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1. 发明申请

US20130039864A1 Non-Intravenous Dosage Form Comprising Solid Formulation of Liquid Biologically Active Agent and Uses Thereof 审中-公开
标题翻译：包含液体生物活性剂固体制剂的非静脉内剂型及其用途
公开(公告)号：US20130039864A1
公开(公告)日：2013-02-14
申请号：US13643038
申请日：2011-04-21
申请人： Francois Ravenelle , Dorothee Le Garrec , David Lessard , Sandra Gori , Damon Smith , Miloud Rahmouni , Vinayak Sant
发明人： Francois Ravenelle , Dorothee Le Garrec , David Lessard , Sandra Gori , Damon Smith , Miloud Rahmouni , Vinayak Sant
IPC分类号： A61K47/34 , A61K9/68 , A61P25/00 , A61P1/08 , A61P23/00 , A61P25/20 , A61P25/06 , A61P25/02 , A61K31/05 , A61P25/04 , B82Y40/00 , B82Y5/00
CPC分类号： A61K31/05 , A61K9/0056 , A61K9/1075 , A61K9/1635 , A61K9/19 , A61K9/2095
摘要： The disclosure relates to a non-intravenous dosage for administration of a liquid biologically active agent. The dosage form contains a solid formulation of the liquid biologically active agent, e.g. propofol, in intimate association with at least one stabilizing agent, e.g. an amphiphilic polymer or surfactant. A liquid biologically active agent is converted to a solid product, e.g. a powder, that can be easily incorporated into a number of different non-intravenous dosage forms. Upon hydration, a nanodispersion or micelle loaded with the active agent is formed. The dosage form can provide a non-intravenous route of administration for active agents that are typically only administered intravenously. Methods, uses, kits and commercial packages related to the non-intravenous dosage form are also disclosed.
摘要翻译：本公开涉及用于施用液体生物活性剂的非静脉内剂量。剂型包含液体生物活性剂的固体制剂，例如，异丙酚，与至少一种稳定剂紧密结合，例如。两亲聚合物或表面活性剂。将液体生物活性剂转化为固体产物，例如一种粉末，其可以容易地并入许多不同的非静脉内剂型中。在水合时，形成负载有活性剂的纳米分散体或胶束。剂型可以为通常仅静脉内施用的活性剂提供非静脉内给药途径。还公开了与非静脉内剂型相关的方法，用途，试剂盒和商业包装。

2. 发明授权

US07262253B2 Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers 有权
标题翻译：制备两亲聚（N-乙烯基-2-吡咯烷酮）嵌段共聚物的方法
公开(公告)号：US07262253B2
公开(公告)日：2007-08-28
申请号：US10727083
申请日：2003-12-02
申请人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Wei Liu
发明人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Wei Liu
IPC分类号： C08F126/10 , C08F226/10
CPC分类号： C08G63/00 , C08F293/005 , C08F297/00 , C08F297/02 , C08L53/00 , C08L2666/02
摘要： The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
摘要翻译：本发明提供了制备两亲聚（N-乙烯基-2-吡咯烷酮），（PVP） - 嵌段 - 聚酯共聚物和由PVP作为一个单元组成的其它二嵌段和三嵌段共聚物的两步聚合方法。本发明的嵌段共聚物可用作药物递送的载体。

3. 发明申请

US20050119404A1 Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers 有权
标题翻译：制备两亲聚（N-乙烯基-2-吡咯烷酮）嵌段共聚物的方法
公开(公告)号：US20050119404A1
公开(公告)日：2005-06-02
申请号：US10727083
申请日：2003-12-02
申请人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Liu
发明人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Liu
IPC分类号： C08F26/10 , C08F265/04 , C08F293/00 , C08F297/00 , C08F297/02 , C08K5/05 , C08L53/00
CPC分类号： C08G63/00 , C08F293/005 , C08F297/00 , C08F297/02 , C08L53/00 , C08L2666/02
摘要： The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
摘要翻译：本发明提供了制备两亲聚（N-乙烯基-2-吡咯烷酮），（PVP） - 嵌段 - 聚酯共聚物和由PVP作为一个单元组成的其它二嵌段和三嵌段共聚物的两步聚合方法。本发明的嵌段共聚物可用作药物递送的载体。

