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1. 发明授权

US4465685A Antiinflammatory pyrazole thioureas 失效
标题翻译：抗炎吡唑硫脲
公开(公告)号：US4465685A
公开(公告)日：1984-08-14
申请号：US331011
申请日：1981-12-15
申请人： Frederick C. Copp , Albert G. Caldwell , David Collard
发明人： Frederick C. Copp , Albert G. Caldwell , David Collard
IPC分类号： C07D231/06 , A61K31/415 , A61P29/00 , A61P37/00 , A61P37/08 , C07D213/06 , C07D401/04 , A61K31/47
CPC分类号： C07D213/06 , C07D401/04
摘要： Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and anti-asthmatic agents.The compounds may be administered as the raw chemical or in association with a carrier as a pharmaceutical formulation.The compounds may be prepared by methods analogous to those known in the art, e.g. by the method of Duffin and Kendall in J. Chem. Soc. (1954), 408-415, or by other methods.
摘要翻译：式（I）化合物（I）抑制花生四烯酸氧合的环加氧酶和脂氧合酶途径，并且可用于例如抗炎和抗哮喘药物的药物中。化合物可以作为原料化学品或与作为药物制剂的载体结合施用。化合物可以通过与本领域已知的方法类似的方法制备，例如通过Duffin和Kendall的方法在J.Chem。 Soc。（1954），408-415或其他方法。

2. 发明授权

US4277498A Amides 失效
标题翻译：酰胺
公开(公告)号：US4277498A
公开(公告)日：1981-07-07
申请号：US59955
申请日：1979-07-23
申请人： Frederick C. Copp , David Collard , Clive V. Denyer
发明人： Frederick C. Copp , David Collard , Clive V. Denyer
IPC分类号： A61K31/16 , A61K31/13 , A61P25/24 , A61P25/26 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/12 , C07C237/00 , C07C237/04 , C07C237/06 , C07D209/48
CPC分类号： C07D209/48 , C07C255/00
摘要： Glycinamides of formula (1):NH.sub.2 CH.sub.2 CONHE (1)wherein E has seven to nine carbon atoms and is branched alkyl, alkylcycloalkyl or cycloalkylalkyl or their acid addition salts, methods of preparing them, pharmaceutical compositions containing them and their use in medicine as anti-depressants.
摘要翻译：式（1）的甘氨酰胺：其中E具有7至9个碳原子并且是支链烷基，烷基环烷基或环烷基烷基或其酸加成盐的NH 2 CH 2 CONHE（1），制备它们的方法，含有它们的药物组合物及其在药物中的用途，抑郁症。

3. 发明授权

US4226876A Arthropodicidal imidazoline derivatives 失效
标题翻译：节肢动物咪唑啉衍生物
公开(公告)号：US4226876A
公开(公告)日：1980-10-07
申请号：US968422
申请日：1978-12-11
申请人： Frederick C. Copp , Peter T. Roberts , Alexander D. Frenkel , David Collard
发明人： Frederick C. Copp , Peter T. Roberts , Alexander D. Frenkel , David Collard
IPC分类号： A01N43/50 , A01N47/16 , A01N47/22 , A01N47/38 , A01N47/42 , C07D233/22 , C07D233/24 , A61K31/415
CPC分类号： A01N47/38 , A01N43/50 , A01N47/16 , A01N47/22 , A01N47/42 , C07D233/22 , C07D233/24
摘要： Compounds of formula (I): ##STR1## wherein Ar is an unsubstituted or mono-, di or tri-substituted phenyl radical in which the substituents are the same or different and are selected from alkyl, alkoxy, halogen, hydroxy, cyano, amino, trifluoromethyl or nitro and in which any two adjacent carbon atoms on the phenyl ring may optionally be joined by a carbon chain having 3 or 4 carbon atoms;X.sup.1 is O or NH;R.sup.1 and R.sup.2 are the same or different and are hydrogen or alkyl; andZ is a group SO.sub.n R.sup.8 or a group ##STR2## in which X.sup.2 is O, S or NR.sup.4 ; R.sup.3 is alkyl, aryl, alkyloxy, aryloxy or NR.sup.5 R.sup.6 ;R.sup.4 is alkyl, aryl, alkyloxy, aryloxy, alkylthio, arylthio or NR.sup.5 R.sup.6 ;R.sup.5 and R.sup.6 are the same or different and are hydrogen, alkyl, aryl, COR.sup.7 or SO.sub.2 R.sup.7 ;R.sup.7 is alkyl, aryl, alkoxy or aryloxy;n is 1 or 2;R.sup.8 is alkyl, aryl or NR.sup.9 R.sup.10 ; andR.sup.9 and R.sup.10 are the same or different and are hydrogen, alkyl or aryl,provided that when Ar is unsubstituted phenyl, X.sup.1 is NH, R.sup.1 and R.sup.2 are H, Z is ##STR3## and X.sup.2 is 0, R.sup.3 is not methyl, methods of making such compounds, pesticidal formulations containing them and their use as pesticides are disclosed.
摘要翻译：式（I）的化合物：其中Ar是未取代的或单，二或三取代的苯基，其中取代基相同或不同，并且选自烷基，烷氧基，卤素，羟基，氰基，氨基，三氟甲基或硝基，并且其中苯环上任何两个相邻的碳原子可任选地被具有3或4个碳原子的碳链连接; X1是O或NH; R1和R2相同或不同，为氢或烷基; Z为X，O，S或NR4的基团SOnR8或基团; R3是烷基，芳基，烷氧基，芳氧基或NR5R6; R4是烷基，芳基，烷氧基，芳氧基，烷硫基，芳硫基或NR5R6; R5和R6相同或不同，为氢，烷基，芳基，COR7或SO2R7; R7是烷基，芳基，烷氧基或芳氧基; n为1或2; R8是烷基，芳基或NR9R10; 并且R 9和R 10相同或不同，为氢，烷基或芳基，条件是当Ar为未取代的苯基时，X 1为NH，R 1和R 2为H，Z为X，X 2为0，R 3不为甲基，公开了制备这些化合物的方法，含有它们的杀虫剂及其作为杀虫剂的用途。

