处抓住和支撑车辆，由此承载组件可以接合许多不同尺寸的车辆，配置框架的每个不同部分的控制和致动优选地从直升机内实现，从而可以从顶部直接接近目标去除的车辆，从而可以在没有地面人员协助的情况下可靠地抓取和提起车辆。

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