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1. 发明授权

US06491730B1 Pre-treatment methods and compositions for carbon dioxide dry cleaning 有权
标题翻译：用于二氧化碳干洗的预处理方法和组合物
公开(公告)号：US06491730B1
公开(公告)日：2002-12-10
申请号：US09621314
申请日：2000-07-20
申请人： David F. Cauble, Jr. , James P. DeYoung , James B. McClain , Bernadette Storey-Laubach
发明人： David F. Cauble, Jr. , James P. DeYoung , James B. McClain , Bernadette Storey-Laubach
IPC分类号： D06L108
CPC分类号： D06L1/00 , D06L1/16
摘要： A method for dry-cleaning articles such as fabrics and clothing in carbon dioxide. The article includes a stained portion or region, which is pretreated with a pretreatment composition prior to initiating the cleaning cycle. The pretreatment step is followed by contacting the pretreated article to be cleaned with a liquid dry cleaning composition for a time sufficient to clean the article. The liquid dry-cleaning composition comprises a mixture of carbon dioxide, a surfactant, and an organic co-solvent. After the contacting step, the article is separated from the liquid dry cleaning composition. The pretreatment composition, in a preferred embodiment, comprises at least one of (a) a surfactant; (b) d-limonene, and (c) a C12-C15 alkane co-solvent. Preferably the pretreatment composition comprises at least two, and in some particularly preferred embodiments, the pretreatment composition comprises all three, of the aforesaid ingredients.
摘要翻译：用于在二氧化碳中干燥诸如织物和衣服的物品的方法。该制品包括染色部分或区域，其在开始清洁循环之前用预处理组合物预处理。预处理步骤之后，将待处理的待处理制品与液体干洗组合物接触足够时间以清洁制品。液体干洗组合物包含二氧化碳，表面活性剂和有机共溶剂的混合物。在接触步骤之后，将物品与液体干洗组合物分离。在优选实施方案中，预处理组合物包含以下中的至少一种：（a）表面活性剂; （b）d-柠檬烯，和（c）C12-C15烷烃共溶剂。优选地，预处理组合物包含至少两种，在一些特别优选的实施方案中，预处理组合物包含所有三种上述成分。

2. 发明授权

US06218353B1 Solid particulate propellant systems and aerosol containers employing the same 有权
标题翻译：固体颗粒推进剂系统和使用其的气溶胶容器
公开(公告)号：US06218353B1
公开(公告)日：2001-04-17
申请号：US09211674
申请日：1998-12-14
申请人： Timothy J. Romack , David F. Cauble, Jr. , James B. McClain
发明人： Timothy J. Romack , David F. Cauble, Jr. , James B. McClain
IPC分类号： D06L100
CPC分类号： D06L1/00 , D06L1/04
摘要： A liquid composition useful for suspending and dispensing a solid particulate comprises carbon dioxide, a surfactant, an organic co-solvent, and the solid particulate to be suspended. The composition may optionally contain water. The composition is useful as a propellant in an aerosol container for spraying the solid particulate from the container.
摘要翻译：用于悬浮和分散固体颗粒的液体组合物包括二氧化碳，表面活性剂，有机共溶剂和要悬浮的固体颗粒。组合物可任选地含有水。该组合物可用作用于从容器喷射固体颗粒的气溶胶容器中的推进剂。

3. 发明授权

US08293747B2 Heterocyclic amide compounds as protein kinase inhibitors 有权
标题翻译：杂环酰胺化合物作为蛋白激酶抑制剂
公开(公告)号：US08293747B2
公开(公告)日：2012-10-23
申请号：US12669334
申请日：2008-07-17
申请人： Panduranga Adulla P. Reddy , Lianyun Zhao , Praveen K. Tadikonda , Tzu Tshin Wong , Shuyi Tang , Luis E. Torres , David F. Cauble, Jr. , Timothy J. Guzi , M. Arshad Siddiqui
发明人： Panduranga Adulla P. Reddy , Lianyun Zhao , Praveen K. Tadikonda , Tzu Tshin Wong , Shuyi Tang , Luis E. Torres , David F. Cauble, Jr. , Timothy J. Guzi , M. Arshad Siddiqui
IPC分类号： A61K31/506 , C07D401/14 , A61K31/496 , A61K31/497 , A61K31/519 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to novel heterocyclic amide compounds of Formula I: as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease.
摘要翻译：本发明涉及式I的新型杂环酰胺化合物：本文所公开的或其药学上可接受的盐，溶剂化物，酯，前药或立体异构体。还公开了包含所述化合物的组合物，以及使用所述化合物治疗或预防增殖性疾病，抗增殖性疾病，炎症，关节炎，神经性或神经变性疾病，心血管疾病，脱发，神经元疾病，缺血性疾病损伤，病毒性疾病或真菌性疾病。

4. 发明申请

US20100286135A1 HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS 有权
标题翻译：杂环化合物作为蛋白激酶抑制剂
公开(公告)号：US20100286135A1
公开(公告)日：2010-11-11
申请号：US12669334
申请日：2008-07-17
申请人： Panduranga Adulla P. Reddy , Lianyun Zhao , Praveen k. Tadikonda , Tzu Tshin Wong , Shuyi Tang , Luis E. Torres , David F. Cauble, JR. , Timothy J. Guzi , M. Arshad Siddiqui
发明人： Panduranga Adulla P. Reddy , Lianyun Zhao , Praveen k. Tadikonda , Tzu Tshin Wong , Shuyi Tang , Luis E. Torres , David F. Cauble, JR. , Timothy J. Guzi , M. Arshad Siddiqui
IPC分类号： A61K31/5383 , C07D401/14 , C07D413/14 , C07D417/14 , C07D409/14 , C07D405/14 , A61K31/5377 , A61K31/497 , A61K31/445
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to novel heterocyclic amide compounds of Formula I: as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease.
摘要翻译：本发明涉及式I的新型杂环酰胺化合物：本文所公开的或其药学上可接受的盐，溶剂化物，酯，前药或立体异构体。还公开了包含所述化合物的组合物，以及使用所述化合物治疗或预防增殖性疾病，抗增殖性疾病，炎症，关节炎，神经性或神经变性疾病，心血管疾病，脱发，神经元疾病，缺血性疾病损伤，病毒性疾病或真菌性疾病。

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