4. 发明授权

US08603705B2 Polymer film-producing methods and devices produced therefrom 有权
标题翻译：由其制造的聚合物膜制造方法和装置
公开(公告)号：US08603705B2
公开(公告)日：2013-12-10
申请号：US13077896
申请日：2011-03-31
申请人： Avishek Aiyar , Rakesh Nambiar , David Collard , Elsa Reichmanis
发明人： Avishek Aiyar , Rakesh Nambiar , David Collard , Elsa Reichmanis
IPC分类号： G03H3/00 , C08J3/28
CPC分类号： H01B1/127 , C08G61/126 , C08G2261/3223 , C08J5/2256 , C08J2353/02 , H01L51/0037 , H01L51/007
摘要： Described herein are improved methods of forming polymer films, the polymer films formed thereby, and electronic devices formed form the polymer films. The methods generally include contacting a polymer with a solvent to at least partially solvate the polymer in the solvent, exposing the at least partially solvated polymer and solvent to ultrasonic energy for a duration effective to form a plurality of ordered assemblies of the polymer in the solvent, and forming a solid film of the polymer, wherein the solid film comprises the plurality of ordered assemblies of the polymer.
摘要翻译：本文描述了形成聚合物膜，由此形成的聚合物膜以及由聚合物膜形成的电子器件的改进方法。方法通常包括使聚合物与溶剂接触以使溶剂中的聚合物至少部分溶剂化，将至少部分溶剂化的聚合物和溶剂暴露于超声波能量，持续时间有效地在溶剂中形成多个有序聚合物，并形成聚合物的固体膜，其中固体膜包含聚合物的多个有序组件。

5. 发明授权

US4572913A Use of 3-(arylmethyleneamino)-1-aryl-2-pyrazolines in the prophylaxis and treatment of inflammation, pain, pyresis, and asthma 失效
标题翻译： 3-（芳基亚甲基氨基）-1-芳基-2-吡唑啉在预防和治疗炎症，疼痛，溶血和哮喘中的应用
公开(公告)号：US4572913A
公开(公告)日：1986-02-25
申请号：US331009
申请日：1981-12-15
申请人： Frederick C. Copp , Albert G. Caldwell , David Collard
发明人： Frederick C. Copp , Albert G. Caldwell , David Collard
IPC分类号： C07D231/06 , A61K31/415 , A61K31/44 , A61K31/47
CPC分类号： C07D231/06
摘要： Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and anti-asthmatic agents.The compounds may be administered as the raw chemical or in association with a carrier as a pharmaceutical formulation.The compounds may be prepared by methods analogous to those known in the art, e.g., by the method of Duffin and Kendall in J. Chem. Soc. (1954), 408-415, or by other methods.
摘要翻译：式（I）化合物（I）抑制花生四烯酸氧合的环加氧酶和脂氧合酶途径，并且可用于例如抗炎和抗哮喘药物的药物中。化合物可以作为原料化学品或与作为药物制剂的载体结合施用。化合物可以通过类似于本领域已知的方法制备，例如通过Duffin和Kendall的方法在J.Chem.Soc。 Soc。（1954），408-415或其他方法。