4. 发明申请

US20050059958A1 Catheter having an overmolded hub 有权
标题翻译：导管有一个包覆成型的轮毂
公开(公告)号：US20050059958A1
公开(公告)日：2005-03-17
申请号：US10937862
申请日：2004-09-09
申请人： David Lessard , Scott Eells , Gregory Frankland , David Drewes
发明人： David Lessard , Scott Eells , Gregory Frankland , David Drewes
IPC分类号： A61M25/00 , A61M25/16 , B29C45/14
CPC分类号： A61M25/0009 , A61M25/0028 , A61M25/0032 , A61M25/0097 , A61M25/1036
摘要： Catheters having an overmolded hub are disclosed. The overmolded catheter hubs may include one or more access hubs that are overmolded with an overmold material. The catheter hub may also be formed as a single piece from the overmold material. The overmolded construction can result in a stronger bond between the catheter body and the hub and can provide for access hubs having sufficient clarity for the observation of air bubbles in a contained fluid. The disclosed catheter hubs may also demonstrate improved balloon deflation rates when utilized with a catheter body having a distal balloon.
摘要翻译：公开了具有包覆成型毂的导管。包覆成型的导管套管可以包括一个或多个通过包覆成型材料包覆成型的接入轮毂。导管座也可以从包覆成型材料形成为单件。包覆成型的结构可以导致导管主体和轮毂之间的更牢固的结合，并且可以提供具有足够透明度的接近轮毂，用于观察容纳流体中的气泡。当与具有远端气囊的导管主体一起使用时，所公开的导管套还可以显示改进的气囊放气速率。

5. 发明申请

US20120289606A1 Solid Formulations of Liquid Biologically Active Agents 审中-公开
标题翻译：液体生物活性剂的固体制剂
公开(公告)号：US20120289606A1
公开(公告)日：2012-11-15
申请号：US13552993
申请日：2012-07-19
申请人： François Ravenelle , Sandra Gori , David Lessard , Laibin Luo , Dorothée Le Garrec , Damon Smith
发明人： François Ravenelle , Sandra Gori , David Lessard , Laibin Luo , Dorothée Le Garrec , Damon Smith
IPC分类号： A61K31/05 , A61P23/00
摘要： The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.
摘要翻译：本发明涉及包含与稳定剂紧密结合的液体生物活性剂的固体产品; 特别是可以重构为透明，稳定，稳定的纳米分散体或负载胶束的固体产物，其包含作为稳定剂的聚合物和液体，优选与水不混溶的生物活性剂。本发明进一步涉及生产上述固体产品的方法; 特别是通过有效处理包含例如作为稳定剂的聚合物如两亲性嵌段共聚物或小分子量表面活性剂的稳定溶液产生的固体产物的饼或粉末的水合产生的胶束或纳米分散体，装载有液体生物活性剂，例如丙泊酚，任选的添加剂和合适的溶剂。

6. 发明授权

US07838600B2 Process for the preparation of amphiphilic poly(N-vinyl-2-pyrrolidone) block copolymers 有权
标题翻译：制备两亲聚（N-乙烯基-2-吡咯烷酮）嵌段共聚物的方法
公开(公告)号：US07838600B2
公开(公告)日：2010-11-23
申请号：US12211551
申请日：2008-09-16
申请人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Wei Liu
发明人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Wei Liu
IPC分类号： C08F126/10 , C08F226/10
CPC分类号： C08G63/00 , C08F293/005 , C08F297/00 , C08F297/02 , C08L53/00 , C08L2666/02
摘要： The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
摘要翻译：本发明提供了制备两亲聚（N-乙烯基-2-吡咯烷酮），（PVP） - 嵌段 - 聚酯共聚物和由PVP作为一个单元组成的其它二嵌段和三嵌段共聚物的两步聚合方法。本发明的嵌段共聚物可用作药物递送的载体。

7. 发明申请

US20060198891A1 Solid formulations of liquid biologically active agents 审中-公开
标题翻译：液体生物活性剂的固体制剂
公开(公告)号：US20060198891A1
公开(公告)日：2006-09-07
申请号：US11286301
申请日：2005-11-25
申请人： Francois Ravenelle , Sandra Gori , David Lessard , Laibin Luo , Dorothee Garrec , Damon Smith
发明人： Francois Ravenelle , Sandra Gori , David Lessard , Laibin Luo , Dorothee Garrec , Damon Smith
IPC分类号： A61K9/14
摘要： The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.
摘要翻译：本发明涉及包含与稳定剂紧密结合的液体生物活性剂的固体产品; 特别是可以重构为透明，稳定，稳定的纳米分散体或负载胶束的固体产物，其包含作为稳定剂的聚合物和液体，优选与水不混溶的生物活性剂。本发明进一步涉及生产上述固体产品的方法; 特别是通过有效处理包含例如作为稳定剂的聚合物如两亲性嵌段共聚物或小分子量表面活性剂的稳定溶液产生的固体产物的饼或粉末的水合产生的胶束或纳米分散体，装载有液体生物活性剂，例如丙泊酚，任选的添加剂和合适的溶剂。

