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1. 发明授权

US07011939B2 Apparatus and method for electrophysiological testing 有权
标题翻译：电生理检测仪器及方法
公开(公告)号：US07011939B2
公开(公告)日：2006-03-14
申请号：US09790871
申请日：2001-02-23
申请人： Jonathan D. Trumbull , Daniel C. Bertrand , Clark A. Briggs , David G. McKenna , Eugene S. Maslana , David P. Blanchard , Jeffrey Y. Pan , Peter Bojan , Thomas A. Nemcek
发明人： Jonathan D. Trumbull , Daniel C. Bertrand , Clark A. Briggs , David G. McKenna , Eugene S. Maslana , David P. Blanchard , Jeffrey Y. Pan , Peter Bojan , Thomas A. Nemcek
IPC分类号： C12Q3/00
CPC分类号： G01N35/028
摘要： A method and apparatus for running a plurality of tests concurrently to obtain data relating to the electrophysiological properties of receptors and channels in biological membranes of test subjects, such as, for example, Xenopus oocytes. The invention further provides software for controlling, acquiring, and recording data relating to electrophysiological properties of receptors and channels in biological membranes of test subjects, such as, for example, oocytes. This invention increases the throughput rate for experiments and assays employing receptors and ion channels expressed in biological membranes of test subjects, such as, for example, oocytes. In the case of an oocyte, these receptors and channels may be natively expressed (endogenous), may be placed into the oocyte (exogenous), or may be expressed from other RNA or DNA previously placed into the oocyte (exogenous).The invention provides a means for a sole researcher to operate a plurality of electrophysiological test stations in the time and space conventionally required by a single electrophysiological test station. The invention automates these stations and provides a means for a sole individual to perform large sets of experiments that would be physically and mentally exhausting in the absence of this invention. In addition, this invention provides efficient database and data analysis software integrated with the data acquisition software, thereby increasing the user's data-handling productivity to keep pace with the augmented data generation capacity.
摘要翻译：一种用于同时运行多个测试以获得与测试对象（例如非洲爪蟾卵母细胞）的生物膜中的受体和通道的电生理学性质有关的数据的方法和装置。本发明还提供了用于控制，获取和记录与测试对象例如卵母细胞的生物膜中的受体和通道的电生理学性质有关的数据的软件。本发明增加了在测试受试者的生物膜（例如卵母细胞）中表达的受体和离子通道的实验和测定的生产率。在卵母细胞的情况下，这些受体和通道可以是天然表达的（内源的），可以被置于卵母细胞（外源的）中，或者可以从先前置于卵母细胞中的其他RNA或DNA表达（外源的）。本发明提供了一种唯一研究者在单个电生理测试台通常所要求的时间和空间中操作多个电生理测试站的手段。本发明使这些站自动化，并提供了一种唯一个体在没有本发明的情况下进行物理和精神上耗尽的大量实验的手段。此外，本发明提供与数据采集软件集成的有效的数据库和数据分析软件，从而增加用户的数据处理生产力，以跟上扩大的数据生成能力。

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