6. 发明授权

US4564684A 3-Amino-1-phenyl-2-pyrazolines 失效
标题翻译： 3-氨基-1-苯基-2-吡唑啉
公开(公告)号：US4564684A
公开(公告)日：1986-01-14
申请号：US614371
申请日：1984-05-23
申请人： Frederick C. Copp , Albert G. Caldwell , David Collard
发明人： Frederick C. Copp , Albert G. Caldwell , David Collard
IPC分类号： A61K31/415 , A61P29/00 , A61P37/08 , A61P43/00 , C07D213/77 , C07D231/06 , C07D401/04
CPC分类号： C07D213/77 , C07D231/06 , C07D401/04
摘要： Heterocyclic compounds of formula (I) and acid addition salts thereof inhibit arachidonic acid oxygenation and are useful in medicine, for example as anti-inflammatory agents. ##STR1## The compounds of formula (I) may be prepared by any method analogous to those known in the art, for example by the method of G. F. Duffin and J. D. Kendall in J. Chem. Soc. (1954), 408-415. When used in medicine, the compounds of formula (I) may be administered as the compound alone or as a pharmaceutical formulation together with a pharmaceutically acceptable carrier.
摘要翻译：式（I）的杂环化合物及其酸加成盐抑制花生四烯酸氧合，可用于医药，例如抗炎剂。（I）式（I）化合物可以通过与本领域已知的方法类似的任何方法制备，例如通过G.F.Duffin和J.D.Kendall在J.Chem.Soc。 Soc。（1954），408-415。当用于药物时，式（I）化合物可以单独或作为药物制剂与药学上可接受的载体一起作为化合物施用。

7. 发明申请

US20120088901A1 POLYMER FILM-PRODUCING METHODS AND DEVICES PRODUCED THEREFROM 有权
标题翻译：聚合物膜生产方法和生产的装置
公开(公告)号：US20120088901A1
公开(公告)日：2012-04-12
申请号：US13077896
申请日：2011-03-31
申请人： Avishek Aiyar , Rakesh Nambiar , David Collard , Elsa Reichmanis
发明人： Avishek Aiyar , Rakesh Nambiar , David Collard , Elsa Reichmanis
IPC分类号： C08G75/06 , B06B1/00
CPC分类号： H01B1/127 , C08G61/126 , C08G2261/3223 , C08J5/2256 , C08J2353/02 , H01L51/0037 , H01L51/007
摘要： Described herein are improved methods of forming polymer films, the polymer films formed thereby, and electronic devices formed form the polymer films. The methods generally include contacting a polymer with a solvent to at least partially solvate the polymer in the solvent, exposing the at least partially solvated polymer and solvent to ultrasonic energy for a duration effective to form a plurality of ordered assemblies of the polymer in the solvent, and forming a solid film of the polymer, wherein the solid film comprises the plurality of ordered assemblies of the polymer.
摘要翻译：本文描述了形成聚合物膜，由此形成的聚合物膜以及由聚合物膜形成的电子器件的改进方法。方法通常包括使聚合物与溶剂接触以使溶剂中的聚合物至少部分溶剂化，将至少部分溶剂化的聚合物和溶剂暴露于超声波能量，持续时间有效地在溶剂中形成多个有序聚合物，并形成聚合物的固体膜，其中固体膜包含聚合物的多个有序组件。

8. 发明授权

US4414223A Pesticidal anilinomethylimidazolines 失效
标题翻译：杀虫剂苯胺基甲基咪唑
公开(公告)号：US4414223A
公开(公告)日：1983-11-08
申请号：US264305
申请日：1981-05-18
申请人： Frederick C. Copp , Peter T. Roberts , Alexander D. Frenkel , David Collard
发明人： Frederick C. Copp , Peter T. Roberts , Alexander D. Frenkel , David Collard
IPC分类号： A01N43/50 , A01N47/16 , A01N47/22 , A01N47/38 , A01N47/42 , C07D233/22 , C07D233/24
CPC分类号： C07D233/22 , A01N43/50 , A01N47/16 , A01N47/22 , A01N47/38 , A01N47/42 , C07D233/24
摘要： 1-Phenoxyalkyl- and 1-anilinoalkyl imidazolines, methods for the preparation thereof, the use thereof as intermediates and pesticides and pesticidal formulations containing such compounds.
摘要翻译： 1-苯氧基烷基和1-苯胺基烷基咪唑啉，其制备方法，其作为中间体的用途和农药以及含有这些化合物的杀虫剂。

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