8. 发明申请

US20090258071A1 COMPOSITIONS AND METHODS FOR PH TARGETED DRUG DELIVERY 审中-公开
标题翻译：用于PH指定药物递送的组合物和方法
公开(公告)号：US20090258071A1
公开(公告)日：2009-10-15
申请号：US12408481
申请日：2009-03-20
申请人： David Lessard , Laibin Luo , Dorothee Le Garrec , Damon Smith
发明人： David Lessard , Laibin Luo , Dorothee Le Garrec , Damon Smith
IPC分类号： A61K9/14 , A61K47/34 , A61K31/437 , A61P35/00
CPC分类号： A61K47/34 , A61K9/19 , A61K31/4745 , C08F297/026 , C08L53/00 , C08L2666/02 , C08L2666/24
摘要： The invention provides compositions and methods for the targeted, in particular, pH targeted, delivery of pharmaceutically active agents in mammals. The compositions comprise pH sensitive diblock copolymers, which permit the release of the pharmaceutically active agent when exposed to an environment having a particular pH. The compositions are particularly useful for the oral delivery of water insoluble pharmaceutically active agents.
摘要翻译：本发明提供了靶向的，特别是靶向靶向的药物活性剂在哺乳动物中的递送的组合物和方法。组合物包含pH敏感的二嵌段共聚物，其允许当暴露于具有特定pH的环境时药物活性剂的释放。所述组合物特别可用于口服递送水不溶性药物活性剂。

9. 发明申请

US20080027205A1 Process for the preparation of amphiphilic poly(n-vinyl-2-pyrrolidone) block copolymers 审中-公开
标题翻译：制备两亲聚（N-乙烯基-2-吡咯烷酮）嵌段共聚物的方法
公开(公告)号：US20080027205A1
公开(公告)日：2008-01-31
申请号：US11834422
申请日：2007-08-06
申请人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Liu
发明人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Liu
IPC分类号： C08G6/00
CPC分类号： C08G63/00 , C08F293/005 , C08F297/00 , C08F297/02 , C08L53/00 , C08L2666/02
摘要： The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
摘要翻译：本发明提供了制备两亲聚（N-乙烯基-2-吡咯烷酮），（PVP） - 嵌段 - 聚酯共聚物和由PVP作为一个单元组成的其它二嵌段和三嵌段共聚物的两步聚合方法。本发明的嵌段共聚物可用作药物递送的载体。

10. 发明申请

US20060016064A1 Medical device including unitary, continuous portion of varying durometer 有权
标题翻译：医疗设备包括单位，连续部分变化的硬度
公开(公告)号：US20060016064A1
公开(公告)日：2006-01-26
申请号：US10813415
申请日：2004-03-30
申请人： Scott Boatman , David Burton , Michael Hoffa , Thomas Osborne , David Drewes , David Lessard , Maggie Hupcey
发明人： Scott Boatman , David Burton , Michael Hoffa , Thomas Osborne , David Drewes , David Lessard , Maggie Hupcey
IPC分类号： B29C47/20 , B29C35/08 , B21B1/46
CPC分类号： A61M25/0009 , A61L29/06 , B29C35/08 , B29K2077/00 , B29L2031/7542 , C08F283/04 , C08G69/48 , Y10T29/4998 , C08L77/00 , C08F218/16
摘要： A medical device (110) including a catheter shaft (111) and a unitarily and continuously formed portion (108) having a varying durometer, and optionally including an expandable balloon (18, 118). One or both of the unitarily and continuously formed portion (108) and the balloon (18, 118) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide.
摘要翻译：一种医疗装置（110），包括导管轴（111）和具有变化的硬度的整体连续形成部分（108），并且可选地包括可膨胀气囊（18,118）。整体和连续形成的部分（108）和球囊（18,118）中的一个或两个由聚酰胺弹性体和至少一种另外的交联反应物的照射交联或可交联混合物制成。聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。芳族分子可以是1,3,5三乙基苯; 1,2,4三乙苯; 和1,3,5三异丙基苯。交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性在其苄基位点处的氢。交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。

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